Growth and differentiation factor 15: An emerging therapeutic target for brain diseases.

IF 5.7 4区 生物学 Q1 BIOLOGY
Bioscience trends Pub Date : 2025-03-06 Epub Date: 2025-01-25 DOI:10.5582/bst.2024.01305
Yingying Zhou, Lei Dou, Luyao Wang, Jiajie Chen, Ruxue Mao, Lingqiang Zhu, Dan Liu, Kai Zheng
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引用次数: 0

Abstract

Growth and differentiation factor 15 (GDF15), a member of the transforming growth factor-βsuperfamily, is considered a stress response factor and has garnered increasing attention in recent years due to its roles in neurological diseases. Although many studies have suggested that GDF15 expression is elevated in patients with neurodegenerative diseases (NDDs), glioma, and ischemic stroke, the effects of increased GDF15 expression and the potential underlying mechanisms remain unclear. Notably, many experimental studies have shown the multidimensional beneficial effects of GDF15 on NDDs, and GDF15 overexpression is able to rescue NDD-associated pathological changes and phenotypes. In glioma, GDF15 exerts opposite effects, it is both protumorigenic and antitumorigenic. The causes of these conflicting findings are not comprehensively clear, but inhibiting GDF15 is helpful for suppressing tumor progression. GDF15 is also regarded as a biomarker of poor clinical outcomes in ischemic stroke patients, and targeting GDF15 may help prevent this disease. Thus, we systematically reviewed the synthesis, transcriptional regulation, and biological functions of GDF15 and its related signaling pathways within the brain. Furthermore, we explored the potential of GDF15 as a therapeutic target and assessed its clinical applicability in interventions for brain diseases. By integrating the latest research findings, this study provides new insights into the future treatment of neurological diseases.

生长分化因子15 (Growth and differentiation factor 15, GDF15)是转化生长因子-β超家族的一员,被认为是一种应激反应因子,近年来因其在神经系统疾病中的作用而受到越来越多的关注。尽管许多研究表明GDF15在神经退行性疾病(ndd)、胶质瘤和缺血性卒中患者中表达升高,但GDF15表达升高的影响及其潜在机制尚不清楚。值得注意的是,许多实验研究表明GDF15对ndd具有多方面的有益作用,并且GDF15过表达能够挽救ndd相关的病理改变和表型。在胶质瘤中,GDF15发挥相反的作用,它具有致蛋白性和抗肿瘤性。这些相互矛盾的发现的原因尚不完全清楚,但抑制GDF15有助于抑制肿瘤进展。GDF15也被认为是缺血性卒中患者临床预后不良的生物标志物,靶向GDF15可能有助于预防这种疾病。因此,我们系统地综述了GDF15的合成、转录调控、生物学功能及其在大脑中的相关信号通路。此外,我们探索了GDF15作为治疗靶点的潜力,并评估了其在脑部疾病干预中的临床适用性。通过整合最新的研究成果,本研究为未来神经系统疾病的治疗提供了新的见解。
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来源期刊
CiteScore
13.60
自引率
1.80%
发文量
47
审稿时长
>12 weeks
期刊介绍: BioScience Trends (Print ISSN 1881-7815, Online ISSN 1881-7823) is an international peer-reviewed journal. BioScience Trends devotes to publishing the latest and most exciting advances in scientific research. Articles cover fields of life science such as biochemistry, molecular biology, clinical research, public health, medical care system, and social science in order to encourage cooperation and exchange among scientists and clinical researchers.
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