Bioscience trends最新文献_第9页

Feasibility of novel intraoperative navigation for anatomical liver resection using real-time virtual sonography combined with indocyanine green fluorescent imaging technology. 利用实时虚拟声像图结合吲哚青绿荧光成像技术，为解剖性肝脏切除术提供新型术中导航的可行性。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-13 DOI: 10.5582/bst.2023.01265

Changsheng Pu, Tiantian Wu, Qiang Wang, Yinmo Yang, Keming Zhang

{"title":"Feasibility of novel intraoperative navigation for anatomical liver resection using real-time virtual sonography combined with indocyanine green fluorescent imaging technology.","authors":"Changsheng Pu, Tiantian Wu, Qiang Wang, Yinmo Yang, Keming Zhang","doi":"10.5582/bst.2023.01265","DOIUrl":"10.5582/bst.2023.01265","url":null,"abstract":"To analyze the feasibility and clinical effect of novel intraoperative navigation of real-time virtual sonography (RVS) combined with indocyanine green (ICG) fluorescent imaging technology in anatomical liver resection (ALR) for hepatocellular carcinoma. The clinical data of 41 patients who underwent ALR using RVS intraoperative navigation combined with ICG fluorescent imaging technology in the Department of Hepatobiliary Surgery of Peking University International Hospital from January 2020 to May 2022 were retrospectively analyzed. RVS was applied to guide the surgical plane through fusing real-time intraoperative ultrasound images with corresponding preoperative CT or MRI images. Operation methods, operation time, intraoperative blood loss, operative margin, hospital stay and postoperative complications were analyzed. The 1-year overall survival rate and tumor-free survival rate of patients were followed up by outpatient review or telephone calls. ALR surgery was performed on each of 41 patients. There were no deaths during perioperative period and postoperative complications occurred in 7 cases (17.1%). The postoperative pathological examinations demonstrated all cases of hepatocellular carcinoma and negative operative margins. The 41 patients were followed up for 12 to 20 months, with a median follow-up time of 14 months. The overall survival rate 1 year after surgery was 100.0% (41/41), 3 patients (7.3%) experienced tumor recurrence, and the tumor-free survival rate of 1 year after surgery was 92.7% (38/41). In conclusion, novel intraoperative navigation of RVS combined with ICG fluorescent imaging technology is safe and feasible in anatomical segmental hepatectomy of hepatocellular carcinoma.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"484-490"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immune response of hepatocellular carcinoma after locoregional and systemic therapies: The available combination option for immunotherapy. 肝细胞癌局部和全身治疗后的免疫反应:免疫治疗的可用组合选择。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-11-19 DOI: 10.5582/bst.2023.01275

Yuxin Duan, Hua Zhang, Tao Tan, Wentao Ye, Kunli Yin, Yanxi Yu, Meiqing Kang, Jian Yang, Rui Liao

{"title":"The immune response of hepatocellular carcinoma after locoregional and systemic therapies: The available combination option for immunotherapy.","authors":"Yuxin Duan, Hua Zhang, Tao Tan, Wentao Ye, Kunli Yin, Yanxi Yu, Meiqing Kang, Jian Yang, Rui Liao","doi":"10.5582/bst.2023.01275","DOIUrl":"10.5582/bst.2023.01275","url":null,"abstract":"Hepatocellular carcinoma (HCC) is associated with a highly heterogeneous immune environment that produces an immune response to various locoregional treatments (LRTs), which in turn affects the effectiveness of immunotherapy. Although LRTs still dominate HCC therapies, 50-60% of patients will ultimately be treated with systemic therapies and might receive those treatments for the rest of their life. TACE, SIRT, and thermal ablation can dramatically increase the immunosuppressive state of HCC, a condition that can be addressed by combination with immunotherapy to restore the activity of lymphocytes and the secretion of cellular immune factors. Immune treatment with locoregional and systemic treatments has dramatically changed the management of HCC. In this review, we examine the research on the changes in the immune microenvironment after locoregional or systemic treatment. We also summarize the regulation of various immune cells and immune factors in the tumor microenvironment and discuss the different infiltration degrees of immune cells and factors on the prognosis of HCC to better compare the efficacy between different treatment methods from the perspective of the tumor microenvironment. This information can be used to help develop treatment options for the upcoming new era of HCC treatment in the future.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"427-444"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on diagnosis and treatment of hepatoblastoma. 肝母细胞瘤诊断和治疗的最新进展。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-23 DOI: 10.5582/bst.2023.01311

Yinbiao Cao, Shurui Wu, Haowen Tang

{"title":"An update on diagnosis and treatment of hepatoblastoma.","authors":"Yinbiao Cao, Shurui Wu, Haowen Tang","doi":"10.5582/bst.2023.01311","DOIUrl":"10.5582/bst.2023.01311","url":null,"abstract":"Hepatoblastoma (HB) remains the most common paediatric liver tumour and survival in children with hepatoblastoma has improved considerably since the advent of sequential surgical regimens of chemotherapy based on platinum-based chemotherapeutic agents in the 1980s. With the advent of modern diagnostic imaging and pathology techniques, new preoperative chemotherapy regimens and the maturation of surgical techniques, new diagnostic and treatment options for patients with hepatoblastoma have emerged and international collaborations are investigating the latest diagnostic approaches, chemotherapy drug combinations and surgical strategies. Diagnosis of hepatoblastoma relies on imaging studies (such as ultrasound, computed tomography, and magnetic resonance imaging), alpha-fetoprotein (AFP) levels, and histological confirmation through biopsy. The standard treatment approach involves a multimodal strategy with neoadjuvant chemotherapy followed by surgical resection. In cases where complete resection is not feasible or tumors exhibit invasive characteristics, liver transplantation is considered. The management of metastatic and recurrent hepatoblastoma poses significant challenges, and ongoing research focuses on developing targeted therapies and exploring the potential of immunotherapy. Further studies are necessary to gain a better understanding of the etiology of hepatoblastoma, develop prevention strategies, and personalize treatment approaches. We aim to review the current status of diagnosis and treatment of hepatoblastoma.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"445-457"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pal power: Demonstration of the functional association of the Helicobacter pylori flagellar motor with peptidoglycan-associated lipoprotein (Pal) and its preliminary crystallographic analysis. Pal的力量幽门螺旋杆菌鞭毛马达与肽聚糖相关脂蛋白（Pal）功能关联的证明及其初步晶体学分析。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-08 DOI: 10.5582/bst.2023.01278

Xiaotian Zhou, Mohammad M Rahman, Sharmin Q Bonny, Yue Xin, Nikki Liddelow, Mohammad F Khan, Alexandra Tikhomirova, Jihane Homman-Ludiye, Anna Roujeinikova

{"title":"Pal power: Demonstration of the functional association of the Helicobacter pylori flagellar motor with peptidoglycan-associated lipoprotein (Pal) and its preliminary crystallographic analysis.","authors":"Xiaotian Zhou, Mohammad M Rahman, Sharmin Q Bonny, Yue Xin, Nikki Liddelow, Mohammad F Khan, Alexandra Tikhomirova, Jihane Homman-Ludiye, Anna Roujeinikova","doi":"10.5582/bst.2023.01278","DOIUrl":"10.5582/bst.2023.01278","url":null,"abstract":"The bacterial flagellar motor is a molecular nanomachine, the assembly and regulation of which requires many accessory proteins. Their identity, structure and function are often discovered through characterisation of mutants with impaired motility. Here, we demonstrate the functional association of the Helicobacter pylori peptidoglycan-associated lipoprotein (HpPal) with the flagellar motor by analysing the motility phenotype of the ∆pal mutant, and present the results of the preliminary X-ray crystallographic analysis of its globular C-terminal domain HpPal-C. Purified HpPal-C behaved as a dimer in solution. Crystals of HpPal-C were grown by the hanging drop vapour diffusion method using medium molecular weight polyethylene glycol (PEG) Smear as the precipitating agent. The crystals belong to the primitive orthorhombic space group P1 with unit cell parameters a = 50.7, b = 63.0, c = 75.1 Å. X-ray diffraction data were collected to 1.8 Å resolution on the Australian Synchrotron beamline MX2. Calculation of the Matthews coefficient (VM=2.24 Å3/Da) and molecular replacement showed that the asymmetric unit contains two protein subunits. This study is an important step towards elucidation of the non-canonical role of H. pylori Pal in the regulation, or function of, the flagellar motor.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"491-498"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of the female genital tract and gut microbiome on reproductive dysfunction. 女性生殖道和肠道微生物群对生殖功能障碍的影响。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-17 DOI: 10.5582/bst.2023.01133

Wenli Cao, Xiayan Fu, Jing Zhou, Qing Qi, Feijun Ye, Lisha Li, Ling Wang

{"title":"The effect of the female genital tract and gut microbiome on reproductive dysfunction.","authors":"Wenli Cao, Xiayan Fu, Jing Zhou, Qing Qi, Feijun Ye, Lisha Li, Ling Wang","doi":"10.5582/bst.2023.01133","DOIUrl":"10.5582/bst.2023.01133","url":null,"abstract":"Microorganisms are ubiquitous in the human body; they are present in various areas including the gut, mouth, skin, respiratory tract, and reproductive tract. The interaction between the microbiome and reproductive health has become an increasingly compelling area of study. Disruption of the female genital tract microbiome can significantly impact the metabolism of amino acids, carbohydrates, and lipids, increasing susceptibility to reproductive tract diseases such as vaginitis, chronic endometritis, endometrial polyps, endometriosis, and polycystic ovary syndrome. The gut microbiome, considered an endocrine organ, plays a crucial role in the reproductive endocrine system by interacting with hormones like estrogen and androgens. Imbalances in the gut microbiome composition can lead to various diseases and conditions, including polycystic ovary syndrome, endometriosis, and cancer, although research on their mechanisms remains limited. This review highlights the latest advancements in understanding the female genital tract and gut microbiomes in gynecological diseases. It also explores the potential of microbial communities in the treatment of reproductive diseases. Future research should focus on identifying the molecular mechanisms underlying the association between the microbiome and reproductive diseases to develop new and effective strategies for disease prevention, diagnosis, and treatment related to female reproductive organs.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"458-474"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conversion therapy for initially unresectable hepatocellular carcinoma: Current status and prospects. 最初无法切除的肝细胞癌的转化疗法：现状与前景。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-23 DOI: 10.5582/bst.2023.01322

Ya-Nan Ma, Xuemei Jiang, Hui Liu, Peipei Song, Wei Tang

{"title":"Conversion therapy for initially unresectable hepatocellular carcinoma: Current status and prospects.","authors":"Ya-Nan Ma, Xuemei Jiang, Hui Liu, Peipei Song, Wei Tang","doi":"10.5582/bst.2023.01322","DOIUrl":"10.5582/bst.2023.01322","url":null,"abstract":"Research has shown that locoregional and/or systemic treatments can reduce the tumor stage, enabling radical surgical resection in patients with initially unresectable hepatocellular carcinoma. This is referred to as conversion therapy. Patients who undergo conversion therapy followed by curative surgery experience a significant survival benefit compared to those who receive chemotherapy alone, those who are successfully downstaged with conversion therapy but not treated with surgery, or those who are treated with upfront surgery. Several treatments have been studied as conversion therapy. However, the success rate of conversion varies greatly, ranging from 0.8% to 60%. Combined locoregional plus systemic conversion therapy has demonstrated significant clinical advantages, with a conversion rate of up to 60%, an objective remission rate of 96% for patients, and a disease control rate of up to 100%. However, patients who underwent conversion therapy experienced significantly more complications than those who underwent direct LR without conversion therapy. Conversion therapy can cause hepatotoxicity, bone marrow suppression, local adhesions, increased fragility of blood vessels and liver tissues, and hepatic edema, which can increase the difficulty of surgery. In addition, criteria need to be established to evaluate the efficacy of conversion therapy and subsequent treatment. Further clinical evidence in this area is urgently needed.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"415-426"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the treatment of advanced pancreatic cancer. 晚期胰腺癌的治疗趋势。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01156

Hirokazu Momose, Shohei Kudo, Tomoyuki Yoshida, Nobuhiro Hasui, Ryota Matsuki, Masaharu Kogure, Yoshihiro Sakamoto

引用次数: 0

Expert consensus on sequential surgery after immune-targeted conversion therapy for advanced hepatocellular carcinoma in China. 中国晚期肝癌免疫靶向转化治疗后序贯手术的专家共识

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01423

Peipei Song, Wei Tang, Norihiro Kokudo

引用次数: 0

Addressing healthy aging in China: Practices and prospects. 中国应对健康老龄化：实践与展望。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01180

Haiyin Wang, Dan Qin, Liang Fang, Hui Liu, Peipei Song

{"title":"Addressing healthy aging in China: Practices and prospects.","authors":"Haiyin Wang, Dan Qin, Liang Fang, Hui Liu, Peipei Song","doi":"10.5582/bst.2024.01180","DOIUrl":"https://doi.org/10.5582/bst.2024.01180","url":null,"abstract":"One important challenge for global development is aging. China is one of the world's countries with the highest elderly population and the most rapid aging; in 2022, the percentage of the population over 65 was 14.9%; by 2050, it is expected to rise to 26.1%. China's health security, elderly care, and healthcare services are facing serious challenges as a result of this aging trend. With 80% of provinces including medical and elderly care in national basic public health care programs, China has adopted a proactive national plan to combat population aging. Moreover, geriatric departments have been established at 69.3% of public general hospitals at secondary and higher tiers, 48% of provinces have devises preventive interventions for disability and dementia in the elderly, 48 percent of provinces are serving as test regions for medical care related to rehabilitation, and 49 cities are involved in long-term care insurance (LTCI) trials that encompass 170 million people. There are 4,259 medical and health care facilities that provide hospice care services, 152 hospice care pilot regions, and 87,000 pairs of contracts between medical and health care facilities and elderly care providers. These developments provide a strong basis, but there are still major obstacles to overcome. The Chinese Government is urged to adopt early preventive measures, offer more ongoing, practical, and cost-effective diagnostic and treatment services, allocate resources equitably, and use intelligent technologies to enhance elderly care. The ultimate goals are to lessen the financial burden, enhance the health of the elderly, and offer a vital global resource.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":"18 3","pages":"212-218"},"PeriodicalIF":5.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia and risk of cardio-cerebrovascular disease: A two-sample Mendelian randomization study. Sarcopenia与心脑血管疾病风险：一项两样本孟德尔随机化研究。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-21 DOI: 10.5582/bst.2023.01246

Qifeng Ou, Ding Pan

{"title":"Sarcopenia and risk of cardio-cerebrovascular disease: A two-sample Mendelian randomization study.","authors":"Qifeng Ou, Ding Pan","doi":"10.5582/bst.2023.01246","DOIUrl":"10.5582/bst.2023.01246","url":null,"abstract":"Based on the association between sarcopenia and the risk of developing cardio-cerebrovascular disease (CCVD) established by a meta-analysis by Fang et al.(Biosci Trends. 2023; 17:293-301), we have used Mendelian randomization (MR) analysis to test the authenticity and accuracy of such an association. In this MR study, appendicular lean mass, handgrip strength, and walking pace were used as sarcopenia-related traits, with cardiovascular diseases and stroke set as outcomes of CCVD. MR analysis was performed using inverse-variance weighting, the MR Egger, weighted median, simple mode, and weighted mode. No heterogeneity or horizontal pleiotropy in MR estimates was observed (Cochran's Q P value > 0.05, MR-PRESSO global test P value > 0.05, and MR-Egger intercept P value > 0.05). Results of that analysis proved a causal relationship between sarcopenia-related traits and cardio-cerebrovascular disease, with a causal association between appendicular lean mass and cardiovascular diseases and an inverse causal relationship between appendicular lean mass and stroke. However, such a relationship was absent in the case of handgrip strength and the risk of cardiovascular diseases as well as in the case of walking pace and lacunar/ischemic stroke. Therefore, the effect of sarcopenia on CCVD should be carefully explained.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"413-414"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0