Bioscience trends最新文献

{"title":"New possibilities for medical support systems utilizing artificial intelligence (AI) and data platforms.","authors":"Kenji Karako,&nbsp;Peipei Song,&nbsp;Yu Chen,&nbsp;Wei Tang","doi":"10.5582/bst.2023.01138","DOIUrl":"https://doi.org/10.5582/bst.2023.01138","url":null,"abstract":"<p><p>In Japan, there is a growing initiative to construct centralized databases and platforms that can aggregate and manage a vast range of medical, health, and caregiving data for research and analysis. Recent advancements in artificial intelligence (AI), particularly in general-purpose models like the Segment Anything model and Chat GPT, promise significant progress towards utilizing such data-rich platforms effectively for healthcare. Traditionally, AI has displayed superior performance by learning specific images or languages, but now it is advancing towards creating models capable of learning universal traits from images and languages by training on extensive datasets. The challenge lies in the fact that these general-purpose models are trained on data that does not sufficiently incorporate medical information, making their direct application to healthcare difficult. However, the introduction of data platforms can potentially solve this problem. This would lead to the development of universally applicable models to process medical images and AI assistants that can support both doctors and patients. These medical AI assistants can function as a \"sub-doctor\" with extensive knowledge, assisting in comprehensive analysis of symptoms, early detection of rare diseases, and more. They can also serve as an intermediary between the doctor and the patient, helping to simplify consultations and enhance patient understanding of medical conditions and treatments. By bridging this gap, the AI assistant can help to reduce doctors' workload, improve the quality of healthcare, and facilitate early detection and prevention in the elderly population.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10176056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Devising novel near-infrared aggregation-induced-emission luminogen labeling for point-of-care diagnosis of Mycobacterium tuberculosis.","authors":"Guiqin Dai,&nbsp;Pengfei Zhao,&nbsp;Lijun Song,&nbsp;Zhuojun He,&nbsp;Deliang Liu,&nbsp;Xiangke Duan,&nbsp;Qianting Yang,&nbsp;Wenchang Zhao,&nbsp;Jiayin Shen,&nbsp;Tetsuya Asakawa,&nbsp;Mingbin Zheng,&nbsp;Hongzhou Lu","doi":"10.5582/bst.2023.01087","DOIUrl":"https://doi.org/10.5582/bst.2023.01087","url":null,"abstract":"<p><p>Detecting and appropriately diagnosing a Mycobacterium tuberculosis infection remains technologically difficult because the pathogen commonly hides in macrophages in a dormant state. Described here is novel near-infrared aggregation-induced-emission luminogen (AIEgen) labeling developed by the current authors' laboratory for point-of-care (POC) diagnosis of an M. tuberculosis infection. The selectivity of AIEgen labeling, the labeling of intracellular M. tuberculosis by AIEgen, and the labeling of M. tuberculosis in sputum samples by AIEgen, along with its accuracy, sensitivity, and specificity, were preliminarily evaluated. Results indicated that this near-infrared AIEgen labeling had satisfactory selectivity and it labeled intracellular M. tuberculosis and M. tuberculosis in sputum samples. It had a satisfactory accuracy (95.7%), sensitivity (95.5%), and specificity (100%) for diagnosis of an M. tuberculosis infection in sputum samples. The current results indicated that near-infrared AIEgen labeling might be a promising novel diagnostic tool for POC diagnosis of M. tuberculosis infection, though further rigorous verification of these findings is required.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9851218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized concurrent hearing and genetic screening in Beijing, China: A cross-sectional study.","authors":"Cheng Wen,&nbsp;Xiaozhe Yang,&nbsp;Xiaohua Cheng,&nbsp;Wei Zhang,&nbsp;Yichen Li,&nbsp;Jing Wang,&nbsp;Chuan Wang,&nbsp;Yu Ruan,&nbsp;Liping Zhao,&nbsp;Hongli Lu,&nbsp;Yingxin Li,&nbsp;Yue Bai,&nbsp;Yiding Yu,&nbsp;Yue Li,&nbsp;Jinge Xie,&nbsp;Bei-Er Qi,&nbsp;Hui En,&nbsp;Hui Liu,&nbsp;Xinxing Fu,&nbsp;Lihui Huang,&nbsp;Demin Han","doi":"10.5582/bst.2023.01051","DOIUrl":"https://doi.org/10.5582/bst.2023.01051","url":null,"abstract":"<p><p>Concurrent screening has been proven to provide a comprehensive approach for management of congenital deafness and prevention of ototoxicity. The SLC26A4 gene is associated with late-onset hearing loss and is of great clinical concern. For much earlier detection of newborns with deafness-causing mutations in the SLC26A4 gene, the Beijing Municipal Government launched a chip for optimized genetic screening of 15 variants of 4 genes causing deafness based on a chip to screen for 9 variants of 4 genes, and 6 variants of the SLC26A4 gene have now been added. To ascertain the advantage of a screening chip including 15 variants of 4 genes, the trends in concurrent hearing and genetic screening were analyzed in 2019 and 2020. Subjects were 76,460 newborns who underwent concurrent hearing and genetic screening at 24 maternal and child care centers in Beijing from January 2019 to December 2020. Hearing screening was conducted using transiently evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic emissions (DPOAE), or the automated auditory brainstem response (AABR). Dried blood spots were collected for genetic testing and 15 variants of 4 genes, namely GJB2, SLC26A4, mtDNA 12S rRNA, and GJB3, were screened for using a DNA microarray platform. The initial referral rate for hearing screening decreased from 3.60% (1,502/41,690) in 2019 to 3.23% (1,124/34,770) in 2020, and the total referral rate for hearing screening dropped form 0.57% (236/41,690) in 2019 to 0.54% (187/34,770) in 2020, indicating the reduced false positive rate of newborn hearing screening and policies to prevent hearing loss conducted by the Beijing Municipal Government have had a significant effect. Positivity according to genetic screening was similar in 2019 (4.970%, 2,072/41,690) and 2020 (4.863%,1,691/34,770), and the most frequent mutant alleles were c.235 del C in the GJB2 gene, followed by c.919-2 A > G in the SLC26A4 gene, and c.299 del AT in the GJB2 gene. In this cohort study, 71.43% (5/7) of newborns with 2 variants of the SLC26A4 gene were screened for newly added mutations, and 28.57% (2/7) of newborns with 2 variants of the SLC26A4 gene passed hearing screening, suggesting that a screening chip including 15 variants of 4 genes was superior at early detection of hearing loss, and especially in early identification of newborns with deafness-causing mutations in the SLC26A4 gene. These findings have clinical significance.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9467818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decrease in CD226 expression on CD4⁺ T cells in patients with endometriosis.","authors":"Cui Li,&nbsp;Jing Zhou,&nbsp;Jun Shao,&nbsp;Lei Yuan,&nbsp;Qiang Cheng,&nbsp;Ling Wang,&nbsp;Zhongliang Duan","doi":"10.5582/bst.2022.01501","DOIUrl":"https://doi.org/10.5582/bst.2022.01501","url":null,"abstract":"<p><p>Endometriosis is a chronic inflammatory disease. The immune-checkpoint molecules CD226 and TIGIT play an important role in regulating T cells' function. However, little is known about the proportion and function of CD226 and TIGIT on CD4⁺ T cells in endometriosis. The current study found no significant differences in the TIGIT percentage on peripheral CD4⁺ T cells between patients with endometriosis and the control group. However, CD226 was lower in patients with endometriosis than that in the control group (P < 0.01). The cytokines TNF-α, IL10, and IFN-γ were significantly elevated in TIGIT⁺ CD4⁺ T cells compared to TIGIT- CD4⁺ T cells. HLA-DR⁺ cells were more numerous among TIGIT⁺ CD4⁺ T cells than among the TIGIT- subset (P <0.001). Similarly, the cytokines TNF-α, IL10, and IFN-γ were significantly elevated in CD226⁺ CD4⁺ T cells compared to levels in CD226- CD4⁺ T cells. The proportion of HLA-DR⁺ CD4⁺ T cells among CD226⁺ CD4⁺ T cells was also significantly higher than that among the CD226- subset (P < 0.001). After TIGIT was blocked, the level of IL-10 in TIGIT⁺ CD4⁺ T cells was higher than that in cells with unblocked TIGIT. There were no differences in TNF-α and IFN-γ. After CD226 was blocked, TNF-α and IFN-γwere lower while IL-10 was higher. In conclusion, there is a diminution of CD226 in CD4⁺ T cells in patients with endometriosis. This is correlated with the effector function of CD4⁺ T cells, and blocking CD226 can suppress this function.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9471771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXA2 plays a critical role in hepatocellular carcinoma progression and lenvatinib-associated drug resistance.","authors":"Zhengxia Wang,&nbsp;Junyi Shen,&nbsp;Chuwen Chen,&nbsp;Tianfu Wen,&nbsp;Chuan Li","doi":"10.5582/bst.2022.01535","DOIUrl":"https://doi.org/10.5582/bst.2022.01535","url":null,"abstract":"<p><p>Hepatic forkhead box protein A2 (FOXA2) is a crucial transcription factor for liver development and metabolic homeostasis. However, its role in hepatocellular carcinoma (HCC) progression and lenvatinib-related drug resistance remains unknown. In this study, the level of FOXA2 expression was found to be lower in HCC tissues than in paired adjacent tumor tissues. A low level of FOXA2 expression was associated with aggressive tumor characteristics (vascular invasion and poor differentiation). A low level of FOXA2 expression was found to be an independent risk factor for tumor recurrence (hazard ratio (HR): 1.899, P < 0.001) and long-term survival (HR: 2.011, P = 0.003) in HCC patients after hepatectomy. In xenograft animal models, FOXA2 overexpression significantly inhibited tumor growth. Moreover, FOXA2 overexpression was found to enhance the inhibitory effect of lenvatinib on HCC cells by upregulating the adenosine monophosphate-activated protein kinase-mechanistic target of rapamycin (AMPK-mTOR) pathway. Conversely, inhibition of adenosine monophosphate-activated protein kinase (AMPK) or stimulation of mechanistic target of rapamycin (mTOR) attenuated the sensitization of cells overexpressing FOXA2 to lenvatinib. Similarly, FOXA2 overexpression augmented the antitumor effect of lenvatinib in animal models with xenograft tumors. FOXA2 overexpression increased autophagy in HCC cells treated with lenvatinib. Lenvatinib treatment activated the platelet-derived growth factor receptor-extracellular regulated protein kinase (PDGFR-ERK) pathway in HCC. FOXA2 overexpression further downregulated the PDGFR-ERK pathway through the activation of the AMPK-mTOR axis. In conclusion, FOXA2 was identified as an independent risk factor for HCC after hepatectomy. FOXA2 was found to be closely associated with the biological progression of HCC. By modulating the AMPK-mTOR-autophagy signaling pathway, FOX2 significantly augmented antitumor effect of lenvatinib in HCC.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9819152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-4 weeks is the optimal time to operate on colorectal liver metastasis after neoadjuvant chemotherapy.","authors":"Yurun Huang,&nbsp;Hang Jiang,&nbsp;Linwei Xu,&nbsp;Xitian Wu,&nbsp;Jia Wu,&nbsp;Yuhua Zhang","doi":"10.5582/bst.2022.01432","DOIUrl":"https://doi.org/10.5582/bst.2022.01432","url":null,"abstract":"<p><p>Neoadjuvant chemotherapy (NAC) is generally accepted for treatment of liver metastasis of colorectal cancer (CRLM), but what is a reasonable interval between the latest NAC and surgery is still unknown. The aim of the current study was to investigate the proper timing of surgery after NAC. Subjects were 141 patients with CRLM who underwent NAC and then surgery were retrospectively identified from 2008 to 2020. They were divided into a short interval group (SIG, ≤ 4 weeks) and long interval group (LIG, > 4 weeks) using the software X-tile. The SIG was subclassified group into 3 time periods (1-2 weeks, 2-3 weeks, and 3-4 weeks) to assess the incidence of complications. Patients in the SIG were more likely to have significantly better recurrence-free survival (RFS) (3-year RFS of 47.4% vs. 20.5%, P = 0.043) and no difference in overall survival (OS) (3-year OS 76.1% vs. 79.9%, P = 0.635). The postoperative complication rate was 23.5% in the SIG and 14.0% in the LIG (P = 0.198). The postoperative complication rate in the 1-2 weeks subgroup was marginally higher than that in the > 4 weeks subgroup (35% vs. 14.3% P = 0.055). Multivariate analysis revealed that chemotherapy-free intervals of 1-2 weeks were an independent predictor of increased postoperative complications (OR = 0.263, 95% CI 0.7-0.985 P = 0.048). Patients who underwent surgery within 4 weeks of NAC had better RFS. In addition, 1-2 weeks was an independent factor influencing the development of more complications. For patients with CRLM, performing surgery within 2-4weeks of NAC was feasible and safe, and it did not increase the incidence of postoperative complications but it did prolong RFS.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9466483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequelae of long COVID, known and unknown: A review of updated information.","authors":"Tetsuya Asakawa,&nbsp;Qingxian Cai,&nbsp;Jiayin Shen,&nbsp;Ying Zhang,&nbsp;Yongshuang Li,&nbsp;Peifen Chen,&nbsp;Wen Luo,&nbsp;Jiangguo Zhang,&nbsp;Jinfeng Zhou,&nbsp;Hui Zeng,&nbsp;Ruihui Weng,&nbsp;Feng Hu,&nbsp;Huiquan Feng,&nbsp;Jun Chen,&nbsp;Jie Huang,&nbsp;Xiaoyin Zhang,&nbsp;Yu Zhao,&nbsp;Liekui Fang,&nbsp;Rongqing Yang,&nbsp;Jia Huang,&nbsp;Fuxiang Wang,&nbsp;Yingxia Liu,&nbsp;Hongzhou Lu","doi":"10.5582/bst.2023.01039","DOIUrl":"https://doi.org/10.5582/bst.2023.01039","url":null,"abstract":"<p><p>Over three years have passed since the COVID-19 pandemic started. The dangerousness and impact of COVID-19 should definitely not be ignored or underestimated. Other than the symptoms of acute infection, the long-term symptoms associated with SARS-CoV-2 infection, which are referred to here as \"sequelae of long COVID (LC)\", are also a conspicuous global public health concern. Although such sequelae were well-documented, the understanding of and insights regarding LC-related sequelae remain inadequate due to the limitations of previous studies (the follow-up, methodological flaws, heterogeneity among studies, etc.). Notably, robust evidence regarding diagnosis and treatment of certain LC sequelae remain insufficient and has been a stumbling block to better management of these patients. This awkward situation motivated us to conduct this review. Here, we comprehensively reviewed the updated information, particularly focusing on clinical issues. We attempt to provide the latest information regarding LC-related sequelae by systematically reviewing the involvement of main organ systems. We also propose paths for future exploration based on available knowledge and the authors' clinical experience. We believe that these take-home messages will be helpful to gain insights into LC and ultimately benefit clinical practice in treating LC-related sequelae.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9467272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor emotional status increases the risk of attempted suicide for the elderly age 55 and older in Shanghai, China: A longitudinal follow-up study.","authors":"Lingshan Wan,&nbsp;Tingting Zhu,&nbsp;Jing Zhang,&nbsp;Wendi Cheng,&nbsp;Duo Chen,&nbsp;Hansheng Ding","doi":"10.5582/bst.2022.01489","DOIUrl":"https://doi.org/10.5582/bst.2022.01489","url":null,"abstract":"<p><p>We conducted a study to explore how one's emotional state affects attempted suicide among the elderly in Shanghai, China. Random sampling was used to select people age 55 and older in Shanghai from 2013 to 2019. A questionnaire was used to collect relevant data, including attempted suicide and emotional status. Subjects were a total of 783 elderly people who participated in this study for two years and more, and they consisted of 569 elderly people did not commit suicide during the study period and 214 elderly people who attempted suicide. Cumulative logistic regression indicated that feeling less interested than usual in hobbies (p < 0.001, OR = 2.805, 95% CI: 0.941-8.360) and being more easily angered (p < 0.0001, OR = 11.972, 95% CI: 6.275-22.843) increase the risk of attempted suicide.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9467305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease.","authors":"Yuzhao Liu,&nbsp;Xiangli Zhao,&nbsp;Jinlong Jian,&nbsp;Sadaf Hasan,&nbsp;Chuanju Liu","doi":"10.5582/bst.2023.01022","DOIUrl":"10.5582/bst.2023.01022","url":null,"abstract":"<p><p>Gaucher disease (GD), one of the most common lysosomal storage diseases, is caused by GBA1 mutations resulting in defective glucocerebrosidase (GCase) and consequent accumulation of its substrates β-glucosylceramide (β-GlcCer). We reported progranulin (PGRN), a secretary growth factor-like molecule and an intracellular lysosomal protein was a crucial co-factor of GCase. PGRN binds to GCase and recruits Heat Shock Protein 70 (Hsp70) to GCase through its C-terminal Granulin (Grn) E domain, termed as ND7. In addition, both PGRN and ND7 are therapeutic against GD. Herein we found that both PGRN and its derived ND7 still displayed significant protective effects against GD in Hsp70 deficient cells. To delineate the molecular mechanisms underlying PGRN's Hsp70-independent regulation of GD, we performed a biochemical co-purification and mass spectrometry with His-tagged PGRN and His-tagged ND7 in Hsp70 deficient cells, which led to the identification of ERp57, also referred to as protein disulfide isomerase A3 (PDIA3), as a protein that binds to both PGRN and ND7. Within type 2 neuropathic GD patient fibroblasts L444P, bearing GBA1 L444P mutation, deletion of ERp57 largely abolished the therapeutic effects of PGRN and ND7, as manifested by loss of effects on lysosomal storage, GCase activity, and β-GlcCer accumulation. Additionally, recombinant ERp57 effectively restored the therapeutic effects of PGRN and ND7 in ERp57 knockout L444P fibroblasts. Collectively, this study reports ERp57 as a previously unrecognized binding partner of PGRN that contributes to PGRN regulation of GD.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514708/pdf/nihms-1930485.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10217552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics, scope of activity, and negative emotions in elderly women with urinary incontinence: Based on a longitudinal follow-up in Shanghai, China.","authors":"Yunwei Zhang,&nbsp;Changying Wang,&nbsp;Xiaoyan Yu,&nbsp;Lingshan Wan,&nbsp;Wendi Cheng,&nbsp;Chunyan Xie,&nbsp;Duo Chen,&nbsp;Yifan Cao,&nbsp;Jia Xue,&nbsp;Yuhong Niu,&nbsp;Hansheng Ding","doi":"10.5582/bst.2022.01507","DOIUrl":"https://doi.org/10.5582/bst.2022.01507","url":null,"abstract":"<p><p>We conducted a study to assess the characteristics, scope of activity, and negative emotions in elderly women with urinary incontinence (UI) based on a longitudinal follow-up conducted in Shanghai, China from 2013 to 2019. A total of 3,531 elderly women were included in the final analysis, and 697 women who experienced UI during follow-up were included in the UI group. Subjects with UI were subdivided into those with partial UI (UI once a day or less) and UI (frequent UI). Two thousand eight hundred and thirty-four women who did not have UI during the same period served as the control group. The prevalence of UI was 19.74% in this study. Logistic regression analysis revealed that being older (> 80 years of age), having a high level of education (> 12 years; elderly people with a high level of education may pay more attention to their health and notice UI more readily), a low personal monthly income (≤ 3,000 RMB), more gravidity/parity, and having a chronic disease (chronic obstructive pulmonary disease (COPD), dementia, or Parkinson's disease) were risk factors for UI (p < 0.05). About 60% of women in the partial UI group engaged in daily activities outdoors, while this number decreased sharply to 3.6% in the UI group. Women in the UI group were more likely to have negative emotions, such as depression, anxiety, irritability, or feeling worthless (p < 0.001). Among elderly women with dementia, those with UI had defects in terms of judgment in everyday life, the ability of convey information, and the ability to understand information (p < 0.05). More attention needs to be paid to the adverse effects of UI on activities of daily living (ADL) and mental health in the future.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9467307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}