Bioscience trends最新文献_第9页

The function and immune role of cuproptosis associated hub gene in Barrett's esophagus and esophageal adenocarcinoma. 铜中毒相关枢纽基因在Barrett食管和食管腺癌中的功能和免疫作用。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-21 DOI: 10.5582/bst.2023.01164

Kailin Lin, Ke Hu, Qiwen Chen, Jiangchun Wu

{"title":"The function and immune role of cuproptosis associated hub gene in Barrett's esophagus and esophageal adenocarcinoma.","authors":"Kailin Lin, Ke Hu, Qiwen Chen, Jiangchun Wu","doi":"10.5582/bst.2023.01164","DOIUrl":"10.5582/bst.2023.01164","url":null,"abstract":"Barrett's esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EAC), with approximately 3-5% of patients developing EAC. Cuproptosis is a kind of programmed cell death phenomenon discovered in recent years, which is related to the occurrence and development of many diseases. However, its role in BE and EAC is not fully understood. We used single sample Gene Set Enrichment Analysis (ssGSEA) for differential analysis of BE in the database, followed by enrichment analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO) and GSEA, Protein-Protein Interaction (PPI), Weighted Gene Co-expression Network Analysis (WGCNA), Receiver Operating Characteristic Curve (ROC) and finally Quantitative Real Time Polymerase Chain Reaction (qRT-PCR) and immunohistochemistry (IHC) of clinical tissues. Two hub genes can be obtained by intersection of the results obtained from the cuproptosis signal analysis based on BE. The ROC curves of these two genes predicted EAC, and the Area Under the Curve (AUC) values could reach 0.950 and 0.946, respectively. The mRNA and protein levels of Centrosome associated protein E (CENPE) and Shc SH2 domain binding protein 1 (SHCBP1) were significantly increased in clinical EAC tissues. When they were grouped by protein expression levels, high expression of CENPE or SHCBP1 had a poor prognosis. The CENPE and SHCBP1 associated with cuproptosis may be a factor promoting the development of BE into EAC which associated with the regulation of NK cells and T cells.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"381-392"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Call for special attention to the caregiver burden of patients with drug-resistant tuberculosis in low- and middle-income countries. 呼吁特别关注中低收入国家耐药结核病患者的护理负担。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-14 DOI: 10.5582/bst.2023.01243

Shuqi Wu, Hailin Zhang, Yi Wang, Jin Wang, Peize Zhang, Tetsuya Asakawa, Yi Lin

引用次数: 0

Clinical characteristics of solitary intrahepatic biliary cyst. 孤立性肝内胆道囊肿的临床特点。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-08-30 DOI: 10.5582/bst.2023.01042

Zhipeng Sun, Bing Liu, Bin Shu, Xin Huang, Liang Wang, Shizhong Yang

引用次数: 0

Genome-wide identification of mammalian cell-cycle invariant and mitotic-specific macroH2A1 domains. 哺乳动物细胞周期不变和有丝分裂特异性大分子H2A1结构域的全基因组鉴定。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-09-29 DOI: 10.5582/bst.2023.01214

Le Zhang, Bishan Ye, Zeqian Xu, Xinhui Li, Czajkowsky D M, Zhifeng Shao

{"title":"Genome-wide identification of mammalian cell-cycle invariant and mitotic-specific macroH2A1 domains.","authors":"Le Zhang, Bishan Ye, Zeqian Xu, Xinhui Li, Czajkowsky D M, Zhifeng Shao","doi":"10.5582/bst.2023.01214","DOIUrl":"10.5582/bst.2023.01214","url":null,"abstract":"The histone variant macroH2A has been found to play important regulatory roles in genomic processes, especially in regulating transcriptomes. However, whether macroH2A nucleosomes are retained on mitotic chromosomes to enable maintenance of cell-specific transcriptomes is not known. Here, examining mouse embryonic fibroblast cells (NIH-3T3) with native chromatin immunoprecipitation and sequencing (nChIP-seq), we show that the overwhelming majority (~90%) of macroH2A1 domains identified at the G1/S stage are indeed stably retained on mitotic chromosomes. Unexpectedly though, we also find that there are a number of macroH2A domains that are specific for either mitotic or G1/S cells. Notably, more than 7,000 interphase expressed genes flanked by macroH2A1 domains are loaded with macroH2A1 nucleosomes on the mitotic chromosome to form extended domains. Overall, these results reveal that, while the majority of macroH2A1 domains are indeed faithfully transmitted through the mitotic chromosomes, there is a previously unknown cell-cycle dependent exchange of macroH2A1 nucleosomes at numerous genomic loci, indicating the existence of molecular machineries for this dynamically regulated process. We anticipate that these findings will prove to be essential for the integrity of mitotic progression and the maintenance of cellular identity.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"393-400"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the accessibility of health care for internal migrants in China: Achieving the aim of equalization. 改善中国境内移民获得医疗保健的机会：实现均等化目标。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-14 DOI: 10.5582/bst.2023.01220

Dan Zhao, Chengchao Zhou

引用次数: 0

Influence of intermittent fasting on autophagy in the liver. 间歇性禁食对肝脏自噬的影响。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-09-01 DOI: 10.5582/bst.2023.01207

Ya-Nan Ma, Xuemei Jiang, Wei Tang, Peipei Song

{"title":"Influence of intermittent fasting on autophagy in the liver.","authors":"Ya-Nan Ma, Xuemei Jiang, Wei Tang, Peipei Song","doi":"10.5582/bst.2023.01207","DOIUrl":"10.5582/bst.2023.01207","url":null,"abstract":"Studies have found that intermittent fasting (IF) can prevent diabetes, cancer, heart disease, and neuropathy, while in humans it has helped to alleviate metabolic syndrome, asthma, rheumatoid arthritis, Alzheimer's disease, and many other disorders. IF involves a series of coordinated metabolic and hormonal changes to maintain the organism's metabolic balance and cellular homeostasis. More importantly, IF can activate hepatic autophagy, which is important for maintaining cellular homeostasis and energy balance, quality control, cell and tissue remodeling, and defense against extracellular damage and pathogens. IF affects hepatic autophagy through multiple interacting pathways and molecular mechanisms, including adenosine monophosphate (AMP)-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), silent mating-type information regulatory 2 homolog-1 (SIRT1), peroxisomal proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR), as well as signaling pathways and molecular mechanisms such as glucagon and fibroblast growth factor 21 (FGF21). These pathways can stimulate the pro-inflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α), play a cytoprotective role, downregulate the expression of aging-related molecules, and prevent the development of steatosis-associated liver tumors. By influencing the metabolism of energy and oxygen radicals as well as cellular stress response systems, IF protects hepatocytes from genetic and environmental factors. By activating hepatic autophagy, IF has a potential role in treating a variety of liver diseases, including non-alcoholic fatty liver disease, drug-induced liver injury, viral hepatitis, hepatic fibrosis, and hepatocellular carcinoma. A better understanding of the effects of IF on liver autophagy may lead to new approaches for the prevention and treatment of liver disease.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"335-355"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10500243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The prognostic nutritional index and tumor pathological characteristics predict the prognosis of elderly patients with early-stage hepatocellular carcinoma after surgery. 预后营养指标和肿瘤病理特征可预测老年早期肝细胞癌患者术后的预后。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-10 DOI: 10.5582/bst.2023.01212

Yafei Hu, Yulong Cai, Wenjie Ma, Haijie Hu, Hanfei Gu, Yanwen Jin, Fuyu Li

{"title":"The prognostic nutritional index and tumor pathological characteristics predict the prognosis of elderly patients with early-stage hepatocellular carcinoma after surgery.","authors":"Yafei Hu, Yulong Cai, Wenjie Ma, Haijie Hu, Hanfei Gu, Yanwen Jin, Fuyu Li","doi":"10.5582/bst.2023.01212","DOIUrl":"10.5582/bst.2023.01212","url":null,"abstract":"The elderly comprises over one-third of hepatocellular carcinoma (HCC) patients, however, they are not adequately represented in prognostic studies. The study aims to determine the prognostic significance of the preoperative prognostic nutritional index (PNI) and develop nomograms for predicting their recurrence-free and overall survival (RFS and OS). The study consisted of 282 elderly patients (aged ≥ 65 years) with early-stage HCC (China Liver Cancer Staging System: I-IIA) after curative resection (R0). They were randomly divided into a training (n = 197) and a test cohort (n = 85). The patients were stratified into two groups: PNI-low (PNI ≤ 49.05) and PNI-high (PNI > 49.05) based on a cut-off value. Most patients' demographics and perioperative outcomes were comparable, while patients in the PNI-high group were younger (P = 0.002), heavier (P < 0.001), and had lower comorbidity rates (P = 0.003). Although the tumor stages were earlier in the PNI-low group (P < 0.001), patients' OS (5-year OS: 48.9% vs. 93.1%) and RFS (5-year RFS: 27.3% vs. 75.7%) were significantly worse compared to the PNI-high group (both P < 0.0001). Patients' OS and RFS nomograms were developed by incorporating independent survival predictors including chronic obstructive pulmonary disease (COPD), age ≥ 75 years, PNI-low, tumor presence of satellite nodules, capsule, and microvascular invasion. The nomograms showed good calibration and discrimination, with all C-indexes ≥ 0.75 and calibration plots essentially coinciding with the diagonal. In conclusion, for elderly HCC patients, COPD, age ≥ 75 years, PNI-low, and tumor presence of satellite nodules, capsule, and microvascular invasion were independent prognostic factors. The nomogram could accurately predict the prognosis of these patients.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"369-380"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan. 限制昼夜节律的饮食调节自噬以改善认知功能和延长寿命。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-09-17 DOI: 10.5582/bst.2023.01221

Xiqi Hu, Jun Peng, Wei Tang, Ying Xia, Peipei Song

{"title":"A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan.","authors":"Xiqi Hu, Jun Peng, Wei Tang, Ying Xia, Peipei Song","doi":"10.5582/bst.2023.01221","DOIUrl":"10.5582/bst.2023.01221","url":null,"abstract":"Diet and circadian rhythms have been found to have a profound impact on health, disease, and aging. Skipping breakfast, eating late, and overeating have adverse effects on the body's metabolism and increase the risk of cardiovascular and metabolic diseases. Disturbance of circadian rhythms has been associated with increased risk of atherosclerosis, Alzheimer's disease, Parkinson's disease, and other diseases. Abnormal deposition of amyloid β (Aβ) and tau proteins in the brain and impaired synaptic function are linked to cognitive dysfunction. A restrictive diet following the circadian rhythm can affect the metabolism of lipids, glucose, and amino acids such as branched chain amino acids and cysteine. These metabolic changes contribute to autophagy through molecular mechanisms such as adenosine monophosphate-activated protein kinase (AMPK), rapamycin (mTOR), D-β-hydroxybutyrate (D-BHB), and neuropeptide Y (NPY). Autophagy, in turn, promotes the removal of abnormally deposited proteins and damaged organelles and improves cognitive function, ultimately prolonging lifespan. In addition, a diet restricted to the circadian rhythm induces increased expression of brain-derived neurotrophic factor (BDNF) in the forebrain region, regulating autophagy and increasing synaptic plasticity, thus enhancing cognitive function. Consequently, circadian rhythm-restricted diets could serve as a promising non-pharmacological treatment for preventing and improving cognitive dysfunction and prolonging lifespan.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"356-368"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facing frailty: Are you ready? 面对脆弱：你准备好了吗？

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-09-15 Epub Date: 2023-08-23 DOI: 10.5582/bst.2023.01191

Tetsuya Asakawa, Takashi Karako

引用次数: 0

The status of surrogacy in China. 代孕在中国的地位。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-09-15 Epub Date: 2023-04-21 DOI: 10.5582/bst.2022.01263

Qing Qi, Xiaolei Gu, Yangyang Zhao, Ziqin Chen, Jing Zhou, Song Chen, Ling Wang

引用次数: 0