Bioscience trends最新文献_第8页

New mechanisms: From lactate to lactylation to rescue heart failure. 新机制：从乳酸到乳化，拯救心力衰竭。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2024.01000

Linfeng Yi, Dan Tang, Xing Xiang, Chungang Xiao, Huifang Tang, Hong Huang

引用次数: 0

Predictive deep learning models for cognitive risk using accessible data. 利用可获取的数据建立认知风险预测深度学习模型。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-20 DOI: 10.5582/bst.2024.01026

Kenji Karako

引用次数: 0

Neoadjuvant therapies in resectable hepatocellular carcinoma: Exploring strategies to improve prognosis. 可切除肝细胞癌的新辅助疗法：探索改善预后的策略。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-20 DOI: 10.5582/bst.2023.01436

Ya-Nan Ma, Xuemei Jiang, Peipei Song, Wei Tang

{"title":"Neoadjuvant therapies in resectable hepatocellular carcinoma: Exploring strategies to improve prognosis.","authors":"Ya-Nan Ma, Xuemei Jiang, Peipei Song, Wei Tang","doi":"10.5582/bst.2023.01436","DOIUrl":"10.5582/bst.2023.01436","url":null,"abstract":"Hepatocellular carcinoma (HCC), a challenging malignancy, often necessitates surgical intervention, notably liver resection. However, the high recurrence rate, reaching 70% within 5 years post-resection, significantly impacts patient outcomes. Neoadjuvant therapies aim to preoperatively address this challenge, reducing lesion size, improving surgical resection rates, deactivating potential micro-metastases, and ultimately lowering postoperative recurrence rates. This review concentrates on advances in research on and clinical use of neoadjuvant therapies for HCC, with particular attention to the use of immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4). Ongoing clinical studies exploring immunotherapy combined with a tyrosine kinase inhibitor (TKI), interventional therapy, radiotherapy, and other modalities offer promising insights into overcoming resistance to monotherapies. In summary, neoadjuvant therapies hold significant promise in terms of improving the prognosis for patients with HCC and enhancing long-term survival, particularly through innovative combination strategies.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"21-41"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated machine learning-based model for the prediction of pedicle screw loosening after degenerative lumbar fusion surgery. 基于机器学习的椎弓根螺钉松动自动预测模型，用于预测退行性腰椎融合手术后的椎弓根螺钉松动。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-27 DOI: 10.5582/bst.2023.01327

Feng Jiang, Xinxin Li, Lei Liu, Zhiyang Xie, Xiaotao Wu, Yuntao Wang

{"title":"Automated machine learning-based model for the prediction of pedicle screw loosening after degenerative lumbar fusion surgery.","authors":"Feng Jiang, Xinxin Li, Lei Liu, Zhiyang Xie, Xiaotao Wu, Yuntao Wang","doi":"10.5582/bst.2023.01327","DOIUrl":"10.5582/bst.2023.01327","url":null,"abstract":"The adequacy of screw anchorage is a critical factor in achieving successful spinal fusion. This study aimed to use machine learning algorithms to identify critical variables and predict pedicle screw loosening after degenerative lumbar fusion surgery. A total of 552 patients who underwent primary transpedicular lumbar fixation for lumbar degenerative disease were included. The LASSO method identified key features associated with pedicle screw loosening. Patient clinical characteristics, intraoperative variables, and radiographic parameters were collected and used to construct eight machine learning models, including a training set (80% of participants) and a test set (20% of participants). The XGBoost model exhibited the best performance, with an AUC of 0.884 (95% CI: 0.825-0.944) in the test set, along with the lowest Brier score. Ten crucial variables, including age, disease diagnosis: degenerative scoliosis, number of fused levels, fixation to S1, HU value, preoperative PT, preoperative PI-LL, postoperative LL, postoperative PT, and postoperative PI-LL were selected. In the prospective cohort, the XGBoost model demonstrated substantial performance with an accuracy of 83.32%. This study identified crucial variables associated with pedicle screw loosening after degenerative lumbar fusion surgery and successfully developed a machine learning model to predict pedicle screw loosening. The findings of this study may provide valuable information for clinical decision-making.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"83-93"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study. 糖尿病、血糖特征、SGLT2 抑制与肺动脉高压风险：孟德尔随机研究

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2024.01006

Jiang-Shan Tan, Yanmin Yang, Jingyang Wang, Yimeng Wang, Tingting Lv, Yuyuan Shu, Wei Xu, Lingtao Chong

{"title":"Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study.","authors":"Jiang-Shan Tan, Yanmin Yang, Jingyang Wang, Yimeng Wang, Tingting Lv, Yuyuan Shu, Wei Xu, Lingtao Chong","doi":"10.5582/bst.2024.01006","DOIUrl":"10.5582/bst.2024.01006","url":null,"abstract":"This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of gene expression and hemoglobin A1c. Results showed that genetically inferred DM demonstrated a causal correlation with an increased risk of PAH, exhibiting an odds ratio (OR) of 1.432, with a 95% confidence interval (CI) of 1.040-1.973, and a p-value of 0.028. The multivariate MR analysis revealed comparable outcomes after potential confounders (OR = 1.469, 95%CI = 1.021-2.115, p = 0.038). Moreover, genetically predicted SGLT2 inhibition was causally linked to a reduced risk of PAH (OR = 1.681*10-7, 95%CI = 7.059*10-12-0.004, p = 0.002). Therefore, our study identified the suggestively causal effect of DM on the risk of PAH, and SGLT2 inhibition may be a potential therapeutic target in patients with PAH.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"94-104"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China. 中国小学学龄自闭症谱系障碍儿童教育安置的社会经济差异。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2023.01319

Yanan Zhao, Rong Zhang, Xiaoying Zheng

{"title":"Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China.","authors":"Yanan Zhao, Rong Zhang, Xiaoying Zheng","doi":"10.5582/bst.2023.01319","DOIUrl":"10.5582/bst.2023.01319","url":null,"abstract":"Relatively little is known about education placements for children with autism spectrum disorder (ASD) in China. While disparities in ASD diagnoses and services for the population broadly are often documented, the presence and determinants of differences in the educational placement of ASD children are less studied and understood. By identifying who is likely to be in segregated settings, we can discern how to best support them and facilitate a possible transition to a less restrictive setting. This study describes four placements (regular schools, special schools, institutions, homes) and their influencing factors retrospectively in a large sample (n = 2,190) of Chinese primary school-aged children (6-12 years old). We divided ASD into severe and mild to moderate categories for analysis. Children with ASD were more likely to study in a regular school (48.60%), while 13.88% were in a special school. Children with severe ASD were placed in less regular settings than children with mild to moderate ASD. However, families with higher socioeconomic status (SES) were more likely to place their children in regular schools than lower SES families if their children experienced mild to moderate symptoms. Children with severe ASD were more likely to be placed in expensive institutions for families with higher SES than those with lower SES. SES disparities in educational placement existed and had two manifestations. It is important to characterize educational placements of students with ASD to determine the extent to which they are placed in general education settings, which are often the preferred placement.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"73-82"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of diagnosis-related groups (DRG)-based hospital payment system design and implementation strategies in different countries: The case of ischemic stroke. 比较不同国家基于诊断相关分组（DRG）的医院支付系统设计和实施策略：以缺血性中风为例。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-24 DOI: 10.5582/bst.2023.01027

Yuan Liu, Gang Wang, Tian-Ge Qin, Susumu Kobayashi, Takashi Karako, Peipei Song

{"title":"Comparison of diagnosis-related groups (DRG)-based hospital payment system design and implementation strategies in different countries: The case of ischemic stroke.","authors":"Yuan Liu, Gang Wang, Tian-Ge Qin, Susumu Kobayashi, Takashi Karako, Peipei Song","doi":"10.5582/bst.2023.01027","DOIUrl":"10.5582/bst.2023.01027","url":null,"abstract":"Diagnosis-related groups (DRG) based hospital payment systems are gradually becoming the main mechanism for reimbursement of acute inpatient care. We reviewed the existing literature to ascertain the global use of DRG-based hospital payment systems, compared the similarities and differences of original DRG versions in ten countries, and used ischemic stroke as an example to ascertain the design and implementation strategies for various DRG systems. The current challenges with and direction for the development of DRG-based hospital payment systems are also analyzed. We found that the DRG systems vary greatly in countries in terms of their purpose, grouping, coding, and payment mechanisms although based on the same classification concept and that they have tended to develop differently in countries with different income classifications. In high-income countries, DRG-based hospital payment systems have gradually begun to weaken as a mainstream payment method, while in middle-income countries DRG-based hospital payment systems have attracted increasing attention and increased use. The example of ischemic stroke provides suggestions for mutual promotion of DRG-based hospital payment systems and disease management. How to determine the level of DRG payment incentives and improve system flexibility, balance payment goals and disease management goals, and integrate development with other payment methods are areas for future research on DRG-based hospital payment systems.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"1-10"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel cholesterol tag-based system for trans-membrane transport of protein drugs. 开发基于胆固醇标签的新型蛋白质药物跨膜转运系统。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-08 DOI: 10.5582/bst.2023.01285

Pengfei Zhao, Shuo Song, Zhuojun He, Guiqin Dai, Deliang Liu, Jiayin Shen, Tetsuya Asakawa, Mingbin Zheng, Hongzhou Lu

{"title":"Development of a novel cholesterol tag-based system for trans-membrane transport of protein drugs.","authors":"Pengfei Zhao, Shuo Song, Zhuojun He, Guiqin Dai, Deliang Liu, Jiayin Shen, Tetsuya Asakawa, Mingbin Zheng, Hongzhou Lu","doi":"10.5582/bst.2023.01285","DOIUrl":"10.5582/bst.2023.01285","url":null,"abstract":"The main technological difficulties of developing an intracellular (transmembrane) transport system for protein drugs lie in two points: i) overcoming the barriers in the cellular membrane, and ii) loading enough protein drugs, and particularly high-dose proteins, into particles. To address these two technological problems, we recently developed a novel cholesterol tag (C-Tag)-based transmembrane transport system. This pilot study found that the C-Tag dramatically improved the cellular uptake of Fab (902-fold, vs. Fab alone) into living cells, indicating that it successfully achieved transmembrane transport. Moreover, C-Tag-mediated membrane transport was verified using micron-scale large unilamellar vesicles (LUVs, approximately 1.5 μm)-based particles. The C-Tagged Fab was able to permeate the liposomal bilayer and it greatly enhanced (a 10.1-fold increase vs. Fab alone) internalization of proteins into the LUV-based particles, indicating that the C-Tag loaded enough proteins into particles for use of high-dose proteins. Accordingly, we established a novel C-Tag-based transport system that has overcome the known technological difficulties of protein transmembrane delivery, and this might be a useful technology for drug development in the future.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"503-507"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for postoperative recurrence of pT2-3N0M0 esophageal squamous cell carcinoma and patterns of its recurrence. pT2-3N0M0 食管鳞癌术后复发的风险因素及其复发模式。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-20 DOI: 10.5582/bst.2023.01294

Li Niu, Bo Hu, Li Zhang, Mei Kang

{"title":"Risk factors for postoperative recurrence of pT2-3N0M0 esophageal squamous cell carcinoma and patterns of its recurrence.","authors":"Li Niu, Bo Hu, Li Zhang, Mei Kang","doi":"10.5582/bst.2023.01294","DOIUrl":"10.5582/bst.2023.01294","url":null,"abstract":"This study aimed to explore the patterns of postoperative recurrence in patients with pT2-3N0M0 esophageal squamous cell carcinoma (ESCC) and to identify the risk factors for the recurrence. Patients with pT2-3N0M0 ESCC who were treated at our hospital from January 2010 to August 2019 were divided into three categories: those with anastomotic recurrence, those with lymph node recurrence, and those with hematogenous metastasis. The sites of initial recurrence and metastasis were counted and potential risk factors were analyzed using univariate and multivariate Cox proportional hazard regression. Four hundred and eighty-five patients with pT2-3N0M0 ESCC were ultimately included, 176 (36.29%) of whom experienced tumor recurrence or metastasis. Cox multivariate analysis revealed that the postoperative T-stage, procedure, tumor location, and degree of differentiation were independent risk factors for postoperative recurrence (P < 0.05). The median time of recurrence was 38 months, and the most common site of recurrence was the lymph nodes in 126 patients (71.59%), followed by hematogenous metastasis in 73 patients (41.47%), and anastomotic recurrence in 21 patients (11.93%). 119 patients (67.61%) experienced recurrence within 36 months, with a probability of recurrence of 84.09% within 5 years, and recurrence remained relatively unchanged after 5 years. The proportion of postoperative lymph node recurrence and hematogenous metastasis in patients with pT3N0M0 ESCC was significantly higher than that in patients with pT2N0M0 ESCC (P < 0.05). At higher tumor locations in the body, the proportion of lymph node recurrence increased (P < 0.05). In conclusion, postoperative T-stage, procedure, tumor location, and degree of differentiation were independent risk factors for postoperative recurrence in pT2-3N0M0 ESCC, with regional lymph node recurrence being the most common pattern, emphasizing the importance of regional lymph nodes in this context.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"475-483"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunity debt: Hospitals need to be prepared in advance for multiple respiratory diseases that tend to co-occur. 免疫债务：医院需要提前做好应对多种呼吸道疾病并发的准备。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-08 DOI: 10.5582/bst.2023.01303

Ting Li, Cordia Chu, Biying Wei, Hongzhou Lu

引用次数: 0