Bioscience trends最新文献_第7页

Risk factors for postoperative recurrence of pT2-3N0M0 esophageal squamous cell carcinoma and patterns of its recurrence. pT2-3N0M0 食管鳞癌术后复发的风险因素及其复发模式。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-20 DOI: 10.5582/bst.2023.01294

Li Niu, Bo Hu, Li Zhang, Mei Kang

{"title":"Risk factors for postoperative recurrence of pT2-3N0M0 esophageal squamous cell carcinoma and patterns of its recurrence.","authors":"Li Niu, Bo Hu, Li Zhang, Mei Kang","doi":"10.5582/bst.2023.01294","DOIUrl":"10.5582/bst.2023.01294","url":null,"abstract":"This study aimed to explore the patterns of postoperative recurrence in patients with pT2-3N0M0 esophageal squamous cell carcinoma (ESCC) and to identify the risk factors for the recurrence. Patients with pT2-3N0M0 ESCC who were treated at our hospital from January 2010 to August 2019 were divided into three categories: those with anastomotic recurrence, those with lymph node recurrence, and those with hematogenous metastasis. The sites of initial recurrence and metastasis were counted and potential risk factors were analyzed using univariate and multivariate Cox proportional hazard regression. Four hundred and eighty-five patients with pT2-3N0M0 ESCC were ultimately included, 176 (36.29%) of whom experienced tumor recurrence or metastasis. Cox multivariate analysis revealed that the postoperative T-stage, procedure, tumor location, and degree of differentiation were independent risk factors for postoperative recurrence (P < 0.05). The median time of recurrence was 38 months, and the most common site of recurrence was the lymph nodes in 126 patients (71.59%), followed by hematogenous metastasis in 73 patients (41.47%), and anastomotic recurrence in 21 patients (11.93%). 119 patients (67.61%) experienced recurrence within 36 months, with a probability of recurrence of 84.09% within 5 years, and recurrence remained relatively unchanged after 5 years. The proportion of postoperative lymph node recurrence and hematogenous metastasis in patients with pT3N0M0 ESCC was significantly higher than that in patients with pT2N0M0 ESCC (P < 0.05). At higher tumor locations in the body, the proportion of lymph node recurrence increased (P < 0.05). In conclusion, postoperative T-stage, procedure, tumor location, and degree of differentiation were independent risk factors for postoperative recurrence in pT2-3N0M0 ESCC, with regional lymph node recurrence being the most common pattern, emphasizing the importance of regional lymph nodes in this context.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"475-483"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunity debt: Hospitals need to be prepared in advance for multiple respiratory diseases that tend to co-occur. 免疫债务：医院需要提前做好应对多种呼吸道疾病并发的准备。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-08 DOI: 10.5582/bst.2023.01303

Ting Li, Cordia Chu, Biying Wei, Hongzhou Lu

引用次数: 0

Feasibility of novel intraoperative navigation for anatomical liver resection using real-time virtual sonography combined with indocyanine green fluorescent imaging technology. 利用实时虚拟声像图结合吲哚青绿荧光成像技术，为解剖性肝脏切除术提供新型术中导航的可行性。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-13 DOI: 10.5582/bst.2023.01265

Changsheng Pu, Tiantian Wu, Qiang Wang, Yinmo Yang, Keming Zhang

{"title":"Feasibility of novel intraoperative navigation for anatomical liver resection using real-time virtual sonography combined with indocyanine green fluorescent imaging technology.","authors":"Changsheng Pu, Tiantian Wu, Qiang Wang, Yinmo Yang, Keming Zhang","doi":"10.5582/bst.2023.01265","DOIUrl":"10.5582/bst.2023.01265","url":null,"abstract":"To analyze the feasibility and clinical effect of novel intraoperative navigation of real-time virtual sonography (RVS) combined with indocyanine green (ICG) fluorescent imaging technology in anatomical liver resection (ALR) for hepatocellular carcinoma. The clinical data of 41 patients who underwent ALR using RVS intraoperative navigation combined with ICG fluorescent imaging technology in the Department of Hepatobiliary Surgery of Peking University International Hospital from January 2020 to May 2022 were retrospectively analyzed. RVS was applied to guide the surgical plane through fusing real-time intraoperative ultrasound images with corresponding preoperative CT or MRI images. Operation methods, operation time, intraoperative blood loss, operative margin, hospital stay and postoperative complications were analyzed. The 1-year overall survival rate and tumor-free survival rate of patients were followed up by outpatient review or telephone calls. ALR surgery was performed on each of 41 patients. There were no deaths during perioperative period and postoperative complications occurred in 7 cases (17.1%). The postoperative pathological examinations demonstrated all cases of hepatocellular carcinoma and negative operative margins. The 41 patients were followed up for 12 to 20 months, with a median follow-up time of 14 months. The overall survival rate 1 year after surgery was 100.0% (41/41), 3 patients (7.3%) experienced tumor recurrence, and the tumor-free survival rate of 1 year after surgery was 92.7% (38/41). In conclusion, novel intraoperative navigation of RVS combined with ICG fluorescent imaging technology is safe and feasible in anatomical segmental hepatectomy of hepatocellular carcinoma.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"484-490"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immune response of hepatocellular carcinoma after locoregional and systemic therapies: The available combination option for immunotherapy. 肝细胞癌局部和全身治疗后的免疫反应:免疫治疗的可用组合选择。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-11-19 DOI: 10.5582/bst.2023.01275

Yuxin Duan, Hua Zhang, Tao Tan, Wentao Ye, Kunli Yin, Yanxi Yu, Meiqing Kang, Jian Yang, Rui Liao

{"title":"The immune response of hepatocellular carcinoma after locoregional and systemic therapies: The available combination option for immunotherapy.","authors":"Yuxin Duan, Hua Zhang, Tao Tan, Wentao Ye, Kunli Yin, Yanxi Yu, Meiqing Kang, Jian Yang, Rui Liao","doi":"10.5582/bst.2023.01275","DOIUrl":"10.5582/bst.2023.01275","url":null,"abstract":"Hepatocellular carcinoma (HCC) is associated with a highly heterogeneous immune environment that produces an immune response to various locoregional treatments (LRTs), which in turn affects the effectiveness of immunotherapy. Although LRTs still dominate HCC therapies, 50-60% of patients will ultimately be treated with systemic therapies and might receive those treatments for the rest of their life. TACE, SIRT, and thermal ablation can dramatically increase the immunosuppressive state of HCC, a condition that can be addressed by combination with immunotherapy to restore the activity of lymphocytes and the secretion of cellular immune factors. Immune treatment with locoregional and systemic treatments has dramatically changed the management of HCC. In this review, we examine the research on the changes in the immune microenvironment after locoregional or systemic treatment. We also summarize the regulation of various immune cells and immune factors in the tumor microenvironment and discuss the different infiltration degrees of immune cells and factors on the prognosis of HCC to better compare the efficacy between different treatment methods from the perspective of the tumor microenvironment. This information can be used to help develop treatment options for the upcoming new era of HCC treatment in the future.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"427-444"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on diagnosis and treatment of hepatoblastoma. 肝母细胞瘤诊断和治疗的最新进展。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-23 DOI: 10.5582/bst.2023.01311

Yinbiao Cao, Shurui Wu, Haowen Tang

{"title":"An update on diagnosis and treatment of hepatoblastoma.","authors":"Yinbiao Cao, Shurui Wu, Haowen Tang","doi":"10.5582/bst.2023.01311","DOIUrl":"10.5582/bst.2023.01311","url":null,"abstract":"Hepatoblastoma (HB) remains the most common paediatric liver tumour and survival in children with hepatoblastoma has improved considerably since the advent of sequential surgical regimens of chemotherapy based on platinum-based chemotherapeutic agents in the 1980s. With the advent of modern diagnostic imaging and pathology techniques, new preoperative chemotherapy regimens and the maturation of surgical techniques, new diagnostic and treatment options for patients with hepatoblastoma have emerged and international collaborations are investigating the latest diagnostic approaches, chemotherapy drug combinations and surgical strategies. Diagnosis of hepatoblastoma relies on imaging studies (such as ultrasound, computed tomography, and magnetic resonance imaging), alpha-fetoprotein (AFP) levels, and histological confirmation through biopsy. The standard treatment approach involves a multimodal strategy with neoadjuvant chemotherapy followed by surgical resection. In cases where complete resection is not feasible or tumors exhibit invasive characteristics, liver transplantation is considered. The management of metastatic and recurrent hepatoblastoma poses significant challenges, and ongoing research focuses on developing targeted therapies and exploring the potential of immunotherapy. Further studies are necessary to gain a better understanding of the etiology of hepatoblastoma, develop prevention strategies, and personalize treatment approaches. We aim to review the current status of diagnosis and treatment of hepatoblastoma.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"445-457"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pal power: Demonstration of the functional association of the Helicobacter pylori flagellar motor with peptidoglycan-associated lipoprotein (Pal) and its preliminary crystallographic analysis. Pal的力量幽门螺旋杆菌鞭毛马达与肽聚糖相关脂蛋白（Pal）功能关联的证明及其初步晶体学分析。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-08 DOI: 10.5582/bst.2023.01278

Xiaotian Zhou, Mohammad M Rahman, Sharmin Q Bonny, Yue Xin, Nikki Liddelow, Mohammad F Khan, Alexandra Tikhomirova, Jihane Homman-Ludiye, Anna Roujeinikova

{"title":"Pal power: Demonstration of the functional association of the Helicobacter pylori flagellar motor with peptidoglycan-associated lipoprotein (Pal) and its preliminary crystallographic analysis.","authors":"Xiaotian Zhou, Mohammad M Rahman, Sharmin Q Bonny, Yue Xin, Nikki Liddelow, Mohammad F Khan, Alexandra Tikhomirova, Jihane Homman-Ludiye, Anna Roujeinikova","doi":"10.5582/bst.2023.01278","DOIUrl":"10.5582/bst.2023.01278","url":null,"abstract":"The bacterial flagellar motor is a molecular nanomachine, the assembly and regulation of which requires many accessory proteins. Their identity, structure and function are often discovered through characterisation of mutants with impaired motility. Here, we demonstrate the functional association of the Helicobacter pylori peptidoglycan-associated lipoprotein (HpPal) with the flagellar motor by analysing the motility phenotype of the ∆pal mutant, and present the results of the preliminary X-ray crystallographic analysis of its globular C-terminal domain HpPal-C. Purified HpPal-C behaved as a dimer in solution. Crystals of HpPal-C were grown by the hanging drop vapour diffusion method using medium molecular weight polyethylene glycol (PEG) Smear as the precipitating agent. The crystals belong to the primitive orthorhombic space group P1 with unit cell parameters a = 50.7, b = 63.0, c = 75.1 Å. X-ray diffraction data were collected to 1.8 Å resolution on the Australian Synchrotron beamline MX2. Calculation of the Matthews coefficient (VM=2.24 Å3/Da) and molecular replacement showed that the asymmetric unit contains two protein subunits. This study is an important step towards elucidation of the non-canonical role of H. pylori Pal in the regulation, or function of, the flagellar motor.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"491-498"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of the female genital tract and gut microbiome on reproductive dysfunction. 女性生殖道和肠道微生物群对生殖功能障碍的影响。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-17 DOI: 10.5582/bst.2023.01133

Wenli Cao, Xiayan Fu, Jing Zhou, Qing Qi, Feijun Ye, Lisha Li, Ling Wang

{"title":"The effect of the female genital tract and gut microbiome on reproductive dysfunction.","authors":"Wenli Cao, Xiayan Fu, Jing Zhou, Qing Qi, Feijun Ye, Lisha Li, Ling Wang","doi":"10.5582/bst.2023.01133","DOIUrl":"10.5582/bst.2023.01133","url":null,"abstract":"Microorganisms are ubiquitous in the human body; they are present in various areas including the gut, mouth, skin, respiratory tract, and reproductive tract. The interaction between the microbiome and reproductive health has become an increasingly compelling area of study. Disruption of the female genital tract microbiome can significantly impact the metabolism of amino acids, carbohydrates, and lipids, increasing susceptibility to reproductive tract diseases such as vaginitis, chronic endometritis, endometrial polyps, endometriosis, and polycystic ovary syndrome. The gut microbiome, considered an endocrine organ, plays a crucial role in the reproductive endocrine system by interacting with hormones like estrogen and androgens. Imbalances in the gut microbiome composition can lead to various diseases and conditions, including polycystic ovary syndrome, endometriosis, and cancer, although research on their mechanisms remains limited. This review highlights the latest advancements in understanding the female genital tract and gut microbiomes in gynecological diseases. It also explores the potential of microbial communities in the treatment of reproductive diseases. Future research should focus on identifying the molecular mechanisms underlying the association between the microbiome and reproductive diseases to develop new and effective strategies for disease prevention, diagnosis, and treatment related to female reproductive organs.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"458-474"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conversion therapy for initially unresectable hepatocellular carcinoma: Current status and prospects. 最初无法切除的肝细胞癌的转化疗法：现状与前景。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-23 DOI: 10.5582/bst.2023.01322

Ya-Nan Ma, Xuemei Jiang, Hui Liu, Peipei Song, Wei Tang

{"title":"Conversion therapy for initially unresectable hepatocellular carcinoma: Current status and prospects.","authors":"Ya-Nan Ma, Xuemei Jiang, Hui Liu, Peipei Song, Wei Tang","doi":"10.5582/bst.2023.01322","DOIUrl":"10.5582/bst.2023.01322","url":null,"abstract":"Research has shown that locoregional and/or systemic treatments can reduce the tumor stage, enabling radical surgical resection in patients with initially unresectable hepatocellular carcinoma. This is referred to as conversion therapy. Patients who undergo conversion therapy followed by curative surgery experience a significant survival benefit compared to those who receive chemotherapy alone, those who are successfully downstaged with conversion therapy but not treated with surgery, or those who are treated with upfront surgery. Several treatments have been studied as conversion therapy. However, the success rate of conversion varies greatly, ranging from 0.8% to 60%. Combined locoregional plus systemic conversion therapy has demonstrated significant clinical advantages, with a conversion rate of up to 60%, an objective remission rate of 96% for patients, and a disease control rate of up to 100%. However, patients who underwent conversion therapy experienced significantly more complications than those who underwent direct LR without conversion therapy. Conversion therapy can cause hepatotoxicity, bone marrow suppression, local adhesions, increased fragility of blood vessels and liver tissues, and hepatic edema, which can increase the difficulty of surgery. In addition, criteria need to be established to evaluate the efficacy of conversion therapy and subsequent treatment. Further clinical evidence in this area is urgently needed.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"415-426"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the treatment of advanced pancreatic cancer. 晚期胰腺癌的治疗趋势。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01156

Hirokazu Momose, Shohei Kudo, Tomoyuki Yoshida, Nobuhiro Hasui, Ryota Matsuki, Masaharu Kogure, Yoshihiro Sakamoto

引用次数: 0

Expert consensus on sequential surgery after immune-targeted conversion therapy for advanced hepatocellular carcinoma in China. 中国晚期肝癌免疫靶向转化治疗后序贯手术的专家共识

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01423

Peipei Song, Wei Tang, Norihiro Kokudo

{"title":"Expert consensus on sequential surgery after immune-targeted conversion therapy for advanced hepatocellular carcinoma in China.","authors":"Peipei Song, Wei Tang, Norihiro Kokudo","doi":"10.5582/bst.2024.01423","DOIUrl":"https://doi.org/10.5582/bst.2024.01423","url":null,"abstract":"Hepatocellular carcinoma (HCC) represents a significant global health burden, particularly in the Asia-Pacific region, where it is a leading cause of cancer-related mortality. In China alone, HCC accounts for approximately 367,700 new cases and 316,500 deaths annually; over 50% of patients are diagnosed at an advanced stage, limiting curative treatment options and resulting in poor survival outcomes. Systemic therapies combining immune checkpoint inhibitors (ICIs) with antiangiogenic targeted drugs have shown promise in converting unresectable HCC into resectable cases, potentially transforming clinical outcomes. The Chines expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition) provides an updated, multidisciplinary framework emphasizing sequential surgery post-conversion therapy. The consensus highlights treatment protocols, efficacy evaluation, and innovative adjuvant strategies to refine clinical practice and enhance survival outcomes in advanced HCC.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":"18 6","pages":"495-496"},"PeriodicalIF":5.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0