Bioscience trends最新文献_第7页

Efficacy and effect on lipid profiles of Ainuovirine-based regimen versus Efavirenz-based regimen in treatment-naïve people with HIV-1 at week 24: A real-world, retrospective, multi-center cohort study. 基于阿依诺韦林的治疗方案与基于依非韦伦的治疗方案在第24周对HIV-1病毒感染者的疗效及其对血脂的影响：一项真实世界、回顾性、多中心队列研究。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-06-06 Epub Date: 2024-04-27 DOI: 10.5582/bst.2024.01070

Hai Long, Quanying He, Yanmei Bi, Yingchun Ke, Xiaoxin Xie, Xiuhong Zhao, Si Tan, Yanhe Luo, Zhong Chen, Xiaoli Yu, Linghua Li

{"title":"Efficacy and effect on lipid profiles of Ainuovirine-based regimen versus Efavirenz-based regimen in treatment-naïve people with HIV-1 at week 24: A real-world, retrospective, multi-center cohort study.","authors":"Hai Long, Quanying He, Yanmei Bi, Yingchun Ke, Xiaoxin Xie, Xiuhong Zhao, Si Tan, Yanhe Luo, Zhong Chen, Xiaoli Yu, Linghua Li","doi":"10.5582/bst.2024.01070","DOIUrl":"10.5582/bst.2024.01070","url":null,"abstract":"This study aimed to compare the efficacy and effect on lipid profiles of Ainuovirine (ANV)- and efavirenz (EFV) -based regimens in treatment-naïve people living with HIV-1 (PLWH) at week 24. The proportion of PLWH achieving HIV-1 RNA < the limit of quantification in the ANV group was significantly higher than that in the EFV group (89.18% vs. 76.04%, P = 0.002). The mean change of log10 HIV-1 RNA from baseline was greater (-4.34 vs. -4.18, P < 0.001), the median change from baseline in CD4+ T cell count increased more (106.00 cells/μL vs. 92.00 cells/μL, P = 0.007) in the ANV group, while the CD4+/CD8+ ratio was similar (0.15 vs. 0.20, P = 0.167) between the two groups. The mean changes from baseline in total cholesterol (-0.02 for ANV vs. 0.25 mmol/L for EFV, P < 0.001), triglyceride (-0.14 for ANV vs. 0.11 mmol/L for EFV, P = 0.024), and low-density lipoprotein cholesterol (-0.07 for ANV vs. 0.15 mmol/L for EFV, P < 0.001) was significantly different between the two groups. The percentage of patients with improved lipid profiles was significantly higher in the ANV group (37.44 %) than in the EFV group (29.55%, P = 0.0495). The incidence of any adverse events in the ANV group was significantly lower than that in the EFV group at week 12 (6.2% vs. 30.7%, P < 0.001) and was comparable at week 24 (3.6% vs. 5.5%, P = 0.28). The ANV-based regimen was well tolerated and lipid-friendly in treatment-naïve PLWH.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"176-186"},"PeriodicalIF":5.7,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considering traditional Chinese medicine as adjunct therapy in the management of chronic constipation by regulating intestinal flora. 考虑将传统中药作为辅助疗法，通过调节肠道菌群治疗慢性便秘。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-06-06 Epub Date: 2024-03-25 DOI: 10.5582/bst.2024.01036

Ke Wang, Hua Qiu, Fang Chen, Pingping Cai, Fanghua Qi

{"title":"Considering traditional Chinese medicine as adjunct therapy in the management of chronic constipation by regulating intestinal flora.","authors":"Ke Wang, Hua Qiu, Fang Chen, Pingping Cai, Fanghua Qi","doi":"10.5582/bst.2024.01036","DOIUrl":"10.5582/bst.2024.01036","url":null,"abstract":"Chronic constipation is one of the most common gastrointestinal disorders worldwide. Due to changes in diet, lifestyle, and the aging population, the incidence of chronic constipation has increased year by year. It has had an impact on daily life and poses a considerable economic burden. Nowadays, many patients with chronic constipation try to seek help from complementary and alternative therapies, and traditional Chinese medicine (TCM) is often their choice. The intestinal flora play an important role in the pathogenesis of constipation by affecting the body's metabolism, secretion, and immunity. Regulating the intestinal flora and optimizing its composition might become an important prevention and treatment for chronic constipation. TCM has unique advantages in regulating the imbalance of intestinal flora, and its curative effect is precise. Therefore, we reviewed the relationship between intestinal flora and chronic constipation as well as advances in research on TCM as adjunct therapy in the management of chronic constipation by regulating intestinal flora. Some single Chinese herbs and their active ingredients (e.g., Rheum palmatum, Radix Astragalus, and Cistanche deserticola), some traditional herbal formulations (e.g., Jichuan decoction, Zengye decoction, and Zhizhu decoction) and some Chinese patent medicines (e.g., Maren pills and Shouhui Tongbian capsules) that are commonly used to treat chronic constipation by regulating intestinal flora are highlighted and summarized. Moreover, some external forms of TCM, and especially acupuncture, have also been found to improve intestinal movement and alleviate constipation symptoms by regulating intestinal flora. We hope this review can contribute to an understanding of TCM as an adjunct therapy for chronic constipation and that it can provide useful information for the development of more effective constipation therapies.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"127-140"},"PeriodicalIF":5.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibody therapy for Alzheimer's disease focusing on intracerebral targets. 以脑内靶点为重点的阿尔茨海默病单克隆抗体疗法。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-21 DOI: 10.5582/bst.2023.01288

Xiaolei Gu, Long Qi, Qing Qi, Jing Zhou, Song Chen, Ling Wang

引用次数: 0

Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti-PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics. 经导管动脉化疗栓塞联合来伐替尼+抗PD-1抗体治疗不可切除肝细胞癌的效果：一种具有中国特色的治疗方法

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2023.01326

Jiayi Wu, Junyi Wu, Shuqun Li, Mengchao Luo, Zhenxin Zeng, Yinan Li, Yangkai Fu, Han Li, Deyi Liu, Xiangye Ou, Zhongtai Lin, Shaoming Wei, Maolin Yan

{"title":"Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti-PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics.","authors":"Jiayi Wu, Junyi Wu, Shuqun Li, Mengchao Luo, Zhenxin Zeng, Yinan Li, Yangkai Fu, Han Li, Deyi Liu, Xiangye Ou, Zhongtai Lin, Shaoming Wei, Maolin Yan","doi":"10.5582/bst.2023.01326","DOIUrl":"10.5582/bst.2023.01326","url":null,"abstract":"Therapies for patients with unresectable hepatocellular carcinoma (uHCC) are currently popular. Current first-line standard-of-care treatments for uHCC are systematic therapies. However, treatments that combine locoregional therapy with systemic therapy are widely accepted in China and have demonstrated high rates of tumor response and conversion to resection with manageable toxicity. A literature review was performed by searching published literature in PubMed and Web of Science up to December 2023 for relevant articles on the use of triple therapy (transarterial chemoembolization combined with lenvatinib and anti-PD-1 antibodies) in uHCC. This review concentrates on the efficacy and safety of triple therapy with Chinese characteristics in patients with uHCC and describes the outcome of conversion surgery, degree of pathological necrosis, and effect prediction. This article will contribute to a comprehensive understanding of the role of triple therapy with Chinese characteristics in patients with uHCC.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"42-48"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New mechanisms: From lactate to lactylation to rescue heart failure. 新机制：从乳酸到乳化，拯救心力衰竭。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2024.01000

Linfeng Yi, Dan Tang, Xing Xiang, Chungang Xiao, Huifang Tang, Hong Huang

引用次数: 0

Predictive deep learning models for cognitive risk using accessible data. 利用可获取的数据建立认知风险预测深度学习模型。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-20 DOI: 10.5582/bst.2024.01026

Kenji Karako

引用次数: 0

Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study. 糖尿病、血糖特征、SGLT2 抑制与肺动脉高压风险：孟德尔随机研究

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2024.01006

Jiang-Shan Tan, Yanmin Yang, Jingyang Wang, Yimeng Wang, Tingting Lv, Yuyuan Shu, Wei Xu, Lingtao Chong

{"title":"Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study.","authors":"Jiang-Shan Tan, Yanmin Yang, Jingyang Wang, Yimeng Wang, Tingting Lv, Yuyuan Shu, Wei Xu, Lingtao Chong","doi":"10.5582/bst.2024.01006","DOIUrl":"10.5582/bst.2024.01006","url":null,"abstract":"This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of gene expression and hemoglobin A1c. Results showed that genetically inferred DM demonstrated a causal correlation with an increased risk of PAH, exhibiting an odds ratio (OR) of 1.432, with a 95% confidence interval (CI) of 1.040-1.973, and a p-value of 0.028. The multivariate MR analysis revealed comparable outcomes after potential confounders (OR = 1.469, 95%CI = 1.021-2.115, p = 0.038). Moreover, genetically predicted SGLT2 inhibition was causally linked to a reduced risk of PAH (OR = 1.681*10-7, 95%CI = 7.059*10-12-0.004, p = 0.002). Therefore, our study identified the suggestively causal effect of DM on the risk of PAH, and SGLT2 inhibition may be a potential therapeutic target in patients with PAH.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"94-104"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China. 中国小学学龄自闭症谱系障碍儿童教育安置的社会经济差异。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2023.01319

Yanan Zhao, Rong Zhang, Xiaoying Zheng

{"title":"Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China.","authors":"Yanan Zhao, Rong Zhang, Xiaoying Zheng","doi":"10.5582/bst.2023.01319","DOIUrl":"10.5582/bst.2023.01319","url":null,"abstract":"Relatively little is known about education placements for children with autism spectrum disorder (ASD) in China. While disparities in ASD diagnoses and services for the population broadly are often documented, the presence and determinants of differences in the educational placement of ASD children are less studied and understood. By identifying who is likely to be in segregated settings, we can discern how to best support them and facilitate a possible transition to a less restrictive setting. This study describes four placements (regular schools, special schools, institutions, homes) and their influencing factors retrospectively in a large sample (n = 2,190) of Chinese primary school-aged children (6-12 years old). We divided ASD into severe and mild to moderate categories for analysis. Children with ASD were more likely to study in a regular school (48.60%), while 13.88% were in a special school. Children with severe ASD were placed in less regular settings than children with mild to moderate ASD. However, families with higher socioeconomic status (SES) were more likely to place their children in regular schools than lower SES families if their children experienced mild to moderate symptoms. Children with severe ASD were more likely to be placed in expensive institutions for families with higher SES than those with lower SES. SES disparities in educational placement existed and had two manifestations. It is important to characterize educational placements of students with ASD to determine the extent to which they are placed in general education settings, which are often the preferred placement.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"73-82"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of diagnosis-related groups (DRG)-based hospital payment system design and implementation strategies in different countries: The case of ischemic stroke. 比较不同国家基于诊断相关分组（DRG）的医院支付系统设计和实施策略：以缺血性中风为例。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-24 DOI: 10.5582/bst.2023.01027

Yuan Liu, Gang Wang, Tian-Ge Qin, Susumu Kobayashi, Takashi Karako, Peipei Song

{"title":"Comparison of diagnosis-related groups (DRG)-based hospital payment system design and implementation strategies in different countries: The case of ischemic stroke.","authors":"Yuan Liu, Gang Wang, Tian-Ge Qin, Susumu Kobayashi, Takashi Karako, Peipei Song","doi":"10.5582/bst.2023.01027","DOIUrl":"10.5582/bst.2023.01027","url":null,"abstract":"Diagnosis-related groups (DRG) based hospital payment systems are gradually becoming the main mechanism for reimbursement of acute inpatient care. We reviewed the existing literature to ascertain the global use of DRG-based hospital payment systems, compared the similarities and differences of original DRG versions in ten countries, and used ischemic stroke as an example to ascertain the design and implementation strategies for various DRG systems. The current challenges with and direction for the development of DRG-based hospital payment systems are also analyzed. We found that the DRG systems vary greatly in countries in terms of their purpose, grouping, coding, and payment mechanisms although based on the same classification concept and that they have tended to develop differently in countries with different income classifications. In high-income countries, DRG-based hospital payment systems have gradually begun to weaken as a mainstream payment method, while in middle-income countries DRG-based hospital payment systems have attracted increasing attention and increased use. The example of ischemic stroke provides suggestions for mutual promotion of DRG-based hospital payment systems and disease management. How to determine the level of DRG payment incentives and improve system flexibility, balance payment goals and disease management goals, and integrate development with other payment methods are areas for future research on DRG-based hospital payment systems.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"1-10"},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel cholesterol tag-based system for trans-membrane transport of protein drugs. 开发基于胆固醇标签的新型蛋白质药物跨膜转运系统。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-08 DOI: 10.5582/bst.2023.01285

Pengfei Zhao, Shuo Song, Zhuojun He, Guiqin Dai, Deliang Liu, Jiayin Shen, Tetsuya Asakawa, Mingbin Zheng, Hongzhou Lu

{"title":"Development of a novel cholesterol tag-based system for trans-membrane transport of protein drugs.","authors":"Pengfei Zhao, Shuo Song, Zhuojun He, Guiqin Dai, Deliang Liu, Jiayin Shen, Tetsuya Asakawa, Mingbin Zheng, Hongzhou Lu","doi":"10.5582/bst.2023.01285","DOIUrl":"10.5582/bst.2023.01285","url":null,"abstract":"The main technological difficulties of developing an intracellular (transmembrane) transport system for protein drugs lie in two points: i) overcoming the barriers in the cellular membrane, and ii) loading enough protein drugs, and particularly high-dose proteins, into particles. To address these two technological problems, we recently developed a novel cholesterol tag (C-Tag)-based transmembrane transport system. This pilot study found that the C-Tag dramatically improved the cellular uptake of Fab (902-fold, vs. Fab alone) into living cells, indicating that it successfully achieved transmembrane transport. Moreover, C-Tag-mediated membrane transport was verified using micron-scale large unilamellar vesicles (LUVs, approximately 1.5 μm)-based particles. The C-Tagged Fab was able to permeate the liposomal bilayer and it greatly enhanced (a 10.1-fold increase vs. Fab alone) internalization of proteins into the LUV-based particles, indicating that the C-Tag loaded enough proteins into particles for use of high-dose proteins. Accordingly, we established a novel C-Tag-based transport system that has overcome the known technological difficulties of protein transmembrane delivery, and this might be a useful technology for drug development in the future.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"503-507"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0