Exosomes derived from olfactory mucosa mesenchymal stem cells attenuate cognitive impairment in a mouse model of Alzheimer's disease.

IF 5.7 4区 生物学 Q1 BIOLOGY
Xiqi Hu, Ya-Nan Ma, Jun Peng, Zijie Wang, Yuchang Liang, Ying Xia
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引用次数: 0

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, neuroinflammation, and endoplasmic reticulum (ER) stress. In recent years, exosomes have garnered significant attention as a potential therapeutic tool for neurodegenerative diseases. This study, for the first time, investigates the neuroprotective effects of exosomes derived from olfactory mucosa mesenchymal stem cells (OM-MSCs-Exos) in AD and further explore the potential role of low-density lipoprotein receptor-related protein 1 (LRP1) in this process. Using an Aβ1-42-induced AD mouse model, we observed that OM-MSCs-Exos significantly improved cognitive function in behavioral tests, reduced neuroinflammatory responses, alleviated ER stress, and decreased neuronal apoptosis. Further analysis revealed that OM-MSCs-Exos exert neuroprotective effects by modulating the activation of microglia and astrocytes and influencing the ER stress response, a process that may involve LRP1. Although these findings support the potential neuroprotective effects of OM-MSCs-Exos, further studies are required to explore their long-term stability, dose dependency, and immunogenicity to assess their feasibility for clinical applications.

来自嗅觉粘膜间充质干细胞的外泌体减轻阿尔茨海默病小鼠模型的认知障碍。
阿尔茨海默病(AD)是一种以认知能力下降、神经炎症和内质网应激为特征的进行性神经退行性疾病。近年来,外泌体作为神经退行性疾病的潜在治疗工具引起了极大的关注。本研究首次探讨了嗅粘膜间充质干细胞外泌体(OM-MSCs-Exos)在AD中的神经保护作用,并进一步探讨了低密度脂蛋白受体相关蛋白1 (LRP1)在这一过程中的潜在作用。通过a β1-42诱导的AD小鼠模型,我们观察到om - msc - exos显著改善行为测试中的认知功能,减少神经炎症反应,减轻内质网应激,减少神经元凋亡。进一步分析表明,om - msc - exos通过调节小胶质细胞和星形胶质细胞的激活并影响内质网应激反应来发挥神经保护作用,这一过程可能与LRP1有关。尽管这些发现支持om - msc - exos潜在的神经保护作用,但仍需进一步研究其长期稳定性、剂量依赖性和免疫原性,以评估其临床应用的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
13.60
自引率
1.80%
发文量
47
审稿时长
>12 weeks
期刊介绍: BioScience Trends (Print ISSN 1881-7815, Online ISSN 1881-7823) is an international peer-reviewed journal. BioScience Trends devotes to publishing the latest and most exciting advances in scientific research. Articles cover fields of life science such as biochemistry, molecular biology, clinical research, public health, medical care system, and social science in order to encourage cooperation and exchange among scientists and clinical researchers.
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