Biomedicines最新文献

{"title":"Special Issue \"Brain Injury: New Insights into Mechanisms and Future Promising Treatments\".","authors":"Kristina Pilipović, Petra Dolenec","doi":"10.3390/biomedicines13051190","DOIUrl":"10.3390/biomedicines13051190","url":null,"abstract":"<p><p>This Special Issue of <i>Biomedicines</i> presents 12 published, peer-reviewed articles on the theme of \"Brain Injury: New Insights into Mechanisms and Future Promising Treatments\", including 10 original research papers and 2 reviews covering the topics related to the pathophysiology of acquired central nervous system (CNS) injuries, as well as biomarker discovery, diagnosis, and potential pharmacological and non-pharmacological approaches in the treatment of these disorders [...].</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA Signatures in Endometrial Receptivity-Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review.","authors":"Charalampos Voros, Antonia Varthaliti, Diamantis Athanasiou, Despoina Mavrogianni, Kyriakos Bananis, Antonia Athanasiou, Aikaterini Athanasiou, Anthi-Maria Papahliou, Constantinos G Zografos, Panagiota Kondili, Maria Anastasia Daskalaki, Dimitris Mazis Kourakos, Dimitrios Vaitsis, Marianna Theodora, Panagiotis Antsaklis, Dimitrios Loutradis, Georgios Daskalakis","doi":"10.3390/biomedicines13051189","DOIUrl":"10.3390/biomedicines13051189","url":null,"abstract":"<p><p><b>Background:</b> Endometrial receptivity is crucial for successful embryo implantation in assisted reproductive technologies (ARTs). MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as important post-transcriptional regulators of endometrial function, although their diagnostic and molecular functions are poorly understood. <b>Methods:</b> A systematic review was conducted following PRISMA 2020 principles and registered in PROSPERO (CRD420251001811). We looked at 28 peer-reviewed publications published between 2010 and 2025 that used endometrial tissue, blood, uterine fluid, saliva, and embryo culture medium to study miRNAs and other non-coding RNAs in endometrial receptivity, recurrent implantation failure (RIF), and infertility. <b>Results:</b> MiRNAs like miR-145, miR-30d, miR-223-3p, and miR-125b influence implantation-related pathways such as HOXA10, LIF-STAT3, PI3K-Akt, and Wnt/β-catenin. Dysregulated expression profiles were linked to inadequate decidualization, immunological imbalance, and poor angiogenesis. CeRNA networks that include lncRNAs (e.g., H19 and NEAT1) and circRNAs (e.g., circ_0038383) further regulate miRNA activity. Non-invasive biomarkers derived from plasma, uterine fluid, and embryo media showed high prediction accuracy for implantation outcomes. <b>Conclusions:</b> MiRNA signatures offer a functional and diagnostic blueprint for endometrial receptivity. This systematic review provides a timely and thorough synthesis of the existing literature, with the goal of bridging the gap between molecular discoveries and therapeutic applications. By emphasizing both the mechanistic importance and diagnostic value of certain miRNA signatures, it paves the way for future precision-based techniques in embryo transfer and endometrial assessment in ART.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Genetic Variants, Such as the μ-Opioid Receptor 1 (<i>OPRM1</i>) <i>rs1799971</i> and Catechol-O-Methyltransferase (<i>COMT</i>) <i>rs4680,</i> with Phenotypic Expression of Fibromyalgia.","authors":"Isabel Erenas Ondategui, Julia Gómez Castro, Sandra Estepa Hernández, Celia Chicharro Miguel, Regina Peiró Cárdenas, Ana Fernández-Araque, Zoraida Verde","doi":"10.3390/biomedicines13051183","DOIUrl":"10.3390/biomedicines13051183","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Genetic variants, such as the µ-opioid receptor 1 (<i>OPRM1</i>) <i>rs1799971</i> and the catechol-O-methyltransferase (<i>COMT</i>) <i>rs4680</i>, have been considered among the potential causes in the development of some chronic pain conditions. In this regard, there are controversial results regarding their roles in fibromyalgia (FM). We aimed to investigate whether the OPRM1 rs1799971 and COMT rs4680 polymorphisms are associated with the development of or susceptibility to FM, as well as their potential association with syndrome characteristic variables, in a sample of the Spanish population with and without FM. <b>Methods</b>: The present study analysed <i>COMT</i> Val158Met and <i>OPRM1</i> Asn40Asp genetic variants in 311 FM patients (301 women and 10 men) and 135 non-FM participants (120 women and 15 men). In addition to clinical variables, widespread pain index (WPI), symptom severity scale (SSS) (fatigue, rest quality, and cognitive symptoms), pain, stress episodes, and Borg scale were collected. <b>Results</b>: The main results indicate that women carrying the Val/Val genotype (i.e., high COMT activity) exhibited significantly lower levels of fatigue, cognitive impairment, and total SSS than heterozygote carriers. In addition, Met allele carriers (i.e., lower COMT activity) showed higher probabilities of suffering a stress episode and higher levels of exertion during daily activities. <b>Conclusions</b>: The present research suggests a link between dopaminergic dysfunction and exacerbated, frequently described symptoms in female FM patients. Although further research with wider genetic variants and recruited patients is needed, these results point out the necessity of considering gender as a separate category in chronic pain studies.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracardiac Echo Versus Fluoroscopic Guidance for Pulsed Field Ablation: Single-Center Real-Life Study.","authors":"Vivek Joseph Varughese, James Pollock, Chandler Richardson, Dominic Vacca, Hata Mujadzic, Sultan Siddique","doi":"10.3390/biomedicines13051186","DOIUrl":"10.3390/biomedicines13051186","url":null,"abstract":"<p><p><b>Background:</b> Pulsed field ablation (PFA) is a novel non-thermal modality for catheter ablation (CA) in atrial fibrillation (AF) and has been replacing traditional thermal modalities. There have been studies in the past comparing fluoroscopic (FL) versus intracardiac echocardiogram (ICE) guidance for thermal ablation modalities. However, there have not been studies that compare outcomes for PFA performed under ICE versus FL guidance. <b>Methods:</b> This study was designed in a longitudinal cross-sectional format. A total of 196 patients who underwent PFA for AF at Prisma Health Richland were selected for the retrospective analysis. Patients were divided into two groups: those who underwent PFA under FL guidance (103 patients) versus ICE guidance (93 patients). The recurrence of atrial arrhythmias in the six-month follow-up period was studied. Multivariate regression analysis was performed to assess the difference in the association of either modality with recurrence of atrial arrhythmias. Bayesian non-inferiority models were used to analyze the non-inferiority between the modalities. <b>Results:</b> A total of 31 patients (30.1%) in the fluoro group had documented atrial arrhythmias in the six months following ablation. While 23 patients (24.7%) in the ICE group had documented atrial arrhythmias in the six-month follow-up period. The recurrence of AF was noted in 22.3% (22 patients) in the fluoro group and 14% (13 patients) in the ICE group. After running the multivariate regression analysis models, PFA under fluoroscopic guidance did not differ from ICE guidance, in terms of the recurrent atrial arrhythmias in the six-month follow-up (Adjusted Odds Ratio: 0.964; 95% CI: 0.336-2.772). The fluoro and ICE groups also did not differ in terms of six-month atrial fibrillation recurrence (Adjusted Odds Ratio: 2.43; 95% CI: 0.649-9.19). Non-inferiority analysis with Bayesian model was carried out, comparing the fluoro group and the ICE group in terms of freedom from arrhythmias in the six-month follow-up, and no inferiority was proved (95% confidence interval: -0.18-0.053), with a 61.03% chance of ICE-guided PFA being superior to fluoro guidance in terms of recurrence free interval, but statistical significance was not reached. <b>Conclusions:</b> Mean fluoroscopic time in the FL guidance group was 15.9 min, while no radiation exposure was documented in the ICE group. CA performed under FL versus ICE guidance did not differ statistically in terms of six-month recurrence of atrial arrhythmias in general and AF in particular.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal Weight, Overweight and Obesity Conditions Associated to Prostate Neoplasm Stages-A Systematic Review and Meta-Analysis.","authors":"Elsa Vitale, Alessandro Rizzo, Kurvatteppa Halemani, Asha P Shetty, Omar Cauli, Francesco Massari, Matteo Santoni","doi":"10.3390/biomedicines13051182","DOIUrl":"10.3390/biomedicines13051182","url":null,"abstract":"<p><p><b>Background/Objective:</b> Prostate cancer (PCa) represents the second-most common cancer among men worldwide. Obesity is generally considered as a risk factor for cancer and it has been associated with a 20-30% increased risk of PCa death. The present systematic review and meta-analyses aimed to highlight any existing trends between prostate neoplasm stages according to normal weight, overweight and obesity conditions. <b>Methods:</b> All interventional records such as randomized clinical trials, quasi-experimental studies and observational studies were included in the present systematic review and meta-analysis which reported PCa stages according to Gleason (GS) or TNM scores according to the BMI-related incidence, as normal weight, overweight and obesity groups. <b>Results:</b> Twenty-nine studies were included in the present study. As regards the GS scoring system, 1.09% of high grade in GS was reported among PCa normal weights. Among PCa overweights, 0.98% of low grade was registered in GS. The same trend was recorded among obese PCa patients, since 0.79% of low grade in GS was also registered. As regards TNM scores, both normal weight, overweight and obese PCa patients registered a significant incidence in non-advanced TNM score, without any significant differences considering higher TNM assessments. <b>Conclusions:</b> Although the literature seemed to be more in favor of associations between BMI and GS, no specific mechanisms were highlighted between obesity and PCa progression. In this regard, the low androgen microenvironment in obese men could play an important role, but further studies will be necessary in this direction.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters.","authors":"Mahira Ismayilova, Aytakin Hasanova, Andrei Semikhodskii","doi":"10.3390/biomedicines13051191","DOIUrl":"10.3390/biomedicines13051191","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall. Men with abnormal semen parameters have a significantly increased risk of aneuploidy, presenting a serious concern in programmes of assisted reproductive technologies. Recently, the introduction of preimplantation genetic testing for aneuploidies (PGT-A) has increased the pregnancy rate and live births. We investigated the effect of PGT-A on the success of IVF treatment in couples with the male factor of infertility. <b>Methods:</b> Two experimental groups and one control group were studied: Group A (110 couples)-male partners with abnormal semen parameters, with PGT-A; Group B (110 couples)-male partners with abnormal semen parameters, without PGT-A; and Group C (105 couples)-control, male partners with normal spermograms, with PGT-A. A Day 3 blastomere biopsy was followed by FISH-based PGT-A. A total of 880 embryos from Group A and 890 embryos from Group C was analysed. <b>Results:</b> In patients with abnormal semen parameters, embryonic aneuploidy was twice as common compared to the control (13.6% vs. 5.8%, <i>p</i> < 0.001). Group B had the lowest clinical pregnancy rate (28.2%), with two out of three pregnancies ending in a miscarriage. Only 10% of IVF cycles in this group resulted in live birth compared with 35.5% for Group A and 49.5% for Group C. <b>Conclusions:</b> Our data demonstrate that PGT-A screening as part of IVF treatment drastically increases the clinical pregnancy rate and chances of live birth in couples where male partners have semen abnormality.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Dietary Patterns to Autism Severity and Developmental Outcomes: A Correlational Study Using Food Frequency Questionnaires; The Childhood Autism Rating Scale, Second Edition; And Developmental Profile 3.","authors":"Dimitar Marinov, Sevdzhihan Eyubova, Albena Toneva, Rositsa Chamova, Rozalina Braykova, Stanislava Hadzhieva, Ruzha Pancheva","doi":"10.3390/biomedicines13051178","DOIUrl":"10.3390/biomedicines13051178","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Autism Spectrum Disorder (ASD) is characterized by social communication challenges and repetitive behaviors. Children with ASD often exhibit selective eating habits that may result in nutritional deficiencies and exacerbate developmental issues. While food frequency questionnaires (FFQs) are effective for dietary assessment, the links between food preferences, ASD severity, and developmental outcomes remain underexplored, particularly in Bulgaria. This study examines these relationships using validated tools. <b>Methods</b>: The present report constitutes a pilot, hypothesis-generating substudy of the broader NutriLect project. This substudy involved 49 children aged 2-12 years diagnosed with ASD. Dietary patterns were evaluated with a modified FFQ, while ASD severity and developmental profiles were assessed using the Childhood Autism Rating Scale, Second Edition (CARS-2) and the Developmental Profile 3 (DP-3). <b>Results</b>: Among 49 ASD children (mean age = 6.89 ± 2.15 years; 86% boys), 73.4% consumed grains/potatoes daily. Only 34.7% met combined fruit and vegetable recommendations. Only 36.7% met the recommendation for daily milk or other dairy product consumption. Fish was consumed at least twice weekly by only 22,4%. Furthermore, children with more severe autism were approximately 9.4 times more likely to consume grains daily (χ² = 14.319, <i>p</i> = 0.006). Logistic regression analyses indicated that higher cognitive scores were strongly associated with lower grain (OR ≈ 0.044) and other dairy products consumption (OR ≈ 0.337), yet with greater fish intake (OR ≈ 3.317). In contrast, better communication skills corresponded to increased milk consumption (OR ≈ 5.76), and higher physical development scores predicted more frequent egg consumption (OR ≈ 4.40). <b>Conclusions</b>: The pronounced preference for grain and meat products, which are frequently ultra-processed, and avoidance of nutrient-dense foods in children with severe ASD symptoms underscore the need for tailored dietary interventions. These interventions must address sensory sensitivities, nutritional inadequacies, and the risks that selective nutrition can have on the nutritional status and development of the children.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulation and Immunotherapy for Patients with Prostate Cancer: An Up-to-Date Review.","authors":"Nigel P Murray","doi":"10.3390/biomedicines13051179","DOIUrl":"10.3390/biomedicines13051179","url":null,"abstract":"<p><p>Immunotherapy alone or in combination with chemotherapy or radiotherapy is the frontline treatment for melanoma and lung cancer. However, its role in prostate cancer is usually as a fourth-line treatment. It is usually employed in patients with metastasis, after androgen blockade and chemotherapy. This article reviews the immunosuppressive effects of prostate cancer and possible uses of various types of immunotherapies. It also considers when would be the optimal time to employ this type of therapy.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Merkel Cell Polyomavirus (MCPyV) and Its Possible Role in Head and Neck Cancers.","authors":"Sara Passerini, Sara Messina, Ugo Moens, Valeria Pietropaolo","doi":"10.3390/biomedicines13051180","DOIUrl":"10.3390/biomedicines13051180","url":null,"abstract":"<p><p>Despite significant progress in its prevention, diagnosis, and treatment, head and neck cancer (HNC) remains a major global health issue due to its multifactorial pathogenesis. Indeed, HNCs have been found to be associated with different environmental and lifestyle factors, as well as with infection with oncogenic viruses. To date, seven viruses are recognized for their tumorigenic properties and have been proposed as implicated in HNC development, including Merkel Cell Polyomavirus (MCPyV). MCPyV is well recognized as the major etiological agent of Merkel cell carcinoma (MCC), a rare but rapidly metastasizing skin neoplasm. Specifically, in almost 80% of MCC cases, viral genome integration occurs, and a truncated form of Large T Antigen (tLT) is expressed. Although MCC is a rare cancer, MCPyV is a ubiquitous virus, widely distributed among the human population. Therefore, a plausible role of the virus has been proposed, even for other tumors. The current review provides an overview of the available data describing the presence of MCPyV in non-MCC tumors, such as HNCs, with the aim of elucidating the potential contribution of MCPyV to oral cancer. Understanding the role of viral infections in the etiology of cancer opens up the opportunity for developing preventive measures and targeted therapies that effectively address HNC progression while reducing treatment-related side effects.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transposable Element Is Predictive of Chemotherapy- and Immunotherapy-Related Overall Survival in Glioma.","authors":"Bi Peng, Fan Shen, Ziqi Chen, Yongkai Yu, Rundong Liu, Yiling Zhang, Guoxian Long, Guangyuan Hu, Yuanhui Liu","doi":"10.3390/biomedicines13051177","DOIUrl":"10.3390/biomedicines13051177","url":null,"abstract":"<p><p><b>Background:</b> Glioma is the most common type of malignant brain tumor. Temozolomide (TMZ) is a limited systematic treatment option for glioma, including low-grade glioma (LGG) and glioblastoma (GBM). However, not all patients benefit from TMZ and some develop resistance to it. MGMT methylation has been used to identify patients who may benefit from TMZ, but it is not effective in all cases. <b>Objectives:</b> There is an urgent need for new biomarkers to predict the survival of patients who receive TMZ. <b>Methods:</b> We utilized a recently developed method called REdiscoverTE to precisely measure the expression of transposable elements (TE). We performed Cox regression analysis to assess the predictive ability for prognosis and conducted a series of correlation studies to uncover potential mechanisms. <b>Results:</b> We identified three TEs, LTR81B, LTR27B, and MER39B, that were strongly predictive of longer survival in glioma patients receiving chemotherapy. We discovered that the expression of these TEs was positively associated with immune cells that enhance the immune system and negatively associated with immune cells suppressing the immune response, as well as molecules that control immune checkpoints. These three TEs were also found to predict better survival in patients receiving immunotherapy. <b>Conclusions:</b> In conclusion, we demonstrate that the expression of TEs can serve as a novel biomarker for the overall survival of glioma patients who receive TMZ chemotherapy or immunotherapy.</p>","PeriodicalId":8937,"journal":{"name":"Biomedicines","volume":"13 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}