BioMedical Engineering OnLine最新文献

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Effect of nano-hydroxyapatite filling on masticatory function and gingival sulcular fluid inflammatory factor levels in periapical inflammation. 纳米羟基磷灰石充填对牙根尖周炎症患者咀嚼功能及龈沟液炎症因子水平的影响。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-21 DOI: 10.1186/s12938-025-01374-9
Honghui Xie, Aihong Tan, Zhijian Su, Chao Pan, Shuangjiang Li, Haibo Xiao
{"title":"Effect of nano-hydroxyapatite filling on masticatory function and gingival sulcular fluid inflammatory factor levels in periapical inflammation.","authors":"Honghui Xie, Aihong Tan, Zhijian Su, Chao Pan, Shuangjiang Li, Haibo Xiao","doi":"10.1186/s12938-025-01374-9","DOIUrl":"10.1186/s12938-025-01374-9","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to investigate the influence of nano-hydroxyapatite (nano-HA) filling on the restoration of masticatory function and the modulation of inflammatory factors within gingival sulcular fluid in patients suffering from periapical inflammation.</p><p><strong>Methods: </strong>98 patients with periapical inflammation were selected and divided into a control group and a nano group using the red blue ball method, with 49 cases in each group. The control group was treated with conventional root canal therapy only, and the nano group underwent endodontic treatment with the nano-HA filling method. Gingival fluid samples were collected from all patients at enrollment, 1 week, and 3 months postoperatively to analyze the levels of interleukin- 1β (IL- 1β) and tumor necrosis factor-α (TNF-α). At the time of enrollment and 3 months after surgery, patients were monitored for bite force, masticatory efficiency, and clinical efficacy.</p><p><strong>Results: </strong>In this study, compared to the control group, the experimental group treated with nano-HA filling showed significantly better improvement in bite force and masticatory efficiency, with the difference being statistically significant (P < 0.01). Moreover, the experimental group significantly inhibited the expression of inflammatory factors such as IL- 1β and TNF-α, with a continuous decrease in their levels over time. In terms of filling effect, healing rate, and total efficacy rate, the experimental group also achieved superior results compared to the control group, with the difference being statistically significant (P < 0.05). There was a negative correlation between the application of nano-HA fillers and the gingival sulcus inflammatory factor at 1 week postoperatively and 3 months postoperatively.</p><p><strong>Conclusion: </strong>In comparison with conventional restorative materials, nano-HA restorative has been shown to possess several notable advantages. These include the promotion of recovery of masticatory function, the regulation of inflammatory factor expression in gingival sulcular fluid, and the enhancement of clinical efficacy and filling effect. This study provides a theoretical basis for the clinical promotion of the use of nano-HA restorative materials in the treatment of periapical inflammation.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"63"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A KNN-based model for non-invasive prediction of hemorrhagic shock severity in prehospital settings: integrating MAP, PBUCO2, PTCO2, and PPV. 基于knn的院前无创预测失血性休克严重程度模型:整合MAP、PBUCO2、PTCO2和PPV
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-20 DOI: 10.1186/s12938-025-01394-5
Peng Zhao, Wencai Pan, Xin Zou, Jiaqing Yang, Shihui Zhang, Yufei Liu, Yang Li
{"title":"A KNN-based model for non-invasive prediction of hemorrhagic shock severity in prehospital settings: integrating MAP, P<sub>BU</sub>CO<sub>2</sub>, P<sub>TC</sub>O<sub>2</sub>, and PPV.","authors":"Peng Zhao, Wencai Pan, Xin Zou, Jiaqing Yang, Shihui Zhang, Yufei Liu, Yang Li","doi":"10.1186/s12938-025-01394-5","DOIUrl":"10.1186/s12938-025-01394-5","url":null,"abstract":"<p><strong>Background: </strong>Rapid prehospital assessment of hemorrhagic shock severity is critical for trauma triage and intervention. Current non-invasive single-parameter monitoring shows limited diagnostic reliability. We developed a multi-parameter predictive model integrating mean arterial pressure (MAP), buccal mucosal CO₂ (P<sub>BU</sub>CO₂), transcutaneous oxygen (P<sub>TC</sub>O₂), and pulse pressure variation (PPV). using K-nearest neighbors (KNN) algorithm.</p><p><strong>Methods: </strong>Forty-five Wistar rats were randomly divided into five groups (n = 9) with different blood loss amounts. MAP, P<sub>BU</sub>CO<sub>2</sub>, P<sub>TC</sub>O<sub>2</sub>, and PPV measurements were continuously obtained. A multi-parameter shock severity prediction model was established based on the KNN algorithm. Leave-one-out cross-validation was used to determine the value of K. Meanwhile, a prediction model based on the support vector machine (SVM) algorithm was established. The performance of the two prediction models was compared using confusion matrices and receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>When the training vs testing data set ratio is 7:3 or 6:4, and K = 3, the KNN-based model has the best prediction accuracy (94.82% and 93.51%). The confusion matrix and ROC evaluation showed that the overall performance of the KNN-based model is superior to that of the SVM-based model, at all levels of blood loss (F1 = 95.09% and 93.99%, AUC = 1 and 0.97 for the KNN-based model at 7:3 and 6:4 dataset ratio; F1 = 83.84% and 84.86%, AUC = 0.97 and 0.97 for the SVM-based model at 7:3 and 6:4 dataset ratio).</p><p><strong>Conclusions: </strong>Using the detection indicators MAP, P<sub>BU</sub>CO<sub>2</sub>, P<sub>TC</sub>O<sub>2</sub> and PPV, the KNN-based rat hemorrhagic shock severity prediction model has high accuracy and stability, and demonstrates potential feasibility for severity stratification of hemorrhagic shock in standardized preclinical models, providing a foundation for future clinical validation in prehospital environments.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"62"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, construction, and deployment of a multi-locus transcranial magnetic stimulation system for clinical use. 临床应用的多位点经颅磁刺激系统的设计、构建和部署。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-18 DOI: 10.1186/s12938-025-01393-6
Heikki Sinisalo, Olli-Pekka Kahilakoski, Victor H Souza, Jaakko O Nieminen, Robin Rantala, Timo Tommila, Isabel Usuga, Mikael Laine, Oskari Ahola, Eva Gallegos, Gábor Kozák, David Emanuel Vetter, Ilkka Rissanen, Andreas Jooß, Renan Matsuda, Ana M Soto, Dezhou Li, Dania Humaidan, Matti Stenroos, Timo Roine, Dubravko Kičić, Ulf Ziemann, Risto J Ilmoniemi
{"title":"Design, construction, and deployment of a multi-locus transcranial magnetic stimulation system for clinical use.","authors":"Heikki Sinisalo, Olli-Pekka Kahilakoski, Victor H Souza, Jaakko O Nieminen, Robin Rantala, Timo Tommila, Isabel Usuga, Mikael Laine, Oskari Ahola, Eva Gallegos, Gábor Kozák, David Emanuel Vetter, Ilkka Rissanen, Andreas Jooß, Renan Matsuda, Ana M Soto, Dezhou Li, Dania Humaidan, Matti Stenroos, Timo Roine, Dubravko Kičić, Ulf Ziemann, Risto J Ilmoniemi","doi":"10.1186/s12938-025-01393-6","DOIUrl":"10.1186/s12938-025-01393-6","url":null,"abstract":"<p><strong>Background: </strong>Transcranial magnetic stimulation (TMS) is an established method for noninvasive brain stimulation, used for investigating and treating brain disorders. Recently, multi-locus TMS (mTMS) has expanded the capabilities of TMS by employing an array of overlapping stimulation coils, enabling delivery of stimulation pulses at different cortical locations without physical coil movement. We aimed to design, construct, and deploy an mTMS device and a five-coil array for clinical environment, emphasizing safety of the system.</p><p><strong>Methods: </strong>Our mTMS device is controlled by a field-programmable gate array (FPGA). The power electronics comprises five stimulation channels, each consisting of a high-voltage capacitor connected to a pulse circuit, controlling a single coil in the array. The device contains custom-designed circuit boards, with functions such as monitoring the system state, reporting errors, and delivering pulses. Our design utilizes redundancy in both hardware and firmware to ensure robust operation and safety. We performed an automated motor mapping test to verify the electronic targeting capabilities of the device.</p><p><strong>Results: </strong>We constructed the mTMS device and deployed it to the Hertie Institute for Clinical Brain Research (Tübingen, Germany). Compared to our earlier prototype, the new design improves patient and operator safety. The motor mapping test confirmed that our device can accurately target stimulation pulses in the cortex.</p><p><strong>Significance: </strong>mTMS or other similar technologies are currently not available for hospital use. The present device and its installation are major steps toward establishing multicoil TMS as an accessible clinical tool for investigation and treatment of the brain.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"61"},"PeriodicalIF":2.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent vs. sequential chemoradiotherapy: a survival boost for lung cancer patients. 同步放化疗与序贯放化疗:提高肺癌患者的生存率
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-16 DOI: 10.1186/s12938-025-01390-9
Jinbiao Xu, Qiao Ji, Jianxiong Deng, Feng Yu
{"title":"Concurrent vs. sequential chemoradiotherapy: a survival boost for lung cancer patients.","authors":"Jinbiao Xu, Qiao Ji, Jianxiong Deng, Feng Yu","doi":"10.1186/s12938-025-01390-9","DOIUrl":"10.1186/s12938-025-01390-9","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the clinical efficacy, incidence of radiation pneumonitis, and impact on lung function of sequential chemoradiotherapy (SCRT) and concurrent chemoradiotherapy (CCRT) in the treatment of lung cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;From January 2020 to December 2022, 158 patients with non-small cell lung cancer (NSCLC) were admitted to our hospital and chosen as the study subjects. Their clinical data were analyzed retrospectively and organized into a control group (n = 78, received SCRT) and an observation group (n = 80, received CCRT). Lesion sizes measured through CT scans were used to compare the clinical efficacy between the two groups. The study also compared the rates of adverse reactions, radiation pneumonitis, and lung function pre- and post-treatment, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. The comparison of serum tumor marker levels was conducted between two groups, with patients being observed over a 36-month period. Kaplan-Meier survival curves were used to analyze the changes in overall survival rate (OSR), progression-free survival (PFS), and overall survival (OS) between two groups of patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;For the observation group, the remission rate was 90.00%, and for the control group, it was 74.36%. The control rates were 96.25% for the observation group and 89.74% for the control group. Significantly higher remission and control rates were observed in the observation group than in the control group (P &lt; 0.05). The hemoglobin reduction grade 0 was 81.2% in the observation group, compared to 58.9% in the control group. In terms of leukopenia reduction (grades 0-III) and hemoglobin reduction (grades 0-II), the observation group outperformed the control group (P &lt; 0.05). In the observation group, 25.00% of patients experienced radiation pneumonitis, a higher rate compared to the 8.97% in the control group (P &lt; 0.05). Overall, the control group experienced more severe radiation-induced lung injury compared to the observation group, with 6.41% of cases reaching grade IV, unlike the 0.00% in the observation group. Grade II accounted for 1.28% in the control group, a figure significantly lower than the 21.25% in the observation group (P &lt; 0.05). Post-treatment, the FEV1, FVC, and FEV1/FVC values rose in both groups, with the observation group displaying significantly greater increases than the control group (P &lt; 0.05). Also, after treatment, there was a decrease in CA125, SCC Ag, and CYFRA21-1 levels in both groups, with the observation group having significantly lower levels than the control group (P &lt; 0.05). According to the Kaplan-Meier survival curve analysis, the observation group achieved an OSR of 90.00%, which exceeded the 83.33% of the control group (P &gt; 0.05). Furthermore, PFS and OS levels were elevated in the observation group relative to the control group (P &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion:","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"60"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and characterization of human decellularized ovarian scaffold based on supercritical carbon dioxide protocol. 基于超临界二氧化碳协议的人去细胞卵巢支架的制备与表征。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-13 DOI: 10.1186/s12938-025-01392-7
Fatemeh Hosseinpour, Ali Zeinolabedini Hezave, Tahereh Talaei-Khozani, Mojtaba Rastgou-Maeini, Ashraf Hassanpour-Dehnavi
{"title":"Preparation and characterization of human decellularized ovarian scaffold based on supercritical carbon dioxide protocol.","authors":"Fatemeh Hosseinpour, Ali Zeinolabedini Hezave, Tahereh Talaei-Khozani, Mojtaba Rastgou-Maeini, Ashraf Hassanpour-Dehnavi","doi":"10.1186/s12938-025-01392-7","DOIUrl":"10.1186/s12938-025-01392-7","url":null,"abstract":"<p><strong>Background: </strong>Primary ovarian insufficiency affecting 1-3% of women under 40, causes premature menopause and estrogen deficiency. With increasing life expectancy, a large percentage of women also face estrogen-related symptoms. A bioengineered ovary is one of the strategies to replace or enhance ovarian tissue function. A key advancement in bioengineering is the development of ovarian decellularized extracellular matrix scaffolds that mimic natural ovarian niche. Recent studies indicate that supercritical carbon dioxide (scCo<sub>2</sub>), with a density comparable to liquids and viscosity and diffusion coefficients properties similar to gases, holds substantial promise for application in engineered scaffolds. Therefore, we established a human decellularized ovarian scaffold based on a scCo<sub>2</sub> process, as an optimized protocol.</p><p><strong>Methods: </strong>We evaluated two distinct pressure conditions (200 and 300 bar), while maintaining identical thermal (40 °C) and temporal (1.5 h) parameters, during the scCO<sub>2</sub> decellularization process. In addition, two modifications were implemented to identify the most optimal protocol for enhancing the decellularization process: the inclusion of 70% ethanol as a co-solvent and the application of 1% sodium dodecyl sulfate (SDS) as a pretreatment for 4 h while utilizing the scCO<sub>2</sub> system under the previously established conditions. Cell removal was confirmed by DNA quantification and H&E staining. Extracellular matrix structure evaluated by histological staining and scanning electron microscopy (SEM). Glycosaminoglycans (GAGs) content was quantified using a dimethyl methylene blue assay following extraction with HCL and MTT test was conducted to evaluate scaffold's cytocompatibility.</p><p><strong>Results: </strong>Application of 1% SDS, while utilizing the scCO<sub>2</sub> system at 200 bar and 40 °C for 1.5 h, established an optimal protocol for preserving the essential characteristics of the ovarian ECM. This protocol is able to meet previously established decellularization criteria and histological staining and SEM showed that the ECM architecture was satisfactorily preserved. GAGs quantification indicated adequate preservation of GAGs content. Finally, MTT test presented the scaffolds had suitable cytocompatibility.</p><p><strong>Conclusions: </strong>We propose an optimal protocol utilizing 1% SDS as a pretreatment, followed by the scCO<sub>2</sub> system. This protocol addresses common challenges associated with traditional decellularization methods and presents a promising avenue for advancing ovarian tissue engineering applications.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"59"},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning based on ultrasound images to predict platinum resistance in patients with epithelial ovarian cancer. 基于超声图像的深度学习预测上皮性卵巢癌患者的铂耐药性。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-13 DOI: 10.1186/s12938-025-01391-8
Chang Su, Kuo Miao, Liwei Zhang, Xiaoqiu Dong
{"title":"Deep learning based on ultrasound images to predict platinum resistance in patients with epithelial ovarian cancer.","authors":"Chang Su, Kuo Miao, Liwei Zhang, Xiaoqiu Dong","doi":"10.1186/s12938-025-01391-8","DOIUrl":"10.1186/s12938-025-01391-8","url":null,"abstract":"<p><strong>Background: </strong>The study aimed at developing and validating a deep learning (DL) model based on the ultrasound imaging for predicting the platinum resistance of patients with epithelial ovarian cancer (EOC).</p><p><strong>Methods: </strong>392 patients were enrolled in this retrospective study who had been diagnosed with EOC between 2014 and 2020 and underwent pelvic ultrasound before initial treatment. A DL model was developed to predict patients' platinum resistance, and the model underwent evaluation through receiver-operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curve.</p><p><strong>Results: </strong>The ROC curves showed that the area under the curve (AUC) of the DL model for predicting patients' platinum resistance in the internal and external test sets were 0.86 (95% CI 0.83-0.90) and 0.86 (95% CI 0.84-0.89), respectively. The model demonstrated high clinical value through clinical decision curve analysis and exhibited good calibration efficiency in the training cohort. Kaplan-Meier analyses showed that the model's optimal cutoff value successfully distinguished between patients at high and low risk of recurrence, with hazard ratios of 3.1 (95% CI 2.3-4.1, P < 0.0001) and 2.9 (95% CI 2.3-3.9; P < 0.0001) in the high-risk group of the internal and external test sets, serving as a prognostic indicator.</p><p><strong>Conclusions: </strong>The DL model based on ultrasound imaging can predict platinum resistance in patients with EOC and may support clinicians in making the most appropriate treatment decisions.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"58"},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the correlation between smoking and blood pressure via photoplethysmography. 通过光容积脉搏波描记术研究吸烟与血压的关系。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-12 DOI: 10.1186/s12938-025-01373-w
Q Qananwah, H Quran, A Dagamseh, V Blazek, S Leonhardt
{"title":"Investigating the correlation between smoking and blood pressure via photoplethysmography.","authors":"Q Qananwah, H Quran, A Dagamseh, V Blazek, S Leonhardt","doi":"10.1186/s12938-025-01373-w","DOIUrl":"10.1186/s12938-025-01373-w","url":null,"abstract":"<p><p>Smoking has been widely identified for its detrimental effects on human health, particularly on the cardiovascular health. The prediction of these effects can be anticipated by monitoring the dynamic changes in vital signs and other physiological signals or parameters such as heart rate, blood pressure (BP), Electrocardiogram (ECG), and Photoplethysmogram (PPG), which subtly encode smoking-related effects. We investigated the influence of different smoking habits-normal cigarettes (NC), electronic cigarettes (EC), and shisha (SH)-on BP through analysis of ECG and PPG signals. The measurements of these physiological signals were taken across three distinct smoking phases: \"before\", \"during\", and \"after\" smoking. The study assessed changes in heart rate, as well as morphological and statistical characteristics of ECG and PPG signals, induced by smoking. A machine learning (ML) model was developed to predict BP values with different smoking habits and smoking phases, while also evaluating the temporal effects of smoking phases. Results show that smoking markedly alters PPG features in such it significantly affects systolic time, heart rate, peak pulse interval variability, and augmentation index. BP variations were evident across all smoking habits and phases. The ML model demonstrated strong accuracy in estimating systolic blood pressure (SBP) and diastolic blood pressure (DBP) during and post-smoking, with a mean error of 0.01 ± 0.29 mmHg and a root mean square error (RMSE) of 0.2924 mmHg for DBP and RMSE of 0.0082 mmHg for SBP. Such a study underscores the pronounced effect of smoking on BP and its potential role in cardiovascular system alterations, offering insights into the development of related diseases.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"57"},"PeriodicalIF":2.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SS-OCT-based ocular biometric characteristics of patients with nuclear cataract. 基于ss - oct的核性白内障患者眼部生物特征分析。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-09 DOI: 10.1186/s12938-025-01386-5
Zhao Xu, Ke Yin, Liming Wang, Lijie Dong, Jing Sun, Aihua Liu
{"title":"SS-OCT-based ocular biometric characteristics of patients with nuclear cataract.","authors":"Zhao Xu, Ke Yin, Liming Wang, Lijie Dong, Jing Sun, Aihua Liu","doi":"10.1186/s12938-025-01386-5","DOIUrl":"https://doi.org/10.1186/s12938-025-01386-5","url":null,"abstract":"<p><strong>Background: </strong>This observational, prospective, analytical, and cross-sectional study was designed to systematically analyze ocular biometric parameters in patients with nuclear cataract exhibiting nuclear hardness grade ≥ 3 according to the Emery-Little classification under slit-lamp examination who scheduled for phacoemulsification. Ocular biometric measurements were acquired using the IOL Master 700, a swept-source optical coherence tomography (SS-OCT) device.</p><p><strong>Results: </strong>Age was negatively correlated with axial length (AL), anterior chamber depth (ACD), white-to-white (WTW), and pupil diameter (PD) (r<sub>AL</sub> = - 0.13, r<sub>ACD</sub> = - 0.26, r<sub>WTW</sub> = - 0.18, all P < 0.001; r<sub>PD</sub> = - 0.09, P < 0.01) but positively correlated with total steep keratometry (TKs) (r<sub>TKs</sub> = 0.13, P < 0.001). AL was negatively correlated with total flat keratometry (TKf), TKs, and WTW (r<sub>TKf</sub> = - 0.3, r<sub>TKs</sub> = - 0.27, r<sub>WTW</sub> = - 0.18, all P < 0.001) but positively correlated with ACD and PD (r<sub>ACD</sub> = 0.43, r<sub>PD</sub> = 0.10, all P < 0.001). Men had smaller TK and PD but larger WTW than women.</p><p><strong>Conclusions: </strong>These findings highlight significant sex-related differences in biometric parameters among patients with nuclear cataract, which are closely related to AL and age. Considering variation with these parameters helps personalize surgical plans and prevent complications.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"56"},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability analysis of hospital infusion pumps: a case study. 医院输液泵可靠性分析:个案研究。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-07 DOI: 10.1186/s12938-025-01389-2
Mayla Dos S Silva, Maria Alzira de A Nunes, Suélia de Siqueira R F Rosa, Antônio Piratelli-Filho
{"title":"Reliability analysis of hospital infusion pumps: a case study.","authors":"Mayla Dos S Silva, Maria Alzira de A Nunes, Suélia de Siqueira R F Rosa, Antônio Piratelli-Filho","doi":"10.1186/s12938-025-01389-2","DOIUrl":"https://doi.org/10.1186/s12938-025-01389-2","url":null,"abstract":"<p><strong>Background: </strong>Infusion pumps (IPs) are medical devices used for the continuous and precise delivery of medications or nutrients. Their use has expanded and is now widespread in emergency rooms, ICUs, pediatrics, and other hospital departments. Failures in IPs can lead to adverse events, compromising patient health. In addition to the risks to patients, IPs are the medical devices most frequently associated with reports of adverse events in Brazil, highlighting the need to monitor their operational conditions to minimize failures during use.</p><p><strong>Results: </strong>Thus, the objective of this research is to analyze the reliability of infusion pumps (IPs) in a Brazilian hospital using an internal database from Clinical Engineering software. Probability distributions for repair time and time between failures were modeled, and parameters such as reliability and availability were calculated, with a focus on investigating hospital departments with recurring failures.</p><p><strong>Conclusion: </strong>In evaluating the operating equipment, a lack of detail in failure notes and service order openings was observed, which can hinder maintenance planning. The longest repair times were recorded in the ICU (Neurology), which houses the majority of IPs. Graphical analysis and testing demonstrated that the Weibull distribution effectively models both time between failures and repair time. The IP A model showed better results in terms of availability and reliability, thereby improving the security of the IPs.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"55"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modification of the toronto rehabilitation institute-hand function test for integration into robot-assisted therapy: technical validation and usability. 修改多伦多康复研究所-手功能测试集成到机器人辅助治疗:技术验证和可用性。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2025-05-07 DOI: 10.1186/s12938-025-01384-7
Aisha Raji, Stephanie DiNunzio, Andrew Whitmell, Cesar Marquez-Chin, Milos R Popovic
{"title":"Modification of the toronto rehabilitation institute-hand function test for integration into robot-assisted therapy: technical validation and usability.","authors":"Aisha Raji, Stephanie DiNunzio, Andrew Whitmell, Cesar Marquez-Chin, Milos R Popovic","doi":"10.1186/s12938-025-01384-7","DOIUrl":"https://doi.org/10.1186/s12938-025-01384-7","url":null,"abstract":"<p><strong>Background: </strong>Effective rehabilitation of the upper extremity function is vital for individuals recovering from stroke or cervical spinal cord injury, as it can enable them to regain independence in daily tasks. While robotic therapy provides precise and consistent motor training, it often lacks the integration of real-world objects that stimulate sensorimotor experiences. The Toronto Rehabilitation Institute-Hand Function Test (TRI-HFT) utilizes 19 everyday items to assess hand function. This study aims to modify the 3D-printed TRI-HFT objects to ensure their compatibility with robotic manipulation, thereby enhancing the functional relevance of robot-assisted rehabilitation, and to evaluate the usability of the new robotic system to ensure its safety and technical performance.</p><p><strong>Results: </strong>We successfully redesigned the 3D-TRI-HFT objects to enable manipulation by a robotic arm equipped with a gripper. The modified 3D-printed objects closely matched the original specifications, with most weight and size deviations within acceptable limits. Performance tests demonstrated reliable robotic manipulation, achieving a 100% success rate in 50 pick-and-place trials for each object without any breakage or slippage. Usability assessments further supported the system's performance, indicating that participants found the system engaging, useful, and comfortable.</p><p><strong>Conclusions: </strong>The modified 3D-printed TRI-HFT objects allow seamless integration into robotic therapy, facilitating the use of real-world objects in rehabilitation exercises. These modifications enhance functional engagement without compromising user interaction with the objects, demonstrating the feasibility of combining traditional rehabilitation tools with robotic systems, potentially leading to improved outcomes in upper extremity rehabilitation. Future research may focus on adapting these designs for compatibility with a broader range of robotic equipment, reducing the cost of the objects as 3D printing technology advances, and evaluating the system's performance among individuals with stroke and SCI.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"54"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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