Biogerontology最新文献_第4页

From adaptation to exhaustion: defining exposure-related malnutrition as a bioenergetic phenotype of aging. 从适应到衰竭：将暴露相关的营养不良定义为衰老的生物能量表型。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-13 DOI: 10.1007/s10522-025-10302-2

Torsak Tippairote, Pruettithada Hoonkaew, Aunchisa Suksawang, Prayfan Tippairote

{"title":"From adaptation to exhaustion: defining exposure-related malnutrition as a bioenergetic phenotype of aging.","authors":"Torsak Tippairote, Pruettithada Hoonkaew, Aunchisa Suksawang, Prayfan Tippairote","doi":"10.1007/s10522-025-10302-2","DOIUrl":"10.1007/s10522-025-10302-2","url":null,"abstract":"Aging is increasingly understood not as the passive accumulation of molecular damage, but as the cumulative cost of unresolved physiological adaptation under bioenergetic constraint. This review introduces Exposure-Related Malnutrition (ERM) as a mechanistically grounded and clinically actionable phenotype of early maladaptation. ERM arises from sustained metabolic strain during chronic stress exposure and manifests not through overt weight loss or nutrient deficiency, but through subtle, multisystem declines in physical, cognitive, and regenerative capacity. These include fatigue, impaired recovery, cognitive slowing, immune dysregulation, chronic pain, anabolic resistance, and reproductive decline-features often missed by classical malnutrition criteria. We propose a unifying framework-Respond → Adapt → Resolve-to model the trajectory of stress response and resolution, emphasizing the critical role of bioenergetic availability in shaping divergent outcomes. When metabolic substrates are insufficient, resolution fails and the system defaults to a trade-off state, prioritizing immediate survival over long-term maintenance. ERM represents this inflection point: a reversible, energy-constrained condition that precedes frailty and chronic disease. We review interconnected mechanisms-including neuroendocrine activation, immune reprogramming, skeletal muscle catabolism, translational suppression, and mitochondrial distress-that create a self-perpetuating loop of maladaptive adaptation. We map ERM onto key hallmarks of aging, propose a multidimensional staging model, and outline clinical strategies to detect and reverse ERM using dynamic biomarkers, functional assessments, and circadian-aligned lifestyle interventions. By reframing aging as a failure of adaptive resolution, this framework offers a novel lens to extend healthspan-via early detection of metabolic compromise and restoration of resilience before functional decline becomes irreversible.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 5","pages":"161"},"PeriodicalIF":4.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytoskeleton-associated protein 4: a double-edged sword in cell growth and aging. 细胞骨架相关蛋白4：细胞生长和衰老的双刃剑。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-13 DOI: 10.1007/s10522-025-10304-0

Peijie Luo, Miao Yu, Shuncong Zhang, Danqing Guo

{"title":"Cytoskeleton-associated protein 4: a double-edged sword in cell growth and aging.","authors":"Peijie Luo, Miao Yu, Shuncong Zhang, Danqing Guo","doi":"10.1007/s10522-025-10304-0","DOIUrl":"10.1007/s10522-025-10304-0","url":null,"abstract":"Cytoskeleton-Associated Protein 4 (CKAP4) is a multifunctional protein implicated in diverse cellular processes, including cytoskeletal organization, signal transduction, and extracellular matrix remodeling. Recent studies have highlighted the dual role of CKAP4 in regulating cell growth and aging. On one hand, CKAP4 can promote cell proliferation and survival by activating signaling pathways such as PI3K/Akt, thereby delaying cellular senescence under physiological conditions. On the other hand, under chronic stress or pathological stimuli, CKAP4 may induce cell cycle arrest and accelerate aging by interacting with ligands such as antiproliferative factor (APF) and Dickkopf-1 (DKK1), leading to the upregulation of cell cycle inhibitors and the suppression of autophagy. Moreover, CKAP4 has emerged as a key mediator linking extracellular matrix remodeling to inflammatory responses, which are closely associated with age-related diseases. This review comprehensively summarizes the current understanding of CKAP4's molecular mechanisms in cell longevity and aging, discusses its involvement in inflammation and tissue homeostasis, and explores its potential as a therapeutic target for aging-related disorders.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 5","pages":"162"},"PeriodicalIF":4.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous and exogenous viral reactivation as a driver of epigenetic drift and mitophagy failure in aging. 内源性和外源性病毒再激活作为衰老中表观遗传漂移和线粒体自噬失败的驱动因素。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-12 DOI: 10.1007/s10522-025-10286-z

Evgeniia Bakaleinikova

{"title":"Endogenous and exogenous viral reactivation as a driver of epigenetic drift and mitophagy failure in aging.","authors":"Evgeniia Bakaleinikova","doi":"10.1007/s10522-025-10286-z","DOIUrl":"https://doi.org/10.1007/s10522-025-10286-z","url":null,"abstract":"Aging is increasingly understood as a multifactorial process involving mitochondrial dysfunction, epigenetic drift, and chronic inflammation. While many age-related pathologies have been linked to impaired mitophagy and transcriptional deregulation, the upstream mechanisms driving these phenomena remain elusive. Here, a unifying hypothesis is proposed: that the progressive reactivation of human endogenous retroviruses (HERVs), combined with latent viral infections acquired during life, imposes an escalating burden on the epigenetic regulatory system. This \"virome pressure\" demands continuous silencing via DNA methylation, histone deacetylation, and NAD⁺-dependent pathways. With age, these silencing mechanisms deteriorate, leading to HERV reactivation, disruption of key mitochondrial quality control genes, and activation of innate immune responses. This is likened to a molecular peat bog, a simmering threat buried beneath the surface, where silencing mechanisms struggle to contain viral elements until pressure builds and erupts as the organism ages. This model integrates virology, epigenetics, and mitochondrial biology to offer novel insights into the aging process and suggests new targets for therapeutic intervention research.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 5","pages":"159"},"PeriodicalIF":4.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of cannabidiol to circadian period, sleep, life span, close-proximity rhythm, egg reproduction and motor function in Drosophila melanogaster. 大麻二酚对黑腹果蝇昼夜节律、睡眠、寿命、近距离节律、卵子繁殖和运动功能的影响。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-12 DOI: 10.1007/s10522-025-10305-z

Haruhisa Kawasaki, Toshihiko Sato, Norio Ishida

{"title":"Effects of cannabidiol to circadian period, sleep, life span, close-proximity rhythm, egg reproduction and motor function in Drosophila melanogaster.","authors":"Haruhisa Kawasaki, Toshihiko Sato, Norio Ishida","doi":"10.1007/s10522-025-10305-z","DOIUrl":"10.1007/s10522-025-10305-z","url":null,"abstract":"Cannabidiol (CBD), a non-psychoactive cannabinoid, has been studied for its various health-promoting effects recently. This study investigates the effects of dietary CBD to the circadian clock of Drosophila melanogaster as a model animal and its many physiological effect to flies. We showed that CBD extended the period of locomotor activity in a dose-dependent manner, suggesting its influence on the circadian clock. Additionally, CBD improved sleep quality and extended lifespan under starvation conditions. The study also revealed enhanced rhythmicity in Close Proximity (CP) rhythm and increased eggs reproduction with dietary CBD supplementation. Furthermor, CBD attenuates age-related motor dysfunction in wild-type and Parkinson's disease (PD) model in Drosophila. These findings strongly suggest that appropriate amount of CBD affects the circadian rhythms, sleep, life span, CP rhythm, egg reproduction and motor function of Drosophila melanogaster, and providing a basic data for exploring its potential applications in managing circadian-related disorders in other animals.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 5","pages":"160"},"PeriodicalIF":4.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in the investigation of the mechanisms underlying cognitive aging. 认知老化机制的研究进展。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-10 DOI: 10.1007/s10522-025-10300-4

Honglu Zou, Shuo Zhang, Xinxin Cui, Hongyan Xu, Zhangying Zhou, Danmeng Cheng, Yanan Han, Youcai Tang, Anqin Dong, Xianwen Dong

{"title":"Advancements in the investigation of the mechanisms underlying cognitive aging.","authors":"Honglu Zou, Shuo Zhang, Xinxin Cui, Hongyan Xu, Zhangying Zhou, Danmeng Cheng, Yanan Han, Youcai Tang, Anqin Dong, Xianwen Dong","doi":"10.1007/s10522-025-10300-4","DOIUrl":"10.1007/s10522-025-10300-4","url":null,"abstract":"Cognitive aging, a pivotal domain at the intersection of neuroscience and psychology, exhibits a strong association with neurodegenerative disorders; however, its comprehensive underlying mechanisms remain incompletely elucidated. This review aims to provide a thorough synthesis of recent advancements in the investigation of cognitive aging in the brain, highlighting multidimensional assessment techniques, neurobiological foundations, molecular regulatory pathways, systemic changes, environmental-gene interactions, and intervention strategies. Evidence suggests that cognitive aging is marked not only by widespread neuronal loss but also by subtle modifications within neural networks, protein homeostasis, mitochondrial functionality, and epigenetic regulation. The integration of various technological methodologies has shed light on the continuum that exists between cognitive aging and neurodegenerative disorders. Concurrently, multidimensional intervention strategies are being proposed; however, current research frameworks face challenges due to limitations in biomarker systems, indicating a need for a paradigm shift. Future investigations should leverage emerging technologies to develop more precise regulatory frameworks and personalized intervention strategies aimed at addressing the global challenges associated with aging, thereby enhancing the prevention and treatment of related pathologies.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 4","pages":"158"},"PeriodicalIF":4.1,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the geometry of circadian synchronization and period across aging. 建模几何昼夜同步和周期跨越老化。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-09 DOI: 10.1007/s10522-025-10303-1

Jihwan Myung, Hélène Vitet, Sheena Yin Xin Tiong

{"title":"Modeling the geometry of circadian synchronization and period across aging.","authors":"Jihwan Myung, Hélène Vitet, Sheena Yin Xin Tiong","doi":"10.1007/s10522-025-10303-1","DOIUrl":"10.1007/s10522-025-10303-1","url":null,"abstract":"Circadian freerunning periods change across the lifespan, yet most computational models do not reproduce these shifts without assuming additional mechanisms. Although the maturation and later deterioration of the suprachiasmatic nucleus (SCN) shape behavioral and humoral rhythms, the underlying driver of period change is more general. We show that it arises from an inherent property of a positively skewed frequency distribution, which naturally follows from a symmetric Gaussian distribution of intrinsic periods. Using a Kuramoto framework with a time-dependent coupling strength and age-related widening of period variability, we map the geometry of synchronization and macroscopic period and trace a developmental trajectory across this surface. Strong coupling in early adulthood pulls the synchronized period below the mean, matching data from C57BL/6 mice, whereas declining coupling and greater heterogeneity in late life lengthen the period and reduce amplitude. The same mechanism explains the negative correlation between amplitude and macroscopic period when period variability is high. This \"circadian geometry\" reveals that age-dependent variations in the macroscopic period are sufficiently explained by coupling and the width of the period distribution, and provides a parsimonious framework applicable to the SCN and other oscillator populations for understanding long-term changes in circadian dynamics during development and aging.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 4","pages":"157"},"PeriodicalIF":4.1,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intricate link between circadian rhythms and aging: can resetting our circadian clock hold the key to longevity? 昼夜节律和衰老之间的复杂联系：重置生物钟是长寿的关键吗？

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-06 DOI: 10.1007/s10522-025-10299-8

Najm Ul Hassan, William Kojo Smith, Hafiza Ayesha Nawaz, Han Wang

{"title":"The intricate link between circadian rhythms and aging: can resetting our circadian clock hold the key to longevity?","authors":"Najm Ul Hassan, William Kojo Smith, Hafiza Ayesha Nawaz, Han Wang","doi":"10.1007/s10522-025-10299-8","DOIUrl":"10.1007/s10522-025-10299-8","url":null,"abstract":"The desire to increase life expectancy, coupled with the decline in biological functions that occurs as we age, represents one of the most significant challenges facing our society. Age-related declines in biological functions contribute to frailty and morbidity, demanding innovative strategies to promote healthy aging. The circadian clock, which controls daily physiological processes, is intricately linked to aging and overall health. Circadian disruptions can lead to metabolic dysfunction, impaired immune responses, increased DNA damage, and elevated disease susceptibility. On the other hand, maintaining robust circadian rhythms through interventions such as regular sleep-wake patterns, time-restricted feeding, and physical activity may extend health span and longevity. The circadian clock affects various molecular pathways associated with aging, including the insulin/IGF, mTOR, and sirtuin signaling pathways. Enhancing circadian rhythms presents a promising avenue for mitigating age-related disorders and promoting healthy aging. This review highlights the potential of circadian clock-based interventions as a transformative strategy to improve the quality of life and extend the healthspan of aging individuals.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 4","pages":"156"},"PeriodicalIF":4.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo anti-aging effects of naringin, a bioflavonoid: insights from the budding yeast Saccharomyces cerevisiae as a model organism. 生物类黄酮柚皮苷在体内的抗衰老作用：从出芽酵母酿酒酵母作为模式生物的见解。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-05 DOI: 10.1007/s10522-025-10295-y

Phaniendra Alugoju, Pipob Suwanchaikasem, Apinan Senabunyarith, Ankush Prasad, Tewin Tencomnao

{"title":"In vivo anti-aging effects of naringin, a bioflavonoid: insights from the budding yeast Saccharomyces cerevisiae as a model organism.","authors":"Phaniendra Alugoju, Pipob Suwanchaikasem, Apinan Senabunyarith, Ankush Prasad, Tewin Tencomnao","doi":"10.1007/s10522-025-10295-y","DOIUrl":"10.1007/s10522-025-10295-y","url":null,"abstract":"Naringin is an antioxidant flavonoid rich in diverse plant species, including citrus plants. While the antioxidant activity of naringin is well documented, there has been limited research on its anti-aging potential. The aim of this study is to investigate the in vivo anti-aging effects of naringin in the budding yeast Saccharomyces cerevisiae as a model. Our findings showed that naringin substantially increased cell viability during the chronological lifespan of wild-type yeast by mitigating oxidative and apoptotic stress markers. However, naringin did not affect the viability of yeast null mutants lacking antioxidant enzymes (sod2Δ, cta1Δ, ctt1Δ, gpx1Δ, gpx2Δ, gsh1Δ; except sod1Δ and tsa1Δ), but slightly increased the viability of only pep4Δ and fis1Δ mutants, not mca1Δ. Gene expression results indicate that naringin altered the expression of genes associated with the TORC1 signaling pathway and other anti-aging genes such as SIR2 and ATG1. The study's findings also demonstrate that naringin could not increase cell viability of yeast null mutants lacking signaling pathway genes (tor1Δ, rim15Δ ras2Δ, and atg1Δ), except sch9Δ mutant during CLS. Metabolomic studies suggest that naringin treatment affects the levels of diverse class of metabolites such as amino acids, nucleotides and related compounds, vitamins, carbohydrates, and lipids in stationary phase yeast. Altogether, these findings suggest that naringin might exerts its anti-aging effects via modulating the nutrient sensing TORC1 signaling pathway, paving the way for future research to explore other aging associated gene targets.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 4","pages":"155"},"PeriodicalIF":4.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of different types of calorie restrictions on epigenetic modifications of age-related genes in aging mouse brain. 不同类型的卡路里限制对衰老小鼠大脑中年龄相关基因表观遗传修饰的影响。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-04 DOI: 10.1007/s10522-025-10297-w

Aysenur Dogan, Bilge Guvenc Tuna, Oznur Suakar, Omer Faruk Bayrak, Soner Dogan

{"title":"The effects of different types of calorie restrictions on epigenetic modifications of age-related genes in aging mouse brain.","authors":"Aysenur Dogan, Bilge Guvenc Tuna, Oznur Suakar, Omer Faruk Bayrak, Soner Dogan","doi":"10.1007/s10522-025-10297-w","DOIUrl":"10.1007/s10522-025-10297-w","url":null,"abstract":"The effects of calorie restriction (CR) on age-related epigenetic modifications have recently been exposed, yet there is a road ahead in explaining the effects of CR on the epigenetic regulations. Although the exact mechanism(s) underlying the beneficial effects of CR on healthy brain aging is still unclear, increasing evidence suggests that epigenetic modifications are promising regulators that may be involved in this phenomenon. Here, we assessed the long-term effects of two different types of CR on DNA methylation levels of nutrient and aging related Igf1r, Adipor1, and Foxo1 genes in aging mice brains. Mice underwent different types of CR-application for up to 72 weeks: Ad-libitum (AL), chronic CR (CCR, 15% CR), and intermittent CR (ICR) alternating one week 60% CR (ICR-R) with three weeks AL feeding (ICR-RF) cyclically. DNA methylation levels were analyzed by pyrosequencing. Expressions of mRNA levels were measured by RT-PCR. Pyrosequencing results revealed that the methylation levels of CpG1 in Igf1r and CpG2-5-68 in Foxo1 were significantly changed by age in different dietary groups. Average DNA methylation levels were similar in calorie-restricted groups for all genes of interest. The gene expression level of only Igf1r was correlated with the average DNA methylation. In addition, there was a significant negative correlation between CpG5 methylation and Igf1r expression. These findings report that CR may exert its preventive effects on the regulation of nutrient sensing and aging related genes, Igf1r, Adipor1, and Foxo1, by modulating the methylation levels of specific CpG sites rather than altering overall methylation levels.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 4","pages":"154"},"PeriodicalIF":4.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing. 破译分子钟：探索皮肤老化的分子机制和遗传影响。

IF 4.1 4区医学

Biogerontology Pub Date : 2025-08-02 DOI: 10.1007/s10522-025-10296-x

Horng Yih Ng, Yuan Seng Wu, Mohitosh Biswas, Maw Shin Sim

{"title":"Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing.","authors":"Horng Yih Ng, Yuan Seng Wu, Mohitosh Biswas, Maw Shin Sim","doi":"10.1007/s10522-025-10296-x","DOIUrl":"10.1007/s10522-025-10296-x","url":null,"abstract":"Skin ageing is a multifaceted process influenced by both intrinsic genetic factors and extrinsic environmental exposures. This review explores the genetic variants and molecular mechanisms underlying skin ageing phenotypes, while identifying gaps in current research to inform future studies. A systematic search of the Scopus and Web of Science databases was conducted, with articles screened based on criteria including a focus on human genetic association studies and indexing in either Scopus or the Institute for Scientific Information (ISI) Web of Science. The quality of included studies was assessed using the Q-Genie tool. Thirteen studies met the inclusion criteria, collectively analysing 115 single nucleotide polymorphisms (SNPs) across 99 genes. The OCA2 gene emerged as the most frequently investigated, consistently linked to hyperpigmentation. Overall, findings indicate that skin ageing phenotypes are associated with genes involved in collagen metabolism, melanogenesis, oxidative stress, and mechanical properties of the skin. Notably, SPATA33 rs35063026 and IRF4 rs12203592 polymorphisms exhibit pleiotropic effects, contributing to both wrinkling and pigmentation changes. Interestingly, some variants, such as SPTLC1 rs7042102 and REEP3 rs11961184, display paradoxical effects, underscoring the complexity of genetic modulation. Genes implicated in extracellular matrix (ECM) degradation, such as SMYD3, and those responsive to environmental pollutants, like CYP1A1, were associated with increased skin sagging. Conversely, variants in genes such as COL1A2 and COL13A1, which support ECM integrity and skin resilience, were linked to protective effects. Despite these insights, many genetic associations remain poorly understood, highlighting substantial gaps in knowledge and the need for more comprehensive genetic research into skin ageing.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 4","pages":"153"},"PeriodicalIF":4.1,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0