Biogerontology最新文献

Correction: Directionality theory and mortality patterns across the primate lineage. 更正：灵长类的方向性理论和死亡率模式。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10155-1

Lloyd A Demetrius, Anand Sahasranaman, Martin Ziehe

引用次数: 0

Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats. 全身振动通过海马星形胶质细胞突触引起雄性大鼠大脑皮层40赫兹伽马振荡，并改善与年龄相关的认知障碍。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10154-2

Mingsong Liu, Lei Li, Ruizhe Chen, Qilin Wang, Tongfei Zeng, Junhong Hu, Changzhi Yan, Jing Xiao, Xuewei Xia

{"title":"Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats.","authors":"Mingsong Liu, Lei Li, Ruizhe Chen, Qilin Wang, Tongfei Zeng, Junhong Hu, Changzhi Yan, Jing Xiao, Xuewei Xia","doi":"10.1007/s10522-024-10154-2","DOIUrl":"10.1007/s10522-024-10154-2","url":null,"abstract":"Age-related cognitive impairment is a prevalent issue in developed societies. Gamma oscil2lations at 40 Hz have been identified as a potential therapeutic approach for age-related cognitive decline and can be induced through various modalities, including auditory, visual, electrical, and magnetic stimulation. In this study, we investigated a novel modality of stimulation: whole-body vibration at 40 Hz. We examined the effects of 40 Hz vibration on cognitive performance and associated neuronal activity in the brains of aged male rats. Our findings revealed that only vibration at 40 Hz, rather than 20 Hz or 80 Hz, elicited cortical gamma oscillations in aged male rats. Additionally, following 8 weeks of prolonged treatment, the implementation of 40 Hz whole-body vibration significantly augmented the cognitive function of aged male rats as evidenced by behavioral assessments. Mechanistic studies demonstrated that these beneficial effects were attributed to the reduction of neuronal apoptosis in hippocampal CA1 through regulation of synaptic connections between astrocytes and neurons via 40 Hz gamma oscillations. Collectively, this suggests a promising intervention for age-related cognitive decline and identifies neuron-astrocyte synapses as potential therapeutic targets.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"11"},"PeriodicalIF":4.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis. 衰老、ROS 和细胞衰老：肝纤维化进展的三部曲。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10153-3

Waleed Hassan Almalki, Salem Salman Almujri

{"title":"Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis.","authors":"Waleed Hassan Almalki, Salem Salman Almujri","doi":"10.1007/s10522-024-10153-3","DOIUrl":"10.1007/s10522-024-10153-3","url":null,"abstract":"Ageing is an inevitable and multifaceted biological process that impacts a wide range of cellular and molecular mechanisms, leading to the development of various diseases, such as liver fibrosis. Liver fibrosis progresses to cirrhosis, which is an advanced form due to high amounts of extracellular matrix and restoration of normal liver structure with failure to repair damaged tissue and cells, marking the end of liver function and total liver failure, ultimately death. The most important factors are reactive oxygen species (ROS) and cellular senescence. Oxidative stress is defined as an impairment by ROS, which are by-products of the mitochondrial electron transport chain and other key molecular pathways that induce cell damage and can activate cellular senescence pathways. Cellular senescence is characterized by pro-inflammatory cytokines, growth factors, and proteases secreted by senescent cells, collectively known as the senescence-associated secretory phenotype (SASP). The presence of senescent cells, which disrupt tissue architecture and function and increase senescent cell production in liver tissues, contributes to fibrogenesis. Hepatic stellate cells (HSCs) are activated in response to chronic liver injury, oxidative stress, and senescence signals that drive excessive production and deposition of extracellular matrix. This review article aims to provide a comprehensive overview of the pathogenic role of ROS and cellular senescence in the aging liver and their contribution to fibrosis.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"10"},"PeriodicalIF":4.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing dynamics in daily rhythms of oxidative stress indicators in SCN and extra-SCN brain regions with aging in male Wistar rats. 雄性Wistar大鼠SCN和SCN外脑区氧化应激指标的日节律随衰老而变化的动态。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10150-6

M Sultan Khan, Anita Jagota

{"title":"Changing dynamics in daily rhythms of oxidative stress indicators in SCN and extra-SCN brain regions with aging in male Wistar rats.","authors":"M Sultan Khan, Anita Jagota","doi":"10.1007/s10522-024-10150-6","DOIUrl":"10.1007/s10522-024-10150-6","url":null,"abstract":"The suprachiasmatic nucleus (SCN) in the hypothalamus regulates circadian timing system (CTS) by co-ordinating peripheral tissue clocks and extra-SCN oscillators in the brain. Aging disrupts the CTS, impairing physiological functions and reducing antioxidant defences, which contribute to neurodegeneration. The brain is vulnerable to oxidative damage due to its high metabolic activity, oxygen consumption, and levels of iron and lipids. Antioxidant enzymes, such as catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), and lipid peroxidation (LPO), help against oxidative damage. In this study, we examined the temporal patterns of these antioxidant stress indicators in the SCN and extra-SCN brain regions (frontal cortex, cerebellum, and hippocampus) at various time points in male Wistar rats 3, 12, and 24 months. The rhythmicity of GST and LPO levels persisted across brain regions with aging, while CAT rhythmicity was lost in the SCN and hippocampus of older rats. SOD rhythmicity persisted in cortex, cerebellum, and hippocampus but was lost in the SCN. The daily rhythm parameters of CAT were affected most significantly, followed by SOD, GST, and LPO. Our findings demonstrate that aging leads to desynchronization of oxidative stress indicators potentially contributing to neurodegeneration and circadian dysfunction with varying effects across different brain tissues.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"9"},"PeriodicalIF":4.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cochlea extracellular matrix in age-related hearing loss. 耳蜗细胞外基质在老年性听力损失中的作用

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-13 DOI: 10.1007/s10522-024-10149-z

Weiyi Huang, Yiming Zhong, Kaili Chen, Bing Kong, Andi Zhang, Dongye Guo, Tianyuan Zou, Mingliang Xiang, Bin Ye

{"title":"The role of cochlea extracellular matrix in age-related hearing loss.","authors":"Weiyi Huang, Yiming Zhong, Kaili Chen, Bing Kong, Andi Zhang, Dongye Guo, Tianyuan Zou, Mingliang Xiang, Bin Ye","doi":"10.1007/s10522-024-10149-z","DOIUrl":"https://doi.org/10.1007/s10522-024-10149-z","url":null,"abstract":"Age-related hearing loss (ARHL) is a common disease among the elderly. Although its pathogenesis remains unclear by now, it is widely accepted that ARHL is associated with the degenerative alterations within each component of the cochlea. Extracellular matrix (ECM) plays a crucial role in cochlear structure and function, providing not only structural support but also participating in vital physiological processes including the development, differentiation, survival of auditory sensory cells, and sound perception. ECM is implicated in the pathogenesis of various neurodegenerative diseases, with certain ECM proteins or associated molecules emerging as potential therapeutic targets. However, few research were carried out on ECM in the cochlea and ECM associated molecules in ARHL. This review aims to delineate the composition of ECM in the cochlea, the changes of the main ECM structure in the cochlea such as the tectorial membrane (TM), the basilar membrane (BM) and the spiral ligament (SL) during aging, as well as the role of ECM associated molecules in ARHL. We hope that this review will foster further research into ARHL.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"8"},"PeriodicalIF":4.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of biological sex in human skeletal muscle transcriptome during ageing. 衰老过程中生物性别对人类骨骼肌转录组的影响。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-06-01 Epub Date: 2023-10-04 DOI: 10.1007/s10522-023-10070-x

Xiaoyu Huang, Mao Chen, Ya Xiao, Fangyi Zhu, Liying Chen, Xiaoyu Tian, Li Hong

{"title":"The influence of biological sex in human skeletal muscle transcriptome during ageing.","authors":"Xiaoyu Huang, Mao Chen, Ya Xiao, Fangyi Zhu, Liying Chen, Xiaoyu Tian, Li Hong","doi":"10.1007/s10522-023-10070-x","DOIUrl":"10.1007/s10522-023-10070-x","url":null,"abstract":"Sex is a crucial biological variable, and influence of biological sex on the change of gene expression in ageing skeletal muscle has not yet been fully revealed. In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriched in the female subgroup were more similar to the pathways enriched in the older groups without taking sex difference into consideration. The pathways enriched in the female subgroup were more similar to the pathways enriched in the older groups without taking sex difference into consideration. The muscle myosin filament pathways were downregulated in the both aged female and male samples whereas transforming growth factor beta pathway and extracellular matrix-related pathways were upregulated. With muscle ageing, the metabolism-related pathways, protein synthesis and degradation pathways, results of predicted immune cell infiltration, and gene cluster associated with slow-type myofibers drastically different between the female and male subgroups. This finding may indicate that changes in muscle type with ageing may differ between the sexes in vastus lateralis muscle.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"461-478"},"PeriodicalIF":4.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects" as a form of hormesis: an interview with Professor Sataro Goto. “适量饮用清酒会造成轻微的化学损伤，可能会产生有益的效果”，这是一种兴奋症：对后藤佐太郎教授的采访。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-06-01 Epub Date: 2023-10-26 DOI: 10.1007/s10522-023-10069-4

Zsolt Radak

引用次数: 0

Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model. 利用秀丽隐杆线虫模型研究京芳颗粒的抗衰老和抗感染特性

IF 4.5 4区医学

Biogerontology Pub Date : 2024-06-01 Epub Date: 2023-08-12 DOI: 10.1007/s10522-023-10058-7

Xin Yin, Yiwei Meng, Chenghong Sun, Yanqiu Zhao, Weitao Wang, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jingchun Yao, Lixin Zhang, Xuekui Xia

{"title":"Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model.","authors":"Xin Yin, Yiwei Meng, Chenghong Sun, Yanqiu Zhao, Weitao Wang, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jingchun Yao, Lixin Zhang, Xuekui Xia","doi":"10.1007/s10522-023-10058-7","DOIUrl":"10.1007/s10522-023-10058-7","url":null,"abstract":"Jingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the pharyngeal pumping rate or nematode motility. Moreover, JFG notably increased oviposition by 11.3%. Subsequent investigations revealed that JFG enhanced oxidative stress resistance in C. elegans by reducing reactive oxygen species levels and significantly improved survival rates in nematodes infected with Pseudomonas aeruginosa ATCC 9027. These findings suggest that JFG delays reproductive senescence in C. elegans and protects them from oxidative stress, thereby extending their lifespan. Additionally, JFG improves the survival of P. aeruginosa-infected nematodes. Consequently, JFG has potential as a candidate for the development of anti-aging and anti-infection functional medicines.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"433-445"},"PeriodicalIF":4.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9981966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-cell lymphocytes' aging clock: telomeres, telomerase and aging. T细胞淋巴细胞的衰老时钟：端粒、端粒酶和衰老。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-04-01 Epub Date: 2023-11-02 DOI: 10.1007/s10522-023-10075-6

Alain Chebly, Charbel Khalil, Alexandra Kuzyk, Marie Beylot-Barry, Edith Chevret

引用次数: 0

Chromosome ends and the theory of marginotomy: implications for reproduction. 染色体末端与边缘切除理论：对生殖的启示。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-04-01 Epub Date: 2023-11-09 DOI: 10.1007/s10522-023-10071-w

Isabel Córdova-Oriz, Alba M Polonio, Isabel Cuadrado-Torroglosa, Lucía Chico-Sordo, Marta Medrano, Juan A García-Velasco, Elisa Varela

{"title":"Chromosome ends and the theory of marginotomy: implications for reproduction.","authors":"Isabel Córdova-Oriz, Alba M Polonio, Isabel Cuadrado-Torroglosa, Lucía Chico-Sordo, Marta Medrano, Juan A García-Velasco, Elisa Varela","doi":"10.1007/s10522-023-10071-w","DOIUrl":"10.1007/s10522-023-10071-w","url":null,"abstract":"Telomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the \"duration of life\" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-marginotomy). The impact of proliferative telomere shortening on life expectancy was later confirmed. In humans, telomere shortening is counteracted by telomerase, an enzyme that is undetectable in most adult somatic cells, but present in cancer cells and adult and embryonic stem and germ cells. Although telomere length dynamics are different in male and female gametes during gametogenesis, telomere lengths are reset at the blastocyst stage, setting the initial length of the species. The role of the telomere pathway in reproduction has been explored for years, mainly because of increased infertility resulting from delayed childbearing. Short telomere length in ovarian somatic cells is associated to decreased fertility and higher aneuploidy rates in embryos. Consequently, there is a growing interest in telomere lengthening strategies, aimed at improving fertility. It has also been observed that lifestyle factors can affect telomere length and improve fertility outcomes. In this review, we discuss the implications of telomere theory in fertility, especially in oocytes, spermatozoa, and embryos, as well as therapies to enhance reproductive success.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"227-248"},"PeriodicalIF":4.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0