Biogerontology最新文献

{"title":"Correction to: Investigating cognitive impairments and hippocampal proteome alterations in aged male rats with TAA-induced minimal hepatic encephalopathy.","authors":"Vishal Vikram Singh, Shambhu Kumar Prasad, Arup Acharjee, Sanjeeva Srivastava, Papia Acharjee","doi":"10.1007/s10522-025-10235-w","DOIUrl":"https://doi.org/10.1007/s10522-025-10235-w","url":null,"abstract":"","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"89"},"PeriodicalIF":4.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolvable Soma Theory of Ageing: insights from computer simulations.","authors":"Alessandro Fontana, Marios Kyriazis","doi":"10.1007/s10522-025-10224-z","DOIUrl":"https://doi.org/10.1007/s10522-025-10224-z","url":null,"abstract":"<p><p>Biological evolution continuously refines the design of species, resulting in highly optimised organisms over hundreds of millennia. Intuitively, we expect that random changes-evolution's primary mechanism-are more likely to be harmful than beneficial, leading to widespread detrimental effects in evolving species. The Evolvable Soma Theory of Ageing (ESTA) suggests that ageing is the cumulative result of these harmful effects, which predominantly cause bodily damage, while a few may lead to beneficial adaptations that evolution can exploit. While standard evolutionary ageing theories view aging as a consequence of limited evolutionary pressure, ESTA posits that ageing is essentially evolution in action. In this study, we gather evidence supporting this theory through computer simulations. We conduct experiments using a platform where genes are linked to onset values that determine when they are expressed. Three scenarios are tested: one with single-point fitness evaluation, constant mutation rate and fixed gene onsets; one with single-point fitness evaluation, onset-dependent mutation rate and fixed gene onsets; and one with spread fitness evaluation, onset-dependent mutation rate and evolvable gene onsets. The last scenario, which embodies the evolvable soma hypothesis, demonstrates superior performance in both algorithmic efficiency and biological plausibility compared to the others.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"87"},"PeriodicalIF":4.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice.","authors":"Hanlin Jiang, Shota Inoue, Junpei Hatakeyama, Peng Liu, Tingrui Zhao, Yifan Zhang, Bin Liu, Chunxiao He, Hideki Moriyama","doi":"10.1007/s10522-025-10234-x","DOIUrl":"https://doi.org/10.1007/s10522-025-10234-x","url":null,"abstract":"<p><p>Skeletal muscle aging, characterized by progressive declines in muscle mass and strength, correlates with reduced quality of life and increased mortality. Resistance exercise is known to be critical for maintaining skeletal muscle health. This study investigated the effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in mice. Twenty-eight-week-old senescence-accelerated mouse prone 8 (SAMP8) mice were used as a model for muscle aging, with senescence-accelerated mouse resistant 1 (SAMR1) mice serving as healthy controls. The mice underwent a 12-week regimen of ladder-climbing training, a form of resistance exercise, performed three days per week. After the training, muscle strength and muscle weight were measured. Levels of the longevity proteins adenosine monophosphate-activated kinase (AMPK), mammalian target of rapamycin (mTOR), and sirtuin 1 (SIRT1) were assessed via western blotting, and telomere length was evaluated by qPCR. SAMP8 mice exhibited significantly lower muscle mass and strength than SAMR1 mice, while resistance exercise attenuated these deficits in SAMP8 mice. SAMP8 mice showed elevated AMPK phosphorylation and SIRT1 levels compared to SAMR1 mice; resistance exercise normalized AMPK phosphorylation levels to approximate those of SAMR1 mice. mTOR activity was significantly reduced in SAMP8 mice but tended to be restored by resistance exercise. Telomere length remained unchanged in SAMP8 mice after resistance exercise compared to their sedentary controls. In conclusion, aging reduces muscle function and disrupts levels of longevity proteins. Resistance exercise mitigates these effects by improving muscle function and restoring molecular balance.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"88"},"PeriodicalIF":4.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating transcriptional alterations associated with ageing and developing age prediction models based on the human blood transcriptome.","authors":"Ivan Duran, Amy Tsurumi","doi":"10.1007/s10522-025-10216-z","DOIUrl":"https://doi.org/10.1007/s10522-025-10216-z","url":null,"abstract":"<p><p>Ageing-related DNA methylome and proteome changes and machine-learned ageing clock models have been described previously; however, there is a dearth of ageing clock prediction models based on human blood transcript information. Applying various machine learning algorithms is expected to aid in the development of age prediction models. Using blood transcriptome data from healthy subjects ranging in age from 21 to 90 in the 10 K Immunomes repository, we evaluated differentially regulated transcripts, assessed enriched gene ontology, pathway and disease ontology analysis to characterize biological functions associated with the genes associated with age. Furthermore, we constructed and compared age prediction models developed by applying the Least Absolute Shrinkage and Selection Operator (LASSO), Elastic Net (EN), eXtreme Gradient Boosting (XGBoost) and Light Gradient-Boosting Machine (LightGBM) algorithms. Compared to LASSO (7 genes) and EN (9 genes) regularized regression, XGBoost (142 genes) and LightGBM (149 genes) Gradient Boosted Decision Tree methods performed better in this dataset (training set r = 0.836 (LASSO), 0.837 (EN), 1.000 (XGBoost) and 0.995 (LightGBM); test set: r = 0.883 (LASSO), 0.876 (EN), 0.931 (XGBoost) and 0.915 (LightGBM); external validation set: r = 0.535 (LASSO), 0.534 (EN), 0.591 (XGBoost) and 0.645 (LightGBM)). Blood transcriptome-based age prediction models may provide a simple method to monitor biological ageing, and provide additional molecular insight. Future studies to externally validate these models in various diverse large populations and molecular studies to elucidate the underlying mechanisms by which the gene expression levels may be related to ageing phenotypes would be advantageous.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"86"},"PeriodicalIF":4.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The L-shaped link between total antioxidant capacity and phenotypic age acceleration: evidence from NHANES 2003-2010.","authors":"Yukun Wu, Mengxiang Xiang, Yangcheng Zhao, Yu Zhang, Wenxiang Cheng, Jiangbei Deng","doi":"10.1007/s10522-025-10223-0","DOIUrl":"10.1007/s10522-025-10223-0","url":null,"abstract":"<p><p>This study aimed to investigate the relationship between total antioxidant capacity (TAC) and phenotypic age acceleration (PhenoAgeAccel), a measure of accelerated biological aging, using data from the National Health and Nutrition Examination Survey (NHANES). Data from the 2003-2010 NHANES surveys, encompassing 16,395 participants, were analyzed. Principal component analysis (PCA) was used to reduce data dimensionality. Multivariate logistic regression models were employed to evaluate the association between TAC and antioxidant vitamins (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein-zeaxanthin, vitamin A, vitamin C, vitamin E) with PhenoAgeAccel, adjusting for demographic, lifestyle, and clinical factors. Smoothed curve fitting and threshold effects analysis were conducted to explore the nonlinear relationship between log-transformed TAC and PhenoAgeAccel. Subgroup analyses were performed to assess potential effect modifiers based on age, gender, race, education, smoking, alcohol use, diabetes, hypertension, and hyperlipidemia. The weak correlations between the original variables prevent PCA from effectively capturing the primary variability within the data. Higher TAC was significantly inversely associated with PhenoAgeAccel in both unadjusted and adjusted models. Participants in the second tertile (T2) of TAC exhibited 11% lower odds of PhenoAgeAccel compared to those in the first tertile (T1) (OR = 0.89, 95% CI: 0.81-0.98, P = 0.0176). Intake of several antioxidant vitamins, including α-carotene, β-carotene, lutein-zeaxanthin, vitamin A, vitamin C, and vitamin E, was also inversely associated with the odds of PhenoAgeAccel. A nonlinear relationship between log-transformed TAC and PhenoAgeAccel was observed, with a significant protective effect within a specific range of TAC. Subgroup analyses revealed no significant effect modification by most factors, except for gender, smoking, and alcohol consumption. TAC is closely associated with PhenoAgeAccel. A nonlinear relationship was observed, with higher TAC exhibiting significant protective effects within a specific range, particularly among males, smokers, and alcohol consumer. These findings underscore the potential value of TAC in mitigating the aging process.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"85"},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis reveals the potential mechanisms underlying long-term exercise-induced enhancement of learning and memory in male mice.","authors":"Qiu-Xia Xiao, Hao-Yue Qin, Jun-Jie Chen, Chang-Le Fang, Qiu-Lin Wang, Qi-Jun Li, Shuai-Yu Zhu, Liu-Lin Xiong","doi":"10.1007/s10522-025-10225-y","DOIUrl":"https://doi.org/10.1007/s10522-025-10225-y","url":null,"abstract":"<p><p>Exercise is widely recognized for improving physical functions, learning, and memory. However, the mechanisms behind these effects are not fully understood. This study aims to investigate the potential mechanisms through which exercise enhances learning and memory in mice using multi-omics analysis. Twenty male C57BL/6J mice were divided into exercise and control groups. The exercise group underwent a 4-month treadmill training regimen (12 m/min). Learning and memory abilities were assessed using the Morris water maze test. Brain, serum, and fecal samples were collected for neurotransmitter analysis, serum metabolomics analysis, and gut microbiota analysis. Data from neurotransmitter and serum metabolomics analyses were integrated with gut microbiota analysis. For comparisons between the two groups, the independent sample t-test was employed. For comparisons involving multiple groups, a repeated measures one-way analysis of variance (ANOVA) with random unit group design was applied. Statistical significance was defined as P < 0.05. The Morris water maze test significantly improved learning and memory in the exercise group (P < 0.05). Neurotransmitter analysis revealed significant differences in cognitive function-related neurotransmitters and pathways between the exercise and control groups (P < 0.05). Serum metabolomics analysis identified differences in serum metabolites between the two groups, which were linked to key pathways involved in neural repair and cognitive function. Microbial sequencing showed greater gut microbiota diversity in the exercise group, with the most notable changes at the genus level, particularly in Allobaculum, A2, and Clostridium_sensu_stricto_1 (P < 0.05). Integrated analysis indicated correlations between changes in gut microbiota and serum metabolites associated with cognitive function. Long-term exercise enhances learning and memory in mice through multiple mechanisms, including neurotransmitter regulation, serum metabolite changes, and modulation of gut microbiota. These findings provide new insights into the neuroprotective effects of exercise.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"84"},"PeriodicalIF":4.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring new markers for biological aging from bioimpedance analysis and cognitive functions in older adults.","authors":"Dieu Ni Thi Doan, Boncho Ku, Kahye Kim, Kunho Lee, Jaeuk U Kim","doi":"10.1007/s10522-025-10222-1","DOIUrl":"10.1007/s10522-025-10222-1","url":null,"abstract":"<p><p>Aging is a complex process that affects human health and lifespan. While chronological age (CA) is a significant risk factor for many diseases, it does not fully capture biological changes that influence health span. This study explores cognitive measures using the Seoul Neuropsychological Screening Battery and body composition profiles as potential biological age (BA) markers in the older population. Multiple linear regression, principal component analysis (PCA), and the Klemera-Doubal (KDM) methods were used to construct sex-specific BA formulas from 296 healthy individuals (160 women, 136 men, mean age: 70.3 years). The BA formulas were applied to a new cohort of 708 diseased people (376 women, 332 men, mean age: 73.5 years) to generate BAs for each sex. Subsequently, we compared the classification power of CA, BAs, and selected variables when differentiating the healthy group from the comorbidity cohort, with sex stratification. As a result, we found that BAs from PCA and KDM were significantly higher than CA in the diseased group but comparable in the healthy group. BAs from PCA and KDM methods yielded higher classification accuracies than CA alone. Notably, frontal executive domain score and body reactance emerged as two promising markers for aging. These findings suggest that body composition measures and cognitive assessments offer a more accurate reflection of biological health than CA alone. A cohort with a wider age range is needed to generalize these findings.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"80"},"PeriodicalIF":4.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomeres in skin aging.","authors":"Zibin Liu, Chang Sun, Zhaofeng Zhang, Yanfei Jiang, Chunyue Zhao","doi":"10.1007/s10522-025-10228-9","DOIUrl":"https://doi.org/10.1007/s10522-025-10228-9","url":null,"abstract":"<p><p>Skin aging is influenced by both intrinsic and extrinsic factors. The gradual manifestation of changes in telomere length and telomerase activity, as crucial indicators of aging, elucidates the underlying mechanism of skin aging. This review aims to comprehensively analyze the association between telomeres and aging, along with their impact on skin biological function. Firstly, we summarize the structure and function of telomeres and their role in cell division. Subsequently, we discuss the mechanisms through which telomere regulation contributes to aging processes while analyzing its involvement in skin aging by elaborating on biological markers. Furthermore, this paper presents a summary of recent research progress that reveals the correlation between telomere length and skin aging as well as model building methods; it also proposes telomere length as a potential indicator for predicting skin aging. Finally, anti-aging strategies based on telomere protection are discussed including drug therapy and lifestyle adjustments. This paper provides a systematic overview of the role played by telomeres in the field of skin aging for the first time, offering new perspectives and ideas for future prevention and treatment.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"83"},"PeriodicalIF":4.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring TGF-β signaling in benign prostatic hyperplasia: from cellular senescence to fibrosis and therapeutic implications.","authors":"Abida Khan, Hayat Ali Alzahrani, Shatha Ghazi Felemban, Alanood Saeed Algarni, Amani Baqqan S Alenezi, Mehnaz Kamal, Zia Ur Rehman, Syed Mohammed Basheeruddin Asdaq, Naveed Ahmed, Bashayer Mohammed Alharbi, Bander Sharqi Alanazi, Mohd Imran","doi":"10.1007/s10522-025-10226-x","DOIUrl":"https://doi.org/10.1007/s10522-025-10226-x","url":null,"abstract":"<p><p>As men get older, they often develop benign prostatic hyperplasia (BPH), an enlarged prostate that is not cancerous or dangerous. Although the etiology of BPH is unknown, increasing evidence indicates that the TGF-β signaling pathway might be a key player in its pathogenesis. TGF-β is a pleiotropic cytokine involved in proliferation, differentiation, and extracellular matrix re-modeling, which are all dysregulated in BPH. Cellular senescence is primarily initiated by TGF-β--induced, irreversible growth arrest and usually limits the prostate gland's hyperplastic growth. Moreover, senescent cells generate a Senescence-Associated Secretory Phenotype (SASP), which consists of numerous proinflammatory and profibrotic factors that can worsen disease ontogeny. In addition, TGF-β is among the most fibrogenic factors. At the same time, fibrosis involves a massive accumulation of extracellular matrix proteins, which can increase tissue stiffness and a loss of normal organ functions. TGF-β-mediated fibrosis in BPH changes the mechanical properties of the prostate and surrounding tissues to contribute to lower urinary tract symptoms. This review discusses the complicated molecular signaling of TGF-β underlying changes in cellular senescence and fibrosis during BPH concerning its therapeutic potential.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"79"},"PeriodicalIF":4.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the role of peripheral monocyte nicotinic acetylcholine receptors and inflammation in cognitive outcomes in older adults.","authors":"Jordan N Kohn, Gavrila Ang, Christopher Pruitt, Isabel Gandarilla, Xin Tu, Suzi Hong","doi":"10.1007/s10522-025-10220-3","DOIUrl":"10.1007/s10522-025-10220-3","url":null,"abstract":"<p><p>Nicotinic acetylcholine receptors (nAChRs) are important regulators of brain and immune function that play critical roles in the neuropathology and progression of Alzheimer's disease and related dementias (ADRD). However, quantifying nAChRs in the brain remains elusive, and little is known about peripheral measures of nAChR in older adults or their relationship to cognition. Here, we examined associations between nAChR expression and immunoregulatory function in peripheral blood monocytes and cognitive performance among 167 older adults (age 72.3 ± 7.6 years; 71% female). Penalized linear and logistic regression were used to identify nAChR-related features in classical, intermediate, and nonclassical monocytes, as well as immunophenotypes, clinical and sociodemographic factors, associated with cognitive status (Montreal Cognitive Assessment; MoCA). Intermediate monocytes had the highest expression of alpha-7 nAChRs and greater ex vivo inflammatory responses (83.7% TNF-ɑ⁺ cells) relative to classical (68.4%, d = 1.98, P < 0.001) or nonclassical monocytes (58.9%, d = 3.20, P < 0.001). Participants with mild cognitive impairment (MCI: N = 76) had higher soluble CD14 levels (1777 ± 377 pg/uL) and greater anticholinergic medication burden (ACB; mean = 1.76) than normocognitive participants (NC: N = 91; 1638 ± 352 pg/uL sCD14, t₁₅₅ = 2.78, P = 0.006; mean ACB: 1.05, t₁₄₃ = 3.13, P = 0.002). Multivariate regression models indicated that stronger nAChR-mediated immunoregulation in intermediate monocytes was associated with higher MoCA scores (beta = 0.13) and 14% lower odds of MCI, as well as lower ACB (beta = - 2.10; 95% CI - 4.14, - 0.61). This study demonstrates that peripheral monocytes exhibit subset-specific differences in nAChR phenotypes in older adults and provides preliminary evidence for their association with cognitive function and a potential mediating role between ACB and cognitive impairment.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"82"},"PeriodicalIF":4.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}