Neuroimmunology in ageing and longevity: a special collection issue of Biogerontology.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-07-09 DOI:10.1007/s10522-025-10284-1

Gurcharan Kaur, Tamas Fulop, Arpita Konar, Jaspreet Singh

引用次数: 0

Abstract

Ageing is associated with neuroimmune shifts from a resting to a hyperactive and inflammatory state, termed 'Neuroinflammageing', attributed to microglial priming, hyperactive astrocytes, cytokine and chemokine release, blood brain barrier leakage, and infiltration of peripheral immune cells. This special issue of Biogerontology on 'Neuroimmunology in Ageing and Longevity' brings together 11 reviews and original research papers dealing with the complex cross-talk between CNS and peripheral immune cells and molecules in the context of ageing. The articles compiled under this issue further address how understanding neuroimmune pathways may help to identify targets to design interventional regimens for healthy brain ageing and longevity.

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衰老和长寿中的神经免疫学：生物老年学特刊。

衰老与神经免疫从静止状态转变为过度活跃和炎症状态有关，称为“神经炎症”，归因于小胶质细胞启动、星形胶质细胞过度活跃、细胞因子和趋化因子释放、血脑屏障渗漏和外周免疫细胞浸润。本期《老年生物学》特刊“衰老与长寿中的神经免疫学”汇集了11篇综述和原创研究论文，这些论文涉及衰老背景下中枢神经系统与外周免疫细胞和分子之间复杂的串扰。本期编辑的文章进一步阐述了如何理解神经免疫途径可能有助于确定目标，以设计健康的大脑衰老和长寿的干预方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.