Biogerontology最新文献_第2页

GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process.

IF 4.4 4区医学

Biogerontology Pub Date : 2024-12-06 DOI: 10.1007/s10522-024-10164-0

Antero Salminen

{"title":"GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process.","authors":"Antero Salminen","doi":"10.1007/s10522-024-10164-0","DOIUrl":"10.1007/s10522-024-10164-0","url":null,"abstract":"The GDF15 protein, a member of the TGF-β superfamily, is a stress-induced multifunctional protein with many of its functions associated with the regulation of the immune system. GDF15 signaling provides a defence against the excessive inflammation induced by diverse stresses and tissue injuries. Given that the aging process is associated with a low-grade inflammatory state, called inflammaging, it is not surprising that the expression of GDF15 gradually increases with aging. In fact, the GDF15 protein is a core factor secreted by senescent cells, a state called senescence-associated secretory phenotype (SASP). Many age-related stresses, e.g., mitochondrial and endoplasmic reticulum stresses as well as inflammatory, metabolic, and oxidative stresses, induce the expression of GDF15. Although GDF15 signaling is an effective anti-inflammatory modulator, there is robust evidence that it is a pro-aging factor promoting the aging process. GDF15 signaling is not only an anti-inflammatory modulator but it is also a potent immunosuppressive enhancer in chronic inflammatory states. The GDF15 protein can stimulate immune responses either non-specifically via receptors of the TGF-β superfamily or specifically through the GFRAL/HPA/glucocorticoid pathway. GDF15 signaling stimulates the immunosuppressive network activating the functions of MDSCs, Tregs, and M2 macrophages and triggering inhibitory immune checkpoint signaling in senescent cells. Immunosuppressive responses not only suppress chronic inflammatory processes but they evoke many detrimental effects in aged tissues, such as cellular senescence, fibrosis, and tissue atrophy/sarcopenia. It seems that the survival functions of GDF15 go awry in persistent inflammation thus promoting the aging process and age-related diseases.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"19"},"PeriodicalIF":4.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AcidAGE: a biological age determination neural network based on urine organic acids.

IF 4.4 4区医学

Biogerontology Pub Date : 2024-12-06 DOI: 10.1007/s10522-024-10161-3

Anastasia A Kobelyatskaya, Fedor I Isaev, Anna V Kudryavtseva, Zulfiya G Guvatova, Alexey A Moskalev

引用次数: 0

Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth.

IF 4.4 4区医学

Biogerontology Pub Date : 2024-12-04 DOI: 10.1007/s10522-024-10162-2

Jun Wakabayashi, Takahiro Hamaguchi, Masashi Morifuji, Masashi Nagata

{"title":"Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth.","authors":"Jun Wakabayashi, Takahiro Hamaguchi, Masashi Morifuji, Masashi Nagata","doi":"10.1007/s10522-024-10162-2","DOIUrl":"https://doi.org/10.1007/s10522-024-10162-2","url":null,"abstract":"Dry mouth results from decreased saliva secretion due to aging or drug side effects. Decreased saliva secretion causes dryness in the oral cavity that makes swallowing difficult and increases the risk of aspiration pneumonia. There are few fundamental treatments for dry mouth. Here we investigated whether treatment of old mice with nicotinamide mononucleotide (NMN) improved factors associated with dry mouth. Young (16-week-old) and old (113-week-old) male mice were treated subcutaneously with saline or NMN (300 mg/kg) once every two days for four weeks and saliva secretion was measured. The amount of nicotinamide adenine dinucleotide (NAD+) in salivary gland tissues was measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Gene expression in the intestinal tract and salivary glands was measured by real-time PCR. The population of cells with acetylation in the submandibular gland was quantified by immunohistological staining. SA-β-gal activity in the submandibular gland was measured to assess cell senescence. Statistical analysis was performed by one-way analysis of variance with Tukey post hoc analysis. The submandibular glands from old mice treated with NMN exhibited increased saliva secretion and NAD+ levels, which both decrease with aging. In addition, the submandibular glands from NMN-treated old mice had decreased acetylation, numbers of senescent cells, and levels of senescence-associated secretory phenotype (SASP) factors, which all increase with aging, as well as increased aquaporin5 (AQP5) mRNA expression. NMN administration may improve dry mouth by regulating cellular senescence in the submandibular gland and increasing expression of AQP5, a water channel involved in saliva secretion, to inhibit age-related decreases in saliva secretion. It is necessary to elucidate further mechanism and confirm its effectiveness in humans.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"18"},"PeriodicalIF":4.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dichotomic role of cytokines in aging.

IF 4.4 4区医学

Biogerontology Pub Date : 2024-12-02 DOI: 10.1007/s10522-024-10152-4

Rafael Cardoso Maciel Costa Silva

引用次数: 0

Revealing the molecular links between coronary heart disease and cognitive impairment: the role of aging-related genes and therapeutic potential of stellate ganglion block.

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-28 DOI: 10.1007/s10522-024-10159-x

Zhehao Jin, Yuling Xing, Pengyu Duan, Yonghong Bi, Xiaoyan Li, Weiyu Feng, Bing Zhang

{"title":"Revealing the molecular links between coronary heart disease and cognitive impairment: the role of aging-related genes and therapeutic potential of stellate ganglion block.","authors":"Zhehao Jin, Yuling Xing, Pengyu Duan, Yonghong Bi, Xiaoyan Li, Weiyu Feng, Bing Zhang","doi":"10.1007/s10522-024-10159-x","DOIUrl":"10.1007/s10522-024-10159-x","url":null,"abstract":"Coronary heart disease (CHD) and cognitive impairment frequently co-occur in aging populations, yet the molecular mechanisms linking these conditions remain unclear. This study aims to elucidate the roles of key aging-related genes (ARGs), specifically FKBP5 and DDIT3, in the pathophysiology of CHD and cognitive impairment, and to evaluate the therapeutic potential of stellate ganglion block (SGB). Using single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (bulk RNA-seq) data, we identified FKBP5 and DDIT3 as pivotal genes upregulated in both conditions. Experimental findings show that SGB effectively modulates these ARG-related pathways through autonomic regulation, specifically suppressing estrogen and NF-κB signaling pathways, thereby reducing the expression of pro-inflammatory cytokines such as SRC, MMP2, FKBP5, IRAK1, and MYD88, while upregulating the vasodilation-related gene NOS3. This modulation improved endothelial and cardiac function and enhanced cerebral blood flow (CBF), leading to cognitive improvement. Behavioral assessments, including novel object recognition (NOR) and Morris water maze (MWM) tests, demonstrated that SGB-treated rats outperformed untreated MI rats, with significant cognitive recovery over time. Further support from laser Doppler flowmetry (LDF) and electroencephalogram (EEG) analyses revealed increased left frontal blood flow and stabilized neural activity, indicating a favorable neurophysiological environment for cognitive rehabilitation. Our findings suggest that left stellate ganglion block (LSGB) provides both cardiac and cognitive benefits through targeted gene modulation, establishing its therapeutic potential for addressing the intersecting pathologies of CHD and cognitive impairment.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"16"},"PeriodicalIF":4.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geroprotective effects of GdVO₄:Eu^3 + nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis. GdVO4:Eu3 + 纳米粒子、二甲双胍和热量限制对因出生后早期营养过剩而加速衰老的雄性大鼠的老年保护作用。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-25 DOI: 10.1007/s10522-024-10156-0

Yuri V Nikitchenko, Vladimir K Klochkov, Nataliya S Kavok, Nina A Karpenko, Svetlana L Yefimova, Vladimir P Semynozhenko, Irina V Nikitchenko, Anatoly I Bozhkov

{"title":"Geroprotective effects of GdVO4:Eu3 + nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis.","authors":"Yuri V Nikitchenko, Vladimir K Klochkov, Nataliya S Kavok, Nina A Karpenko, Svetlana L Yefimova, Vladimir P Semynozhenko, Irina V Nikitchenko, Anatoly I Bozhkov","doi":"10.1007/s10522-024-10156-0","DOIUrl":"https://doi.org/10.1007/s10522-024-10156-0","url":null,"abstract":"GdVO4:Eu3+ nanoparticles (OVNPs) have previously been shown to exhibit anti-aging effects in old rats.The accelerated aging model (overnutrition in early postnatal ontogenesis (POF)) was used to confirm the effect of OVNPs as a potential geroprotector. A comparative study of the effect of OVNPs, calorierestriction (CR) and CR-mimetic-metformin was carried out using a number of criteria: survival, prooxidant-antioxidant balance in the liver and blood, physiological parameters of male Wistar rats with accelerated aging. It was found that the survival of rats with POF was lower than that of control animals.It was found that the rate of superoxide radical formation and the content of lipid hydroperoxides in the mitochondria and microsomes of the liver and blood serum of rats with POF were higher, and the activities of glutathione peroxidases and the GSH content were significantly lower than in the control animals.It was also found that POF leads to perturbation of physiological parameters (body weight, liver weight, liver mass coefficient, body temperature and blood thyroxine concentration) characterizing the quality of life. Long-term use of OVNPs, CR or metformin in rats with accelerated aging normalized the imbalance of the prooxidant-antioxidant system, improved the physiological parameters, and increased the survival of these experimental animals. Moreover, the increase in survival was most pronounced with the use of CR and OVNPs. Considering our results andthe inadmissibility of long-term use of CR, it should be concluded that GdVO4:Eu3+ nanoparticles are promising for the development of agents that slow down the accelerated aging of an organism.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"14"},"PeriodicalIF":4.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome. 叉头盒 P1 通过使 NLRP3 炎症小体失活，转录激活 IGF-1，从而减轻 ox-LDL 诱导的内皮细胞衰老。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-25 DOI: 10.1007/s10522-024-10151-5

Siqi Deng, Meili Lao, Huihui Zheng, Jingwen Hao

{"title":"Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome.","authors":"Siqi Deng, Meili Lao, Huihui Zheng, Jingwen Hao","doi":"10.1007/s10522-024-10151-5","DOIUrl":"https://doi.org/10.1007/s10522-024-10151-5","url":null,"abstract":"Endothelial cell (EC) senescence is a major contributor in atherosclerosis (AS) development. Herein, the role of forkhead box P transcription factor 1 (FOXP1) and insulin-like growth factor (IGF)-1 in regulating EC senescence during AS progression was investigated. The mRNA and protein expressions were assessed using qRT-PCR and western blot. IL-1β and IL-18 secretion levels were analyzed by ELISA. Cell viability and pyroptosis were determined by MTT assay and flow cytometry, respectively. SA β-Gal staining was used to measure cell senescence. Tube formation assay was adopted to detect the angiogenesis ability. Dual-luciferase reporter and ChIP assays were used to investigate the relationship between FOXP1 and IGF‑1. ox-LDL stimulation significantly reduced FOXP1 and IGF-1 expression levels in human aortic endothelial cells (HAECs). FOXP1 or IGF-1 overexpression both mitigated ox-LDL-induced cellular senescence and NLRP3 activation in HAECs. It was subsequently revealed that FOXB1 transcriptionally activated IGF-1 expression in HAECs by binding to IGF-1 promoter. Rescue experiments demonstrated that IGF-1 silencing abolished the inhibitory impact of FOXP1 overexpression on ox-LDL-induced cellular senescence and NLRP3 activation in HAECs. FOXP1 transcriptionally activated IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"15"},"PeriodicalIF":4.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public alignment with longevity biotechnology: an analysis of framing in surveys and opinion studies. 公众与长寿生物技术的一致性：调查和舆论研究中的框架分析。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-25 DOI: 10.1007/s10522-024-10157-z

Alberto Aparicio

{"title":"Public alignment with longevity biotechnology: an analysis of framing in surveys and opinion studies.","authors":"Alberto Aparicio","doi":"10.1007/s10522-024-10157-z","DOIUrl":"10.1007/s10522-024-10157-z","url":null,"abstract":"This article examines the framing and public perception of longevity biotechnology, or geroscience, which aims to extend both healthspan and lifespan by targeting the biological processes of aging. Although often seen as moving into the mainstream, questions remain about its ability to meet these ambitious goals, given the complexities of understanding and manipulating aging biology. Drawing on an analysis of qualitative studies and surveys conducted over the past two decades, this paper explores how public attitudes toward anti-aging science are framed, suggesting that studies often emphasize life extension over healthspan gains. Findings reveal mixed reactions, with both interest in and ambivalence about the desirability of extended lifespans. In response, this paper recommends that stakeholders in longevity biotechnology engage with the public by understanding unmet health needs rather than assuming a widespread embrace of lifespan extension. The article underscores the importance of aligning public engagement strategies with realistic scientific expectations to foster credibility and trust; promises should be grounded in current scientific evidence and tempered by feasibility. Addressing societal concerns and fostering dialogue on the ethical and social implications of manipulating aging processes could lay a foundation for responsible progress in geroscience and biogerontology, supporting a more informed, inclusive conversation between science and society as these fields advance.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"13"},"PeriodicalIF":4.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Directionality theory and mortality patterns across the primate lineage. 更正：灵长类的方向性理论和死亡率模式。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10155-1

Lloyd A Demetrius, Anand Sahasranaman, Martin Ziehe

引用次数: 0

Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats. 全身振动通过海马星形胶质细胞突触引起雄性大鼠大脑皮层40赫兹伽马振荡，并改善与年龄相关的认知障碍。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10154-2

Mingsong Liu, Lei Li, Ruizhe Chen, Qilin Wang, Tongfei Zeng, Junhong Hu, Changzhi Yan, Jing Xiao, Xuewei Xia

{"title":"Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats.","authors":"Mingsong Liu, Lei Li, Ruizhe Chen, Qilin Wang, Tongfei Zeng, Junhong Hu, Changzhi Yan, Jing Xiao, Xuewei Xia","doi":"10.1007/s10522-024-10154-2","DOIUrl":"10.1007/s10522-024-10154-2","url":null,"abstract":"Age-related cognitive impairment is a prevalent issue in developed societies. Gamma oscil2lations at 40 Hz have been identified as a potential therapeutic approach for age-related cognitive decline and can be induced through various modalities, including auditory, visual, electrical, and magnetic stimulation. In this study, we investigated a novel modality of stimulation: whole-body vibration at 40 Hz. We examined the effects of 40 Hz vibration on cognitive performance and associated neuronal activity in the brains of aged male rats. Our findings revealed that only vibration at 40 Hz, rather than 20 Hz or 80 Hz, elicited cortical gamma oscillations in aged male rats. Additionally, following 8 weeks of prolonged treatment, the implementation of 40 Hz whole-body vibration significantly augmented the cognitive function of aged male rats as evidenced by behavioral assessments. Mechanistic studies demonstrated that these beneficial effects were attributed to the reduction of neuronal apoptosis in hippocampal CA1 through regulation of synaptic connections between astrocytes and neurons via 40 Hz gamma oscillations. Collectively, this suggests a promising intervention for age-related cognitive decline and identifies neuron-astrocyte synapses as potential therapeutic targets.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"11"},"PeriodicalIF":4.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0