Biogerontology最新文献_第2页

Maternal malnutrition induces inflammatory pathways and oxidative stress in the dorsolateral prostate of male offspring rats. 母体营养不良诱导雄性后代大鼠前列腺背外侧炎症通路和氧化应激。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-17 DOI: 10.1007/s10522-025-10251-w

Renato Mattos, Matheus Naia Fioretto, Sérgio Alexandre Alcantara Dos Santos, Isabelle Tenori Ribeiro, Maycon Tavares Emílio-Silva, Luiz Marcos Frediani Portela, Clélia Akiko Hiruma Lima, Fabio Rodrigues Ferreira Seiva, Luis A Justulin

{"title":"Maternal malnutrition induces inflammatory pathways and oxidative stress in the dorsolateral prostate of male offspring rats.","authors":"Renato Mattos, Matheus Naia Fioretto, Sérgio Alexandre Alcantara Dos Santos, Isabelle Tenori Ribeiro, Maycon Tavares Emílio-Silva, Luiz Marcos Frediani Portela, Clélia Akiko Hiruma Lima, Fabio Rodrigues Ferreira Seiva, Luis A Justulin","doi":"10.1007/s10522-025-10251-w","DOIUrl":"https://doi.org/10.1007/s10522-025-10251-w","url":null,"abstract":"Maternal conditions during pregnancy can influence the long-term health of offspring. In particular, maternal malnutrition (MM), such as protein restriction, affects the development of several organs, including the male reproductive system. This study examined how a low-protein maternal diet impacts the structure and function of the dorsolateral prostate (DLP) in aging male rats. Male offspring were divided into two groups: A control group (CTR), whose mothers received a normal protein diet (17%) during pregnancy and lactation, and a low-protein group (GLLP), whose mothers received a low-protein diet (6%) during the same period. At 540 days of age, the offspring were euthanized, and the DLPs were collected for analysis. The GLLP group showed significant structural changes in the DLP, including increased epithelial and reduced stromal compartments. These rats also had lower levels of probasin (a prostate-specific protein), along with a higher number of mast cells, CD68 + macrophages, and IL-10 protein expression, indicating inflammation. Antioxidant balance was disrupted: Glutathione (GSH) levels increased, while catalase (CAT) and superoxide dismutase (SOD) decreased. The expression of SIRT1, a protein linked to aging and oxidative stress control, was reduced. In silico analysis using human prostate cancer data (PRAD-TCGA) revealed that biological pathways related to oxidative stress, immune response, and tissue remodeling were disrupted in both the rat model and human prostate cancer. In summary, maternal protein restriction leads to long-term changes in the dorsolateral prostate of aging male offspring, including inflammation, oxidative stress, and tissue remodeling. The reduced expression of SIRT1 may play a key role in these effects.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"109"},"PeriodicalIF":4.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calorie-restriction treatment mitigates the aging in rat liver model. 热量限制治疗可减轻大鼠肝脏模型的衰老。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-07 DOI: 10.1007/s10522-025-10245-8

L Urlandini, A E Leonetti, F Conforti, A Perri, D Lofaro, G Antonucci, M Mandalà, S Bossio, S Di Agostino, V Rago

{"title":"Calorie-restriction treatment mitigates the aging in rat liver model.","authors":"L Urlandini, A E Leonetti, F Conforti, A Perri, D Lofaro, G Antonucci, M Mandalà, S Bossio, S Di Agostino, V Rago","doi":"10.1007/s10522-025-10245-8","DOIUrl":"https://doi.org/10.1007/s10522-025-10245-8","url":null,"abstract":"The aging process promotes progressive impairment of homeostasis and the increase of the risk of disease and death. A major hallmark of the aging process is the systemic chronic inflammation which strongly contributes to the onset of aging-related diseases. In the liver, the aging condition drives the hepatocytes to develop a metabolic dysfunction-associated steatosis. Caloric restriction (CR) is a remarkable strategy to delay biological aging, occurring through several mechanisms. In this study we aimed to explore, employing an in vivo rat model, the impact of CR on aging-mediated liver inflammation markers. The experiments were performed on 14 male Sprague-Dawley rats (24 months old). At 18 months old, rats were allocated into two groups: the normal diet (ND) group was continued ad libitum diet, and the CR regimen group was fed a diet of the same chow restricted to 60% of the intake. All animals were sacrificed at 24 months old. Compared to the ND group, morphological examination of the liver revealed a lower level of fibrosis in the CR group, concomitantly with a reduced expression of key fibrotic markers, such as collagen I, fibronectin, and αSMA. Furthermore, CR improved the liver oxidative balance, as showed by the increased expression of two scavenging enzymes, SOD1/SOD. Moreover, we reported concomitant reduction of NLRP3 inflammasome signalling. Interestingly, CR significantly improved the signalling of key members of the nutrition-sensitizing affected by aging, AMPK/SIRT1/LKB1. Collectively our findings support the evidence on the metabolic benefits of CR about aging-related liver inflammation, by inducing a morphological improvement that mirrors the decrease in the expression of inflammatory molecular markers.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"108"},"PeriodicalIF":4.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do circulating sphingolipid species correlate with age? A study in a normoglycemic biracial population. 循环鞘脂种类与年龄相关吗？血糖正常的混血儿人群的研究。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10244-9

Naser Aliye Feto, Peace Asuzu, Jim Wan, Frankie Stentz, Sam Dagogo-Jack, Nawajes Mandal

{"title":"Do circulating sphingolipid species correlate with age? A study in a normoglycemic biracial population.","authors":"Naser Aliye Feto, Peace Asuzu, Jim Wan, Frankie Stentz, Sam Dagogo-Jack, Nawajes Mandal","doi":"10.1007/s10522-025-10244-9","DOIUrl":"https://doi.org/10.1007/s10522-025-10244-9","url":null,"abstract":"Sphingolipids (SPLs) are essential membrane lipids with significant bioactive roles involved in various cellular processes, and their alterations have been found to be linked to many diseases, including age-related diseases. However, comprehensive studies on the association of plasma sphingolipids with aging in large, diverse cohorts remain limited. The objective of this study was to investigate the relationship between plasma sphingolipid levels and aging in a cohort of 240 normoglycemic, biracial individuals (Black and White), aged 19-65 years. Using a targeted lipidomics approach, we measured 76 sphingolipid species using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in picomole/mL and determined changes in their levels with age and their correlations with aging. We found significant age-related changes in several sphingolipid species, including ceramide C18:1 and several very long-chain sphingomyelins (VLC SMs), such as C28:1 and C30:1, increases with age, showing a positive correlation. On the other hand, glycosphingolipids (monohexosylceramide, MHC; lactosylceramide, LacCer) and sphingosine (So) showed strong negative correlations with aging. A significant correlation was also observed between the ratios of saturate/monosaturated sphingolipid species with aging. In conclusion, our findings provide novel insights into the dynamic changes of circulating sphingolipids with aging. Specific sphingolipid species, such as Ceramide C18:1 and SM, accumulate with age, while others, including MHC, LacCer, and So decrease. These results suggest that the plasma SPL profile may provide valuable information about healthy aging and age-associated disease conditions.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"106"},"PeriodicalIF":4.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATM and p53 in aging and cancer: a double-edged sword in genomic integrity. 衰老和癌症中的ATM和p53：基因组完整性的双刃剑。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10249-4

Surya Nath Pandey, Muhammad Afzal, Jyoti Uikey, Subbulakshmi Ganesan, Swati Mishra, Pooja Bansal, Imran Kazmi, Sami I Alzarea, Waleed Hassan Almalk, Kavita Goyal, Gaurav Gupta, Mohit Rana

{"title":"ATM and p53 in aging and cancer: a double-edged sword in genomic integrity.","authors":"Surya Nath Pandey, Muhammad Afzal, Jyoti Uikey, Subbulakshmi Ganesan, Swati Mishra, Pooja Bansal, Imran Kazmi, Sami I Alzarea, Waleed Hassan Almalk, Kavita Goyal, Gaurav Gupta, Mohit Rana","doi":"10.1007/s10522-025-10249-4","DOIUrl":"https://doi.org/10.1007/s10522-025-10249-4","url":null,"abstract":"Maintaining genomic stability is essential for detecting DNA damage and activating appropriate responses such as repair, apoptosis, or senescence, primarily mediated by the ATM-p53 axis. ATM is the main sensor of double-strand breaks, and once activated, it will either promote the repair of damaged DNA or eliminate the damaged cells through apoptosis. ATM and p53 mutations upset this equilibrium to cause genomic instability, therapy resistance, and tumor progression in the context of cancer. Oncogene-induced senescence is bypassed by ATM inactivation, which allows cells to progress to become tumors, and p53 mutations allow for uncontrolled proliferation and sensitivity to apoptosis. In addition, persistent ATM signaling can trigger a SASP, which paradoxically further enhances an inflammatory tumor microenvironment and contributes to aging-related diseases and cancer progression. Chemical small molecule p53 activators (PRIMA-1, Nutlin-3) and ATM inhibitors (AZD0156, M4076) sensitize cancer to DNA damaging therapy in cells and nude mice without p53. It remains to be seen whether ATM loss results in ATM/p53 signaling that is always detrimental to tumor proliferation or has context-dependent effects since ATM loss can also promote p53-dependent tumor suppression through senescence and apoptosis in specific cancer types. In this review, we consolidate state-of-the-art findings on ATM and p53 coordination in the processes involved in DNA repair, apoptosis, and senescence to show how ATM and p53 dual involvement in tumor suppression and cancer progression is occurring. It also focuses on therapeutic approaches targeting these pathways to benefit from senescence and intimidating cancer treatment outcomes.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"102"},"PeriodicalIF":4.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan. 从端粒和衰老到综合长寿医学：重新定义延长健康寿命的途径。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10246-7

Virginia Boccardi

引用次数: 0

Analyzing different aging theories in the context of the brain: DNA damage, inflammation, redox imbalance, and neurodevelopment intertwine. 在大脑的背景下分析不同的衰老理论：DNA损伤、炎症、氧化还原失衡和神经发育交织在一起。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10243-w

Bruno César Feltes

引用次数: 0

Circulating immune cells in cerebral small vessel disease: a systematic review. 循环免疫细胞在脑血管疾病中的作用：系统综述。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10250-x

L Van der Taelen, A M Briones, T Unger, J Staals, R J van Oostenbrugge, S Foulquier

{"title":"Circulating immune cells in cerebral small vessel disease: a systematic review.","authors":"L Van der Taelen, A M Briones, T Unger, J Staals, R J van Oostenbrugge, S Foulquier","doi":"10.1007/s10522-025-10250-x","DOIUrl":"10.1007/s10522-025-10250-x","url":null,"abstract":"Cerebral small vessel disease (cSVD) refers to all pathologies of the brain's arterioles, capillaries, and venules. cSVD is highly prevalent with ageing and is diagnosed by its characteristic neuro-imaging features. Emerging evidence suggests that circulating immune cells play an important role in cSVD's pathology. However, the specific immune cell populations involved remain poorly understood. This systematic review synthesizes current evidence on circulating immune cells in cSVD and their associations with cSVD features. A systematic search was conducted using PubMed, Embase, and Web of Science databases. All studies investigating the association between peripheral immune cells and imaging features of cSVD were included. Data were extracted on study design, immune cells and cSVD measures, and outcomes. A total of 18 studies were included. Pro-inflammatory monocytes were associated with the severity and progression of cSVD over time. The neutrophil-to-lymphocyte ratio (NLR) showed positive associations with white matter hyperintensities (WMH) and enlarged perivascular spaces. The monocyte-to-HDL ratio (MHR) demonstrated a stronger association than the NLR with WMH, lacunes, and cerebral microbleeds. The lymphocyte-to-monocyte ratio (LMR) was linked to slower WMH progression and lower cSVD prevalence. Key findings highlight a role for pro-inflammatory circulating monocytes, NLR, MHR, and LMR in cSVD patients. These derived ratios serve as more reliable disease predictors than individual blood counts, showing potential as innovative diagnostic and prognostic markers. However, the reviewed studies predominantly employed cross-sectional and retrospective designs, suggesting the need for large-scale, prospective investigations to determine the role of these inflammatory markers in cSVD's pathogenesis.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"101"},"PeriodicalIF":4.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CHIP and aging: a key regulator of proteostasis and cellular senescence. CHIP与衰老：蛋白质平衡和细胞衰老的关键调节因子。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10247-6

Surya Nath Pandey, Neetu Agrawal, Ehssan Moglad, G Padma Priya, Manish Srivastava, Kattela Chennakesavulu, Biswaranjan Mohanty, Renu Arya, Imran Kazmi, Sami I Alzarea, Waleed Hassan Almalk, Kavita Goyal

引用次数: 0

SENS vs. the hallmarks of aging: competing visions, shared challenges. SENS与衰老的标志：相互竞争的愿景，共同的挑战。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-05 DOI: 10.1007/s10522-025-10248-5

Pablo García-Barranquero, Saúl Pérez-González

引用次数: 0

Synbiotic pineapple beverage increases life span in Caenorhabditis elegans, ameliorates cognitive impairment, and restores gut microbiome diversity in D-galactose-induced aged C57BL/6 mice. 在d -半乳糖诱导的衰老C57BL/6小鼠中，合成菠萝饮料可延长秀丽隐杆线虫的寿命，改善认知障碍，并恢复肠道微生物群多样性。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-05-03 DOI: 10.1007/s10522-025-10239-6

Neelam Anil Revankar, Siddaraju Anusha, Serva Peddha Muthukumar, Pradeep Singh Negi

{"title":"Synbiotic pineapple beverage increases life span in Caenorhabditis elegans, ameliorates cognitive impairment, and restores gut microbiome diversity in D-galactose-induced aged C57BL/6 mice.","authors":"Neelam Anil Revankar, Siddaraju Anusha, Serva Peddha Muthukumar, Pradeep Singh Negi","doi":"10.1007/s10522-025-10239-6","DOIUrl":"https://doi.org/10.1007/s10522-025-10239-6","url":null,"abstract":"The incidence of age-associated ailments has increased proportionately with the expansion of the aging demographic. This study aimed to evaluate the anti-aging potential of synbiotic pineapple beverage formulated with 100% pineapple juice, 1% inulin, and Lacticaseibacillus rhamnosus ATCC 53103 (10 log CFU) in Caenorhabditis elegans and D-galactose age-induced mice. The synbiotic juice-treated nematodes exhibited a 24.52% increase in their lifespan, accompanied by lower levels of reactive oxygen species and improved structural functions. In vivo studies demonstrated that synbiotic treatment positively influences age-induced mice's cerebellar function and spatial memory. Additionally, the synbiotic beverage containing 8-10 log CFU of Lacticaseibacillus rhamnosus showed a protective effect against hippocampal neuron damage. The control group displayed a higher Firmicutes/Bacteroides (F/B) ratio, whereas the significantly lower F/B ratio in the diseased groups indicated a reversal of microbial imbalance caused by D-galactose exposure. Furthermore, the consumption of synbiotic beverage mitigated telomere shortening in aged mice. The results highlight the anti-aging effects of a pineapple beverage formulated with Lacticaseibacillus rhamnosus and inulin as a synbiotic intervention. This study suggests that dietary interventions incorporating prebiotics and probiotics may serve as promising strategy for combating age-related disorders and promoting healthy aging.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 3","pages":"99"},"PeriodicalIF":4.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0