Biogerontology最新文献_第2页

Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-13 DOI: 10.1007/s10522-025-10191-5

Ignacia González, Sebastián B Arredondo, Rodrigo Maldonado-Agurto

{"title":"Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells.","authors":"Ignacia González, Sebastián B Arredondo, Rodrigo Maldonado-Agurto","doi":"10.1007/s10522-025-10191-5","DOIUrl":"10.1007/s10522-025-10191-5","url":null,"abstract":"Cellular senescence is a stable cell cycle arrest that occurs in response to various stress stimuli and affects multiple cell types, including endothelial cells (ECs). Senescent cells accumulate with age, and their removal has been linked to reduced age-related diseases. However, some senescent cells are important for tissue homeostasis. Therefore, understanding the diversity of senescent cells in a cell-type-specific manner and their underlying molecular mechanisms is essential. Senescence impairs key ECs functions which are necessary for vascular homeostasis, leading to endothelial dysfunction and age-related vascular diseases. In order to gain insights into these mechanisms, we analyzed publicly available RNA-seq datasets to identify gene expression changes in senescent ECs induced by doxorubicin, irradiation, and replication exhaustion. While only a few genes were consistently differentially expressed across all conditions, some gene ontologies (GO) were shared. Among these, our analysis focused on validating the expression of genes associated with the matrisome, which includes genes encoding for extracellular matrix (ECM) structural components and ECM-associated proteins, in a doxorubicin-induced senescence model. Our results show that the matrisome transcriptome undergoes significant remodeling in senescent endothelial cells, regardless of the specific inducers of senescence, highlighting the importance of understanding how ECM alterations affect senescence.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"59"},"PeriodicalIF":4.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma therapy: a novel intervention to improve age-induced decline in deudenal cell proliferation in female rat model.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-07 DOI: 10.1007/s10522-025-10197-z

Ender Deniz Asmaz, Taha Ceylani, Aysun İnan Genc, Zeynep Tuğçe Sertkaya, Hikmet Taner Teker

{"title":"Plasma therapy: a novel intervention to improve age-induced decline in deudenal cell proliferation in female rat model.","authors":"Ender Deniz Asmaz, Taha Ceylani, Aysun İnan Genc, Zeynep Tuğçe Sertkaya, Hikmet Taner Teker","doi":"10.1007/s10522-025-10197-z","DOIUrl":"10.1007/s10522-025-10197-z","url":null,"abstract":"Aging is associated with a disruptive decline in gastrointestinal health leading to decreased duodenal cell proliferation ultimately affecting the digestive and absorptive capacity of intestines in all species. This study investigates the novel application of blood plasma therapy to enhance duodenal cell proliferation associated with aging. In the presented study, the effects of middle aged plasma therapy on the aged rat duodenum were investigated. For this purpose, using a randomized controlled design, Female Wistar rats (aged 12-15 months) (n:7) were treated with heterologus pooled plasma (0.5 mL per day for 30 days, infused intravenously into the tail vein) collected from middle aged (6 months old, n:28) rats during all stages of the estrous cycle. The groups were divided into three as the Experimental group (aged 12-15 months) receiving middle aged plasma, the control group (aged 12-15 months) not receiving treatment, and the middle aged rat (6 months) as the positive control group. At the end of the experiment, each group's duodenum were collected, fixed, and analyzed using histological techniques for morphometric parameters. Additionally cell proliferation density and proliferation index were determined by proliferating cell nuclear antigen (PCNA). The finding of the study suggests that plasma therapy significantly improves cell proliferation, villus height (µm), crypt depth (µm), total mucosal thickness (µm), the ratio of villus height to crypt depth (µm), and surface absorption area (mm2) in the experimental group compared to control. Likewise, we determined that middle aged plasma application supports cell proliferation. However, further research is warranted to explore the underlying mechanisms and potential clinical applications of this innovative approach.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"57"},"PeriodicalIF":4.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The transcription factor STAT3 and aging: an intermediate medium.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-07 DOI: 10.1007/s10522-025-10193-3

Min Shi, Honyu Li, Runyu Liang, Haiyan Lin, Qiang Tang

引用次数: 0

Investigating genetic links between biological aging and adverse pregnancy outcomes.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-07 DOI: 10.1007/s10522-025-10198-y

Ning Sun, Kaiyan Yang, Huihui Wang, Wenbo Zhou

{"title":"Investigating genetic links between biological aging and adverse pregnancy outcomes.","authors":"Ning Sun, Kaiyan Yang, Huihui Wang, Wenbo Zhou","doi":"10.1007/s10522-025-10198-y","DOIUrl":"https://doi.org/10.1007/s10522-025-10198-y","url":null,"abstract":"Observational studies suggest a link between biological aging and adverse pregnancy outcomes (APOs), but causal relationships remain unclear. This study aimed to investigate the relationship between genetically predicted biological aging traits and APOs. Genetic summary statistics from the genome-wide association study (GWAS) of the IEU open GWAS, FinnGen, and meta-analysis were analyzed using Mendelian randomization (MR) to infer causality. Biological aging indicators included facial aging, frailty index, and epigenetic aging markers. APOs included gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HTP), preterm birth (PTB), and pregnancy loss (PL). The primary MR analyses utilized the inverse variance weighted method, followed by sensitivity analyses. Reverse MR and multivariable MR were employed to explore reverse causality and potential mediating effects. We found that the frailty index was positively associated with GDM (OR = 2.00, 95% CI 1.44-2.77, P = 3.41E - 5), HTP (OR = 2.09, 95% CI 1.33-3.29, P = 0.001), and PL (OR = 1.22, 95% CI 1.03-1.46, P = 0.023) risks. Inverse MR showed that susceptibility to HTP (β = 0.05, 95% CI 0.03-0.07, P = 4.43E - 6) and PL (β = 0.06, 95% CI 0.01-0.11, P = 0.011) was positively correlated with the frailty index, while PTB was positively correlated with PhenoAge (β = 0.24, 95% CI 0.02-0.46, P = 0.035). Our findings suggest a genetic association between the frailty index and susceptibility to GDM, HTP, and PL. Closer monitoring of biological aging indicators during pregnancy may be necessary to prevent APOs.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"56"},"PeriodicalIF":4.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-07 DOI: 10.1007/s10522-025-10202-5

Mehran Izadi, Nariman Sadri, Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Sana Sadatipour, Ghazalnaz Baghdadi, Dorsa Jalaei, Safa Tahmasebi

{"title":"Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity.","authors":"Mehran Izadi, Nariman Sadri, Amirhossein Abdi, Mohammad Mahdi Raeis Zadeh, Sana Sadatipour, Ghazalnaz Baghdadi, Dorsa Jalaei, Safa Tahmasebi","doi":"10.1007/s10522-025-10202-5","DOIUrl":"10.1007/s10522-025-10202-5","url":null,"abstract":"Aging is a complex and heterogeneous biological process characterized by telomere attrition, genomic instability, mitochondrial dysfunction, and disruption in nutrient sensing. Besides contributing to the progression of cancer, metabolic disorders, and neurodegenerative diseases, these manifestations of aging also adversely affect organ function. It is crucial to understand these mechanisms and identify interventions to modulate them to promote healthy aging and prevent age-related diseases. Vitamins have emerged as potential modulators of aging beyond their traditional roles in health maintenance. There is an increasing body of evidence that hormetic effects of vitamins are responsible for activating cellular stress responses, repair mechanisms, and homeostatic processes when mild stress is induced by certain vitamins. It is evident from this dual role that vitamins play a significant role in preventing frailty, promoting resilience, and mitigating age-related cellular damage. Moreover, addressing vitamin deficiencies in the elderly could have a significant impact on slowing aging and extending life expectancy. A review of recent advances in the role of vitamins in delaying aging processes and promoting multiorgan health is presented in this article. The purpose of this paper is to provide a comprehensive framework for using vitamins as strategic tools for fostering longevity and vitality. It offers a fresh perspective on vitamins' role in aging research by bridging biological mechanisms and clinical opportunities.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"58"},"PeriodicalIF":4.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disturbances in cell wall biogenesis as a key factor in the replicative aging of budding yeast.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-05 DOI: 10.1007/s10522-025-10196-0

Mateusz Mołoń, Gabriela Małek, Anna Bzducha-Wróbel, Monika Kula-Maximenko, Agnieszka Mołoń, Sabina Galiniak, Krzysztof Skrzypiec, Jacek Zebrowski

{"title":"Disturbances in cell wall biogenesis as a key factor in the replicative aging of budding yeast.","authors":"Mateusz Mołoń, Gabriela Małek, Anna Bzducha-Wróbel, Monika Kula-Maximenko, Agnieszka Mołoń, Sabina Galiniak, Krzysztof Skrzypiec, Jacek Zebrowski","doi":"10.1007/s10522-025-10196-0","DOIUrl":"https://doi.org/10.1007/s10522-025-10196-0","url":null,"abstract":"Aging is a multifactorial process that significantly impairs organismal function. Yeast is one of the model organisms used in aging research. Our understanding of the impact of the cell wall on aging remains elusive. Yeast cell wall is a complex and dynamic structure that plays a crucial role in the growth, survival, and aging of Saccharomyces cerevisiae. In this study, we demonstrated for the first time that the deletion of genes involved in cell wall biogenesis leads to significant impact on aging. In this study, we analysed five deletion mutants: crh2Δ, cwp1Δ, flo11Δ, gas1Δ and hsp12Δ. We showed a correlation between Raman spectroscopy signatures assigned to proteins, nucleic acids and RNA and replicative aging. Using Raman spectroscopy, we also revealed that a lack GAS1 gene results in significant changes in the biochemical composition of the cells that may increase sensitivity to environmental stressors. Our data unequivocally indicate that employing yeast as a model in aging research is appropriate, as long as the factors under analysis are not implicated in cell wall biogenesis.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"54"},"PeriodicalIF":4.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between lifestyle factors, physiological conditions, and epigenetic age acceleration in an Asian population. 亚洲人群中生活方式因素、生理条件与表观遗传年龄加速之间的关联。

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-05 DOI: 10.1007/s10522-025-10195-1

Yu-Ru Wu, Wan-Yu Lin

{"title":"Associations between lifestyle factors, physiological conditions, and epigenetic age acceleration in an Asian population.","authors":"Yu-Ru Wu, Wan-Yu Lin","doi":"10.1007/s10522-025-10195-1","DOIUrl":"10.1007/s10522-025-10195-1","url":null,"abstract":"Epigenetic clocks use DNA methylation (DNAm) levels to predict an individual's biological age. However, relationships between lifestyle/biomarkers and epigenetic age acceleration (EAA) in Asian populations remain unknown. We here explored associations between lifestyle factors, physiological conditions, and epigenetic markers, including HannumEAA, IEAA, PhenoEAA, GrimEAA, DunedinPACE, DNAm-based smoking pack-years (DNAmPACKYRS), and DNAm plasminogen activator inhibitor 1 level (DNAmPAI1). A total of 2474 Taiwan Biobank (TWB) individuals aged between 30 and 70 provided physical health examinations, lifestyle questionnaire surveys, and blood and urine samples. Partial correlation analysis (while adjusting for chronological age, smoking, and drinking status) demonstrated that 29 factors were significantly correlated with at least one epigenetic marker (Pearson's correlation coefficient |r|> 0.15). Subsequently, by exploring the model with the smallest Akaike information criterion (AIC), we identified the best model for each epigenetic marker. As a DNAm-based marker demonstrated to predict healthspan and lifespan with greater accuracy, GrimEAA was also found to be better explained by lifestyle factors and physiological conditions. Totally 15 factors explained 44.7% variability in GrimEAA, including sex, body mass index (BMI), waist-hip ratio (WHR), smoking, hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDL-C), creatinine, uric acid, gamma-glutamyl transferase (GGT), hemoglobin, and five cell-type proportions. In summary, smoking, elevated HbA1c, BMI, WHR, GGT, and uric acid were associated with more than one kind of EAA. At the same time, higher HDL-C and hemoglobin were related to epigenetic age deceleration (EAD). These findings offer valuable insights into biological aging.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"51"},"PeriodicalIF":4.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-05 DOI: 10.1007/s10522-025-10194-2

Ashok Kumar Balaraman, Muhammad Afzal, Ehssan Moglad, M Arockia Babu, G Padma Priya, Pooja Bansal, Sumit Rajotiya, Benod Kumar Kondapavuluri, Imran Kazmi, Sami I Alzarea, Kavita Goyal, Haider Ali

{"title":"The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer.","authors":"Ashok Kumar Balaraman, Muhammad Afzal, Ehssan Moglad, M Arockia Babu, G Padma Priya, Pooja Bansal, Sumit Rajotiya, Benod Kumar Kondapavuluri, Imran Kazmi, Sami I Alzarea, Kavita Goyal, Haider Ali","doi":"10.1007/s10522-025-10194-2","DOIUrl":"https://doi.org/10.1007/s10522-025-10194-2","url":null,"abstract":"p16INK4a is a crucial tumor suppressor and regulator of cellular senescence, forming a molecular bridge between aging and cancer. Dysregulated p16INK4a expression is linked to both premature aging and cancer progression, where non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and small interfering RNAs (siRNAs) play key roles in modulating its function. These ncRNAs interact with p16INK4a through complex post-transcriptional and epigenetic mechanisms, influencing pathways critical to senescence and tumor suppression. In this review, we explore ncRNAs, including ANRIL, MIR31HG, UCA1, MALAT1, miR-24, miR-30, and miR-141, which collectively regulate p16INK4a expression, promoting or inhibiting pathways associated with cancer and aging. ANRIL and MIR31HG modulate p16INK4a silencing via interactions with polycomb repressive complexes (PRC), while miRNAs such as miR-24 and miR-30 target p16INK4a to influence cellular proliferation and senescence. This regulatory interplay underscores the therapeutic potential of ncRNA-targeted strategies to restore p16INK4a function. We summarize recent studies supporting that ncRNAs that control p16INK4a may be diagnostic biomarkers and therapeutic targets for age-related diseases and cancer.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"50"},"PeriodicalIF":4.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-05 DOI: 10.1007/s10522-025-10188-0

Amisha Bisht, Anita Nayal, Disha Tewari, Sanjay Kumar, Subhash Chandra

{"title":"Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach.","authors":"Amisha Bisht, Anita Nayal, Disha Tewari, Sanjay Kumar, Subhash Chandra","doi":"10.1007/s10522-025-10188-0","DOIUrl":"https://doi.org/10.1007/s10522-025-10188-0","url":null,"abstract":"This study investigates the impact and mechanisms of Rasayana Churna, an Ayurvedic poly-herbal formulation, in treating aging-related disorders through text mining, network pharmacology, molecular docking simulation, Super-MMPBSA, and density functional theory. The text mining of Rasayana Churna highlighted the diverse therapeutic potential of Phyllanthus emblica, Tinospora cordifolia, and Tribulus terrestris in managing aging-related disorders through their antidiabetic, antioxidant, and anti-inflammatory properties. Using network pharmacology, 17 bioactive compounds and 137 corresponding potential targets of Rasayana Churna were identified and used to construct protein-protein interaction and hub gene networks. Key targets such as AKT1, BCL2, ESR1, and GSK3B were linked to aging-related pathways, with GO and KEGG enrichment analyses highlighting processes like apoptosis, oxidative stress response, and pathways like PI3K-Akt signaling. Molecular docking analysis identified 14 compounds with strong binding affinity toward the key aging target AKT1. Three bioactive compounds-Kaempferol, N-Caffeoyltyramine, and Multifidol glucoside-exhibited superior stability and binding interactions in MD simulations, confirmed by RMSD, RMSF, Rg, hydrogen bonding, SASA, PCA, and free energy landscape analysis. Super-MMPBSA (last 30 ns) calculation was performed to analyze dynamic behavior and protein-ligand stability, revealing significantly lower ΔG binding free energy values for the three hit compounds (- 177.871, - 164.855, - 199.649 kJ/mol, respectively) compared to the AKT1-reference complex (- 109.463 kJ/mol). DFT analysis revealed favorable electronic properties and kinetic stability for these compounds. Integrating traditional Ayurvedic knowledge with computational techniques suggests Rasayana Churna could prevent and manage aging-related conditions. However, further in vitro, in vivo, and clinical studies are needed to validate its aging-modulatory potential.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"53"},"PeriodicalIF":4.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroinflammaging and the Immune Landscape: The Role of Autophagy and Senescence in Aging Brain.

IF 4.4 4区医学

Biogerontology Pub Date : 2025-02-05 DOI: 10.1007/s10522-025-10199-x

Rajesh Tamatta, Varsha Pai, Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh

{"title":"Neuroinflammaging and the Immune Landscape: The Role of Autophagy and Senescence in Aging Brain.","authors":"Rajesh Tamatta, Varsha Pai, Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh","doi":"10.1007/s10522-025-10199-x","DOIUrl":"10.1007/s10522-025-10199-x","url":null,"abstract":"Neuroinflammation is closely linked to aging, which damages the structure and function of the brain. It is caused by the intricate interactions of immune cells in the aged brain, such as the dysregulated glial cells and the dysfunctional astrocytes. Aging-associated chronic low inflammation, referred to as neuroinflammaging, shows an upregulated proinflammatory response. Autophagy and senescence play crucial roles as moderators of aging and neuroinflammatory responses. The dysregulated neuroimmune system, dystrophic glial cells, and release of proinflammatory factors alter blood-brain barrier, causing a neuroinflammatory landscape. Chronic inflammation combined with deteriorating neurons exacerbate neurological disorders and decline in cognitive function. This review highlights the neuroinflammaging and mechanism associated with immune cells interplay with central nervous system and aging, cellular senescence, and autophagy regulation in the brain's immune system under neuroinflammatory conditions. Moreover, the roles of microglia and peripheral immune cells in the neuroinflammatory process in the aging brain have also been discussed. Determining treatment targets and comprehending mechanisms that influence immune cells in the aged brain is necessary to decrease neuroinflammation.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 2","pages":"52"},"PeriodicalIF":4.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0