Biogerontology最新文献_第3页

Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis. 衰老、ROS 和细胞衰老：肝纤维化进展的三部曲。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10153-3

Waleed Hassan Almalki, Salem Salman Almujri

{"title":"Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis.","authors":"Waleed Hassan Almalki, Salem Salman Almujri","doi":"10.1007/s10522-024-10153-3","DOIUrl":"10.1007/s10522-024-10153-3","url":null,"abstract":"Ageing is an inevitable and multifaceted biological process that impacts a wide range of cellular and molecular mechanisms, leading to the development of various diseases, such as liver fibrosis. Liver fibrosis progresses to cirrhosis, which is an advanced form due to high amounts of extracellular matrix and restoration of normal liver structure with failure to repair damaged tissue and cells, marking the end of liver function and total liver failure, ultimately death. The most important factors are reactive oxygen species (ROS) and cellular senescence. Oxidative stress is defined as an impairment by ROS, which are by-products of the mitochondrial electron transport chain and other key molecular pathways that induce cell damage and can activate cellular senescence pathways. Cellular senescence is characterized by pro-inflammatory cytokines, growth factors, and proteases secreted by senescent cells, collectively known as the senescence-associated secretory phenotype (SASP). The presence of senescent cells, which disrupt tissue architecture and function and increase senescent cell production in liver tissues, contributes to fibrogenesis. Hepatic stellate cells (HSCs) are activated in response to chronic liver injury, oxidative stress, and senescence signals that drive excessive production and deposition of extracellular matrix. This review article aims to provide a comprehensive overview of the pathogenic role of ROS and cellular senescence in the aging liver and their contribution to fibrosis.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"10"},"PeriodicalIF":4.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing dynamics in daily rhythms of oxidative stress indicators in SCN and extra-SCN brain regions with aging in male Wistar rats. 雄性Wistar大鼠SCN和SCN外脑区氧化应激指标的日节律随衰老而变化的动态。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-15 DOI: 10.1007/s10522-024-10150-6

M Sultan Khan, Anita Jagota

{"title":"Changing dynamics in daily rhythms of oxidative stress indicators in SCN and extra-SCN brain regions with aging in male Wistar rats.","authors":"M Sultan Khan, Anita Jagota","doi":"10.1007/s10522-024-10150-6","DOIUrl":"10.1007/s10522-024-10150-6","url":null,"abstract":"The suprachiasmatic nucleus (SCN) in the hypothalamus regulates circadian timing system (CTS) by co-ordinating peripheral tissue clocks and extra-SCN oscillators in the brain. Aging disrupts the CTS, impairing physiological functions and reducing antioxidant defences, which contribute to neurodegeneration. The brain is vulnerable to oxidative damage due to its high metabolic activity, oxygen consumption, and levels of iron and lipids. Antioxidant enzymes, such as catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), and lipid peroxidation (LPO), help against oxidative damage. In this study, we examined the temporal patterns of these antioxidant stress indicators in the SCN and extra-SCN brain regions (frontal cortex, cerebellum, and hippocampus) at various time points in male Wistar rats 3, 12, and 24 months. The rhythmicity of GST and LPO levels persisted across brain regions with aging, while CAT rhythmicity was lost in the SCN and hippocampus of older rats. SOD rhythmicity persisted in cortex, cerebellum, and hippocampus but was lost in the SCN. The daily rhythm parameters of CAT were affected most significantly, followed by SOD, GST, and LPO. Our findings demonstrate that aging leads to desynchronization of oxidative stress indicators potentially contributing to neurodegeneration and circadian dysfunction with varying effects across different brain tissues.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"9"},"PeriodicalIF":4.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cochlea extracellular matrix in age-related hearing loss. 耳蜗细胞外基质在老年性听力损失中的作用

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-13 DOI: 10.1007/s10522-024-10149-z

Weiyi Huang, Yiming Zhong, Kaili Chen, Bing Kong, Andi Zhang, Dongye Guo, Tianyuan Zou, Mingliang Xiang, Bin Ye

{"title":"The role of cochlea extracellular matrix in age-related hearing loss.","authors":"Weiyi Huang, Yiming Zhong, Kaili Chen, Bing Kong, Andi Zhang, Dongye Guo, Tianyuan Zou, Mingliang Xiang, Bin Ye","doi":"10.1007/s10522-024-10149-z","DOIUrl":"https://doi.org/10.1007/s10522-024-10149-z","url":null,"abstract":"Age-related hearing loss (ARHL) is a common disease among the elderly. Although its pathogenesis remains unclear by now, it is widely accepted that ARHL is associated with the degenerative alterations within each component of the cochlea. Extracellular matrix (ECM) plays a crucial role in cochlear structure and function, providing not only structural support but also participating in vital physiological processes including the development, differentiation, survival of auditory sensory cells, and sound perception. ECM is implicated in the pathogenesis of various neurodegenerative diseases, with certain ECM proteins or associated molecules emerging as potential therapeutic targets. However, few research were carried out on ECM in the cochlea and ECM associated molecules in ARHL. This review aims to delineate the composition of ECM in the cochlea, the changes of the main ECM structure in the cochlea such as the tectorial membrane (TM), the basilar membrane (BM) and the spiral ligament (SL) during aging, as well as the role of ECM associated molecules in ARHL. We hope that this review will foster further research into ARHL.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"8"},"PeriodicalIF":4.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing the causal role of blood cells in aging: a Mendelian randomization study. 分析血细胞在衰老中的因果作用：孟德尔随机研究。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-04 DOI: 10.1007/s10522-024-10148-0

Jingjing Zhang, Xin Zhang, Boan Xiao, Jiecai Ouyang, Peng Wang, Xiaobin Peng

{"title":"Analyzing the causal role of blood cells in aging: a Mendelian randomization study.","authors":"Jingjing Zhang, Xin Zhang, Boan Xiao, Jiecai Ouyang, Peng Wang, Xiaobin Peng","doi":"10.1007/s10522-024-10148-0","DOIUrl":"10.1007/s10522-024-10148-0","url":null,"abstract":"Blood cells are crucial components of the human body, closely linked to the aging process. This study aims to explore the causal relationship between 91 blood cell phenotypes and aging through Mendelian randomization (MR) analysis. Exposure data from genome-wide association studies (GWAS) was extracted from the GWAS of blood cell perturbation phenotypes in 2,600 European individuals. Initial analysis utilized GWAS data related to aging from the GWAS Catalog database GCST90014288, with inverse-variance weighting as the primary method for causal analysis. Sensitivity analyses included Cochran's Q test, MR-Egger intercept test, MR-PRESSO, and leave-one-out analysis. For significant associations, replication and meta-analysis were conducted using independent aging GWAS data from GCST90014300. Initial analysis revealed that environmental peroxide-impacted red blood cells and ciprofloxacin-impacted reticulocytes accelerated aging. Additionally, elevated neutrophil levels were found to accelerate aging, while LiCl-impacted neutrophils reduced aging risk. Replication and meta-analysis showed consistent results: ciprofloxacin-impacted reticulocytes and elevated neutrophil levels increased the risk of aging, while LiCl-impacted neutrophils reduced the risk. RBCs showed no significant impact on aging progression. Sensitivity analyses confirmed the robustness and reliability of these positive findings. Our study provides evidence of a causal relationship between three blood cell disturbance phenotypes and human aging.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":"26 1","pages":"7"},"PeriodicalIF":4.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age. 高龄男性 Y 染色体马赛克缺失（mLOY）的影响。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-09-02 DOI: 10.1007/s10522-024-10133-7

Farid Abou Abdallah, Christine Abdel Massih, Charbel Attieh, Alain Chebly

引用次数: 0

The long noncoding RNA (LINC-RBE) expression in testicular cells is associated with aging of the rat. 睾丸细胞中长非编码 RNA（LINC-RBE）的表达与大鼠的衰老有关。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI: 10.1007/s10522-024-10119-5

Ajay Kumar Danga, Sukhleen Kour, Anita Kumari, Pramod C Rath

{"title":"The long noncoding RNA (LINC-RBE) expression in testicular cells is associated with aging of the rat.","authors":"Ajay Kumar Danga, Sukhleen Kour, Anita Kumari, Pramod C Rath","doi":"10.1007/s10522-024-10119-5","DOIUrl":"10.1007/s10522-024-10119-5","url":null,"abstract":"Long noncoding RNAs (lncRNAs) are important regulatory biomolecules responsible for many cellular processes. The aging of mammals is manifested by a slow and gradual decline of physiological functions after adulthood, progressively resulting in age-related diseases. Testis comprises different cell-types with defined functions for producing haploid gametes and androgens in males, contributing gene-pool to the next generation with genetic variations to species for evolutionary advantage. The LINC-RBE (long intergenic noncoding-rat brain expressed) RNA showed highest expression in the Leydig cells, responsible for steroidogenesis and production of testosterone; higher expression in primary spermatocytes (pachytene cells), responsible for generation of haploid gametes and high expression in Sertoli cells, the nursing cells of the testes. Testes of immature (4-weeks), adult (16- and 44-weeks), and nearly-old (70-weeks) rats showed low, high, and again low levels of expression, respectively. This along with the nuclear-cytoplasmic localization of LINC-RBE RNA showed age-related expression and function. Thus, expression of LINC-RBE is involved in the molecular physiology of testes, especially Leydig cells, primary spermatocytes, and Sertoli cells. The decline in its expression correlates with diminishing reproductive function of the testes during aging of the rat.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"1053-1067"},"PeriodicalIF":4.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study. 健康老龄化过程中端粒结构异常和端粒功能障碍的血清标志物：一项初步研究。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-07-13 DOI: 10.1007/s10522-024-10120-y

Virginia Boccardi, Luigi Cari, Patrizia Bastiani, Michela Scamosci, Roberta Cecchetti, Giuseppe Nocentini, Patrizia Mecocci

{"title":"Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study.","authors":"Virginia Boccardi, Luigi Cari, Patrizia Bastiani, Michela Scamosci, Roberta Cecchetti, Giuseppe Nocentini, Patrizia Mecocci","doi":"10.1007/s10522-024-10120-y","DOIUrl":"10.1007/s10522-024-10120-y","url":null,"abstract":"Telomeres undergo a progressive shortening process as individuals age, and it has been proposed that severely shortened and dysfunctional telomeres play a role in the aging process and the onset of age-related diseases in human beings. An emerging body of evidence indicates that the shortening of telomeres in cultured human cells is also influenced by other replication defects occurring within telomeric repeats. These abnormalities can be detected on metaphase chromosomes. Recent studies have also identified a set of serological markers for telomere dysfunction and DNA damage (elongation factor 1α [EF-1α], stathmin, and N-acetyl-glucosaminidase). With this study, the correlation between telomere abnormalities (by FISH) and these biomarkers as measured in blood serum (by ELISA) from a cohort of 22 healthy subjects at different ages (range 26-101 years) was analyzed. A strong positive correlation between aging and the presence of aberrant telomere structures, sister telomere loss (STL), and sister telomere chromatid fusions (STCF) was detected. When serum markers of telomere dysfunction were correlated with telomere abnormalities, we found that stathmin correlated with total aberrant telomeres structures (r = 0.431, p = 0.0453) and STCF (r = 0.533, p = 0.0107). These findings suggest that serum stathmin can be considered an easy-to-get marker of telomere dysfunction and may serve as valuable indicators of aging.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"1069-1077"},"PeriodicalIF":4.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary nitrate maintains intestinal epithelia homeostasis in aged mice. 膳食硝酸盐可维持老年小鼠肠上皮细胞的稳态。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.1007/s10522-024-10127-5

Xue Wang, Huan Liu, Mingwei Yue, Jinsong Wang, Chunmei Zhang, Lizheng Qin, Songlin Wang, Lei Hu

{"title":"Dietary nitrate maintains intestinal epithelia homeostasis in aged mice.","authors":"Xue Wang, Huan Liu, Mingwei Yue, Jinsong Wang, Chunmei Zhang, Lizheng Qin, Songlin Wang, Lei Hu","doi":"10.1007/s10522-024-10127-5","DOIUrl":"10.1007/s10522-024-10127-5","url":null,"abstract":"The intestinal tract, which is the primary site of digestion and absorption of nutrients, is one of the most vulnerable organs during aging. Dietary nitrate, which is mainly derived from the diet and absorbed in the intestinal tract, is a key messenger that connecting oral and general health. However, whether dietary nitrate regulates intestinal tract homeostasis remains unclear. Our data revealed that the serum and salivary nitrate levels decreased during mice aging. The functional proteins of the epithelial barrier (E-cadherin, Claudin-1 and Zonula Occludens-1) in the colon tissues decreased during the aging process. Long-term nitrate supplement in drinking water restored the serum and salivary nitrate levels and increased the functional proteins expression of the colon epithelial barrier. Dietary nitrates increase the relative abundance of some intestinal probiotics, particularly those associated with the production of short-chain fatty acids, such as Blautia, Alloprevotella, Butyricicoccus, and Ruminococcaceae, while promoting the butyric acid production in the colon. Moreover, the expression of Sialin (encoded by Slc17a5), which is a nitrate transporter, increased in the colon epithelial cells by nitrate supplementation. The epithelial cell-conditional Slc17a5-knockout mutant mice (K14-cre; Slc17a5fl/fl) revealed that the functional proteins expression of the colon epithelial barrier and the proliferation of PCNA-positive intestinal epithelial cells in the colon crypts was significantly decreased compared with those of the K14-cre; Slc17a5fl/+ mice. Taken together, our findings suggested that nitrate supplementations were associated with the increased expression of colonic epithelial barriers-related proteins and the increased Sialin expression. Nitrate may serve as a potential therapeutic approach in maintaining aged colonic homeostasis.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"1171-1187"},"PeriodicalIF":4.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directionality theory and mortality patterns across the primate lineage. 灵长类的方向性理论和死亡率模式。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1007/s10522-024-10134-6

Lloyd A Demetrius, Anand Sahasranaman, Martin Ziehe

{"title":"Directionality theory and mortality patterns across the primate lineage.","authors":"Lloyd A Demetrius, Anand Sahasranaman, Martin Ziehe","doi":"10.1007/s10522-024-10134-6","DOIUrl":"10.1007/s10522-024-10134-6","url":null,"abstract":"Empirical studies of aging in primates show that local selective forces rather than phylogenetic history determine the exceptional nature of human longevity (Bronikowski et al., Science 331:1325-1328, 2011). This article proposes an evolutionary rationale for this pattern of primate mortality by invoking the parameter, Life-Table Entropy, a measure of the uncertainty in the life span of a randomly chosen newborn. Life-table entropy is positively correlated with maximal life span, that is, the mean life span of a species living under favourable conditions.The logic which underlies the exceptional nature of human longevity derives from the terrestrial life-history of humans - a singularity within the primate lineage; and the concomitant ecological constraints-the hunter-gatherer, agricultural, and industrial modes of subsistence, that have defined human evolutionary history. The effect of these ecological constraints on the evolution of life span is encoded in the Entropic Principle of Longevity: life-table entropy increases in equilibrium species, populations evolving in environments with stable, renewable resources; and decreases in opportunistic species, populations subject to fluctuating resource endowments.The Entropic Principle of Longevity is a derivative of Directionality Theory, an analytic study of the evolutionary process of variation and selection based on Evolutionary Entropy, a statistical measure of the uncertainty in the age of the mother of a randomly chosen newborn. Evolutionary entropy is the organizing concept of The Entropic Principle of Evolution: Evolutionary Entropy increases in equilibrium species and decreases in opportunistic species.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"1215-1237"},"PeriodicalIF":4.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brown adipose tissue: a potential target for aging interventions and healthy longevity. 棕色脂肪组织：干预衰老和健康长寿的潜在目标。

IF 4.4 4区医学

Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-10-08 DOI: 10.1007/s10522-024-10137-3

Hongde Li, Junli Li, Chengxiang Song, Haoran Yang, Qiang Luo, Mao Chen

引用次数: 0