Role of branched chain amino acid metabolism on aging.

IF 4.1 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-08-23 DOI:10.1007/s10522-025-10309-9

Zhaojia Wang, Shiran Yu, Xiao Du, Xuzhen Yan, Yanguo Xin

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引用次数: 0

Abstract

Aging is a complex biochemical phenomenon that considerably impacts both individual health and societal dynamics. Recent researches have emphasized the essential function of metabolism in the processes of aging and longevity. Metabolites-chemical byproducts produced by the host organism and its symbiotic partners, including the microbiota, are generated through numerous metabolic pathways. In the last fifteen years, major progress has been made in elucidating the metabolism of BCAAs and the detailed molecular mechanisms that connect BCAAs homeostasis to the aging process. The growing body of literature presents a comprehensive view of the tissue- and disease-specific regulatory mechanisms governing BCAAs and their activation of various molecular pathways. These pathways link fluctuations in BCAA levels to the onset and progression of age-related diseases. This review seeks to consolidate current knowledge on the factors influencing BCAA levels and their metabolic pathways. It further aims to elucidate the molecular mechanisms linking dysregulated BCAA homeostasis to age-related diseases, evaluate epidemiological evidence correlating BCAAs with various cardiovascular conditions, and identify gaps in current understanding that warrant further investigation.

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支链氨基酸代谢在衰老中的作用。

衰老是一种复杂的生化现象，对个人健康和社会动态都有很大的影响。近年来的研究强调了代谢在衰老和长寿过程中的重要作用。代谢物是宿主及其共生伙伴（包括微生物群）通过多种代谢途径产生的化学副产物。在过去的15年中，在阐明支链氨基酸的代谢以及支链氨基酸稳态与衰老过程之间的详细分子机制方面取得了重大进展。越来越多的文献对BCAAs的组织和疾病特异性调控机制及其各种分子途径的激活进行了全面的研究。这些途径将BCAA水平的波动与年龄相关疾病的发生和进展联系起来。本综述旨在巩固目前对影响BCAA水平及其代谢途径的因素的了解。该研究进一步旨在阐明BCAA稳态失调与年龄相关疾病的分子机制，评估BCAA与各种心血管疾病相关的流行病学证据，并确定目前认识的空白，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.