Circadian clock and its effect on aging and lifespan.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-06-27 DOI:10.1007/s10522-025-10281-4

Avnish Kumar Verma, Sandeep Singh, Syed Ibrahim Rizvi

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引用次数: 0

Abstract

The circadian clocks of the cell orchestrate a daily transcriptional rhythm that schedules key activities of the cell to maintain homeostasis and support resilience. Circadian rhythm is driven by the periodic oscillations of transcriptional activators and translational repressors, occurring in both the central and peripheral clocks. Accumulating evidence shows that aging impairs the functional synchrony of the circadian system which further escalate age-related disorders. In addition, the technological aspects of modern society, including constant work schedules and extensive use of personal electronics, have led to a significant rise in circadian disorders. Circadian dysfunction seems to adversely impact aging and longevity in animal models. Therefore, it is essential to conduct comprehensive studies to identify factors that worsen with aging and to discover therapeutic options for promoting healthy aging. This review examines how aging affects circadian function and the reciprocal effects of circadian disruption (CD) on aging and longevity. Further, we highlight the recent findings on non-pharmacological aspects such as dietary restrictions and physical exercise as a regulator of circadian rhythms, aging attenuation, and extending lifespan in mammals. Thus, resetting the circadian clock may lead to better synchrony in cellular homeodynamics and physiology which offers healthy aging and increased life span.

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生理时钟及其对衰老和寿命的影响。

细胞的生理时钟编排每日的转录节奏，安排细胞的关键活动，以维持体内平衡和支持弹性。昼夜节律是由转录激活因子和翻译抑制因子的周期性振荡驱动的，发生在中枢和外周时钟中。越来越多的证据表明，衰老会损害昼夜节律系统的功能同步性，从而进一步加剧与年龄相关的疾病。此外，现代社会的技术方面，包括持续的工作安排和个人电子产品的广泛使用，导致了昼夜节律紊乱的显著增加。在动物模型中，昼夜节律障碍似乎对衰老和寿命有不利影响。因此，有必要进行全面的研究，以确定随着年龄的增长而恶化的因素，并发现促进健康老龄化的治疗方案。本文综述了衰老如何影响昼夜节律功能以及昼夜节律紊乱（CD）对衰老和长寿的相互影响。此外，我们强调了最近在非药物方面的发现，如饮食限制和体育锻炼作为哺乳动物昼夜节律、衰老衰减和延长寿命的调节器。因此，重置生物钟可能会导致细胞动力学和生理学更好的同步，从而提供健康的衰老和延长寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.