Effects of cannabidiol to circadian period, sleep, life span, close-proximity rhythm, egg reproduction and motor function in Drosophila melanogaster.

IF 4.1 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-08-12 DOI:10.1007/s10522-025-10305-z

Haruhisa Kawasaki, Toshihiko Sato, Norio Ishida

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Abstract

Cannabidiol (CBD), a non-psychoactive cannabinoid, has been studied for its various health-promoting effects recently. This study investigates the effects of dietary CBD to the circadian clock of Drosophila melanogaster as a model animal and its many physiological effect to flies. We showed that CBD extended the period of locomotor activity in a dose-dependent manner, suggesting its influence on the circadian clock. Additionally, CBD improved sleep quality and extended lifespan under starvation conditions. The study also revealed enhanced rhythmicity in Close Proximity (CP) rhythm and increased eggs reproduction with dietary CBD supplementation. Furthermor, CBD attenuates age-related motor dysfunction in wild-type and Parkinson's disease (PD) model in Drosophila. These findings strongly suggest that appropriate amount of CBD affects the circadian rhythms, sleep, life span, CP rhythm, egg reproduction and motor function of Drosophila melanogaster, and providing a basic data for exploring its potential applications in managing circadian-related disorders in other animals.

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大麻二酚对黑腹果蝇昼夜节律、睡眠、寿命、近距离节律、卵子繁殖和运动功能的影响。

大麻二酚（CBD）是一种非精神活性大麻素，近年来因其多种促进健康的作用而受到研究。本研究以黑腹果蝇为模型动物，探讨了饮食中添加CBD对其生物钟的影响及其对果蝇的诸多生理影响。我们发现，CBD以剂量依赖的方式延长了运动活动的时间，这表明它对生物钟的影响。此外，CBD改善了饥饿条件下的睡眠质量，延长了寿命。该研究还显示，饮食中添加CBD可以增强近距离（CP）节律的节律性，并增加卵子繁殖。此外，CBD可以减轻野生型和帕金森病（PD）模型果蝇的年龄相关运动功能障碍。这些发现有力地提示了适量的CBD对果蝇的昼夜节律、睡眠、寿命、CP节律、卵子繁殖和运动功能的影响，并为探索其在其他动物昼夜节律相关疾病的潜在应用提供了基础数据。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.