Biomimetics最新文献_第2页

Nature-Inspired Solutions for Sustainable Mining: Applications of NIAs, Swarm Robotics, and Other Biomimicry-Based Technologies.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-14 DOI: 10.3390/biomimetics10030181

Joven Tan, Noune Melkoumian, David Harvey, Rini Akmeliawati

{"title":"Nature-Inspired Solutions for Sustainable Mining: Applications of NIAs, Swarm Robotics, and Other Biomimicry-Based Technologies.","authors":"Joven Tan, Noune Melkoumian, David Harvey, Rini Akmeliawati","doi":"10.3390/biomimetics10030181","DOIUrl":"10.3390/biomimetics10030181","url":null,"abstract":"Environmental challenges, high safety risks and operational inefficiencies are some of the issues facing the mining sector. The paper offers an integrated viewpoint to address these issues by combining swarm robotics, nature-inspired algorithms (NIAs) and other biomimicry-based technologies into a single framework. It presents a systematic classification of each methodology, emphasizing their key advantages and disadvantages as well as considering real-life mining application scenarios, including hazard detection, autonomous transportation and energy-efficient drilling. Case studies are citied to demonstrate how these methodologies work together, and an extensive comparison table considering their applications at mines, such as Boliden, Diavik Diamond Mine, Olympic Dam and others, presents a summary of their scalability and practicality. This paper highlights future directions such as multi-robot coordination and hybrid NIAs, to improve operational resilience and sustainability. It also provides a broad overview of biomimicry and critically examines unresolved issues like real-time adaptation, parameter tuning and mechanical wear. The paper aims to offer a comprehensive insight into using bio-inspired models to enhance mining efficiency, safety and environmental management, while proposing a road map for resolving the issues that continue to be a hurdle for wide adaptation of these technologies in the mining industry.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Swarm Intelligence and Human-Inspired Optimization for Urban Drone Path Planning.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-14 DOI: 10.3390/biomimetics10030180

Yidao Ji, Qiqi Liu, Cheng Zhou, Zhiji Han, Wei Wu

{"title":"Hybrid Swarm Intelligence and Human-Inspired Optimization for Urban Drone Path Planning.","authors":"Yidao Ji, Qiqi Liu, Cheng Zhou, Zhiji Han, Wei Wu","doi":"10.3390/biomimetics10030180","DOIUrl":"10.3390/biomimetics10030180","url":null,"abstract":"Urban drone applications require efficient path planning to ensure safe and optimal navigation through complex environments. Drawing inspiration from the collective intelligence of animal groups and electoral processes in human societies, this study integrates hierarchical structures and group interaction behaviors into the standard Particle Swarm Optimization algorithm. Specifically, competitive and supportive behaviors are mathematically modeled to enhance particle learning strategies and improve global search capabilities in the mid-optimization phase. To mitigate the risk of convergence to local optima in later stages, a mutation mechanism is introduced to enhance population diversity and overall accuracy. To address the challenges of urban drone path planning, this paper proposes an innovative method that combines a path segmentation and prioritized update algorithm with a cubic B-spline curve algorithm. This method enhances both path optimality and smoothness, ensuring safe and efficient navigation in complex urban settings. Comparative simulations demonstrate the effectiveness of the proposed approach, yielding smoother trajectories and improved real-time performance. Additionally, the method significantly reduces energy consumption and operation time. Overall, this research advances drone path planning technology and broadens its applicability in diverse urban environments.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on Ship Replenishment Path Planning Based on the Modified Whale Optimization Algorithm.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-13 DOI: 10.3390/biomimetics10030179

Qinghua Chen, Gang Yao, Lin Yang, Tangying Liu, Jin Sun, Shuxiang Cai

{"title":"Research on Ship Replenishment Path Planning Based on the Modified Whale Optimization Algorithm.","authors":"Qinghua Chen, Gang Yao, Lin Yang, Tangying Liu, Jin Sun, Shuxiang Cai","doi":"10.3390/biomimetics10030179","DOIUrl":"10.3390/biomimetics10030179","url":null,"abstract":"Ship replenishment path planning has always been a critical concern for researchers in the field of security. This study proposes a modified whale optimization algorithm (MWOA) to address single-task ship replenishment path planning problems. To ensure high-quality initial solutions and maintain population diversity, a hybrid approach combining the nearest neighbor search with random search is employed for initial population generation. Additionally, crossover operations and destroy and repair operators are integrated to update the whale's position, significantly enhancing the algorithm's search efficiency and optimization performance. Furthermore, variable neighborhood search is utilized for local optimization to refine the solutions. The proposed MWOA has been tested against several algorithms, including the original whale optimization algorithm, genetic algorithm, ant colony optimization, hybrid particle swarm optimization, and simulated annealing, using traveling salesman problems as benchmarks. Results demonstrate that MWOA outperforms these algorithms in both solution quality and stability. Moreover, when applied to ship replenishment path planning problems of varying scales, MWOA consistently achieves superior performance compared to the other algorithms. The proposed algorithm demonstrates high adaptability in addressing diverse ship replenishment path planning problems, delivering efficient, high-quality, and reliable solutions.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MSBiLSTM-Attention: EEG Emotion Recognition Model Based on Spatiotemporal Feature Fusion.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-13 DOI: 10.3390/biomimetics10030178

Yahong Ma, Zhentao Huang, Yuyao Yang, Zuowen Chen, Qi Dong, Shanwen Zhang, Yuan Li

{"title":"MSBiLSTM-Attention: EEG Emotion Recognition Model Based on Spatiotemporal Feature Fusion.","authors":"Yahong Ma, Zhentao Huang, Yuyao Yang, Zuowen Chen, Qi Dong, Shanwen Zhang, Yuan Li","doi":"10.3390/biomimetics10030178","DOIUrl":"10.3390/biomimetics10030178","url":null,"abstract":"Emotional states play a crucial role in shaping decision-making and social interactions, with sentiment analysis becoming an essential technology in human-computer emotional engagement, garnering increasing interest in artificial intelligence research. In EEG-based emotion analysis, the main challenges are feature extraction and classifier design, making the extraction of spatiotemporal information from EEG signals vital for effective emotion classification. Current methods largely depend on machine learning with manual feature extraction, while deep learning offers the advantage of automatic feature extraction and classification. Nonetheless, many deep learning approaches still necessitate manual preprocessing, which hampers accuracy and convenience. This paper introduces a novel deep learning technique that integrates multi-scale convolution and bidirectional long short-term memory networks with an attention mechanism for automatic EEG feature extraction and classification. By using raw EEG data, the method applies multi-scale convolutional neural networks and bidirectional long short-term memory networks to extract and merge features, selects key features via an attention mechanism, and classifies emotional EEG signals through a fully connected layer. The proposed model was evaluated on the SEED dataset for emotion classification. Experimental results demonstrate that this method effectively classifies EEG-based emotions, achieving classification accuracies of 99.44% for the three-class task and 99.85% for the four-class task in single validation, with average 10-fold-cross-validation accuracies of 99.49% and 99.70%, respectively. These findings suggest that the MSBiLSTM-Attention model is a powerful approach for emotion recognition.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress Analysis and Stiffness Degradation of Open Cracks Composite Laminates Subjected to External Loads.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-12 DOI: 10.3390/biomimetics10030177

Zhicheng Huang, Shengyun Su, Xingguo Wang, Fulei Chu

{"title":"Stress Analysis and Stiffness Degradation of Open Cracks Composite Laminates Subjected to External Loads.","authors":"Zhicheng Huang, Shengyun Su, Xingguo Wang, Fulei Chu","doi":"10.3390/biomimetics10030177","DOIUrl":"10.3390/biomimetics10030177","url":null,"abstract":"Composite laminated structures have extensive applications in the field of bionic engineering. Proficient comprehension of the mechanical properties of these structures is instrumental in the advancement of bionic composite materials. The objective of this study is to investigate the stress distribution and degradation of stiffness in composite laminates exhibiting open smooth surface cracks under varying external loads and structural parameters. Utilizing the general series function of the laminate's axial stress, the general expression for the stress components of the damaged laminate is derived by integrating the equilibrium differential equation, boundary conditions, and stress continuity conditions. The influence of fiber orientation and material properties on the stress distribution within each layer of symmetric composite laminates was examined. Thereafter, the reduction in cross-layer shear modulus was assessed by employing the principle of complementary energy minimization. The impact of structural parameters on shear modulus reduction was explored. The findings indicate that structural and material parameters of symmetric laminates featuring transverse matrix cracks exert a notable influence on the stress distribution and degradation of stiffness within each layer, imparting practical significance to the research outcomes in engineering applications.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Numerical Analysis of the Aerodynamic Interactions in Tandem Flying Snake Airfoils.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-12 DOI: 10.3390/biomimetics10030174

Yuchen Gong, Jiacheng Guo, Alexander He, Ye Sun, Haibo Dong

{"title":"Numerical Analysis of the Aerodynamic Interactions in Tandem Flying Snake Airfoils.","authors":"Yuchen Gong, Jiacheng Guo, Alexander He, Ye Sun, Haibo Dong","doi":"10.3390/biomimetics10030174","DOIUrl":"10.3390/biomimetics10030174","url":null,"abstract":"During gliding, flying snakes flatten their ribs to create an airfoil-like cross-section and adopt S-shape postures, allowing upstream body segments to generate wake structures that affect the aerodynamic performance of downstream segments. This study investigates these interactions using numerical simulations of two-dimensional snake cross-sectional airfoils. By employing an immersed-boundary-method-based incompressible flow solver with tree topological local mesh refinement, various foil positions and movements were analyzed. The results show that aligning the downstream foil with the upstream foil reduces lift production by 86.5% and drag by 96.3%, leading to a 3.77-fold increase in the lift-to-drag ratio compared to a single airfoil. This improvement is attributed to the vortex-wedge interaction between the upstream vortex and the following foil's leading edge (wedge), which enhances the gliding efficiency of the posterior body. Furthermore, integrating specific pitching motions with coordinated vortex shedding could further optimize its lift production. These findings provide valuable insights into the aerodynamics of tandem flying snake airfoils, offering guidance for configuring optimal body postures for improving gliding efficiency.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing Biomechanical Properties of Bioabsorbable Suture Anchors: A Comprehensive Review.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-12 DOI: 10.3390/biomimetics10030175

Dorien I Schonebaum, Noelle Garbaccio, Maria J Escobar-Domingo, Sasha Wood, Jade E Smith, Lacey Foster, Morvarid Mehdizadeh, Justin J Cordero, Jose A Foppiani, Umar Choudry, David L Kaplan, Samuel J Lin

{"title":"Comparing Biomechanical Properties of Bioabsorbable Suture Anchors: A Comprehensive Review.","authors":"Dorien I Schonebaum, Noelle Garbaccio, Maria J Escobar-Domingo, Sasha Wood, Jade E Smith, Lacey Foster, Morvarid Mehdizadeh, Justin J Cordero, Jose A Foppiani, Umar Choudry, David L Kaplan, Samuel J Lin","doi":"10.3390/biomimetics10030175","DOIUrl":"10.3390/biomimetics10030175","url":null,"abstract":"Suture anchors (SAs) are medical devices used to connect soft tissue to bone. Traditionally these were made of metal; however, in the past few decades, bio-absorbable suture anchors have been created to overcome revision surgeries and other complications caused by metallic SAs. This systematic review aims to analyze the biomechanical properties of these SAs to gain a better understanding of their safety and utilization. A comprehensive systematic review that adhered to the PRISMA guidelines was conducted. Primary outcomes were that the pull-out strength of SAs, the rate of degradation secondarily, and the biocompatibility of all SAs were analyzed. After screening 347 articles, 16 were included in this review. These studies revealed that the pull-out strength of bio-absorbable SAs was not inferior to that of their non-absorbable comparatives. The studies also revealed that the rate of degradation varies widely from 7 to 90 months. It also showed that not all absorbable SAs were fully absorbed within the expected timeframe. This systematic review demonstrates that existing suture anchor materials exhibit comparable pull-out strengths, material-specific degradation rates, and variable biocompatibility. All-suture anchors had promising results in biocompatibility, but evidence fails to identify a single most favorable material. Higher-powered studies that incorporate tissue-specific characteristics, such as rotator cuff tear size, are warranted. To meet demonstrated shortcomings in strength and biocompatibility, we propose silk fibroin as a novel material for suture anchor design for its customizable properties and superior strength.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EDECO: An Enhanced Educational Competition Optimizer for Numerical Optimization Problems.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-12 DOI: 10.3390/biomimetics10030176

Wenkai Tang, Shangqing Shi, Zengtong Lu, Mengying Lin, Hao Cheng

{"title":"EDECO: An Enhanced Educational Competition Optimizer for Numerical Optimization Problems.","authors":"Wenkai Tang, Shangqing Shi, Zengtong Lu, Mengying Lin, Hao Cheng","doi":"10.3390/biomimetics10030176","DOIUrl":"10.3390/biomimetics10030176","url":null,"abstract":"The Educational Competition Optimizer (ECO) is a newly proposed human-based metaheuristic algorithm. It derives from the phenomenon of educational competition in society with good performance. However, the basic ECO is constrained by its limited exploitation and exploration abilities when tackling complex optimization problems and exhibits the drawbacks of premature convergence and diminished population diversity. To this end, this paper proposes an enhanced educational competition optimizer, named EDECO, by incorporating estimation of distribution algorithm and replacing some of the best individual(s) using a dynamic fitness distance balancing strategy. On the one hand, the estimation of distribution algorithm enhances the global exploration ability and improves the population quality by establishing a probabilistic model based on the dominant individuals provided by EDECO, which solves the problem that the algorithm is unable to search the neighborhood of the optimal solution. On the other hand, the dynamic fitness distance balancing strategy increases the convergence speed of the algorithm and balances the exploitation and exploration through an adaptive mechanism. Finally, this paper conducts experiments on the proposed EDECO algorithm with 29 CEC 2017 benchmark functions and compares EDECO with four basic algorithms as well as four advanced improved algorithms. The results show that EDECO indeed achieves significant improvements compared to the basic ECO and other compared algorithms, and performs noticeably better than its competitors. Next, this study applies EDECO to 10 engineering constrained optimization problems, and the experimental results show the significant superiority of EDECO in solving real engineering optimization problems. These findings further support the effectiveness and usefulness of our proposed algorithm in solving complex engineering optimization challenges.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of Platelet-Rich Fibrin (PRF) Membranes Alone or in Combination with Biomimetic Materials in Oral Regeneration: A Narrative Review.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-11 DOI: 10.3390/biomimetics10030172

Javier Valenzuela-Mencia, Francisco Javier Manzano-Moreno

{"title":"Applications of Platelet-Rich Fibrin (PRF) Membranes Alone or in Combination with Biomimetic Materials in Oral Regeneration: A Narrative Review.","authors":"Javier Valenzuela-Mencia, Francisco Javier Manzano-Moreno","doi":"10.3390/biomimetics10030172","DOIUrl":"10.3390/biomimetics10030172","url":null,"abstract":"Platelet-rich fibrin (PRF) membranes are a biomaterial derived from the patient's own blood, used in different medical and dental areas for their ability to promote healing, tissue regeneration, and reduce inflammation. They are obtained by centrifuging the blood, which separates the components and concentrates the platelets and growth factors in a fibrin matrix. This material is then moulded into a membrane that can be applied directly to tissues. The use of these PRF membranes is often associated with the use of different biomimetic materials such as deproteinized bovine bone mineral (DBBM), β-tricalcium phosphate (β-TCP), enamel matrix derivative (EMD), and hydroxyapatite (HA). Different indications of PRF membranes have been proposed, like alveolar ridge preservation, alveolar ridge augmentation, guided tissue regeneration (GTR), and sinus floor augmentation. The aim of this narrative review is to check the state-of-the-art and to analyze the existing gaps in the use of PRF membranes in combination with biomimetic materials in alveolar ridge preservation, alveolar ridge augmentation, guided tissue regeneration (GTR), and sinus floor augmentation.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytocompatibility Study of Stainless Steel 316l Against Differentiated SH-SY5Y Cells.

IF 3.4 3区医学

Biomimetics Pub Date : 2025-03-11 DOI: 10.3390/biomimetics10030169

Eleni Zingkou, Asimina Kolianou, Georgios Angelis, Michail Lykouras, Malvina Orkoula, Georgios Pampalakis, Georgia Sotiropoulou

{"title":"Cytocompatibility Study of Stainless Steel 316l Against Differentiated SH-SY5Y Cells.","authors":"Eleni Zingkou, Asimina Kolianou, Georgios Angelis, Michail Lykouras, Malvina Orkoula, Georgios Pampalakis, Georgia Sotiropoulou","doi":"10.3390/biomimetics10030169","DOIUrl":"10.3390/biomimetics10030169","url":null,"abstract":"Stainless steel (SS) 316l constitutes a popular biomaterial with various applications as implants in cardiovascular and orthopedic surgery, as well as in dentistry. Nevertheless, its cytocompatibility against neuronal cells has not been investigated, a feature that is important for the construction of implants that require contact with neurons, e.g., neuronal electrodes. In addition, most cytocompatibility studies have focused on decorated or surface-modified SS 316l. On the other hand, SH-SY5Y cells are an established cellular model for cytocompatibility studies of potential biomaterials given their ability to differentiate into neuron-like cells. Here, we used retinoic-acid-differentiated SH-SY5Y cells and SH-SY5Y controls to investigate the cytocompatibility and biomimetics of uncoated SS 316l. The assessment of cytocompatibility was based on the determination of differentiation markers by immunofluorescence, RT-qPCR, and the neurite growth of these cells attached on SS 316l and standard tissue culture polystyrene (TCP) surfaces. Even though the neurite length was shorter in differentiated SH-SY5Y cells grown on SS 316l, no other significant changes were found. In conclusion, our results suggest that the uncoated SS 316l mimics a natural bio-surface and allows the adhesion, growth, and differentiation of SH-SY5Y cells. Therefore, this alloy can be directly applied in the emerging field of biomimetics, especially for the development of implants or devices that contact neurons.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0