Biomimetics最新文献

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Multi-Feature Facial Complexion Classification Algorithms Based on CNN. 基于CNN的多特征面部肤色分类算法。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-13 DOI: 10.3390/biomimetics10060402
Xiyuan Cao, Delong Zhang, Chunyang Jin, Zhidong Zhang, Chenyang Xue
{"title":"Multi-Feature Facial Complexion Classification Algorithms Based on CNN.","authors":"Xiyuan Cao, Delong Zhang, Chunyang Jin, Zhidong Zhang, Chenyang Xue","doi":"10.3390/biomimetics10060402","DOIUrl":"10.3390/biomimetics10060402","url":null,"abstract":"<p><p>Variations in facial complexion serve as a telltale sign of underlying health conditions. Precisely categorizing facial complexions poses a significant challenge due to the subtle distinctions in facial features. Three multi-feature facial complexion classification algorithms leveraging convolutional neural networks (CNNs) are proposed. They fuse, splice, or independently train the features extracted from distinct facial regions of interest (ROI), respectively. Innovative frameworks of the three algorithms can more effectively exploit facial features, improving the utilization rate of feature information and classification performance. We trained and validated the three algorithms on the dataset consisting of 721 facial images that we had collected and preprocessed. The comprehensive evaluation reveals that multi-feature fusion and splicing classification algorithms achieve accuracies of 95.98% and 93.76%, respectively. The optimal approach combining multi-feature CNN with machine learning algorithms attains a remarkable accuracy of 97.78%. Additionally, these experiments proved that the multidomain combination was crucial, and the arrangement of ROI features, including the nose, forehead, philtrum, and right and left cheek, was the optimal choice for classification. Furthermore, we employed the EfficientNet model for training on the face image as a whole, which achieves a classification accuracy of 89.37%. The difference in accuracy underscores the superiority and efficacy of multi-feature classification algorithms. The employment of multi-feature fusion algorithms in facial complexion classification holds substantial advantages, ushering in fresh research directions in the field of facial complexion classification and deep learning.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Structural Design and Optimization of a Novel Independently Driven Bionic Ornithopter. 一种新型自主驱动仿生扑翼机的结构设计与优化。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-13 DOI: 10.3390/biomimetics10060401
Mouhui Dai, Ruien Wu, Mingxuan Ye, Kai Gao, Bin Chen, Xinwang Tao, Zhijie Fan
{"title":"The Structural Design and Optimization of a Novel Independently Driven Bionic Ornithopter.","authors":"Mouhui Dai, Ruien Wu, Mingxuan Ye, Kai Gao, Bin Chen, Xinwang Tao, Zhijie Fan","doi":"10.3390/biomimetics10060401","DOIUrl":"10.3390/biomimetics10060401","url":null,"abstract":"<p><p>To address the limitations of traditional single-motor bionic ornithopters in terms of environmental adaptability and lift capacity, this study proposes a dual-motor independently driven system utilizing a cross-shaft single-gear crank mechanism to achieve adjustable flap speed and wing frequency, thereby enabling asymmetric flapping for enhanced environmental adaptability. The design integrates a two-stage reduction gear group to optimize torque transmission and an S1223 high-lift airfoil to improve aerodynamic efficiency. Multiphysics simulations combining computational fluid dynamics (CFD) and finite element analysis (FEA) demonstrate that, under flapping frequencies of 1-3.45 Hz and wind speeds of 1.2-3 m/s, the optimized model achieves 50% and 60% improvements in lift and thrust coefficients, respectively, compared to the baseline. Concurrently, peak stress in critical components (e.g., cam disks and wing rods) is reduced by 37% to 41 MPa, with significantly improved stress uniformity. These results validate the dual-motor system's capability to dynamically adapt to turbulent airflow through the precise control of wing kinematics, offering innovative solutions for applications such as aerial inspection and precision agriculture.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards Self-Assembling 3D-Printed Shapes Through Βiomimetic Μechanical Interlocking. 通过Βiomimetic Μechanical互锁实现3d打印形状的自组装。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-13 DOI: 10.3390/biomimetics10060400
Tino Marte, Savvas Koltsakidis, Thomas Profitiliotis, Emmanouil Tzimtzimis, Dimitrios Tzetzis
{"title":"Towards Self-Assembling 3D-Printed Shapes Through Βiomimetic Μechanical Interlocking.","authors":"Tino Marte, Savvas Koltsakidis, Thomas Profitiliotis, Emmanouil Tzimtzimis, Dimitrios Tzetzis","doi":"10.3390/biomimetics10060400","DOIUrl":"10.3390/biomimetics10060400","url":null,"abstract":"<p><p>While early studies on macroscopic self-assembly peaked in the late 20th century, recent research continues to explore and expand the field's potential through innovative materials and external control strategies. To harness this potential, a unit cell was designed and 3D-printed that could form a face-centered cubic lattice and stabilize it through a biomimetic mechanism for mechanical interlocking. The wing coupling structures of the brown marmorated stink bug were examined under a scanning electron microscope to be used as a source of bio-inspiration for the interlocking mechanism. A total of 20 unit cells were studied in five different self-assembly processes and in different compression scenarios. A maximum average of 34% of unit cells remained stable, and 20% were mechanically interlocked after self-assembly tests. The compression tests performed on a single unit cell revealed that the cell can withstand forces up to 1000 N without any plastic deformation. Pyramid configurations from 5-unit cells were manually assembled and assessed in compression tests. They showed an average compression force of 294 N. As the first study focused on self-assembly through mechanical interlocking, further studies that change the unit cell production and self-assembly processes are expected to improve upon these results.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain-Inspired Multisensory Learning: A Systematic Review of Neuroplasticity and Cognitive Outcomes in Adult Multicultural and Second Language Acquisition. 脑启发的多感官学习:成人多元文化和第二语言习得的神经可塑性和认知结果的系统综述。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-12 DOI: 10.3390/biomimetics10060397
Evgenia Gkintoni, Stephanos P Vassilopoulos, Georgios Nikolaou
{"title":"Brain-Inspired Multisensory Learning: A Systematic Review of Neuroplasticity and Cognitive Outcomes in Adult Multicultural and Second Language Acquisition.","authors":"Evgenia Gkintoni, Stephanos P Vassilopoulos, Georgios Nikolaou","doi":"10.3390/biomimetics10060397","DOIUrl":"10.3390/biomimetics10060397","url":null,"abstract":"<p><strong>Background: </strong>Multicultural education and second-language acquisition engaged neural networks, supporting executive function, memory, and social cognition in adulthood, represent powerful forms of brain-inspired multisensory learning. The neuroeducational framework integrates neuroscience with pedagogical practice to understand how linguistically and culturally rich environments drive neuroplasticity and cognitive adaptation in adult learners.</p><p><strong>Objective: </strong>This systematic review synthesizes findings from 80 studies examining neuroplasticity and cognitive outcomes in adults undergoing multicultural and second-language acquisition, focusing on underlying neural mechanisms and educational effectiveness.</p><p><strong>Methods: </strong>The analysis included randomized controlled trials and longitudinal studies employing diverse neuroimaging techniques (fMRI, MEG, DTI) to assess structural and functional brain network changes. Interventions varied in terms of immersion intensity (ranging from limited classroom contact to complete environmental immersion), multimodal approaches (integrating visual, auditory, and kinesthetic elements), feedback mechanisms (immediate vs. delayed, social vs. automated), and learning contexts (formal instruction, naturalistic acquisition, and technology-enhanced environments). Outcomes encompassed cognitive domains (executive function, working memory, attention) and socio-emotional processes (empathy, cultural adaptation).</p><p><strong>Results: </strong>Strong evidence demonstrates that multicultural and second-language acquisition induce specific neuroplastic adaptations, including enhanced connectivity between language and executive networks, increased cortical thickness in frontal-temporal regions, and white matter reorganization supporting processing efficiency. These neural changes are correlated with significant improvements in working memory, attentional control, and cognitive flexibility. Immersion intensity, multimodal design features, learning context, and individual differences, including age and sociocultural background, moderate the effectiveness of interventions across adult populations.</p><p><strong>Conclusions: </strong>Adult multicultural and second-language acquisition represents a biologically aligned educational approach that leverages natural neuroplastic mechanisms to enhance cognitive resilience. Findings support the design of interventions that engage integrated neural networks through rich, culturally relevant environments, with significant implications for cognitive health across the adult lifespan and for evidence-based educational practice.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silanised Fluoride Hydrotalcites as Functional and Multicomponent Fillers for Dental Composites. 氟化硅水滑石作为牙科复合材料的功能性和多组分填料。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-12 DOI: 10.3390/biomimetics10060398
Morena Nocchetti, Michela Piccinini, Antonio Scafuri, Alessandro Di Michele, Valeria Ambrogi
{"title":"Silanised Fluoride Hydrotalcites as Functional and Multicomponent Fillers for Dental Composites.","authors":"Morena Nocchetti, Michela Piccinini, Antonio Scafuri, Alessandro Di Michele, Valeria Ambrogi","doi":"10.3390/biomimetics10060398","DOIUrl":"10.3390/biomimetics10060398","url":null,"abstract":"<p><p>Acrylic resin composites with a high filler loading, consisting of a fluoride-containing hydrotalcite incorporated into silica nanoparticles, were prepared. The filler was obtained by a multi-step process. First, ZnAl hydrotalcite in fluoride form (HTlc/F) was functionalised with tetraethoxysilane to form Si-O-M bonds (M = Al or Zn) with the brucitic layers. The ethoxysilane groups exposed on the layers were used as nucleation seeds for silica nanoparticles. The composite, named SiO<sub>2</sub>@HTlc/F, was then functionalised with 3-(trimethoxysilyl)-propyl methacrylate groups and used as a filler for acrylic resins. The methacrylate groups on the surface of the inorganic composite participated in the polymerisation process of the resin by minimising the phase separation between inorganic and polymer through the formation of chemical bonds at the polymer-inorganic interface. The filler in the resin increases the degree of polymerisation, bringing it to values very close to 100%. Finally, preliminary studies on the release of fluoride anions showed that they are released slowly over time.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Three-Dimensional Stabilization Thread Design on Biomechanical Fixation and Osseointegration in Type IV Bone. 三维稳定螺纹设计对IV型骨生物力学固定和骨整合的影响。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-12 DOI: 10.3390/biomimetics10060395
Nicholas J Iglesias, Vasudev Vivekanand Nayak, Arthur Castellano, Lukasz Witek, Bruno Martins de Souza, Edmara T P Bergamo, Ricky Almada, Blaire V Slavin, Estevam A Bonfante, Paulo G Coelho
{"title":"The Effect of Three-Dimensional Stabilization Thread Design on Biomechanical Fixation and Osseointegration in Type IV Bone.","authors":"Nicholas J Iglesias, Vasudev Vivekanand Nayak, Arthur Castellano, Lukasz Witek, Bruno Martins de Souza, Edmara T P Bergamo, Ricky Almada, Blaire V Slavin, Estevam A Bonfante, Paulo G Coelho","doi":"10.3390/biomimetics10060395","DOIUrl":"10.3390/biomimetics10060395","url":null,"abstract":"<p><p>Achieving the appropriate primary stability for immediate or early loading in areas with low-density bone, such as the posterior maxilla, is challenging. A three-dimensional (3D) stabilization implant design featuring a tapered body with continuous cutting flutes along the length of the external thread form, with a combination of curved and linear geometric surfaces on the thread's crest, has the capacity to enhance early biomechanical and osseointegration outcomes compared to implants with traditional buttressed thread profiles. Commercially available implants with a buttress thread design (TP), and an experimental implant that incorporated the 3D stabilization trimmed-thread design (TP 3DS) were used in this study. Six osteotomies were surgically created in the ilium of adult sheep (N = 14). Osteotomy sites were randomized to receive either the TP or TP 3DS implant to reduce site bias. Subjects were allowed to heal for either 3 or 12 weeks (N = 7 sheep/time point), after which samples were collected en bloc (including the implants and surrounding bone) and implants were either subjected to bench-top biomechanical testing (e.g., lateral loading), histological/histomorphometric analysis, or nanoindentation testing. Both implant designs yielded high insertion torque (ITV ≥ 30 N⋅cm) and implant stability quotient (ISQ ≥ 70) values, indicative of high primary stability. Qualitative histomorphological analysis revealed that the TP 3DS group exhibited a continuous bone-implant interface along the threaded region, in contrast to the TP group at the early, 3-week, healing time point. Furthermore, TP 3DS's cutting flutes along the entire length of the implant permitted the distribution of autologous bone chips within the healing chambers. Histological evaluation at 12 weeks revealed an increase in woven bone containing a greater presence of lacunae within the healing chambers in both groups, consistent with an intramembranous-like healing pattern and absence of bone dieback. The TP 3DS macrogeometry yielded a ~66% increase in average lateral load during pushout testing at baseline (T = 0 weeks, <i>p</i> = 0.036) and significantly higher bone-to-implant contact (BIC) values at 3 weeks post-implantation (<i>p</i> = 0.006), relative to the traditional TP implant. In a low-density (Type IV) bone model, the TP 3DS implant demonstrated improved performance compared to the conventional TP, as evidenced by an increase in baseline lateral loading capacity and increased BIC during the early stages of osseointegration. These findings indicate that the modified implant configuration of the TP 3DS facilitates more favorable biomechanical integration and may promote more rapid and stable bone anchorage under compromised bone quality conditions. Therefore, such improvements could have important clinical implications for the success and longevity of dental implants placed in regions with low bone density.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Cuttlefish-Inspired Amphibious Robot with Wave-Motion Propulsion and Rigid-Flexible Coupling. 以墨鱼为灵感的波浪推进刚柔耦合水陆两栖机器人的研制。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-12 DOI: 10.3390/biomimetics10060396
Yichao Gao, Felix Pancheri, Tim C Lueth, Yilun Sun
{"title":"Development of a Cuttlefish-Inspired Amphibious Robot with Wave-Motion Propulsion and Rigid-Flexible Coupling.","authors":"Yichao Gao, Felix Pancheri, Tim C Lueth, Yilun Sun","doi":"10.3390/biomimetics10060396","DOIUrl":"10.3390/biomimetics10060396","url":null,"abstract":"<p><p>Amphibious robots require efficient locomotion strategies to enable smooth transitions between terrestrial and aquatic environments. Drawing inspiration from the undulatory movements of aquatic organisms such as cuttlefish and knifefish, this study introduces a bio-inspired propulsion system that emulates natural wave-based locomotion to improve adaptability and propulsion efficiency. A novel mechanism combining crank-rocker and sliding components is proposed to generate wave-like motions in robotic legs and fins, supporting both land crawling and aquatic paddling. By adopting a rigid-flexible coupling design, the system achieves a balance between structural integrity and motion flexibility. The effectiveness of the mechanism is systematically investigated through kinematic modeling, animation-based simulation, and experimental validation. The developed kinematic model captures the principles of wave propagation via the Crank-Slider-Rocker structure, offering insights into motion efficiency and thrust generation. Animation simulations are employed to visually validate the locomotion patterns and assess coordination across the mechanism. A functional prototype is fabricated and tested in both terrestrial and aquatic settings, demonstrating successful amphibious locomotion. The findings confirm the feasibility of the proposed design and underscore its potential in biomimetic robotics and amphibious exploration.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bio-Inspired Compliant Joints and Economic MPC Co-Design for Energy-Efficient, High-Speed Locomotion in Snake-like Robots. 仿生柔性关节和经济型MPC协同设计的高效、高速蛇形机器人。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-11 DOI: 10.3390/biomimetics10060389
Shuai Zhou, Gengbiao Chen, Mingyu Gong, Jing Liu, Peng Xu, Binshuo Liu, Nian Yin
{"title":"Bio-Inspired Compliant Joints and Economic MPC Co-Design for Energy-Efficient, High-Speed Locomotion in Snake-like Robots.","authors":"Shuai Zhou, Gengbiao Chen, Mingyu Gong, Jing Liu, Peng Xu, Binshuo Liu, Nian Yin","doi":"10.3390/biomimetics10060389","DOIUrl":"10.3390/biomimetics10060389","url":null,"abstract":"<p><p>Snake-like robots face critical challenges in energy-efficient locomotion and smooth gait transitions, limiting their real-world deployment. This study introduces a bio-inspired compliant joint design integrated with a hierarchical neural oscillator network and an energy-optimized control framework. The joint mimics biological skeletal flexibility using specialized wheeled mechanisms and adaptive parallel linkages, while the control network enables adaptive gait generation and seamless transitions through a phase-smoothing algorithm. Critically, this work adopts a synergistic design philosophy where mechanical components and control parameters are co-optimized through shared dynamic modeling. The proposed predictive control strategy optimizes locomotion speed while minimizing energy consumption. Experimental simulations demonstrate that the method achieves an 18% higher average forward speed (0.0563 m/s vs. 0.0478 m/s) with 7% lower energy use (0.1952 J vs. 0.2107 J) compared to conventional approaches. Physical prototype testing confirms these improvements under real-world conditions, showing a 12.9% speed increase (0.0531 m/s vs. 0.0470 m/s) and 7.3% energy reduction (0.2147 J vs. 0.2317 J). By unifying mechanical flexibility and adaptive control parameter tuning, this work bridges dynamic performance and energy efficiency, offering a robust solution for unstructured environments.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radionuclide-Labeled Biomaterials: A Novel Strategy for Tumor-Targeted Therapy. 放射性核素标记生物材料:肿瘤靶向治疗的新策略。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-11 DOI: 10.3390/biomimetics10060394
Shu Zhang, Aiyue Zhang, Xunhao Qi, Zongtai Han, Luqi Song, Jiayu Zhou, Guanglin Wang, Ran Zhu, Jianguo Li
{"title":"Radionuclide-Labeled Biomaterials: A Novel Strategy for Tumor-Targeted Therapy.","authors":"Shu Zhang, Aiyue Zhang, Xunhao Qi, Zongtai Han, Luqi Song, Jiayu Zhou, Guanglin Wang, Ran Zhu, Jianguo Li","doi":"10.3390/biomimetics10060394","DOIUrl":"10.3390/biomimetics10060394","url":null,"abstract":"<p><p>This paper presents a comprehensive review of recent advancements in radionuclide-labeled biomaterials for cancer therapy, with a particular focus on the characteristics, production methods, and labeling techniques of α-particle, β-particle, and Auger electron-based radiotherapy. It explores innovative strategies for targeted delivery systems and highlights the advantages of theranostics and combination therapies. The application of radionuclide-labeled biomaterials in various cancer types, including prostate cancer, breast cancer, neuroendocrine tumors, gliomas, and melanoma, is systematically summarized. Furthermore, the article critically examines current technological bottlenecks and challenges in clinical translation, while proposing future directions such as AI-assisted dose optimization and multimodal combination therapies. This review provides essential theoretical foundations and practical insights to facilitate the clinical translation of radionuclide-labeled biomaterials.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Enhanced Snow Geese Optimizer Integrating Multiple Strategies for Numerical Optimization. 一种集成多种优化策略的增强型雪雁优化器。
IF 3.4 3区 医学
Biomimetics Pub Date : 2025-06-11 DOI: 10.3390/biomimetics10060388
Baoqi Zhao, Yu Fang, Tianyi Chen
{"title":"An Enhanced Snow Geese Optimizer Integrating Multiple Strategies for Numerical Optimization.","authors":"Baoqi Zhao, Yu Fang, Tianyi Chen","doi":"10.3390/biomimetics10060388","DOIUrl":"10.3390/biomimetics10060388","url":null,"abstract":"<p><p>An enhanced snow geese algorithm (ESGA) is proposed to address the problems of the weakened population diversity and unbalanced search tendencies encountered by the snow geese algorithm (SGA) in the search process. First, an adaptive switching strategy is used to dynamically select the search strategy to balance the exploitation and exploration capabilities. Second, a dominant group guidance strategy is introduced to improve the population quality. Finally, a dominant stochastic difference search strategy is designed to enrich the population diversity and help it escape from the local optimum by co-directing effects in multiple directions. Ablation experiments were performed on the CEC2017 test set to illustrate the improvement mechanism and the degree of compatibility of their improved strategies. The proposed ESGA with a highly cited algorithm and the powerful improved algorithm are compared on the CEC2022 test suite, and the experimental results confirm that the ESGA outperforms the compared algorithms. Finally, the ability of the ESGA to solve complex problems is further highlighted by solving the robot path planning problem.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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