Korean diabetes journal最新文献_第8页

The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes 2型糖尿病患者冠状动脉钙化与血清载脂蛋白A-1的关系

Korean diabetes journal Pub Date : 2009-12-01 DOI: 10.4093/KDJ.2009.33.6.485

H. Seo, Yeon-Kyung Choi, Jae-Han Jeon, Jung Eun Lee, J. Jeong, S. Moon, In-kyu Lee, B. W. Kim, J. G. Kim

{"title":"The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes","authors":"H. Seo, Yeon-Kyung Choi, Jae-Han Jeon, Jung Eun Lee, J. Jeong, S. Moon, In-kyu Lee, B. W. Kim, J. G. Kim","doi":"10.4093/KDJ.2009.33.6.485","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.485","url":null,"abstract":"Background: The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels. Methods: We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently. Results: In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (β coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification. Conclusion: The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification. (Korean Diabetes J 33:485-493, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"41 1","pages":"485-493"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77078268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Relationship of Maximal Muscle Strength with Body Mass Index and Aerobics Capacity in Type 2 Diabetic Patients 2型糖尿病患者最大肌力与体重指数及有氧运动能力的关系

Korean diabetes journal Pub Date : 2009-12-01 DOI: 10.4093/KDJ.2009.33.6.511

H. Kwon, K. Han, Y. Ku, H. Ahn, B. Koo, K. Min

{"title":"Relationship of Maximal Muscle Strength with Body Mass Index and Aerobics Capacity in Type 2 Diabetic Patients","authors":"H. Kwon, K. Han, Y. Ku, H. Ahn, B. Koo, K. Min","doi":"10.4093/KDJ.2009.33.6.511","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.511","url":null,"abstract":"Background: Combination fitness regimens (including aerobic and resistance exercises) are effective for improving cardio-respiratory fitness, reducing visceral fat and increasing insulin sensitivity in diabetic patients. The combination exercise intensity that a patient is capable of is limited by his or her aerobic capacity and one repetition maximum (1RM). We investigated the relationships between 1RM, aerobic exercise capacity and body mass index in patients with type 2 diabetes. Methods: A total of 177 (men: 85, women: 92) diabetic subjects with HbA1c ≤ 10% were enrolled. Muscle strength and 1RM were assessed bychest press (upper body) and l eg press (lower body). We assessed aerobic capacity by VO2max and muscle mass by bioimpedance analysis. Results: There was no correlation between 1RM and VO 2max in type 2 diabetic patients (upper: P = 0.122, lower: P = 0.138 for men, and upper: P = 0.952, lower: P = 0.570 for women). However, 1RM was significantly correlated with muscle mass both in men and women (upper: r = 0.493, P < 0.001, r = 0.315, P = 0.002 lower: r = 0.437 P < 0.001, r = 0.307, P =0.003, respectively). There was also a significant correlation between 1RM and BMI. In obese male subjects with BMI ≥ 25 kg/m 2 , we observed a significant correlation between muscle mass and BMI (r = 0.374, P = 0.032), but this correlation was not observed in women. Conclusion: Clinicians treating Korean type 2 diabetic subjects should recommend resistance exercise to their patients. In particular, obese women with diabetes may receive greater benefits by increasing muscle mass through resistance exercises. (Korean Diabetes J 33:511-517, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"73 1","pages":"511-517"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86212795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33(5):401-411, 2009) 有氧运动强度对2型糖尿病患者胰岛素抵抗的影响[J] .韩国糖尿病杂志33(5):401-411,2009。

Korean diabetes journal Pub Date : 2009-12-01 DOI: 10.4093/KDJ.2009.33.6.547

Dong-Lim Kim

{"title":"Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33(5):401-411, 2009)","authors":"Dong-Lim Kim","doi":"10.4093/KDJ.2009.33.6.547","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.547","url":null,"abstract":"547 제2형 당뇨병은 유전적 요인과 함께 환경적 요인이 복합 되어 발생하는 다인성 질환이다. 생활 습관 교정은 당뇨병 발생을 지연시키고 제2형 당뇨병환자에서 혈당을 감소시킨 다고 알려져 있다. 특히 운동은 혈당 조절뿐만 아니라 에너 지 소비로 인한 체중 감소, 인슐린저항성을 개선시킨다. 그 러나 당뇨병환자의 30% 미만에서 운동을 실천하고 있고 또 한, 각 환자에서 운동의 종류, 시간, 강도, 빈도 등에 대해서 는 더 많은 연구가 필요하다 . 당뇨병환자에서 운동으로 인한 인슐린감수성 개선에는 환자의 나이, 운동의 종류 및 강도, 체중 감량 정도, 식사와 복용하는 약물 등에 영향을 받는다고 알려져 있다 . 몇몇 연구에 의하면 유산소 운동의 경우 운동의 강도에 관계없이 주 3회 이상, 매회 400 칼로리 이상 소비할 정도의 운동이 면 인슐린감수성을 호전시킨다고 발표하였다 . 다른 연구에 서는 고강도 운동이 당뇨병의 유병률을 낮추고, 심혈관질환 의 발생률을 낮추는 데에 더욱 효과가 좋다고 하였다 . 당 뇨병 관리에 운동이 권고되지만 연구마다 결과가 달라서 아 직까지 명확한 가이드라인은 부족한 실정이다. 지난 학회지에 보고된 Ku 등의 연구는 제2형 당뇨병환자 에서 운동 강도에 따른 인슐린감수성의 변화 및 염증 물질 변화, 내피세포 기능 변화를 확인하고자 하였다 . 연구 결과 제2형 당뇨병환자에서 고강도 운동이 중강도 운동에 비해 인슐린감수성은 호전 시켰으나 전신 염증 수치나 내피 세포 기능에는 큰 변화가 없었다. 또한 이런 효과는 운동하는 기 간에는 효과가 있었으나 운동 중단 후에는 효과가 장기간 지속되지는 않았다. 운동에 의한 인슐린감수성 개선 효과는 여러 인자에 의 해 좌우된다. 그 중에서도 연령이 하나의 중요한 인자인데, 인슐린감수성은 20세 이상의 건강인에서도 매년 8% 정도 감소하고, 고령에서는 더욱 더 감소하여 인슐린감수성을 호 전시키기 위해서는 고강도 운동이 필요하고 중등도 운동인 경우는 충분한 시간 운동을 해야 한다고 보고하였다 . 또 한 인슐린감수성을 호전시키기 위해서는 체중 감소 자체보 다 체지방 분포가 더 중요하다고도 알려져 있다 . 이 연구 에서 대상자의 연령이 39세에서 70세로, 여성의 경우 폐경 에 따라 체지방 분포에 변화 등이 있을 수 있어, 나이와 체 지방이 비슷한 군에서 운동 강도에 따른 차이가 있는지를 분석하였다면 결과가 달라졌을 수 있었을 것이라 기대해 본다. Ku 등의 연구에서 운동 후 복부와 피하 지방이 감소하였 음에도 불구하고 싸이토카인의 변화나 내피세포 기능의 호 전은 관찰되지 않았다. 운동에 의한 인슐린감수성 개선과 혈당 감소가 체지방 감소에서도 가능하지만 실제로 운동의 효과는 근육세포로 포도당 유입의 증가가 많은 부분을 차지 한다 . 따라서 인슐린감수성 호전이 근육량의 변화를 보정 할 경우 어떤 결과를 보이는지도 고려해야 할 것이다. 고찰에서 지적한 바와 같이 이전 연구에서 운동 후에 hs-CRP나 IL-6 같은 염증 매개성 물질의 수치가 단기간 운 동 후에는 큰 변화가 없으나 12개월 간 중강도 운동 후 감 소했다는 보고가 있다. 따라서 장기간의 운동이 인슐린저항 성에 관련된 염증 매개성 물질을 감소시키는지에 대한 추가 연구가 필요하리라 생각한다. UKPDS 10년 추적 연구나 DCCT 연구의 결과, 당뇨병 발생 초기에 얼마나 혈당 조절을 잘 하느냐가 향후 환자 심 제2형 당뇨병환자에서 유산소 운동 강도에 따른 인슐린저항성의 변화 (Korean Diabetes J 33(5):401-411, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"2017 1","pages":"547-548"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82830640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdifferentiation of Enteroendocrine K-cells into Insulin-expressing Cells 肠内分泌k细胞向胰岛素表达细胞的转分化

Korean diabetes journal Pub Date : 2009-12-01 DOI: 10.4093/KDJ.2009.33.6.475

Esder Lee, Junjie Yu, M. Lee, G. Ryu, S. Ko, Y. Ahn, S. Moon, K. Song

{"title":"Transdifferentiation of Enteroendocrine K-cells into Insulin-expressing Cells","authors":"Esder Lee, Junjie Yu, M. Lee, G. Ryu, S. Ko, Y. Ahn, S. Moon, K. Song","doi":"10.4093/KDJ.2009.33.6.475","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.475","url":null,"abstract":"Background: Despite a recent breakthough in human islet transplantation for treating type 1 diabetes mellitus, the limited availability of donor pancreases remains a major obstacle. Endocrine cells within the gut epithelium (enteroendocrine cells) and pancreatic β cells share similar pathways of differentiation during embryonic development. In particular, K-cells that secrete glucose-dependent insulinotropic polypeptide (GIP) have been shown to express many of the key proteins found in β cells. Therefore, we hypothesize that K-cells can be transdifferentiated into β cells because both cells have remarkable similarities in their embryonic development and cellular phenotypes. Methods: K-cells were purified from heterogeneous STC-1 cells originati ng from an endocrine tumor of a mouse intestine. In addition, a K-cell subclone expressing stable Nkx6.1, called “Kn4-cells,” was successfully obtained. In vitro differentiation of K-cells or Kn4-cells into β cells was completed after exendin-4 treatment and serum deprivation. The expressions of insulin mRNA and prot ein were examined by RT-PCR and immunocytochemistry. The interacellular insulin content was also measured. Results: K-cells were found to express glucokinase and GIP as assessed by RT-PCR and Western blot analysis. RT-PCR showed that K-cells also expressed Pdx-1, Neur oD1/Beta2, and MafA, but not Nkx6.1. After exendin-4 treatment and serum deprivation, insulin mRNA and insulin or C-peptide were clearly detected in Kn4-cells. The intracellular insulin content was al so increased significantly in these cells. Conclusion: K-cells are an attractive potential source of insulin-producing cells for treatment of type 1 diabetes mellitus. However, more experiments are necessary to optimize a strategy for converting K-cells into β cells. (Korean Diabetes J 33:475-484, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"56 1","pages":"475-484"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79438470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Status of Diabetes Mellitus and Effects of Related Factors on Heart Rate Variability in a Community 某社区糖尿病状况及相关因素对心率变异性的影响

Korean diabetes journal Pub Date : 2009-12-01 DOI: 10.4093/KDJ.2009.33.6.537

Kyeong-Soon Chang, Kwan Lee, Hyun-Sul Lim

引用次数: 2

Response: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33:(5)401-411, 2009) 有氧运动强度对2型糖尿病患者胰岛素抵抗的影响[J] .韩国糖尿病杂志33(5):401-411,2009。

Korean diabetes journal Pub Date : 2009-12-01 DOI: 10.4093/KDJ.2009.33.6.549

Y. Ku, B. Koo, K. Min

{"title":"Response: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33:(5)401-411, 2009)","authors":"Y. Ku, B. Koo, K. Min","doi":"10.4093/KDJ.2009.33.6.549","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.549","url":null,"abstract":"549 ‘제2형 당뇨병환자에서 유산소 운동 강도에 따른 인슐린 저항성의 변화' 연구에 귀한 질문을 주셔서 감사드립니다. 지적하신 바와 같이, 나이 특히 폐경 여부는 대사적으로 중요하며 따라서 운동의 효과에 영향을 줄 수 있었을 것입 니다. 본 연구 대상자들의 폐경 여부는 대조군 72.2% (18 명 중 13명), 중강도 운동군 64.7% (17명 중 11명), 고강도 운동군 50% (14명 중 7명)가 연구 시작 시점에서 폐경 상 태였습니다. 각 군 간 폐경 빈도에는 유의한 차이가 없었습 니다(P = 0.445). 그러나 폐경 유무로 운동의 효과를 분석 하기에는 각 군당 대상자수가 너무 적어, 본 연구와는 독립 된 추가 연구가 필요하리라 생각됩니다. 본 연구에서 고강도 운동군에서만 3개월 intervention 후 인슐린감수성이 호전되는 결과를 보였습니다. 조언해 주신 것처럼 운동의 효과가 근육량에 따라 다르게 나타날 수 있 다는점을 고려하여, 고강도 운동군에서 근육량의 변화 및 근육량을 보정한 인슐린감수성의 변화를 확인해 보았습니 다. 분석 결과, 3개월간의 고강도 유산소 운동에 의해 근육 량의 변화는 뚜렷하지 않았으며(운동 전 39.5 ± 3.6 kg, 운 동 후 39.3 ± 3.4 kg, P = 0.113), 근육량으로 보정한 경우 에도 여전히 인슐린감수성이 호전되는 결과를 보였습니다(P = 0.027). 고강도 유산소 운동에 비해 근육량을 증가시키는 효과가 우수한 것으로 알려진 저항운동을 시행하여 이번 연 구 결과와 비교한다면, 인슐린감수성 변화에 대한 근육량의 영향을 파악하는 데에 더욱 도움이 될 것으로 사료됩니다. 염증 매개성 물질에 대한 장기간의 운동 효과에 대한 지 적은 매우 중요한 부분입니다. 이에 대해서는 본 저자의 논 문에서도 언급한 바입니다 . 제2형 당뇨병환자와 같이 인슐 린저항성이 매우 높은 대상에서는 운동 및 식이에 의한 효과 가 일반 정상인에서와는 다를 것으로 생각됩니다. 비슷한 정도의 체중 감량으로 일반인에서는 adiponectin과 resistin level이 유의하게 호전된 반면, 제2형 당뇨병환자에서는 변 화가 없었습니다 . RBP-4의 경우도, 일반적으로 운동 및 식이 조절 에 의해 RBP 4 level은 감소하지만 제2형 당뇨 병환자에서는 이들 생활습관 변화에 의한 RBP4 level의 변 화가 일정치 않습니다. 당뇨병환자에서 5~7% 정도의 체 중 감량 시에는 RBP4 level에 변화가 없었으나 6,7) 20% 이 상의 체중 감량 시 4개월 후 RBP4 level이 감소하였다는 보고가 있습니다. 본 연구의 대상자는 평균 연령 54세, 평 균 유병기간 5년의 제2형 당뇨병환자들입니다. 이들처럼 인 슐린저항성이 높은 사람에서 운동 효과를 알아보기 위해서 는 일반인에서보다 장기간, 혹은 많은 양의 운동이 필요할 수 있고 이에 대한 추가 연구가 필요하리라 생각합니다. 본 연구는 thiazolidinedione 계통의 경구혈당강하제를 제 외한 모든 경구혈당강하제와 인슐린 사용 여부에 제한을 두 지 않았습니다. 단, 연구 시작 시기의 투약 내용을 저혈당이 발생한 경우를 제외하고 3개월의 연구 기간 동안 유지토록 하였습니다. 각 군에서 metformin 사용자는 대조군 22.2% (18명 중 4명), 중강도 운동군 35.3% (17명 중 6명), 고강도 운동군 0%였으며, 어떤 투약도 하지 않은 대상자는 대조군 44.4% (18명 중 8명), 중강도 운동군 47.1% (17명 중 8명), 고강도 운동군 100% (14명 중 14명)이었습니다. 투약 종류 에 각 군당 유의한 차이가 있었지만(P = 0.007) 모든 분석 은 이들 투약을 보정한 채로 진행이 되었습니다. 그럼에도 불구하고, 투약의 이질성은 본 연구의 큰 한계로 생각됩니다. 제2형 당뇨병환자에서 유산소 운동 강도에 따른 인슐린저항성의 변화 (Korean Diabetes J 33:(5)401-411, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"40 1","pages":"549-550"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82044454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications 血清生物标志物在糖尿病心血管并发症中的临床意义

Korean diabetes journal Pub Date : 2009-10-01 DOI: 10.4093/KDJ.2009.33.5.363

J. Son, H. Kwon

{"title":"Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications","authors":"J. Son, H. Kwon","doi":"10.4093/KDJ.2009.33.5.363","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.5.363","url":null,"abstract":"Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis. Diabetes is also associated with hypercoaguable states and endothelial injury. Hyperactivated platelets at injured endothelial surfaces act together due to the increased availability of thrombotic precursors and diminished fibrinolysis. Advances in the understanding of the pathogenesis of atherosclerosis associated with diabetes have yielded new hypotheses regarding the links between risk factors and the cellular and molecular alterations that underlie cardiovascular disease. Rec ently, there has been increasing interest in utilizing novel biomarkers of cardiovascular disease risk that have the potential to be useful indicators for better risk assessment, diagnosis, and prognosis. However, to d ate, most conventional and emerging biomarkers have only modest predictive values, and there remains a need to identify additional biomarkers using new biological approaches. This review highlights the clinical implications of emerging biomarkers associated with cardiovascular disease in patients with diabetes and recent developments in new technologies for the identification of biomarkers. (Korean Diabetes J 33:363-372, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"33 1","pages":"363-372"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87136513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Hypothalamic FoxO1 on Hyperphagia in Streptozotocin-Induced Diabetic Mice 下丘脑fox01在链脲佐菌素诱导的糖尿病小鼠贪食中的作用

Korean diabetes journal Pub Date : 2009-10-01 DOI: 10.4093/KDJ.2009.33.5.375

I. Nam-Goong, Jae Geun Kim, Se Jin Kim, Seong Jae Hur, J. W. Lee, E. Kim, C. H. Yun, B. Lee, Y. Kim

{"title":"The Role of Hypothalamic FoxO1 on Hyperphagia in Streptozotocin-Induced Diabetic Mice","authors":"I. Nam-Goong, Jae Geun Kim, Se Jin Kim, Seong Jae Hur, J. W. Lee, E. Kim, C. H. Yun, B. Lee, Y. Kim","doi":"10.4093/KDJ.2009.33.5.375","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.5.375","url":null,"abstract":"Background: Streptozotocin-induced diabetic animals are characterized by hyperphagia due to deficiencies of insulin and leptin. Forkhead box-containing protein of the O subfamily-1 (FoxO1) regulates energy homeostasis by regulating energy expenditure and food intake as well as mediating insulin and leptin signals in the hypothalamus. To identify the mediator of diabetic hyperphagia, we examined the effects of insulin or leptin on hypothalamic FoxO1 expression in a diabetic animal model. Methods: Diabetes was induced in mice (C57BL/6) by intraperitoneal administration of streptozotocin (200 mg/kg). Stainless steel cannula w as implanted into the lateral ventricle of the brain in each mouse. After three weeks, the mice were administered saline, insulin or leptin via intracerebroventricular (ICV) route. The medial hypothalamus was isolated to evaluate the mRNA expressions of FoxO1 and neuropeptides. Results: Streptozotocin-induced diabetic mice exhibited significant elevations of blood glucose and food intake and significantly low levels of serum insulin and leptin . The levels of hypothalamic FoxO1 mRNA were significantly increased in diabetic mice. The hypothalamic expression of neuropeptide Y (NPY) mRNA was increased, but the expression of preproopiomelanocortin (POMC) mRNA was decreased in diabetic mice. ICV administration of insulin or leptin attenuated the upregula tion of hypothalamic FoxO1 mRNA, and resulted in downregulation of NP Y mRNA and upregulation of POMC mRNA in diabetic mice. Conclusion: We observed that the expression of hypothalamic FoxO1 mRNA was increased in streptozotocin-induced diabetic mice, and that it was significantly attenuated by central administration of insulin or leptin. These results suggest that hypothalamic FoxO1 is the direct mediator of diabetic hyperphagia. (Korean Diabetes J 33:375-381, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"13 1","pages":"375-381"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84175575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiologic Characteristics of Diabetes Mellitus in Korea: Current Status of Diabetic Patients Using Korean Health Insurance Database 韩国糖尿病的流行病学特征:使用韩国健康保险数据库的糖尿病患者现状

Korean diabetes journal Pub Date : 2009-10-01 DOI: 10.4093/KDJ.2009.33.5.357

I. Park, S. Baik

引用次数: 40

Self-Reported Goals in Aged Patients with Type 2 Diabetes Mellitus 老年2型糖尿病患者的自我报告目标

Korean diabetes journal Pub Date : 2009-10-01 DOI: 10.4093/KDJ.2009.33.5.439

H. Jin, Hyun-Kyung Chung

{"title":"Self-Reported Goals in Aged Patients with Type 2 Diabetes Mellitus","authors":"H. Jin, Hyun-Kyung Chung","doi":"10.4093/KDJ.2009.33.5.439","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.5.439","url":null,"abstract":"Background: Type 2 diabetes mellitus (DM) is a growing health problem of the elderly population. Diabetes education based on effective patient-provider communication pla ys a major role in treatment of type 2 DM. In this study, as an effort for making better communication, we examined how older patients with type 2 DM report their healthcare goals, what factors influencing their goals and control their self-care behaviors. Methods: Subjects were thirty three patients with type 2 DM aged 65 and older. An interviewer conducted one-on-one interviews using open questions about 5 categories: concept of “health,” purpose of DM management, causes of DM, practical aspects of DM management, and decision making related to DM management. Interviews were audiotaped, transcribed and two investigators independently reviewed. Results: The majority of our sample (79%) expressed their management go als in a socio-functional language, rather than medical issues. They defined “Healthy” as a status of keeping daily life without any symptoms. Many subjects has not altered their diet habits (33%) and making no efforts to exercise (64%) due to physical and psychological limitations though almost all (91%) older patients recognized the importance of diet control and exercise. Conclusion: When introduce the goal of DM management, it would be better to use socio-functional terms in diabetes education of elderly patients with type 2 DM. To improve the self-care behaviors, it is essential to make efforts not only to give knowledge but also to find their physical and psychological limitations related to poor performances. (Korean Diabetes J 33:439-447, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"4 1","pages":"439-447"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83356500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5