Korean diabetes journal最新文献

{"title":"How can we measure the effects of exercise in daily life?","authors":"Sang Yong Kim","doi":"10.4093/kdj.2010.34.1.21","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.21","url":null,"abstract":"Abdominal obesity and insulin resistance are closely related to the pathogenesis of type 2 diabetes [1]. Inadequate diet, but more importantly, decreased activity are important causes of abdominal obesity. Decreased activity and its effects, seen in diabetic patients, as well as the general population, is already a global issue. Adverse effects include abdominal obesity, leading to the development of chronic disease, such as diabetes and hypertension, as well as increases in the risk of cardiovascular and cerebrovascular events [2]. The most important component in treating diabetes is lifestyle modification involving both diet and exercise management. The American Diabetes Association recommends regular exercise for the prevention and treatment of type 2 diabetes, which is also applied in numerous countries, including Korea [3]. \u0000 \u0000Aerobic exercise, known to effectively decrease visceral fat, is the recommended exercise for both obese and non-obese diabetic patients [4]. Gan et al. [5] reported that a 40-minute aerobic exercise 4 - 5 times a week, with a 55 - 70% maximal oxygen uptake, significantly reduced visceral fat and also increased cardiopulmonary function. Energy expenditure through aerobic exercise plays an important role in treating and preventing disease related to obesity and is especially important to achieve treatment goals effectively. Many studies have quantified aerobic exercise related to training. However, studies quantifying aerobic exercises in daily life are rare. Therefore, accelerometry is used as an efficient method for quantifying daily energy expenditures and serially measuring the intensity, length, and frequency of physical activity for the purpose of obtaining objective data related to an individual's exercise patterns [6]. \u0000 \u0000In this issue, Kwon et al. [7] used accelerometry in obese type 2 diabetic patients to measure aerobic exercise in daily life and study the differences seen in visceral fat load and muscle strength through aerobic exercise. In the 12-week study comparing the aerobic exercise group to the control group, body mass index and waist circumference decreased. Significant decreases in total abdominal fat, visceral fat, and subcutaneous fat were noted. Total energy expenditure and active energy expenditure showed significant increases. These results coincide with the fact that aerobic exercise is an effective method to decrease visceral fat, which, in turn, implies that aerobic exercise in obese diabetic patients can modify risk factors effectively [6]. Although exercise intensity was not correlated with a decrease in visceral fat, moderate-intensity exercise showed an association with a decrease in total abdominal fat and subcutaneous fat, supporting the previous finding that moderate-intensity exercise is the most beneficial for burning fat in chronic diseases [8]. As the author stated, the patients were randomly assigned to each group, and the total energy expenditure showed no significant difference","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"21-2"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of glucose control in people with type 2 diabetes: a review and consensus.","authors":"Jeong-Taek Woo,&nbsp;Kyung Soo Park,&nbsp;Dong-Won Byun,&nbsp;Kyung Soo Ko,&nbsp;Yoon-Sok Chung,&nbsp;Doo Man Kim,&nbsp;Tae Sun Park,&nbsp;Bong Soo Cha,&nbsp;In Kyu Lee,&nbsp;Joong Yeol Park,&nbsp;Hyun Shik Son,&nbsp;Moon-Kyu Lee,&nbsp;Kwang Won Kim,&nbsp;Ho Young Son","doi":"10.4093/kdj.2010.34.1.16","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.16","url":null,"abstract":"<p><p>A conference was convened by the Korean Diabetes Association and the Korean Endocrine Society on September 7, 2009 to discuss and organize the results of research on intensive glucose control for the prevention of cardiovascular disease in patients with type 2 diabetes. Professor Kyung Soo Park led the conference, and Professors Kwang Won Kim and Ho Young Son acted as chairmen. Professors Doo Man Kim, Tae Sun Park, and Bong Soo Cha reported on intensive glucose control and diabetic complications, including the UK Prospective Diabetes Study (UKPDS), Diabetes Control and Complication Trial (DCCT) research results, the recently published Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), and Veterans Affairs Diabetes Trial (VADT) research, as well as meta-analyses. Professor Jeong-Taek Woo reported on the manuscript written by the committee for the Korean Diabetes Association which dealt with the treatment of diabetes mellitus. Professors Kyung Soo Ko, Joong Yeol Park, Hyun Shik Son, Moon-Kyu Lee, Dong-Won Byun, and Yoon-Sok Chung participated in the discussion and collected information for the manuscript from all of the participants. The aim of the debate was to determine how to establish target goals for intensive glucose control and how to individualize those goals. The participants concluded that there was no need to modify the recommendation of maintaining an HbA1c under 6.5%, the current blood glucose treatment goal that is recommended by the Korean Diabetes Association. In addition, individual target goals for glucose control were recommended depending on the situation of each patient. We report on the consensus statement from the meeting.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cutoff Value of HbA1c in Predicting Diabetes in Korean Adults in a University Hospital in Seoul","authors":"J. Bae, E. Rhee, Eun-Suk Choi, Ji Hoon Kim, W. Kim, Seung-Hyun Yoo, Se Eun Park, Cheol-Young Park, Won-Young Lee, K. Oh, S. Park, Sun-Woo Kim","doi":"10.4093/KDJ.2009.33.6.503","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.503","url":null,"abstract":"Background: Glycated hemoglobin (HbA1c) levels represent a 2~3 month average of blood glucose concentration. The use of HbA1c as a diagnostic tool for diabetes is gaining interest. Therefore, we determined the cutoff point of HbA1c for predicting abnormal glucose tolerance status in non-diabetic Korean subjects. Methods: We analyzed the data from 1,482 subjects without diabetes mellitus in whom a 75-g oral glucose tolerance test (OGTT) was performed due to suspected abnormal glucose tolerance. We obtained an HbA1c cutoff point for predicting diabetes using Receiver Operating Characteristic (ROC) curve analysis. Results: A cut-off point of 5.95% HbA1c yielded sensitivity of 60.8% and specificity of 85.6%, respectively, for predicting diabetes. There was a difference in HbA1c cut-off value between men and women, 5.85% and 6.05%, respectively. Conclusion: To use the cut-off point of 5.95% HbA1c for predicting undiagnosed diabetes in Koreans may be reliable. However, studies of different ethnic groups have reported disparate HbA1c cut-off points. Thus, ethnicity, age, gender, and population prevalence of diabetes are important factors to consider in using elevated HbA1c value as a tool to diagnose diabetes.","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"5 1","pages":"503-510"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82562204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Diabetes Education Program on Glycemic Control and Self Management for Patients with Type 2 Diabetes Mellitus","authors":"Ji-Hyun Kim, S. Chang","doi":"10.4093/KDJ.2009.33.6.518","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.518","url":null,"abstract":"Background: Diabetes mellitus is a chronic disease requiring continuous treatment and vigorous self-management. Reinforcement of effective self management and diabetes educati on are important factors in successful treatment. The aim of this study was to evaluate the effectiveness of the current diabetes education program on blood glucose control, self-management, and self-efficacy of patients with type 2 diabetes mellitus. Methods: A total of 592 patients with newly diagnosed or uncontrolled type 2 diabetes mellitus were recruited to the diabetes education program from January to December 2007. We surveyed 338 patients from April to July 2008. A total of 117 patients had biochemical examinations and completed a questionnaire about knowledge, self-management and self-efficacy of diabetes treatment (no education group (n = 23), education group (n = 94)). Results: The total scores from the questionnaires and the results of laboratory data showed no differences between the two groups. However, there were significant reductions in hemoglobin A1c level in the education group, as compared with the no education group (P = 0.039). Although the score for knowledge about diabetes mellitus was significantly higher in the educati on group (P = 0.005), greater knowledge was not reflected in the self-management or self-efficacy of the pa tients. Conclusion: The current diabetes education program had no effect on the self-management or self-efficacy of patients with diabetes, although did show some degree of association with blood glucose control and diabetes knowledge level. We conclude that a more effective diabetes education program needs to be developed and applied to daily practice for the improvement ofself-efficacy in patients with diabetes mellitus. (Korean Diabetes J 33:518-525, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"15 1","pages":"518-525"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83764997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulation of Glucagon Like Peptide-1 Secretion in Enteroendocrine L cells","authors":"Byung-Joon Kim","doi":"10.4093/KDJ.2009.33.6.458","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.458","url":null,"abstract":"GLP-1 (glucagon like peptide-1) is new anti-diabetic drug with a number of beneficial effects. It stimulates glucose dependant insulin secretion and restoration of beta cell mass through enhancement of islet mass. However, it is easily inactivated after being secreted from enteroendocrine L cells. Recent trial to increased GLP-1 is to directly stimulate L cells through its receptor located in the surface of L cell. Taste receptor in the apical surface of L cell is activated by various tastants contained in the food. Tongue perceives taste sense through the heterotrimeric G-protein (-gustducin) and its downstream signaling cascades. Same taste receptors are also expressed in enteroendocrine cells. In duodenal L cell, -gustducin was detected by immunofluorescence stainig at the luminal projections of enteroendocrine cells. And several other taste signaling elements were also found in L cells. Ingestion of sweet or bitter compounds revealed stimulation of GLP-1 secretion and the regulation of plasma insulin and glucose. In this review, I will briefly introduce the possibilities to stimulate GLP-1 secretion though the membrane receptor in enteroendocrine cell. And it will be the good candidate to develop the treatment modality for obesity, diabetes and abnormal gut motility.","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"126 1","pages":"458-463"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87813502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy in Diabetes","authors":"H. Jung, Myung-Shik Lee","doi":"10.4093/KDJ.2009.33.6.453","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.453","url":null,"abstract":"Diabetes mellitus is characterized by decreased insulin secreti on and action. Decreased insulin secretion results from a reduction in mass and/or function of pancreatic β-cells. Apoptosis, oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress responses have been suggested as mechanisms for the changes in β -cells in type 2 diabetes; however, the underlying causes have not been clearly elucidated. Autophagy is an intracellular process that maintains cellular homeostasis through degradation and recycling of organelles. Recently, we reported reduction of β-cell mass in autophagy-deficient mice. Pancreatic insulin content was also decreased due to the decreased β-cell mass and the reduced number of insulin granules. Morphological analysis of these β-cells revealed an accumulation of ubiquitinated proteins, swollen mitochondria, and distended ER. Insulin secretory function ex vivo was also impaired. As a result, autophagy-deficient mice showed hypoinsulinemia and hyperglycemia. These results suggested that autophagy is necessary to maintain the structure, mass and function of β-cells. In addition, as autophagy may play a protective role against ER stress and rejuvenate organelle function, impaired autophagy may lead to mitochondrial dysfunction and ER stress, which have been implicated as causes of insulin resistance. Therefore, in addition to β-cell homeostasis, dysregulated autophagy may possibly be involved in insulin resistance. (Korean Diabetes J 33:453-457, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"5 1","pages":"453-457"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87925464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Type 1 Diabetes through Genetically Engineered K-cell Transplantation in a Mouse Model","authors":"Juyeon Sim, J. Kim, Y. Ahn, K. Song, J. Han, B. Cha, Sook-Kyung Lee, S. Moon","doi":"10.4093/KDJ.2009.33.6.466","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.466","url":null,"abstract":"Background: K-cells function as targets for insulin gene therapy. In a previous study, we constructed EBV-based plasmids expressing rat preproinsulin controlled by glucose-dependent insulinotropic polypeptide promoters. In the present study, we attempted to correct hyperglycemia in vivo using genetically engineered K-cells in a mouse model of type 1 diabetes. Methods: K-cells expressing insulin were transplanted under the kidney capsules of STZ-induced diabetic mice. The blood glucose levels and body weights of the experime ntal animals were measured daily. After four weeks, the mice were injected intra-peritoneally with 2 g/ kg glucose following a 6 hr fast. Blood glucose levels were measured immediately following glucose injections. All animals were sacrificed at the end of the glucose tolerance study, and pancreas and graft-bearing kidney tissue samples were stained with antibodies against insulin, glucagon, and C-peptide. Results: The body weights of K-cell-transplanted diabetic mice increased after transplantation, whereas those of untreated diabetic control mice continued to decline. The blood glucose levels of K-cell-transplanted diabetic mice decreased gradually during the two weeks following transplantation. After intra-peritoneal injection of glucose into K-cell-transplanted diabetic mice, blood glucose levels increased at 30 minutes, and were restored to the normal range between 60 and 90 minutes, while untreated control diabetic mice continued to experience hyperglycemia. Kidney capsules containi ng transplanted K-cells were removed, and sections were stained with anti-insulin antibodies. We detected insulin-positive cells in the kidney capsules of K-cell-transplanted diabetic mice, but not in untreated control mice. Conclusion: We detected glucose-dependent insulin secretion in genetically engineered K-cells in a mouse model of type 1 diabetes. Our results suggest that genetically modified insulin producing K-cells may act as surrogate β-cells to effectively treat type 1 diabetes. (Korean Diabetes J 33:466-474, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"7 1","pages":"466-474"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88809821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Adding ω-3 Fatty Acids to Simvastatin on Lipids, Lipoprotein Size and Subspecies in Type 2 Diabetes Mellitus with Hypertriglyceridemia","authors":"W. Kim, Chang Beom Lee, Cheol-Young Park, Se Eun Park, E. Rhee, Won-Young Lee, K. Oh, S. Park, D. Kim, H. Kim, S. Han, Hong Keum Cho","doi":"10.4093/KDJ.2009.33.6.494","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.494","url":null,"abstract":"Background: ω -3 fatty acids are known to improve lipid profiles, the distribution of lipoprotein subclasses, and secondary prevention against post-myocardial infarction. Rare reports have emerged of synergistic results of ω -3 fatty acids with simvastatin in cases of type 2 diabetes mellitus with hypertriglyceridemia. The purpose of this study was to determine the combined relationship of ω-3 fatty acids plus simvastatin on lipid, lipoprotein size and the types of subspecies. Methods: This randomized, multi-center, comparison study evaluated eight weeks of combination therapy (ω -3 fatty acids (Omacor) 4 g/day plus simvastatin 20 mg/day) or monotherapy (simvastatin 20 mg/day) for at least six weeks in 62 diabetic patients. Subjects with a triglyceride concentration of more than 200 mg/dL were eligible for inclusion. Results: No significant differences for ω-3 fatty acids + simvastatin versus simvastatin alone were observed for triglycerides (-22.7% vs. -14.3%, P = 0.292), HDL peak particle size (+2.8% vs. -0.4%, P = 0.076), LDL mean particle size (+0.4% vs -0.1%, P = 0.376) or LDL subspecies types, although the combination therapy showed a tendency toward lower triglycerides, larger HDL, and LDL particle sizes than did the monotherapy. There were no significant differences between the two groups in regard to HDL-C, LDL-C, or HbA1c levels. There were no serious adverse events and no abnormalities in the laboratory values associated with this study.","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"6 1","pages":"494-502"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84036850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes","authors":"K. Oh","doi":"10.4093/KDJ.2009.33.6.464","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.464","url":null,"abstract":"464 관상동맥질환을 포함한 심혈관계 질환은 제2형 당뇨병의 매우 흔한 합병증이며 주된 사망원인이고, 제2형 당뇨병에 서는 관상동맥질환이 2~5배 높게 발생한다. 현재 제2형 당 뇨병은 관상동맥질환과 위험도가 동등한 것으로 간주되고 있으며, 생활습관 및 체중 교정, 고혈당, 고혈압, 이상지질혈 증의 조절을 통하여 심혈관계 질환의 위험을 감소시키도록 권고되고 있다. 관상동맥칼슘은 전산화 단층촬영으로 측정 하는 죽상경화증의 확립된 지표로, 관상동맥칼슘점수(coronary artery calcium score)는 관상동맥질환의 발병 위험과 사망 률을 예측할 수 있으며, 관상동맥칼슘점수의 예측력은 표준 심혈관계 질환 위험인자보다 높게 보고된다 . 관상동맥칼슘 은 Agatston 등에 의해 고안된 점수체계 를 최근에는 광범 위하게 사용하고 있으며, Agatston 점수는 많은 수의 남성 과 여성의 관상동맥 조직검체상의 죽상경화증과 강력한 연 관성이 확인되었다 . 관상동맥칼슘점수와 표준 심혈관계 질 환 위험인자는 연관됨이 잘 알려져 있으며, 심혈관계 질환 위험인자의 수가 많아질수록 관상동맥칼슘점수도 증가한다. 당뇨병은 질환 자체가 높은 관상동맥칼슘점수와 연관되어 있으며, 제2형 당뇨병에서 전통적인 심혈관계 질환의 위험 인자인 연령, 남성 성별, 비만, 고혈압 등은 관상동맥칼슘점 수와 연관된다 . 제2형 당뇨병에서 고감도 C 반응성 단백질, 호모시스테 인, 아포지방단백 A-1과 B 등 새로운 심혈관계 질환 위험인 자들과 관상동맥칼슘점수와의 관련성에 대한 조사는 최근까 지 많지 않은 상황이다. 본 학회지에 게재된 Seo 등의 연구 에 의하면 254명의 한국인 제2형 당뇨병 남성과 여성에서 관상동맥칼슘점수가 새로운 심혈관계 질환의 위험인자 중 하나인 혈중 아포지방단백 A-1 농도와 역상관관계가 있었 으며, 혈중 아포지방단백 A-1 농도는 관상동맥칼슘점수의 독립적인 예측인자로 관찰되었다 . 그러나 상기 연구에서는 관상동맥칼슘점수가 다른 새로운 심혈관계 질환 위험인자들 인 아포지방단백 B 및 고감도 C 반응성 단백질과는 유의한 상관관계가 관찰되지 않았으며, 고밀도 지단백, 저밀도 지단 백, 총 콜레스테롤과 중성지방 등의 지질과 당대사 지표들 과의 관련성도 관찰되지 않았다. Mazzone 등의 연구 에서 는 제2형 당뇨병에서 관상동맥칼슘점수는 전통적인 심혈관 계 질환 위험인자들과 관련되었으나, Seo 등의 연구와 다르 게 새로운 심혈관계 질환의 위험인자인 아포지방단백 A-1 과는 유의한 상관관계가 없었으며 아포지방단백 B와 유의 한 연관성이 관찰되었고 중성지방과도 관련되었다. 또 다른 제2형 당뇨병에서의 연구인 Godsland 등의 Prospective Evaluation of Diabetic Ischaemic Heart Disease by Coronary Tomography (PREDICT) 연구 에서는 관상동맥칼슘점수는 전통적인 심혈관계 질환의 위험인자들과 관련되었으나, 새 로운 심혈관계 질환의 위험인자 중에서는 아포지방단백 A-1과 B는 유의한 상관관계가 관찰되지 않았으며, 고감도 C 반응성 단백질과 호모시스테인은 매우 약한 연관성만 관 찰되었다. 제2형 당뇨병에서는 전통적인 심혈관계 질환의 위험인자는 일반적으로 관상동맥칼슘점수와 연관성이 유지 된 반면에, 새로운 심혈관계 질환의 위험인자들은 관상동맥 칼슘점수와 관련성이 매우 약하게 관찰되며, 조사된 종족에 따라 그 결과가 상이하게 관찰되었다. Seo 등의 연구는 한국인 제2형 당뇨병을 연구대상으로 관 상동맥칼슘점수와 새로운 심혈관계 질환 위험인자 중의 하나 인 아포지방단백 A-1과의 연관됨을 최초로 보고한 연구로, 한국인 제2형 당뇨병에서 아포지방단백 A-1이 관상동맥석회 화의 위험도를 예측하는 표지자로의 유용성을 제시하였다 . 하지만 Seo 등의 연구는 소규모의 단면연구로 관상동맥칼 슘점수와 아포지방단백 A-1과의 인과 관계를 설명할 수 없 으며, 제2형 당뇨병환자에서 고혈당, 고혈압, 이상지질혈증 제2형 당뇨병환자에서 관상동맥 석회화와 혈중 아포지방단백 A-1과의 관련성","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"124 1","pages":"464-465"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88359687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Low-Calorie Diets on Abdominal Visceral Fat, Muscle Mass, and Dietary Quality in Obese Type 2 Diabetic Subjects","authors":"H. Ahn, Youn-Ok Cho, H. Kwon, Y. Ku, B. Koo, K. Han, K. Min","doi":"10.4093/KDJ.2009.33.6.526","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.6.526","url":null,"abstract":"Background: Weight loss through low-calorie diets (LCDs) decreases visceral fat (VF). However, the effects on muscle mass, changes of dietary quality, and insulin sensiti vity are unknown for Korean obese type 2 diabetic subjects. Therefore, this study examined such effects of LCDs. Methods: A total of 30 obese type 2 diabetic subjects (body mass index, 27.0 ± 2.2 kg/m 2 ) were randomly assigned to an LCD or control group. Subjects on LCDs took 500~1,000 kcal fewer energy than their usual dietary intake (1,000~1,500 kcal/day) over the course of 12 weeks. The abdominal VF and femoral muscle mass were evaluated by computed tomography, and insulin sensitivity was assessed using an insulin tolerance test (Kitt; rate constant for plasma glucose disappea rance, %/min). Dietary nutrient intake consumed by subjects was assessed by 3-day food records. Results: The percent VF reduction was -23.4 ± 17.2% in the LCD group and -9.8 ± 11.8% in the control group after 12 weeks (P < 0.001, P = 0.002). However, significant decrease in femoral mass or proportional change of marcronutrient intake and mean adequacy ratio were not found in the LCD group, as compared to the control group. Insulin sensitivity improved in the LCD group, as compared to the control group (P = 0.040). Conclusion: LCD effectively improved insulin sensitivity and reduced abdominal VF without reduction of femoral muscle and dietary quality in obese type 2 diabetic subjects. (Korean Diabetes J 33:526-536, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"39 1","pages":"526-536"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75566466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}