Korean diabetes journal最新文献

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Development and validation of a semi-quantitative food frequency questionnaire to assess diets of korean type 2 diabetic patients. 半定量食物频率问卷的开发和验证,以评估韩国2型糖尿病患者的饮食。
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.32
Seongbin Hong, Yunjin Choi, Hun-Jae Lee, So Hun Kim, Younju Oe, Seung Youn Lee, Moonsuk Nam, Yong Seong Kim
{"title":"Development and validation of a semi-quantitative food frequency questionnaire to assess diets of korean type 2 diabetic patients.","authors":"Seongbin Hong,&nbsp;Yunjin Choi,&nbsp;Hun-Jae Lee,&nbsp;So Hun Kim,&nbsp;Younju Oe,&nbsp;Seung Youn Lee,&nbsp;Moonsuk Nam,&nbsp;Yong Seong Kim","doi":"10.4093/kdj.2010.34.1.32","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.32","url":null,"abstract":"<p><strong>Background: </strong>Our aim was to assess the validity of a semi-quantitative food frequency questionnaire (FFQ) by comparison with the 3-day diet record (DR) in patients with type 2 diabetes.</p><p><strong>Methods: </strong>Eighty five type 2 diabetic patients (aged 33 to 70 years) from the Korean National Diabetes Program (KNDP) completed 3-day DR and FFQ. The FFQ was designed to reflect the eating pattern of Korean type 2 diabetic patients, and was based on the 2003 Korean National Health and Nutrition Examination Survey. The FFQ consists of 85 food items and 12 food groups. The validity of FFQ was assessed by comparison with the 3-day DR.</p><p><strong>Results: </strong>The mean age was 49 +/- 10 years. Clinical characteristic including body weight, diabetic duration, and HbA1c were not different from the total cohort subjects (n = 1,478). There were no significant differences in the mean intake of protein, fat and calcium estimated by the FFQ and the 3-day DR. Energy and carbohydrate estimated by the FFQ were higher than those estimated by the 3-day DR. The correlation coefficient was highest for energy (r = 0.740; P < 0.00) and lowest for iron (r = 0.269; P < 0.05). The Kappa values for energy, carbohydrate, protein, fat and calcium were 0.54, 0.37, 0.36, 0.46, and 0.19, respectively.</p><p><strong>Conclusion: </strong>The FFQ is a reasonable instrument for assessing the intake of most macronutrients in Korean type 2 diabetes, although careful consideration is required for the food groups and nutrients for which the FFQ had low validity.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"32-9"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Factors that Affect Medication Adherence in Elderly Patients with Diabetes Mellitus. 影响老年糖尿病患者药物依从性的因素
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.55
Kyung-Ae Park, Jung-Guk Kim, Bo-Wan Kim, Sin Kam, Keon-Yeop Kim, Sung-Woo Ha, Sung-Taek Hyun
{"title":"Factors that Affect Medication Adherence in Elderly Patients with Diabetes Mellitus.","authors":"Kyung-Ae Park,&nbsp;Jung-Guk Kim,&nbsp;Bo-Wan Kim,&nbsp;Sin Kam,&nbsp;Keon-Yeop Kim,&nbsp;Sung-Woo Ha,&nbsp;Sung-Taek Hyun","doi":"10.4093/kdj.2010.34.1.55","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.55","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted to evaluate the factors affecting medication adherence in geriatric diabetic patients treated at private clinics and tertiary hospitals. We compared the factors affecting medication adherence between these two patient groups.</p><p><strong>Methods: </strong>We included 108 diabetic patients older than 65 years treated at one tertiary hospital and 157 patients older than 65 years treated at two private clinics. We conducted an interview survey based on the Health Belief Model, and used a questionnaire that included the self-efficacy variable. For the medication adherence, Morisky's self-report was used.</p><p><strong>Results: </strong>The medication adherence based on Morisky's self-report was significantly higher in tertiary hospital patients (61.1%) compared to private clinic patients (43.2%) (P < 0.01). The results showed that drug storage and self-efficacy were factors affecting adherence to medication in tertiary hospital patients (P < 0.05). The adherence was high in cases of proper drug storage (odds ratio [OR], 5.401) and in cases with high self-efficacy (OR, 13.114). In private clinic patients, financial level (P < 0.05), recognition of the seriousness of diabetes complications (P < 0.05) and self-efficacy (P < 0.01) were associated with medication adherence. The medication adherence was significantly lower in patients whose financial state were moderate than those with lower (OR, 0.410), and medication adherence was significantly higher in patients who had higher perceived severity (OR, 2.936) and in patients with higher self-efficacy (OR, 4.040).</p><p><strong>Conclusion: </strong>Different strategies should be used to increase medication adherence in geriatric diabetic patients, depending on institutions whether they are treated.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"55-65"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.55","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29039078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 62
The Incretins and Pancreatic beta-Cells: Use of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide to Cure Type 2 Diabetes Mellitus. 肠促胰岛素和胰腺细胞:胰高血糖素样肽-1和葡萄糖依赖性胰岛素多肽治疗2型糖尿病
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.2
Mi-Hyun Kim, Moon-Kyu Lee
{"title":"The Incretins and Pancreatic beta-Cells: Use of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide to Cure Type 2 Diabetes Mellitus.","authors":"Mi-Hyun Kim,&nbsp;Moon-Kyu Lee","doi":"10.4093/kdj.2010.34.1.2","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.2","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide. The complications associated with T2DM result in increased mortality and financial cost for those affected. T2DM has long been known to be associated with insulin resistance in peripheral tissues and a relative degree of insulin deficiency. However, the concept that insulin secretion and insulin sensitivity are not linked through a hyperbolic relationship in T2DM has continuously been demonstrated in many clinical trials. Thus, in order to prevent and treat T2DM, it is necessary to identify the substance(s) that will improve the function and survival of the pancreatic beta-cells in both normal and pathologic conditions, so that production and secretion of insulin can be enhanced. Incretin hormones, such as glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP), have been shown to lower the postprandial and fasting glucose and the glycated hemoglobin levels, suppress the elevated glucagon level, and stimulate glucose-dependent insulin synthesis and secretion. In this report, we will review the biological actions and mechanisms associated with the actions of incretin hormones, GLP-1 and GIP, on beta-cell health and compare the differences between GLP-1 and GIP.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"2-9"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Risk Factors Associated with Left Ventricular Diastolic Dysfunction in Type 2 Diabetic Patients without Hypertension. 无高血压的2型糖尿病患者左室舒张功能不全的相关危险因素
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.40
Jung Hyun Noh, Joon Hyung Doh, Sung Yun Lee, Tae Nyun Kim, Hyuk Lee, Hwa Young Song, Jeong Hyun Park, Kyung Soo Ko, Byoung Doo Rhee, Dong Jun Kim
{"title":"Risk Factors Associated with Left Ventricular Diastolic Dysfunction in Type 2 Diabetic Patients without Hypertension.","authors":"Jung Hyun Noh,&nbsp;Joon Hyung Doh,&nbsp;Sung Yun Lee,&nbsp;Tae Nyun Kim,&nbsp;Hyuk Lee,&nbsp;Hwa Young Song,&nbsp;Jeong Hyun Park,&nbsp;Kyung Soo Ko,&nbsp;Byoung Doo Rhee,&nbsp;Dong Jun Kim","doi":"10.4093/kdj.2010.34.1.40","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.40","url":null,"abstract":"<p><strong>Background: </strong>Hypertension and age are recognized as important risk factors for left ventricular (LV) diastolic dysfunction. Some studies have shown that diabetes itself may also be an independent risk factor for LV diastolic dysfunction, although this is controversial. The aim of this study was to determine the factors associated with LV diastolic dysfunction in patients with type 2 diabetes in the absence of hypertension or ischemic heart disease (IHD).</p><p><strong>Methods: </strong>Participants in this study consisted of 65 type 2 diabetes patients (M : F = 45 : 20; mean age 51 [26 to 76] years; mean body mass index [BMI] 25.0 +/- 2.5 kg/m(2)) without hypertension, heart disease, or renal disease. Individuals with ischemic electrocardiographic changes were excluded. LV diastolic function was evaluated by Doppler echocardiographic studies.</p><p><strong>Results: </strong>Fifteen patients (23.1%) showed LV diastolic dysfunction on Doppler echocardiographic studies. Patients with LV diastolic dysfunction were older than those without diastolic dysfunction (60.0 +/- 2.5 vs. 50.5 +/- 1.9 years; P < 0.01). After adjusting for age and sex, BMI was higher (26.6 +/- 0.7 vs. 24.6 +/- 0.3 kg/m(2); P < 0.01) and diabetes duration was longer (9.65 +/- 1.48 vs. 4.71 +/- 0.78 years; P < 0.01) in patients with LV diastolic dysfunction than in those without diastolic dysfunction. There were no differences in sex, smoking, blood pressure, lipid profiles, hemoglobin A(1)C, fasting glucose, fasting insulin, or diabetic microvascular complications between the LV diastolic dysfunction group and the normal diastolic function group. After adjusting for age, sex, and BMI, diabetes duration was found to be independently associated with LV diastolic dysfunction (odds ratio 1.38; confidence interval 1.12 to 1.72; P = 0.003).</p><p><strong>Conclusion: </strong>These results suggest that diabetes duration may be a risk factor for LV diastolic dysfunction in type 2 diabetic patients without hypertension or IHD.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"40-6"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.40","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Letter: the effects of low-calorie diets on abdominal visceral fat, muscle mass, and dietary quality in obese type 2 diabetic subjects (korean diabetes j 2009;33:526-36). 信:低热量饮食对肥胖 2 型糖尿病患者腹部内脏脂肪、肌肉质量和饮食质量的影响(Korean diabetes j 2009; 33:526-36)。
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.66
Won-Young Lee
{"title":"Letter: the effects of low-calorie diets on abdominal visceral fat, muscle mass, and dietary quality in obese type 2 diabetic subjects (korean diabetes j 2009;33:526-36).","authors":"Won-Young Lee","doi":"10.4093/kdj.2010.34.1.66","DOIUrl":"10.4093/kdj.2010.34.1.66","url":null,"abstract":"","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"66-7"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/ec/kdj-34-66.PMC2879908.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29039079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response: the effects of low-calorie diets on abdominal visceral fat, muscle mass, and dietary quality in obese type 2 diabetic subjects (korean diabetes j 2009;33:526-36). 低热量饮食对肥胖2型糖尿病患者腹部内脏脂肪、肌肉质量和饮食质量的影响(韩国糖尿病杂志2009;33:526-36)。
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.68
Hee-Jung Ahn, Kyung-Wan Min
{"title":"Response: the effects of low-calorie diets on abdominal visceral fat, muscle mass, and dietary quality in obese type 2 diabetic subjects (korean diabetes j 2009;33:526-36).","authors":"Hee-Jung Ahn,&nbsp;Kyung-Wan Min","doi":"10.4093/kdj.2010.34.1.68","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.68","url":null,"abstract":"We would like to express our appreciation to Dr. Lee for his letter and his interest in our manuscript, \"The effects of low-calorie diets on abdominal visceral fat, muscle mass, and dietary quality in obese type 2 diabetic subjects.\" Our responses to Dr. Lee's comments follow. \u0000 \u0000As Dr. Lee noted, our study has some limitations, including a relatively small sample size that included only female patients. However, we wish to emphasize the controlled nature of this trial. In order to evaluate the clinical impacts of low calorie diets, all participating subjects were selected in a controlled manner so that the data could be adjusted for total energy expenditure and physical activity. A specifically female patient group was selected, because the reduction of visceral fat by low calorie diets is typically less in women than in men [1]. \u0000 \u0000Although a healthy diet is a cornerstone to the reduction of overweight, long term body weight reduction and weight maintenance by simple reductions of dietary energy intake reduction were difficult to maintain. Previous research has shown that only about 20% of overweight individuals are successful at long-term weight loss when weight loss is defined as losing at least 10% of the starting body weight and maintaining the loss for at least one year [2]. Therefore, new strategies need to be developed to improve the achievement of this goal. The National Weight Control Registry (NWCR) provides information about the strategies used by successful weight loss maintainers to achieve and maintain long-term weight loss; these include high levels of physical activity, eating a low-calorie, low-fat diet, eating breakfast regularly, self-monitoring weight, and maintaining a consistent eating pattern across weekdays and weekends [3]. We cannot answer Dr. Lee's question about effective weight loss and the rate at which successful weight loss is maintained, nor the most successful weight reduction strategy in Korean diabetic patients, as there have been no clinical studies or follow-up studies of weight reduction in Korean diabetic patients. However, Song et al. reported that the body mass indexes of diabetic patients who undertook a Structured Diabetes Education Program (SDEP) were similar to those of a conventional education group over four years of follow-up [4]. There is a clear need for Korean diabetic patients to implement more aggressive strategies for successful weight reduction. Additional clinical studies based on this strategy will be necessary to answer Dr. Lee's question. \u0000 \u0000As other reviewers note, recent data show that about 70% of Korean type 2 diabetes patients are overweight or obese. As there are few clinical dietary intervention studies on weight reduction in obese Korean type 2 diabetes patients [5,6], we look forward to additional clinical intervention studies and increasing the numbers of systemic studies of these issues in Korea through the implementation of our new guidelines. More studies are necessary to ","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"68-9"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.68","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29039080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The epidemiology of diabetes in Korea: from the economics to genetics. 韩国糖尿病的流行病学:从经济学到遗传学。
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.10
Nam H Cho
{"title":"The epidemiology of diabetes in Korea: from the economics to genetics.","authors":"Nam H Cho","doi":"10.4093/kdj.2010.34.1.10","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.10","url":null,"abstract":"<p><p>To determine the factors responsible for the dramatic increase in the prevalence of diabetes in Korea. A computerized literature survey was conducted to evaluate the risk factors for Type 2 diabetes mellitus (T2DM) in Korea, including genome-wide association studies. National Statistics gross national income data was integrated with the reported prevalence of diabetes to evaluate the relationship between diabetes and the economic growth. The strength of the association was evaluated using measures of effect size, such as odds ratio and relative risks. The putative risk factors identified in Korean studies are very similar to the risk factors identified from the other countries, including genetic background. Genome-wide association studies reported relative risks of 1.5 or less, indicating that no single gene is associated with the risk of T2DM. The scientific evidence suggests that the dramatic increase in the incidence and prevalence of T2DM in Korea is related to the economic development of Korea, which has a direct influence on health policy, as well as an individual's health behaviors. We expect to observe the current diabetes incidence rates until the key risk factors are present for long enough in our society, at which point we would expect to start observing a more gradual increase in both the incidence and prevalence of T2DM in Korea.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"10-5"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Effects of aerobic exercise on abdominal fat, thigh muscle mass and muscle strength in type 2 diabetic subject. 有氧运动对2型糖尿病患者腹部脂肪、大腿肌肉质量和肌肉力量的影响。
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.23
Hwi Ryun Kwon, Kyung Wan Min, Hee Jung Ahn, Hee Geum Seok, Bo Kyung Koo, Ho Chul Kim, Kyung Ah Han
{"title":"Effects of aerobic exercise on abdominal fat, thigh muscle mass and muscle strength in type 2 diabetic subject.","authors":"Hwi Ryun Kwon,&nbsp;Kyung Wan Min,&nbsp;Hee Jung Ahn,&nbsp;Hee Geum Seok,&nbsp;Bo Kyung Koo,&nbsp;Ho Chul Kim,&nbsp;Kyung Ah Han","doi":"10.4093/kdj.2010.34.1.23","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.23","url":null,"abstract":"<p><strong>Background: </strong>Aerobic exercise can effectively reduce visceral fat. However, few studies have examined the effect of daily physical activity on obesity and cardiopulmonary function in the subjects with diabetes. We examined the effect of moderate intensity of walking in obese diabetes patients by monitoring of daily activity and measuring the change in abdominal fat area, muscle are and maximal muscle strength.</p><p><strong>Methods: </strong>We randomly assigned 27 obese women with type 2 diabetes to an aerobic exercise group (AG, n = 13) and control group (CG, n = 14). The AG performed moderate intensity walking for 60 minutes per exercise, 5 times per week, and for 12 weeks. The activity energy expenditure was monitored by a multi-record accelerometer. The CG maintained routine daily activities. At the time of the initiation of the study and after 12 weeks of exercise, the aerobic exercise capacity was assessed using oxygen consumption rate at anaerobic threshold (VO(2)-AT). The abdominal fat area and the quadriceps muscle area were measured by computed tomography, and the maximum muscle strength of the upper and lower limbs was measured by a chest press and a leg press, respectively.</p><p><strong>Results: </strong>The mean age of the study subjects was 56.6 +/- 8.0 years, the mean duration of diabetes was 6.3 +/- 6.0 years, and the body weight index (BMI) was 27.3 +/- 2.7 kg/m(2). The BMI of the AG was significantly decreased (P = 0.003). In the AG, the visceral fat area and subcutaneous fat area were also significantly decreased (P = 0.018 and P < 0.001, respectively) but not in CG. VO(2)-AT of the AG was significantly improved, while that of the CG did not change (P = 0.009 and P = 0.115, respectively). The quadriceps muscle mass and the maximal muscle strength of the AG did not change, however, the CG showed a significant decrease. Duration of moderate intensity exercise was correlated with the decrease in total abdominal fat area (r = -0.484; P = 0.011) and that of high intensity exercise was correlated with improvement of cardiopulmonary function (r = 0.414; P = 0.032).</p><p><strong>Conclusion: </strong>Daily moderate intensity aerobic exercise is effective at reducing abdominal fat mass, while high intensity exercise improves cardiopulmonary function.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
The Effect of Glucose Fluctuation on Apoptosis and Function of INS-1 Pancreatic Beta Cells. 葡萄糖波动对INS-1胰腺β细胞凋亡及功能的影响。
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.47
Mi Kyung Kim, Hye Sook Jung, Chang Shin Yoon, Jung Hae Ko, Hae Jung Jun, Tae Kyun Kim, Min Jeong Kwon, Soon Hee Lee, Kyung Soo Ko, Byoung Doo Rhee, Jeong Hyun Park
{"title":"The Effect of Glucose Fluctuation on Apoptosis and Function of INS-1 Pancreatic Beta Cells.","authors":"Mi Kyung Kim,&nbsp;Hye Sook Jung,&nbsp;Chang Shin Yoon,&nbsp;Jung Hae Ko,&nbsp;Hae Jung Jun,&nbsp;Tae Kyun Kim,&nbsp;Min Jeong Kwon,&nbsp;Soon Hee Lee,&nbsp;Kyung Soo Ko,&nbsp;Byoung Doo Rhee,&nbsp;Jeong Hyun Park","doi":"10.4093/kdj.2010.34.1.47","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.47","url":null,"abstract":"<p><strong>Background: </strong>Blood glucose level continuously fluctuates within a certain range in the human body. In diabetes patients, the extent of such fluctuation is large, despite the strict control of blood glucose. Blood glucose fluctuation has been shown to mediate more adverse effects on vascular endothelial cells and diabetes complications than chronic hyperglycemia, which has been explained as due to oxidative stress. As few previous studies have reported the effects of chronic and intermittent hyperglycemia on the apoptosis and function of pancreatic beta cells, this study reported herein was performed to investigate such effects on these cells.</p><p><strong>Methods: </strong>For chronic hyperglycemia, INS-1 cells were cultured for 5 days with changes of RPMI 1640 medium containing 33 mM glucose every 12 hours. For intermittent hyperglycemia, the medium containing 11 mM glucose was exchanged with the medium containing 33 mM glucose every 12 hours. Apoptosis was assessed by TUNEL assay Hoechst staining and cleaved caspase 3. Insulin secretory capacity was assessed, and the expression of Mn-SOD and Bcl-2 was measured by Western blotting.</p><p><strong>Results: </strong>In comparison to the control group, INS-1 cells exposed to chronic hyperglycemia and intermittent hyperglycemia showed an increase in apoptosis. The apoptosis of INS-1 cells exposed to intermittent hyperglycemia increased significantly more than the apoptosis of INS-1 cells exposed to chronic hyperglycemia. In comparison to the control group, the insulin secretory capacity in the two hyperglycemic states was decreased, and more with intermittent hyperglycemia than with chronic hyperglycemia. The expression of Mn-SOD and Bcl-2 increased more with chronic hyperglycemia than with intermittent hyperglycemia.</p><p><strong>Conclusion: </strong>Intermittent hyperglycemia induced a higher degree of apoptosis and decreased the insulin secretory capacity more in pancreatic beta cells than chronic hyperglycemia. This activity may be mediated by the anti-oxidative enzyme Mn-SOD and the anti-apoptotic signal Bcl-2.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.47","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29039077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
2010 chairman address: on the occasion of publishing the korean diabetes journal in english. 2010年主席致辞:在韩国糖尿病杂志英文版出版之际。
Korean diabetes journal Pub Date : 2010-02-01 Epub Date: 2010-02-28 DOI: 10.4093/kdj.2010.34.1.1
Sung-Woo Park
{"title":"2010 chairman address: on the occasion of publishing the korean diabetes journal in english.","authors":"Sung-Woo Park","doi":"10.4093/kdj.2010.34.1.1","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.1.1","url":null,"abstract":"Dear Respected Members of Korean Diabetes Association, \u0000 \u0000As an official journal of the Korean Diabetes Association (KDA), the Korean Diabetes Journal has been published with the aim of contributing to the study of diabetes through the exchange of up-to-date academic information with foreign scholars as well as association members. The journal has played a leading role in the development of the study of diabetes in South Korea and I thank to the efforts and active participation of our association members. \u0000 \u0000Now is the time when we should take a new leap forward to actively address domestic and foreign research trends that have changed drastically in recent years. Currently, most Korean scholars place top priority on submitting manuscripts to SCI-level journals, as papers published in SCI-level journals are highly rated when evaluating grant applications and evaluating achievements in South Korea. Accordingly, the number of papers published in domestic academic journals is decreasing. Given the current circumstances, unless the Korean Diabetes Journal is listed in international database such as Medline and SCI, we may witness a reduction in the number of submitted papers and thus the lowering of the journal's level. \u0000 \u0000Therefore, publication of our journal in English is not an option, but a necessity. There are Korean-language journals posted on the SCIE, but only based on a temporary special policy, which will not last for a long time. In addition, the continued globalization of the KDA requires the continued exchange of information with scholars around the world, which necessitates the publication of the journal in English. Many of our members see their papers published in SCI-level journals every year. Furthermore, now is the time when our association should embrace a leadership role. Hence, our objective is to disseminate domestic findings regarding the study of diabetes, contribute to medical development, and play to a leading role on the global stage of diabetes. \u0000 \u0000It is expected that many difficulties will occur during the initial stages of this transition, but they may be thought of as a rite of passage we must go through. Our association will not reach the goal of internationalizing or globalizing our journal without the voluntary cooperation of our members. Therefore, I earnestly ask you to contribute English-language papers to our journal, and to refer to papers from our journal in papers that are to be published in other SCI-level journals. \u0000 \u0000Lastly, I thank to all members of KDA for their devotion to the society and wish your health and happiness.","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.1.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29041384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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