Korean diabetes journal最新文献_第10页

Effects of Vitamin D and Calcium Intervention on the Improvement of Resistance in Patients with Type 2 Diabetes Mellitus 维生素D和钙干预对改善2型糖尿病患者抵抗的影响

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.324

Young Mee Choi, Jun Ho Lee, J. S. Han

{"title":"Effects of Vitamin D and Calcium Intervention on the Improvement of Resistance in Patients with Type 2 Diabetes Mellitus","authors":"Young Mee Choi, Jun Ho Lee, J. S. Han","doi":"10.4093/KDJ.2009.33.4.324","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.4.324","url":null,"abstract":"Background: Recent reports suggest that the intake of vitamin D and calcium may influence insulin resistance. The aim of this study was to assess the effects of vitamin D and calcium intervention on the improvement of blood glucose and insulin resistance in patients with type 2 diabetes mellitus (DM). Methods: Fasting blood glucose, glycosylated hemoglobin A1c (HbA1C), serum 25(OH)D3, serum lipid levels, insulin secretion, and activity and dietary surveys were analyzed in type 2 DM patients both before and after a 12-week vitamin D and calcium intake intervention. Results: The serum 25(OH)D3 level was found to be negatively correlated with insulin resistance and fasting blood glucose. Calcium intake level was also negatively correlated with insulin resistance. Fasting blood glucose, HbA1C, and HOMA-IR decreased significantly (P <0.05) following vitamin D and calcium intake intervention in the medical nutrition therapy (MNT) group, while there was no such change observed in the control group. Dietary calcium and vitamin D intakes were significantly (P <0.05) higher in the MNT group than in the control group. The concentrations of serum 25(OH)D3 and insulin secretion increased slightly in the MNT group following the 12-week intervention; however, these results did not reach statistical significance. Conclusion: The results of the present study indicate that calcium and vitamin D intervention may be helpful in improving fasting blood glucose, HbA1C, serum 25(OH) D3 and HOMA-IR in patients with type 2 DM who have insufficient serum 25(OH)D3 concentrations. (Korean Diabetes J 33:324-334, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"11 1","pages":"324-334"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88716007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Non-invasive Methods for Cardiovascular Risk Assessment in Asymptomatic Type 2 DiabetesMellitus 无症状2型糖尿病心血管风险评估的无创方法

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.267

J. Lee, H. Son

引用次数: 1

Adipokine Concentrations in Pregnant Korean Women with Normal Glucose Tolerance and Gestational Diabetes Mellitus. 糖耐量正常和妊娠期糖尿病的韩国孕妇的脂肪因子浓度。

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.279

E. Oh, J. Han, S. Han, J. Im, E. Rhee, Cheol-Young Park, K. Oh, Won-Young Lee

{"title":"Adipokine Concentrations in Pregnant Korean Women with Normal Glucose Tolerance and Gestational Diabetes Mellitus.","authors":"E. Oh, J. Han, S. Han, J. Im, E. Rhee, Cheol-Young Park, K. Oh, Won-Young Lee","doi":"10.4093/KDJ.2009.33.4.279","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.4.279","url":null,"abstract":"Background: The aims of this study were to compare adipokine concentrations of pregnant women in the 24 th ~28 th weeks of gestation to those of non-pregnant women. We compared the concentrations of adipokines in women with gestational diabetes mellitus (GDM), gestational impaired glucose tolerance (GIGT) and normal glucose tolerance (NGT). We also investigated the role of adipokines in the development of gestational glucose intolerance. Methods: We surveyed 129 pregnant women who underwent a 100 g oral glucose tolerance test (OGTT) during the 24 th ~28 th weeks of gestation. Participants were classified into three groups: (1) NGT (n = 40), (2) GIGT (n = 45), and (3) GDM (n = 44). Pregnant subjects with NGT were matched to non-pregnant controls for BMI and age (n = 41). Results: Pregnant women with NGT exhibited significantly decreased adiponectin levels and elevated leptin levels compared to non-pregnant controls. Mean plasma resistin levels were significantly higher in women with GDM and GIGT than in women with NGT. Resistin and fasting glucose were significant predictors for the development of gestational glucose intolerance. Conclusion: Plasma adiponectin levels were decreased and leptin levels were increased in pregnant subjects with NGT compared to BMI and age matched non-pregnant controls. Women with GDM and GIGT exhibit significantly elevated concentrations of resistin compared with women with NGT. Increased resistin levels were also associated with the development of gestational glucose intolerance. Resistin may play an important role on the development of gesta tional glucose intolerance in Korean women. (Korean Diabetes J 33:279-288, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"33 1","pages":"279-288"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75936751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of the Effects between Positive Message and Negative Message in Diabetes Mellitus Education 积极信息与消极信息在糖尿病教育中的效果比较

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.344

B. Lee, M. Gu

引用次数: 14

The Association Between Urinary Albumin to Creatinine Ratio and Coronary Artery Calcification in Type 2 Diabetic Patients 2型糖尿病患者尿白蛋白/肌酐比值与冠状动脉钙化的关系

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.289

Ju Young Lee, Yeon-Kyung Choi, H. Seo, Jae-Han Jeon, Jung Eun Lee, S. Moon, J. G. Kim, Bo-Wan Kim, I.-K. Lee

{"title":"The Association Between Urinary Albumin to Creatinine Ratio and Coronary Artery Calcification in Type 2 Diabetic Patients","authors":"Ju Young Lee, Yeon-Kyung Choi, H. Seo, Jae-Han Jeon, Jung Eun Lee, S. Moon, J. G. Kim, Bo-Wan Kim, I.-K. Lee","doi":"10.4093/KDJ.2009.33.4.289","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.4.289","url":null,"abstract":"Background: Atherosclerosis, the most commo n cause of death in type 2 diabetic patients, is closely associated with coronary artery calcium deposition. The coronary calcifications can be easily measured using coronary calcium scoring computed tomography (CT). And microalbuminuria is known as an independent risk factor of cardiovascular disease. So, we examined the association of urinary albumin to creatinine ratio (UACR) and coronary calcification score (CCS) in type 2 diabetic patients. Methods: Among type 2 diabetic patients who underwent the multidetector CT scanning for the evaluation of CCS at Kyungpook National University Hospital between December 2007 and May 2008, 155 subjects were included. CCS, demographic and laboratory data were assessed. Results: Coronary artery calcifications were identified in 90 patients (51%) and mean, median CCS was 205.8 ± 476.9, 8.74 (0, 132.0). 60 subjects revealed UACR greater than 30 ug/mg. With the UACR increment, CCS revealed a significant increase (P < 0.001). Age, duration of diabetes, serum Apo A1 level, serum high sensitivity C-reactive protein (hs-CRP) level were also associated with CCS. However, after adjusting for age, UACR and CCS exhibited a significant positive relationship (P = 0.002). Conclusion: Increased UACR is associated with coronary artery calcification in type 2 diabetic patients and these results will be useful in early evaluating the presence of macrovascular complications in these patients. (Korean Diabetes J 33:289-298, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"24 1","pages":"289-298"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85964042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response: The Current Status of Type 2 Diabetes Management at a University Hospital (Korean Diabetes J 33(3):241-250, 2009) 回应:某大学医院2型糖尿病管理现状[韩国糖尿病杂志33(3):241-250,2009]

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.355

Young Sil Lee

引用次数: 1

Incidence of Diabetic Foot and Associated Risk Factors in Type 2 Diabetic Patients: A Five-year Observational Study 2型糖尿病患者糖尿病足的发病率及相关危险因素:一项为期五年的观察性研究

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.315

Shin Ae Park, S. Ko, Seung‐Hwan Lee, Jae-Hyoung Cho, S. Moon, Sang A Jang, H. Son, K. Song, B. Cha, H. Son, Y. Ahn

{"title":"Incidence of Diabetic Foot and Associated Risk Factors in Type 2 Diabetic Patients: A Five-year Observational Study","authors":"Shin Ae Park, S. Ko, Seung‐Hwan Lee, Jae-Hyoung Cho, S. Moon, Sang A Jang, H. Son, K. Song, B. Cha, H. Son, Y. Ahn","doi":"10.4093/KDJ.2009.33.4.315","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.4.315","url":null,"abstract":"Background: The frequency of lower extremity amputation due to diabetic foot has been increasing in type 2 diabetic patients. The aim of this study was to observe the incidence, clinical aspects and associated risk factors for diabetic foot. Methods: We evaluated the incidence of diabetic foot through a five-year observation of type 2 diabetic patients who presented to St. vincent's Hospital between Januar y and December 2003. To identify the risk factors for diabetic foot, we evaluated mean glycosylated hemoglobin A1c (HbA1c) every six months and assessed renal function based on the existence of proteinuria and estimated glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) equation. Patients were also evaluated for retinopathy, peripheral neuropathy and autonomic neuropathy usi ng Ewing's method. Results: From an initial pool of 613 patients, the observational study o f 508 patients (82.9%) was completed. The mean age, duration of diabetes and HbA1c were 50.3 ± 10.6 yrs, 7.2 ± 6.5 yrs and 8.8 ± 2.1%, respectively. Diabetic foot occurred in 32 patients (6.3%). The incidence of diabetic foot increased when diabetic retinopathy (OR = 6.707, 2.314~19.439), peripheral neuropathy (OR = 2.949, 1.075~8.090), and autonomic neuropathy (OR = 3.967, 1.476~10.660) were present and when the MDRD GFR (OR = 5.089, 1.712~15.130) decreased. Mean HbA1c (OR = 12.013, 1.470~98.179) was found to be an independent risk factor for diabetic foot. Conclusion: The present study confirmed the importance of intensive glycemic control and the role of autonomic dysfunction in the development of diabetic foot. In addition, diabetic retinopathy and impaired renal function proved to be factors associated with the occurrence of diabetic foot. Therefore, intensive glycemic control, as well as periodic examination of renal function, are essential for the prevention of diabetic foot. (Korean Diabetes J 33:315-323, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"178 1","pages":"315-323"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74874902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Letter: The Current Status of Type 2 Diabetes Management at a University Hospital (Korean Diabetes J 33(3):241-250, 2009) 信:某大学医院2型糖尿病管理现状[J] .韩国糖尿病杂志33(3):241-250,2009。

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.353

E. Hong

引用次数: 0

Association of Spot Urine Albumin-to-Creatinine Ratio and 24 Hour-Collected Urine Albumin Excretion Rate in Patients with Type 2 Diabetes Mellitus 2型糖尿病患者尿白蛋白与肌酐比值与24小时尿白蛋白排泄率的关系

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.299

J. Lee, H. Kwon, S. Oh, Jung Min Lee, S. Chang, B. Cha, H. Son, T. Sohn

{"title":"Association of Spot Urine Albumin-to-Creatinine Ratio and 24 Hour-Collected Urine Albumin Excretion Rate in Patients with Type 2 Diabetes Mellitus","authors":"J. Lee, H. Kwon, S. Oh, Jung Min Lee, S. Chang, B. Cha, H. Son, T. Sohn","doi":"10.4093/KDJ.2009.33.4.299","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.4.299","url":null,"abstract":"Background: Measuring urine albumin in diabetic patients is an important screening test to identify those individuals at high risk for cardiovascular disease and the progression of kidney disease. Recently, spot urine albumin-to-creatinine ratio (ACR) has replaced 24 hour-collected urine albumin excretion rate (AER) as a screening test for microalbuminuria given its comparative simplicity. The purpose of the current study was to evaluate the degree of correla tion between AER and ACR in the normal, microalbuminuric and macroalbuminuric ranges, and to identify the lower limits of ACR for both genders. Methods: A total of 310 type 2 diabetics admitted to one center were enrolled in the present study. Following the collection of a spot urine sample, urine was coll ected for 24 hours and albumin content was measured in both specimens. Results: Mean patient age was 60.2 years. A total of 25.4% had microalbuminuria and 15.8% had macroalbuminuria. The data revealed a strongly positive correlation between AER and ACR across all ranges of albuminuria (R = 0.8). The cut-off value of ACR for 30 mg/day of AER by the regression equation was 24 μ g/mg for men, 42 μ g/mg for women and 31.2 μ g/mg for all patients. The diagnostic performance expressed as the area under the curve (AUC) was 0.938 (95% CI, 0.911-0.965) for ACR. ACR revealed a sensitivity of 84% and specificity of 84%, when a cut-off value of 31.2 μ g/mg was employed. Conclusion: ACR was highly correlated with AER, particularly in the range of microalbuminuria. The gender combined cut-off value of ACR in type 2 diabetic patients was determined to be 31.2 μg/mg However, additional studies of large outpatient populations, as opposed to the inpatient population used in the present study, are required to confirm the utility of this value. (Korean Diabetes J 33:299-305, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"190 1","pages":"299-305"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76006153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Combination of Fasting Plasma Glucose and Glycosylated Hemoglobin as a Predictor for Type 2 Diabetes in Korean Adults 韩国成人空腹血糖和糖化血红蛋白作为2型糖尿病的预测因子

Korean diabetes journal Pub Date : 2009-08-01 DOI: 10.4093/KDJ.2009.33.4.306

C. Lee, W. Chang, H. H. Chung, Hyun Jung Kim, S. Park, J. Moon, J. Lee, J. Yoon, K. Chun, K. Won, I. Cho, H. Lee

{"title":"The Combination of Fasting Plasma Glucose and Glycosylated Hemoglobin as a Predictor for Type 2 Diabetes in Korean Adults","authors":"C. Lee, W. Chang, H. H. Chung, Hyun Jung Kim, S. Park, J. Moon, J. Lee, J. Yoon, K. Chun, K. Won, I. Cho, H. Lee","doi":"10.4093/KDJ.2009.33.4.306","DOIUrl":"https://doi.org/10.4093/KDJ.2009.33.4.306","url":null,"abstract":"Background: The oral glucose tolerance test (OGTT) for detection of diabetes is difficult to perform in clinical settings. The aim of this study is to evaluate the performance of a more practical detection test, combined fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c), as a predictor of diabetes mellitus (DM) in a Korean sample. Methods: We examined 2,045 (M = 1,276, mean age = 47.8 ± 9.0 yrs) medical check-up program participants between January 2002 to December 2003. FPG, HbA1c and a number of other biochemical tests were performed at baseline and four after years after initial screening. Patients who originally presented with diabetes were excluded. The characteristics of newly-diagnosed DM patients and non-diabetic patients were compared. Results: The incidence of newly diagnosed diabetes was 1.6% (32/2,045) after four years of follow up. The subjects in the DM group were older, had higher levels of SBP, DBP, FPG, HbA1c, triglyceride, HDL cholesterol, GGT and LDH (P < 0.05). In multivariate logistic regression analysis, FPG (odds ratio (OR) 1.124) and HbA1c (OR 4.794) were significantly correlated with onset of diabetes (P < 0.05). The interaction parameter between FPG and HbA1c was more than 1.0, indicating that the two effects are synergistic. The predictive cut-off values of HbA1c and FPG were 5.35% (area under curve (AUC) = 0.944) and 102.5 mg/dL (AUC = 0.930), respectively. Conclusion: The combination of HbA1c above 5.35% and FPG above 102.5 mg/dL predicted the onset of diabetes in a Korean sample. These results suggest that the combination of FPG and HbA1c may be useful for predicting progression to type 2 diabetes in east Asians. (Korean Diabetes J 33:306-314, 2009)","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"20 1","pages":"306-314"},"PeriodicalIF":0.0,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91163103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8