Korean diabetes journal最新文献

{"title":"The effects of small sized rice bowl on carbohydrate intake and dietary patterns in women with type 2 diabetes.","authors":"Hee-Jung Ahn,&nbsp;Yu-Kyung Eom,&nbsp;Kyung-Ah Han,&nbsp;Hwi-Ryun Kwon,&nbsp;Hyun Jin Kim,&nbsp;Kang Seo Park,&nbsp;Kyung-Wan Min","doi":"10.4093/kdj.2010.34.3.166","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.3.166","url":null,"abstract":"<p><strong>Background: </strong>The main source of carbohydrate in the Korean diet is rice, which is usually served in a rice bowl. This study investigated the impact of a meal plan using smaller rice bowls on dietary energy intake and macronutrient composition in overweight or obese patients with type 2 diabetes mellitus.</p><p><strong>Methods: </strong>A total of 67 women with type 2 diabetes were enrolled in our study. We divided these participants into three groups: a normal-weight group (NW; body mass index [BMI] < 23 kg/m(2); n = 17), an overweight group (OW; 23 </= BMI < 25 kg/m(2); n = 24) and an obese group (OB; BMI >/= 25 kg/m(2); n = 26). Three-day dietary records were analyzed for total energy intake (TEI) and macronutrient composition both before enrollment and two weeks after patients received instruction in a dietary plan based on using a small (200 mL) rice bowl.</p><p><strong>Results: </strong>After the intervention, TEI decreased in the OW and OB groups. Decreased carbohydrate (NW, -4 +/- 5%; OW, -4 +/- 5%; OB, -3 +/- 6%) and increased fat intakes were found in all three groups, which complies with Korean Diabetes Association recommendations. The protein proportion of TEI significantly increased only in the OW group. Body weight decreased both in the OW and OB groups.</p><p><strong>Conclusion: </strong>A short-term, small-rice-bowl-based meal plan was effective for body weight control and macronutrient balance in overweight or obese women in Korea with type 2 diabetes.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"166-73"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.3.166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29111436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response: Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients (Korean Diabetes J 2010;34:95-100).","authors":"Eun Hee Kim, Ki-Up Lee","doi":"10.4093/kdj.2010.34.3.209","DOIUrl":"10.4093/kdj.2010.34.3.209","url":null,"abstract":"","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"209-10"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/4f/kdj-34-209.PMC2898936.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29111442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Obesity and Physical Fitness, and Hemoglobin A1c Level and Metabolic Syndrome in Korean Adults.","authors":"Yoonsuk Jekal,&nbsp;Mi-Kyung Lee,&nbsp;Sukyung Park,&nbsp;Seung-Hwan Lee,&nbsp;Jun-Young Kim,&nbsp;Jung-Ui Kang,&nbsp;Masayo Naruse,&nbsp;Sang-Hwan Kim,&nbsp;Sun-Hyeon Kim,&nbsp;Sang Hui Chu,&nbsp;Sang-Hoon Suh,&nbsp;Justin Y Jeon","doi":"10.4093/kdj.2010.34.3.182","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.3.182","url":null,"abstract":"<p><strong>Background: </strong>The purpose of the current study was to investigate the association of obesity level, physical fitness level, hemoglobin A1c (HbA1c) level and metabolic syndrome (MetS) risk factors among Korean adults.</p><p><strong>Methods: </strong>A total of 557 adults (272 males and 285 females) who underwent medical check-up at local hospital were recruited. In addition to regular health check-up, cardiopulmonary fitness, muscular endurance were measured and their association were analyzed.</p><p><strong>Results: </strong>The prevalence of MetS was 31.7% for males and 23.7% for females. Females with the higher muscular endurance had lower waist circumference, triglyceride level, and HbA1c level than those with the lower muscular endurance. Males with the higher level of cardiopulmonary fitness had lower diastolic blood pressure, lower high-sensitivity C-reactive protein level and higher high density lipoprotein cholesterol level than males with the lower level of cardiopulmonary fitness. Females with the higher level of cardiopulmonary fitness had lower body weight, body mass index, systolic blood pressure, and fasting blood glucose level than females with the lower level of cardiopulmonary fitness. Participants with the higher level of adiposity and the lower level of physical fitness were 5.26 times (95% confidence interval [CI], 2.19 to 12.62), 5.71 times (95% CI, 2.23 to 14.60) more likely to have MetS, respectively, in male and female compared to participants who were neither obese nor have the lower level of fitness.</p><p><strong>Conclusion: </strong>This study suggests that maintaining a healthy body weight as well as a certain level of fitness is important for the prevention of MetS.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"182-90"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.3.182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29111438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenine nucleotide translocator as a regulator of mitochondrial function: implication in the pathogenesis of metabolic syndrome.","authors":"Eun Hee Kim,&nbsp;Eun Hee Koh,&nbsp;Joong-Yeol Park,&nbsp;Ki-Up Lee","doi":"10.4093/kdj.2010.34.3.146","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.3.146","url":null,"abstract":"<p><p>Mitochondria play key roles in energy production and intracellular reactive oxygen species (ROS) generation. Lines of evidence have shown that mitochondrial dysfunction contributes to the development of metabolic syndrome. The causes of mitochondrial dysfunction are complex, but overnutrition and sedentary living are among the best known causes of mitochondrial dysfunction. ATP synthesized in the mitochondria is exchanged for cytosolic ADP by adenine nucleotide translocator (ANT) to provide a continuous supply of ADP to mitochondria. We recently found that ANT function is essential for peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1alpha)'s action on endothelial cells. PGC-1alpha is a transcriptional coactivator of nuclear receptors, playing an important role in fatty acid oxidation and mitochondrial biogenesis. Recent studies have shown that PGC-1alpha decreases intracellular ROS generation by increasing the expression of antioxidant genes. In our study, PGC-1alpha reduced cell apoptosis and ROS generation in endothelial cells by increasing ATP/ADP translocase activity of ANT and ANT1 expression. Here we review the role of ANT in maintaining proper mitochondrial function, and possible role of ANT dysfunction in the pathogenesis of metabolic syndrome.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"146-53"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.3.146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29113005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homocysteine as a risk factor for development of microalbuminuria in type 2 diabetes.","authors":"Eun-Hee Cho,&nbsp;Eun Hee Kim,&nbsp;Won Gu Kim,&nbsp;Eun Hui Jeong,&nbsp;Eun Hee Koh,&nbsp;Woo-Je Lee,&nbsp;Min-Seon Kim,&nbsp;Joong-Yeol Park,&nbsp;Ki-Up Lee","doi":"10.4093/kdj.2010.34.3.200","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.3.200","url":null,"abstract":"<p><strong>Background: </strong>Kidney function is critical in homocysteine clearance, and plasma homocysteine level is frequently increased in patients with renal failure. On the other hand, recent studies in animals have shown that hyperhomocysteinemia induces renal injury. In this study, we determined whether hyperhomocysteinemia can be a risk factor for the development of microalbuminuria in patients with type 2 diabetes.</p><p><strong>Methods: </strong>A nested case-control study. Of 887 patients with type 2 diabetes who did not have microalbuminuria at baseline, 76 developed microalbuminuria during follow-up (mean, 36.0 +/- 11.7 months; range, 18 to 76 months). The control group consisted of 152 age- and sex-matched subjects who did not develop microalbuminuria. Baseline plasma homocysteine concentrations were measured in stored samples.</p><p><strong>Results: </strong>Baseline plasma homocysteine concentrations and mean HbA1C levels during follow-up were significantly higher in patients who developed microalbuminuria than in those who remained normoalbuminuric. Multivariate logistic regression analysis showed that baseline plasma homocysteine level and mean HbA1C were independent predictors of microalbuminuria in type 2 diabetes.</p><p><strong>Conclusion: </strong>Hyperhomocysteinemia was associated with increased risk of microalbuminuria in patients with type 2 diabetes supporting the concept that hyperhomocysteinemia has an etiologic role in the pathogenesis of diabetic nephropathy.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"200-6"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.3.200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29111440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and insulin resistance: an old story with new ideas.","authors":"Jason K Kim","doi":"10.4093/kdj.2010.34.3.137","DOIUrl":"10.4093/kdj.2010.34.3.137","url":null,"abstract":"<p><p>Years before insulin was discovered, anti-inflammatory sodium salicylate was used to treat diabetes in 1901. Intriguingly for many years that followed, diabetes was viewed as a disorder of glucose metabolism, and then it was described as a disease of dysregulated lipid metabolism. The diabetes research focused on the causal relationship between obesity and insulin resistance, a major characteristic of type 2 diabetes. It is only within the past 20 years when the notion of inflammation as a cause of insulin resistance began to surface. In obesity, inflammation develops when macrophages infiltrate adipose tissue and stimulate adipocyte secretion of inflammatory cytokines, that in turn affect energy balance, glucose and lipid metabolism, leading to insulin resistance. This report reviews recent discoveries of stress kinase signaling involving molecular scaffolds and endoplasmic reticulum chaperones that regulate energy balance and glucose homeostasis. As we advance from a conceptual understanding to molecular discoveries, a century-old story of inflammation and insulin resistance is re-born with new ideas.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"137-45"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/8f/kdj-34-137.PMC2898926.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29113004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients (Korean Diabetes J 2010;34:95-100).","authors":"Kyu-Chang Won","doi":"10.4093/kdj.2010.34.3.207","DOIUrl":"10.4093/kdj.2010.34.3.207","url":null,"abstract":"","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"207-8"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/e6/kdj-34-207.PMC2898935.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29111441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early insulin secretory dysfunction in korean prediabetic subjects: should we change the criteria for \"prediabetes?\".","authors":"Chul-Hee Kim","doi":"10.4093/kdj.2010.34.3.154","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.3.154","url":null,"abstract":"Impaired insulin secretion and insulin resistance are the two main pathophysiological mechanisms that lead to type 2 diabetes. It is well-known that type 2 diabetes is preceded by a long prediabetic state characterized by mild elevation of fasting and/or postprandial glucose levels. However, previous studies on the relative contributions of insulin secretory defects and insulin resistance in the development of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yielded contradictory results [1-4]. Inconsistencies across the studies have been explained by differences in study populations, study designs and methods to assess insulin resistance and insulin secretion. \u0000 \u0000The nature of progressive β-cell failure occurring as normal glucose-tolerant (NGT) individuals progress to type 2 diabetes is incompletely understood. Moreover, the precise level of hyperglycemia at which β-cell function begins to decline has not yet been established. Research has shown that during the natural development of type 2 diabetes, fasting plasma insulin increases and then decreases as insulin resistance develops, displaying the typical inverted U-shaped curve that has been referred to as \"Starling's curve of the pancreas\" [5]. Earlier studies reported that the plasma insulin response to glucose rises progressively until the fasting plasma glucose reaches 120 to 140 mg/dL, and further increases in fasting glucose levels are associated with a progressive decline in insulin secretion [6]. \u0000 \u0000To date, several studies have examined insulin secretion as a function of glucose concentrations in various populations [7-11]. Some studies have shown that individuals with IFG and/or IGT have a pronounced defect in early insulin secretion [7,12]. Other studies demonstrated that the decline in β-cell function occurs at an earlier stage that is considered normal according to current diagnostic criteria [8,10,11]. Only limited studies have assessed early insulin secretion based on dynamic tests in Koreans [13-16]. In the studies that do exist, the numbers of participants were small; no studies have yet assessed the changes in insulin secretion in relation to the changes in fasting and postprandial glucose levels ranging from NGT to IGT and type 2 diabetes. \u0000 \u0000In this issue, Rhee et al. [17] analyzed early-phase insulin secretion during oral glucose tolerance tests (OGTT) in relation to plasma glucose levels ranging from normal to the diabetic range of hyperglycemia in 873 Korean participants. The key finding of this report was that the decline of early-phase insulin secretion according to the increase of plasma glucose concentration begins early and progresses rapidly during the period generally designated as \"normal.\" According to their results, early-phase insulin secretion was reduced to <50% of the control group in participants with fasting glucose levels of 100 mg/dL, postload 2-hour glucose of 145 mg/dL, and HbA1c of 5.8%. Therefore, the authors claim that the d","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"154-6"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.3.154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29113006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is A1C Variability an Independent Predictor for the Progression of Atherosclerosis in Type 2 Diabetic Patients?","authors":"Chul Sik Kim,&nbsp;So Young Park,&nbsp;Sung Hoon Yu,&nbsp;Jun Goo Kang,&nbsp;Ohk Hyun Ryu,&nbsp;Seong Jin Lee,&nbsp;Eun Gyung Hong,&nbsp;Hyeon Kyu Kim,&nbsp;Doo-Man Kim,&nbsp;Jae Myung Yoo,&nbsp;Sung Hee Ihm,&nbsp;Moon Gi Choi,&nbsp;Hyung Joon Yoo","doi":"10.4093/kdj.2010.34.3.174","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.3.174","url":null,"abstract":"<p><strong>Background: </strong>Little is known about the relative contribution of long-term glycemic variability to the risk of macrovascular complications in type 2 diabetes. This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness (IMT) in type 2 diabetic patients.</p><p><strong>Methods: </strong>Among type 2 diabetic patients who visited Hallym University Sacred Heart Hospital from March 2007 to September 2009, 120 patients who had carotid artery IMT measured annually and A1C checked every three months for at least one year were analyzed. Individual A1C variability was defined as the standard deviation (SD) of five A1C levels taken every three months for approximately one year. Change in IMT was defined as an increase in IMT on follow-up measurement. The association between the SD of A1C and changes in IMT was evaluated.</p><p><strong>Results: </strong>With greater A1C variability, there was a greater increase in the mean IMT (r = 0.350, P < 0.001) of the carotid artery. After adjusting for confounding factors that may influence IMT, A1C variability was significantly associated with the progression of IMT (r = 0.222, P = 0.034). However, the SD of A1C was not a significant independent risk factor for the progression of IMT in multiple regression analysis (beta = 0.158, P = 0.093).</p><p><strong>Conclusion: </strong>Higher A1C variability is associated with IMT progression in type 2 diabetic patients; however, it is not an independent predictor of IMT progression. Overall glycemic control is the most important factor in the progression of IMT.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"174-81"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.3.174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29111437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of rosiglitazone on inflammation in Otsuka long-evans Tokushima Fatty rats.","authors":"Jin Woo Lee,&nbsp;Il Seong Nam-Goong,&nbsp;Jae Geun Kim,&nbsp;Chang Ho Yun,&nbsp;Se Jin Kim,&nbsp;Jung Il Choi,&nbsp;Young Il Kim,&nbsp;Eun Sook Kim","doi":"10.4093/kdj.2010.34.3.191","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.3.191","url":null,"abstract":"<p><strong>Background: </strong>Inflammation plays a role in the response to metabolic stress in type 2 diabetes. However, the effects of rosiglitazone on inflammation of skeletal muscle have not been fully examined in type 2 diabetes.</p><p><strong>Methods: </strong>We investigated the effects of the insulin-sensitizing anti-diabetic agent, rosiglitazone, on the progression of skeletal muscle inflammation in Otsuka Long-Evans Tokushima Fatty (OLETF) type 2 diabetic rats. We examined the expression of serologic markers (serum glucose, insulin and free fatty acid) and inflammatory cytokines (tumor-necrosis factor-alpha, interleukin [IL]-1beta and IL-6) in OLETF rats from early to advanced diabetic stage (from 28 to 40 weeks of age).</p><p><strong>Results: </strong>Serum glucose and insulin concentrations were significantly decreased in rosiglitazone-treated OLETF rats compared to untreated OLETF rats. Rosiglitazone treatment significantly decreased the concentrations of serum inflammatory cytokines from 28 to 40 weeks of age. The mRNA expression of various cytokines in skeletal muscle was reduced in rosiglitazone-treated OLETF rats compared with untreated OLETF rats. Furthermore, rosiglitazone treatment resulted in the downregulation of ERK1/2 phosphorylation and NF-kappaB expression in the skeletal muscle of OLETF rats.</p><p><strong>Conclusion: </strong>These results suggest that rosiglitazone may improve insulin sensitivity with its anti-inflammatory effects on skeletal muscle.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 3","pages":"191-9"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/3e/kdj-34-191.PMC2898933.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29111439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}