Effects of rosiglitazone on inflammation in Otsuka long-evans Tokushima Fatty rats.

Korean diabetes journal Pub Date : 2010-06-01 Epub Date: 2010-06-30 DOI:10.4093/kdj.2010.34.3.191
Jin Woo Lee, Il Seong Nam-Goong, Jae Geun Kim, Chang Ho Yun, Se Jin Kim, Jung Il Choi, Young Il Kim, Eun Sook Kim
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引用次数: 11

Abstract

Background: Inflammation plays a role in the response to metabolic stress in type 2 diabetes. However, the effects of rosiglitazone on inflammation of skeletal muscle have not been fully examined in type 2 diabetes.

Methods: We investigated the effects of the insulin-sensitizing anti-diabetic agent, rosiglitazone, on the progression of skeletal muscle inflammation in Otsuka Long-Evans Tokushima Fatty (OLETF) type 2 diabetic rats. We examined the expression of serologic markers (serum glucose, insulin and free fatty acid) and inflammatory cytokines (tumor-necrosis factor-alpha, interleukin [IL]-1beta and IL-6) in OLETF rats from early to advanced diabetic stage (from 28 to 40 weeks of age).

Results: Serum glucose and insulin concentrations were significantly decreased in rosiglitazone-treated OLETF rats compared to untreated OLETF rats. Rosiglitazone treatment significantly decreased the concentrations of serum inflammatory cytokines from 28 to 40 weeks of age. The mRNA expression of various cytokines in skeletal muscle was reduced in rosiglitazone-treated OLETF rats compared with untreated OLETF rats. Furthermore, rosiglitazone treatment resulted in the downregulation of ERK1/2 phosphorylation and NF-kappaB expression in the skeletal muscle of OLETF rats.

Conclusion: These results suggest that rosiglitazone may improve insulin sensitivity with its anti-inflammatory effects on skeletal muscle.

Abstract Image

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罗格列酮对大冢long-evans德岛脂肪大鼠炎症的影响。
背景:炎症在2型糖尿病患者对代谢应激的反应中起作用。然而,罗格列酮对2型糖尿病骨骼肌炎症的影响尚未得到充分研究。方法:研究胰岛素增敏降糖药罗格列酮对2型糖尿病大鼠骨骼肌炎症进展的影响。我们检测了OLETF大鼠从早期到晚期糖尿病(28 - 40周龄)的血清学标志物(血清葡萄糖、胰岛素和游离脂肪酸)和炎症因子(肿瘤坏死因子- α、白细胞介素[IL]-1 β和IL-6)的表达。结果:与未治疗的OLETF大鼠相比,罗格列酮治疗的OLETF大鼠血清葡萄糖和胰岛素浓度显著降低。罗格列酮治疗显著降低28 ~ 40周龄小鼠血清炎症因子浓度。与未处理的OLETF大鼠相比,罗格列酮处理的OLETF大鼠骨骼肌中各种细胞因子的mRNA表达降低。此外,罗格列酮治疗导致OLETF大鼠骨骼肌ERK1/2磷酸化和NF-kappaB表达下调。结论:罗格列酮可通过对骨骼肌的抗炎作用改善胰岛素敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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