Bioengineering最新文献_第10页

Impact of Hamstring Graft on Hamstring Peak Torque and Maximum Effective Angle After Anterior Cruciate Ligament Reconstruction: An Exploratory and Preliminary Study. 前交叉韧带重建后腘绳肌移植物对腘绳肌峰值扭矩和最大有效角的影响：探索性初步研究。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-28 DOI: 10.3390/bioengineering12050465

Ismail Bouzekraoui Alaoui, Ayrton Moiroux-Sahraoui, Jean Mazeas, Georgios Kakavas, Maciej Biały, Maurice Douryang, Florian Forelli

{"title":"Impact of Hamstring Graft on Hamstring Peak Torque and Maximum Effective Angle After Anterior Cruciate Ligament Reconstruction: An Exploratory and Preliminary Study.","authors":"Ismail Bouzekraoui Alaoui, Ayrton Moiroux-Sahraoui, Jean Mazeas, Georgios Kakavas, Maciej Biały, Maurice Douryang, Florian Forelli","doi":"10.3390/bioengineering12050465","DOIUrl":"https://doi.org/10.3390/bioengineering12050465","url":null,"abstract":"Purpose: Anterior cruciate ligament reconstruction (ACLR) using the hamstring graft is commonly performed to restore knee stability; however, it induces significant neuromuscular and biomechanical changes, particularly in the hamstring. This study aimed to evaluate the changes in maximum effective angle, hamstring strength, and hamstring-to-quadriceps (H/Q) strength ratio at 3 and 6 months post-ACLR and compare these outcomes to a control group.Methods: This prospective controlled study included 20 ACLR patients and 20 age- and gender-matched controls. Hamstring peak torque, maximum effective angle (MEA), and the H/Q ratio were assessed using isokinetic dynamometry at 60°/s. The ACLR group was evaluated postoperatively at 3 and 6 months, while the control group underwent a single evaluation.Results: At 3 and 6 months, the ACLR group exhibited significantly lower MEA (26.3° ± 8.2 and 28.2° ± 9.4) compared to the control group (36.4° ± 12.0; p < 0.01). Hamstring peak torque and H/Q ratios were also lower in the ACLR group but showed slight improvements over time. The H/Q ratio increased significantly between 3 and 6 months (51% to 56%; p = 0.041).Conclusion: The use of hamstring graft in ACLR leads to persistent MEA and strength deficits despite rehabilitation. Advanced, targeted rehabilitation protocols are essential to address these deficits, optimize recovery, and reduce the risk of reinjury.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and Patient Benefit Evaluation of Machine Learning Models for Predicting 90-Day Mortality After Endovascular Thrombectomy Based on Routinely Ready Clinical Information. 基于常规临床信息预测血管内血栓切除术后90天死亡率的机器学习模型的识别和患者受益评估。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-28 DOI: 10.3390/bioengineering12050468

Andrew Tik Ho Ng, Lawrence Wing Chi Chan

{"title":"Identification and Patient Benefit Evaluation of Machine Learning Models for Predicting 90-Day Mortality After Endovascular Thrombectomy Based on Routinely Ready Clinical Information.","authors":"Andrew Tik Ho Ng, Lawrence Wing Chi Chan","doi":"10.3390/bioengineering12050468","DOIUrl":"https://doi.org/10.3390/bioengineering12050468","url":null,"abstract":"Endovascular thrombectomy (EVT) is regarded as the standard of care for acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). However, the mortality rates for these patients remain alarmingly high. Dependable mortality prediction based on timely clinical information is of great importance. This study retrospectively reviewed 151 patients who underwent EVT at Pamela Youde Nethersole Eastern Hospital between 1 April 2017, and 31 October 2023. The primary outcome of this study was 90-day mortality after AIS. The models were developed using two feature selection approaches (model I: sequential forward feature selection, model II: sequential forward feature selection after identifying variables through univariate logistic regression) and six algorithms. Model performance was evaluated by using external validation data of 312 cases and compared with three traditional prediction scores. This study identified support vector machine (SVM) using model II as the best algorithm among the various options. Meanwhile, the Houston Intra-Arterial recanalization 2 (HIAT2) score surpassed all algorithms with an AUC of 0.717. However, most algorithms provided a greater net benefit than the traditional prediction scores. Machine learning (ML) algorithms developed with routinely available variables could offer beneficial insights for predicting mortality in AIS patients undergoing EVT.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Analysis of Rheumatoid Arthritis of the Hand and the Design of Orthotics: A Finite Element Study. 手部类风湿关节炎的生物力学分析及矫形器的设计：一项有限元研究。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-27 DOI: 10.3390/bioengineering12050462

Guiyuan Li, Jie Yang, Pengfei Feng, Xiaona Li, Weiyi Chen

{"title":"Biomechanical Analysis of Rheumatoid Arthritis of the Hand and the Design of Orthotics: A Finite Element Study.","authors":"Guiyuan Li, Jie Yang, Pengfei Feng, Xiaona Li, Weiyi Chen","doi":"10.3390/bioengineering12050462","DOIUrl":"https://doi.org/10.3390/bioengineering12050462","url":null,"abstract":"Hand orthoses are often recommended as a rehabilitation measure for patients with rheumatoid arthritis (RA). However, existing research on the efficacy of hand orthoses has predominantly focused on 3D-printed devices and post-intervention clinical functional assessments, which tend to be subjective. There is a notable lack of biomechanical studies evaluating the effects of wearing orthoses. Therefore, in this study, the finite element method was used to analyze the biomechanical properties of an RA hand. A hand orthosis was designed based on the principle of three-point force, and a composite model of the RA hand and orthosis was constructed to verify its effectiveness. The results showed that the peak stress and displacement of the RA hand were 3.22-183.21% and 28.81-124.23% higher than those of the normal hand. Compared with the RA hand under direct force, the peak stress of the RA hand after wearing orthosis was generally reduced by 3.05-55.60%, and the peak displacement was generally reduced by 20.35-71.43%, verifying the effectiveness of the orthosis. Additionally, variations in the magnitude of three-point forces influenced the orthopedic effects. This study proves the effectiveness of hand orthosis and provides some theoretical data for subsequent research and treatment of rheumatoid arthritis.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marker-Less Navigation System for Anterior Cruciate Ligament Reconstruction with 3D Femoral Analysis and Arthroscopic Guidance. 无标记导航系统在三维股骨分析和关节镜引导下重建前交叉韧带。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-27 DOI: 10.3390/bioengineering12050464

Shuo Wang, Weili Shi, Shuai Yang, Jiahao Cui, Qinwei Guo

{"title":"Marker-Less Navigation System for Anterior Cruciate Ligament Reconstruction with 3D Femoral Analysis and Arthroscopic Guidance.","authors":"Shuo Wang, Weili Shi, Shuai Yang, Jiahao Cui, Qinwei Guo","doi":"10.3390/bioengineering12050464","DOIUrl":"https://doi.org/10.3390/bioengineering12050464","url":null,"abstract":"Accurate femoral tunnel positioning is crucial for successful anterior cruciate ligament reconstruction (ACLR), yet traditional arthroscopic techniques face significant challenges in spatial orientation and precise anatomical localization. This study presents a novel marker-less computer-assisted navigation system that integrates three-dimensional femoral modeling with real-time arthroscopic guidance. The system employs advanced image processing techniques for accurate condyle segmentation and implements the Bernard and Hertel (BH) grid system for standardized positioning. A curvature-based feature extraction approach precisely identifies the capsular line reference (CLR) on the lateral condyle surface, forming the foundation for establishing the BH reference grid. The system's two-stage registration framework, combining SIFT-ICP algorithms, achieves accurate alignment between preoperative models and arthroscopic views. Validation results from expert surgeons demonstrated high precision, with 71.5% of test groups achieving acceptable or excellent performance standards (mean deviation distances: 1.12-1.86 mm). Unlike existing navigation solutions, our system maintains standard surgical workflow without requiring additional surgical instruments or markers, offering an efficient and minimally invasive approach to enhance ACLR precision. This innovation bridges the gap between preoperative planning and intraoperative execution, potentially improving surgical outcomes through standardized tunnel positioning.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Combining EMG, Joint Moments, and GRF from Marker-Less Video-Based Motion Capture Systems. 结合无标记视频运动捕捉系统的肌电图、关节力矩和GRF的挑战。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-27 DOI: 10.3390/bioengineering12050461

H M Rehan Afzal, Borhen Louhichi, Nashmi H Alrasheedi

{"title":"Challenges in Combining EMG, Joint Moments, and GRF from Marker-Less Video-Based Motion Capture Systems.","authors":"H M Rehan Afzal, Borhen Louhichi, Nashmi H Alrasheedi","doi":"10.3390/bioengineering12050461","DOIUrl":"https://doi.org/10.3390/bioengineering12050461","url":null,"abstract":"The evolution of motion capture technology from marker-based to marker-less systems is a promising field, emphasizing the critical role of combining electromyography (EMG), joint moments, and ground reaction forces (GRF) in advancing biomechanical analysis. This review examines the integration of EMG, joint moments, and GRF in marker-less video-based motion capture systems, focusing on current approaches, challenges, and future research directions. This paper recognizes the significant challenges of integrating the aforementioned modalities, which include problems of acquiring and synchronizing data and the issue of validating results. Particular challenges in accuracy, reliability, calibration, and environmental influences are also pointed out, together with the issue of the standard protocols of multimodal data fusion. Using a comparative analysis of significant case studies, the review examines existing methodologies' successes and weaknesses and established best practices. New emerging themes of machine learning techniques, real-time analysis, and advancements in sensing technologies are also addressed to improve data fusion. By highlighting both the limitations and potential advancements, this review provides essential insights and recommendations for future research to optimize marker-less motion capture systems for comprehensive biomechanical assessments.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing Utility of Big Data Analytics in Personalized Cardiovascular Healthcare. 大数据分析在个性化心血管医疗中的革命性应用。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-27 DOI: 10.3390/bioengineering12050463

Praneel Sharma, Pratyusha Sharma, Kamal Sharma, Vansh Varma, Vansh Patel, Jeel Sarvaiya, Jonsi Tavethia, Shubh Mehta, Anshul Bhadania, Ishan Patel, Komal Shah

{"title":"Revolutionizing Utility of Big Data Analytics in Personalized Cardiovascular Healthcare.","authors":"Praneel Sharma, Pratyusha Sharma, Kamal Sharma, Vansh Varma, Vansh Patel, Jeel Sarvaiya, Jonsi Tavethia, Shubh Mehta, Anshul Bhadania, Ishan Patel, Komal Shah","doi":"10.3390/bioengineering12050463","DOIUrl":"https://doi.org/10.3390/bioengineering12050463","url":null,"abstract":"The term \"big data analytics (BDA)\" defines the computational techniques to study complex datasets that are too large for common data processing software, encompassing techniques such as data mining (DM), machine learning (ML), and predictive analytics (PA) to find patterns, correlations, and insights in massive datasets. Cardiovascular diseases (CVDs) are attributed to a combination of various risk factors, including sedentary lifestyle, obesity, diabetes, dyslipidaemia, and hypertension. We searched PubMed and published research using the Google and Cochrane search engines to evaluate existing models of BDA that have been used for CVD prediction models. We critically analyse the pitfalls and advantages of various BDA models using artificial intelligence (AI), machine learning (ML), and artificial neural networks (ANN). BDA with the integration of wide-ranging data sources, such as genomic, proteomic, and lifestyle data, could help understand the complex biological mechanisms behind CVD, including risk stratification in risk-exposed individuals. Predictive modelling is proposed to help in the development of personalized medicines, particularly in pharmacogenomics; understanding genetic variation might help to guide drug selection and dosing, with the consequent improvement in patient outcomes. To summarize, incorporating BDA into cardiovascular research and treatment represents a paradigm shift in our approach to CVD prevention, diagnosis, and management. By leveraging the power of big data, researchers and clinicians can gain deeper insights into disease mechanisms, improve patient care, and ultimately reduce the burden of cardiovascular disease on individuals and healthcare systems.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Evaluation of Bovine- and Porcine-Deproteinized Grafts for Guided Bone Regeneration: An In Vivo Study. 牛和猪去蛋白移植物引导骨再生的比较评价：体内研究。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-26 DOI: 10.3390/bioengineering12050459

Blaire V Slavin, Vasudev Vivekanand Nayak, Marcelo Parra, Robert D Spielman, Matteo S Torquati, Nicholas J Iglesias, Paulo G Coelho, Lukasz Witek

{"title":"Comparative Evaluation of Bovine- and Porcine-Deproteinized Grafts for Guided Bone Regeneration: An In Vivo Study.","authors":"Blaire V Slavin, Vasudev Vivekanand Nayak, Marcelo Parra, Robert D Spielman, Matteo S Torquati, Nicholas J Iglesias, Paulo G Coelho, Lukasz Witek","doi":"10.3390/bioengineering12050459","DOIUrl":"https://doi.org/10.3390/bioengineering12050459","url":null,"abstract":"Guided bone regeneration (GBR) procedures have been indicated to enhance bone response, reliably regenerate lost tissue, and create an anatomically pleasing ridge contour for biomechanically favorable and prosthetically driven implant placement. The aim of the current study was to evaluate and compare the bone regenerative performance of deproteinized bovine bone (DBB) and deproteinized porcine bone (DPB) grafts in a beagle mandibular model for the purposes of GBR. Four bilateral defects of 10 mm × 10 mm were induced through the mandibular thickness in each of the 10 adult beagle dogs being studied. Two of the defects were filled with DPB, while the other two were filled with DBB, after which they were covered with collagen-based membranes to allow compartmentalized healing. Animals were euthanized after 6, 12, 24, or 48 weeks postoperatively. Bone regenerative capacity was evaluated by qualitative histological and quantitative microtomographic analyses. Microcomputed tomography data of the bone (%), graft (%), and space (%) were compared using a mixed model analysis. Qualitatively, no histomorphological differences in healing were observed between the DBB and DPB grafts at any time point. By 48 weeks, the xenografts (DBB and DPB) were observed to have osseointegrated with regenerating spongy bone and a close resemblance to native bone morphology. Quantitatively, a higher amount of bone (%) and a corresponding reduction in empty space (space (%)) were observed in defects treated by DBB and DPB grafts over time. However, no statistically significant differences in bone (%)were observed between DBB (71.04 ± 8.41 at 48 weeks) and DPB grafts (68.38 ± 10.30 at 48 weeks) (p > 0.05). GBR with DBB and DPB showed no signs of adverse immune response and led to similar trends in bone regeneration over 48 weeks of permitted healing.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogas Digestate and Its Electrodialysis Concentrate as Alternative Media Composition for A. platensis Cultivation: A Study on Nutrient Recovery from Dairy Wastewater. 沼气池及其电透析浓缩液作为白僵菌栽培的替代培养基——乳品废水中养分回收的研究。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-26 DOI: 10.3390/bioengineering12050460

Elena Singer, Sun-Hwa Jung, Vivekanand Vivekanand, Christoph Lindenberger

{"title":"Biogas Digestate and Its Electrodialysis Concentrate as Alternative Media Composition for A. platensis Cultivation: A Study on Nutrient Recovery from Dairy Wastewater.","authors":"Elena Singer, Sun-Hwa Jung, Vivekanand Vivekanand, Christoph Lindenberger","doi":"10.3390/bioengineering12050460","DOIUrl":"https://doi.org/10.3390/bioengineering12050460","url":null,"abstract":"The dairy industry generates substantial nutrient-rich wastewater, posing environmental challenges if discharged untreated. This study explores the potential of using the cyanobacterium Arthrospira platensis for nutrient recovery from dairy wastewater, precisely the liquid biogas digestate (BD). The research investigates the feasibility of utilising BD and electrodialysis-concentrated BD (BD concentrate) as alternative media for A. platensis cultivation, with a focus on biomass productivity, nutrient uptake, and high-value product formation. Batch and continuous cultivation modes were employed. In batch experiments, biomass productivity was in the ratio of 0 and 0.27 g L-1 d-1, which was 8-100% lower than simulated values for all five tested media compositions. Phosphate fixation was limited with no fixation during batch cultivation and 8-69% during continuous cultivation, likely due to suboptimal N/P ratios, while ammonium removal remained consistently high (>98%). Phycocyanin yield decreased significantly by 92% at high BD concentrate concentrations compared to standard media. Continuous cultivation with 50% BD concentrate improved biomass productivity to 1.02 g L-1 d-1 and pigment yield to 107.9 mg g-1, suggesting a sufficient supply of nutrients. The findings highlight the potential of BD-based media for nutrient recovery but emphasise the need for optimisation strategies, such as nutrient supplementation and microbial adaptation, to enhance performance.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putative Endoplasmic Reticulum Stress Inducers Enhance Triacylglycerol Accumulation in Chlorella sorokiniana. 内质网应激诱导剂促进小球藻甘油三酯积累。

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-25 DOI: 10.3390/bioengineering12050452

Yoomi Roh, Sujeong Je, Naeun Sheen, Chang Hun Shin, Yasuyo Yamaoka

{"title":"Putative Endoplasmic Reticulum Stress Inducers Enhance Triacylglycerol Accumulation in Chlorella sorokiniana.","authors":"Yoomi Roh, Sujeong Je, Naeun Sheen, Chang Hun Shin, Yasuyo Yamaoka","doi":"10.3390/bioengineering12050452","DOIUrl":"https://doi.org/10.3390/bioengineering12050452","url":null,"abstract":"Chlorella, recognized for its high lipid and protein content, is increasingly studied for its potential in the food and bio industries. To enhance its production and understand the underlying mechanisms of lipid accumulation, this study investigated the role of endoplasmic reticulum (ER) stress in modulating lipid metabolism in Chlorella sorokiniana UTEX 2714, using six putative ER stress inducers: 2-deoxy-D-glucose (2-DG), dithiothreitol (DTT), tunicamycin (TM), thapsigargin (TG), brefeldin A (BFA), and monensin (Mon). The results showed that 2-DG, DTT, TM, BFA, and Mon significantly inhibited cell growth in C. sorokiniana. Treatment with 2-DG, DTT, TM, BFA, or Mon resulted in substantial increases in the triacylglycerol (TAG) to total fatty acid (tFA) ratio, with fold changes of 14.8, 7.9, 6.2, 10.1, and 8.9, respectively. Among the tFAs, cells treated with these compounds exhibited higher levels of saturated fatty acids and lower levels of polyunsaturated fatty acids (PUFAs). In contrast, the fatty acid composition of TAGs showed the opposite trend, with relative enrichment in PUFAs. This study enhances our understanding of Chlorella lipid metabolism, providing valuable insights for optimizing lipid production, particularly TAGs enriched with PUFA content, for applications in functional foods, nutraceuticals, and sustainable bioresources.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiomics Analysis of Whole-Kidney Non-Contrast CT for Early Identification of Chronic Kidney Disease Stages 1-3. 慢性肾脏疾病1-3期早期全肾非对比CT放射组学分析

IF 3.8 3区医学

Bioengineering Pub Date : 2025-04-25 DOI: 10.3390/bioengineering12050454

Guirong Zhang, Pan Zhang, Yuwei Xia, Feng Shi, Yuelang Zhang, Dun Ding

{"title":"Radiomics Analysis of Whole-Kidney Non-Contrast CT for Early Identification of Chronic Kidney Disease Stages 1-3.","authors":"Guirong Zhang, Pan Zhang, Yuwei Xia, Feng Shi, Yuelang Zhang, Dun Ding","doi":"10.3390/bioengineering12050454","DOIUrl":"https://doi.org/10.3390/bioengineering12050454","url":null,"abstract":"Background: The early stages of chronic kidney disease (CKD) are often undetectable on traditional non-contrast computed tomography (NCCT) images through visual assessment by radiologists. This study aims to evaluate the potential of radiomics-based quantitative features extracted from NCCT, combined with machine learning techniques, in differentiating CKD stages 1-3 from healthy controls.Methods: This retrospective study involved 1099 CKD patients (stages 1-3) and 1099 healthy participants who underwent NCCT. Bilateral kidney volumes of interest were automatically segmented using a deep learning-based segmentation approach (VB-net) on CT images. Radiomics models were constructed using the mean values of features extracted from both kidneys. Key features were selected through Relief, MRMR, and LASSO regression algorithms. A machine learning classifier was trained to differentiate CKD from healthy kidneys and compared with the radiologist assessments. Model performance was evaluated using the area under the curve (AUC) of receiver operating characteristic analysis.Results: In the training set, the AUCs for the Gaussian process (GP) classifier model and radiologist assessments were 0.849 and 0.570, respectively. In the testing set, the AUC values were 0.790 for the GP model and 0.575 for radiologist assessments.Conclusions: The NCCT-based radiomics model demonstrates significant clinical utility by enabling non-invasive, early diagnosis of CKD stages 1-3, outperforming radiologist assessments.","PeriodicalId":8874,"journal":{"name":"Bioengineering","volume":"12 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0