Bioscience of Microbiota, Food and Health最新文献_第9页

Isolation, identification, and impact on intestinal barrier integrity of Lactiplantibacillus plantarum from fresh tea leaves (Camellia sinensis). 鲜茶叶植物乳杆菌的分离鉴定及其对肠道屏障完整性的影响

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2021-01-01 Epub Date: 2021-08-06 DOI: 10.12938/bmfh.2020-083

Yuji Tsujikawa, Masahiko Suzuki, Iwao Sakane

{"title":"Isolation, identification, and impact on intestinal barrier integrity of Lactiplantibacillus plantarum from fresh tea leaves (Camellia sinensis).","authors":"Yuji Tsujikawa, Masahiko Suzuki, Iwao Sakane","doi":"10.12938/bmfh.2020-083","DOIUrl":"https://doi.org/10.12938/bmfh.2020-083","url":null,"abstract":"Lactic acid bacteria (LAB) are safe microorganisms that have been used in the processing of fermented food for centuries. The aim of this study was to isolate Lactobacillus from fresh tea leaves and examine the impact of an isolated strain on intestinal barrier integrity. First, the presence of Lactobacillus strains was investigated in fresh tea leaves from Kagoshima, Japan. Strains were isolated by growing on De Man, Rogosa and Sharpe (MRS) agar medium containing sodium carbonate, followed by the identification of one strain by polymerase chain reaction (PCR) and pheS sequence analysis, with the strain identified as Lactiplantibacillus plantarum and named L. plantarum LOC1. Second, the impact of strain LOC1 in its heat-inactivated form on intestinal barrier integrity was investigated. Strain LOC1, but not L. plantarum ATCC 14917T or L. plantarum ATCC 8014, significantly suppressed dextran sulfate sodium (DSS)-induced decreases in transepithelial electrical resistance values of Caco-2:HT29-MTX 100:0 and 90:10 co-cultures. Moreover, in Caco-2:HT29-MTX co-cultures (90:10 and 75:25), levels of occludin mRNA were significantly increased by strain LOC1 compared with untreated co-cultures, and strain LOC1 had higher mRNA levels of MUC2 and MUC4 mucins than L. plantarum ATCC 14917T and L. plantarum YT9. These results indicate that L. plantarum LOC1 may be used as a safe probiotic with beneficial effects on the intestinal barrier, suggesting that fresh tea leaves could be utilized as a safe source for isolating probiotics.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"40 4","pages":"186-195"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/02/bmfh-40-186.PMC8484006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39503447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

16S rDNA analysis of the intestinal microbes in osteoporotic rats. 骨质疏松大鼠肠道微生物16S rDNA分析。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2021-01-01 Epub Date: 2021-02-23 DOI: 10.12938/bmfh.2020-065

Yan Sun, Hui-Jie Zhang, Ran Chen, Hong-Bin Zhao, Wen-Hui Lee

{"title":"16S rDNA analysis of the intestinal microbes in osteoporotic rats.","authors":"Yan Sun, Hui-Jie Zhang, Ran Chen, Hong-Bin Zhao, Wen-Hui Lee","doi":"10.12938/bmfh.2020-065","DOIUrl":"https://doi.org/10.12938/bmfh.2020-065","url":null,"abstract":"This study aimed to reveal the differences in intestinal microbes in osteoporotic rats. The rats were divided into two groups: the control and OP (osteoporosis) groups (n=6). Days 0 and 70 were set as the time points. The rats in the OP group underwent bilateral ovariectomy (OVX). Differences between the control and OP groups were determined by 16S rDNA analysis. The relative abundances of OTUs and alpha/beta diversities were determined at days 0 days and 70. The abundances of Verrucomicrobia at the phylum level and Aerococcus, Coprobacillus, Veillonella, Anaerobiospirillum, Flavobacterium, Comamonadaceae, Ohtaekwangia, etc., at the genus level were found to be different between the control_70d and OP_70d groups. KEGG ontology analysis showed that the function of lipid metabolism could be related to OP. The 16S rDNA analysis in the OP rats revealed that intestinal microbes take part in the processes of OP and could affect lipid metabolism. Further study of the relationship between OP and intestinal microbes is necessary, and the prospect for intestinal microbes is a potential treatment for OP.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"40 3","pages":"156-167"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/66/bmfh-40-156.PMC8279887.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39203676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Isolation and identification of milk oligosaccharide-degrading bacteria from the intestinal contents of suckling rats. 乳大鼠肠道内容物中乳寡糖降解菌的分离鉴定。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2021-01-01 Epub Date: 2020-08-08 DOI: 10.12938/bmfh.2020-024

Hazuki Akazawa, Yuji Tsujikawa, Itsuko Fukuda, Yoshihiro Suzuki, Moonhak Choi, Takane Katayama, Takao Mukai, Ro Osawa

{"title":"Isolation and identification of milk oligosaccharide-degrading bacteria from the intestinal contents of suckling rats.","authors":"Hazuki Akazawa, Yuji Tsujikawa, Itsuko Fukuda, Yoshihiro Suzuki, Moonhak Choi, Takane Katayama, Takao Mukai, Ro Osawa","doi":"10.12938/bmfh.2020-024","DOIUrl":"https://doi.org/10.12938/bmfh.2020-024","url":null,"abstract":"We report the isolation of bacteria capable of degrading milk oligosaccharides from suckling infant rats. The bacteria were successfully isolated via a selective enrichment method, in which the serially diluted intestinal contents of infant rats were individually incubated in an enrichment medium containing 3'-sialyllactose (3'-SL), followed by the isolation of candidate strains from streaked agar plates and selection of 3'-SL-degrading strains using thin-layer chromatography. Subsequent genomic and phenotypic analyses identified all strains as Enterococcus gallinarum. The strains were capable of degrading both 3'-SL and 6'-SL, which was not observed with the type strain of E. gallinarum used as a reference. Furthermore, a time-course study combining high-performance anion-exchange chromatography with pulsed amperometric detection revealed that the representative strain AH4 degraded 3'-SL completely to yield an equimolar amount of lactose and an approximately one-fourth equimolar amount of sialic acid after 24 hr of anaerobic incubation. These findings point to a possibility that the enterococci degrade rat milk oligosaccharides to \"cross-feed\" their degradants to other members of concomitant bacteria in the gut of the infant rat.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"40 1","pages":"27-32"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/93/bmfh-40-027.PMC7817515.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25315817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Correlation of gut Firmicutes/Bacteroidetes ratio with fibrosis and steatosis stratified by body mass index in patients with non-alcoholic fatty liver disease. 非酒精性脂肪肝患者肠道厚壁菌门/拟杆菌门比值与按体重指数分层的纤维化和脂肪变性的相关性

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2021-01-01 Epub Date: 2020-09-15 DOI: 10.12938/bmfh.2020-046

Chyntia Olivia Maurine Jasirwan, Akhmadu Muradi, Irsan Hasan, Marcellus Simadibrata, Ikhwan Rinaldi

{"title":"Correlation of gut Firmicutes/Bacteroidetes ratio with fibrosis and steatosis stratified by body mass index in patients with non-alcoholic fatty liver disease.","authors":"Chyntia Olivia Maurine Jasirwan, Akhmadu Muradi, Irsan Hasan, Marcellus Simadibrata, Ikhwan Rinaldi","doi":"10.12938/bmfh.2020-046","DOIUrl":"https://doi.org/10.12938/bmfh.2020-046","url":null,"abstract":"We investigated the gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) and its correlation with fibrosis and steatosis stratified by body mass index, as reflected in the controlled attenuation parameter and transient elastography values. A cross-sectional study was performed on 37 patients with NAFLD at Cipto Mangunkusumo National General Hospital from December 2018 to March 2019. The gut microbiota was investigated in fecal samples with 16S RNA sequencing using the MiSeq next-generation sequencing platform (Illumina). NAFLD was more common in patients with metabolic syndrome. Firmicutes, Bacteroidetes, and Proteobacteria were the predominant phyla. Bacteroides was more dominant than Prevotella, contrary to the results of previous studies on healthy populations in Indonesia. Microbiota dysbiosis was observed in most samples. The gastrointestinal microbiota diversity was significantly decreased in patients with NAFLD, high triglyceride levels, and central obesity. The Firmicutes/Bacteroidetes ratio correlated with steatosis and obesity, whereas some of the other species in lower taxonomy levels were mostly associated with steatosis and obesity without fibrosis. Proteobacteria was the only phylum strongly correlated with fibrosis in patients with an average body mass index. The gut microbiota diversity was decreased in patients with NAFLD, high triglyceride levels, and central obesity, and certain gut microbes were correlated with fibrosis and steatosis.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"40 1","pages":"50-58"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/71/66/bmfh-40-050.PMC7817510.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25316304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Lowering effect of viable Pediococcus pentosaceus QU 19 on the rise in postprandial glucose. 活菌戊糖Pediococcus qu19对餐后血糖升高的降低作用。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2020-01-01 Epub Date: 2020-01-25 DOI: 10.12938/bmfh.19-041

Miki Fujiwara, Daichi Kuwahara, Masahiro Hayashi, Takeshi Zendo, Masao Sato, Jiro Nakayama, Kenji Sonomoto

{"title":"Lowering effect of viable Pediococcus pentosaceus QU 19 on the rise in postprandial glucose.","authors":"Miki Fujiwara, Daichi Kuwahara, Masahiro Hayashi, Takeshi Zendo, Masao Sato, Jiro Nakayama, Kenji Sonomoto","doi":"10.12938/bmfh.19-041","DOIUrl":"https://doi.org/10.12938/bmfh.19-041","url":null,"abstract":"In the present study, we investigated the glucose-decreasing action of lactic acid bacteria (LAB). The finding of this study could be helpful for people in controlling their blood sugar levels. The LAB candidate was isolated from a Japanese fermented food and identified as Pediococcus pentosaceus by an analysis of its genome sequence. Postprandial blood glucose elevation was investigated using oral starch tolerance tests in mice. Normal mice were fed starch and lyophilized cells of P. pentosaceus QU 19 at the same time. Even without pre-administration of P. pentosaceus QU 19, elevation of the blood glucose level was significantly suppressed by the intake of P. pentosaceus QU 19 at the same time as oral administration of starch. According to the results for its survival in simulated digestive juice and the reduction of blood glucose level in mice, P. pentosaceus QU 19 has potential hypoglycemic activity. In vitro measurements revealed that the glucose-decreasing action of P. pentosaceus QU 19 is probably caused by the glucose assimilation of the strain, not the inhibition of carbohydrate-splitting enzymes which has been reported for other LABs previously. These findings indicate that specific strains of LAB, especially P. pentosaceus QU 19, and foods fermented by LAB may be beneficial for people who must manage glucose ingestion.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"39 2","pages":"57-64"},"PeriodicalIF":3.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.12938/bmfh.19-041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37867425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Reduction of sterigmatocystin biosynthesis and growth of food-borne fungi by lactic acid. 乳酸可减少固型半胱氨酸的生物合成和食源性真菌的生长。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2020-01-01 Epub Date: 2020-02-10 DOI: 10.12938/bmfh.2019-029

Slobodanka StanojeviĆ-NikoliĆ, Gordana DimiĆ, Ljiljana MojoviĆ, Jelena Pejin, Miloš RadosavljeviĆ, Aleksandra ĐukiĆ-VukoviĆ, Dragana MladenoviĆ, Sunčica KociĆ-Tanackov

{"title":"Reduction of sterigmatocystin biosynthesis and growth of food-borne fungi by lactic acid.","authors":"Slobodanka StanojeviĆ-NikoliĆ, Gordana DimiĆ, Ljiljana MojoviĆ, Jelena Pejin, Miloš RadosavljeviĆ, Aleksandra ĐukiĆ-VukoviĆ, Dragana MladenoviĆ, Sunčica KociĆ-Tanackov","doi":"10.12938/bmfh.2019-029","DOIUrl":"10.12938/bmfh.2019-029","url":null,"abstract":"Food contamination by fungi and mycotoxins presents a problem for food safety even today. Since lactic acid (LA) has Generally Recognized As Safe (GRAS) status, the aim of this research was to determine its potential in protection of food against mycological and mycotoxicological contamination. In this study, LA showed an inhibitory effect on the growth of food-borne fungi (Penicillium aurantiogriseum K51, Aspergillus parasiticus KB31, Aspergillus versicolor S72, and Aspergillus niger K95) and on biosynthesis of sterigmatocystin (STE). For the antifungal effect of LA on the growth of food-borne fungi, the disc diffusion and microdilution methods were performed. The effect of LA on the STE biosynthesis by A. versicolor was determined using an LC-MS/MS technique. The largest inhibition zone was observed for A. versicolor (inhibition zone of 24 ± 0.35 mm), while there were no inhibition zones for A. niger and A. parasiticus at all tested LA concentrations. The minimal inhibitory concentration (MIC) of LA on fungi ranged from 25.0 mg/mL to 50.0 mg/mL, while the minimum fungicidal concentrations (MFCs) ranged from 50.0 mg/mL to 100.0 mg/mL. Complete inhibition of STE biosynthesis by A. versicolor was observed at an LA concentration of 50.0 mg/mL. The obtained results showed that LA could be efficient for protection of food against mycological and STE contamination.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"39 3","pages":"83-88"},"PeriodicalIF":3.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/38/bmfh-39-083.PMC7392911.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38247861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and characterization of Streptococcus thermophilus possessing prtS gene from raw milk in Japan. 日本原乳中含prtS基因嗜热链球菌的分离与鉴定。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2020-01-01 Epub Date: 2020-03-20 DOI: 10.12938/bmfh.2019-052

Eri Yamamoto, Reiko Watanabe, Akiko Koizumi, Tatsuya Ishida, Katsunori Kimura

{"title":"Isolation and characterization of Streptococcus thermophilus possessing prtS gene from raw milk in Japan.","authors":"Eri Yamamoto, Reiko Watanabe, Akiko Koizumi, Tatsuya Ishida, Katsunori Kimura","doi":"10.12938/bmfh.2019-052","DOIUrl":"https://doi.org/10.12938/bmfh.2019-052","url":null,"abstract":"Streptococcus thermophilus is widely used for producing fermented dairy products such as yogurt and cheese. Some S. thermophilus strains possessing the cell-wall protease PrtS show high proteolytic activity and fast acidification properties, which are very useful in industrial starters. However, few S. thermophilus strains possessing the prtS gene have been isolated from the environment. To clarify whether or not S. thermophilus strains possessing the prtS gene are present in Japan, we isolated S. thermophilus from raw milk collected in Japan from 2011 to 2017 and investigated the strains for the presence of prtS by PCR. A total of 172 S. thermophilus strains were isolated, and 59 strains were confirmed to possess prtS. We measured fermentation times of 59 prtS-positive strains in skim milk broth and found that 53 strains showed fast acidification properties, finishing fermentation within 10 hr. However, the remaining 6 prtS-positive strains showed slow acidification properties, and they had several amino acid mutations in PrtS compared with fast acidifying S. thermophilus LMD-9 and 4F44. These results demonstrate that S. thermophilus strains possessing prtS are prevalent in Japan and that some prtS-positive strains could lose their fast acidifying properties through mutations in PrtS.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"39 3","pages":"169-174"},"PeriodicalIF":3.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/1d/bmfh-39-169.PMC7392909.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38256330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Differences in gut microbial patterns associated with salivary biomarkers in young Japanese adults. 日本年轻人唾液生物标志物与肠道微生物模式的差异

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2020-01-01 Epub Date: 2020-08-01 DOI: 10.12938/bmfh.2019-034

Takahiro Seura, Tsutomu Fukuwatari

{"title":"Differences in gut microbial patterns associated with salivary biomarkers in young Japanese adults.","authors":"Takahiro Seura, Tsutomu Fukuwatari","doi":"10.12938/bmfh.2019-034","DOIUrl":"https://doi.org/10.12938/bmfh.2019-034","url":null,"abstract":"Recent evidence suggests that psychological stress is associated with gut microbiota; however, there are no reports of its association with gut microbial structure. This cross-sectional study examined the relationship between psychological stress and gut microbial patterns in young Japanese adults. Analysis of fecal microbiota was performed using terminal restriction fragment length polymorphism (T-RFLP). Psychological stress was assessed using salivary biomarkers, including cortisol, alpha-amylase, and secretory IgA (S-IgA). Fecal microbial patterns were defined using principal component analysis of the T-RFLP profile and were classified into two enterotype-like clusters, which were defined by the B (microbiota dominated by Bacteroides) and BL patterns (microbiota dominated by Bifidobacterium and Lactobacillales), respectively. The Simpson index was significantly higher for the BL pattern than for the B pattern. The salivary cortisol level was significantly lower for the BL pattern than for the B pattern. Salivary alpha-amylase and S-IgA levels showed a negative correlation with the Simpson index. Our results raise the possibility that salivary biomarkers may be involved in the observed differences in microbial patterns.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"39 4","pages":"243-249"},"PeriodicalIF":3.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38644057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Corrigendum: Suppressive effect of dietary resistant maltodextrin on systemic immunity in a mouse model of food allergy. 更正：在食物过敏小鼠模型中，膳食抗性麦芽糊精对系统免疫的抑制作用。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2020-01-01 Epub Date: 2020-10-13 DOI: 10.12938/bmfh.18-025c

引用次数: 0

Gut microbiota-derived metabolites in obesity: a systematic review. 肥胖症中肠道微生物衍生代谢物:系统综述。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2020-01-01 Epub Date: 2020-02-13 DOI: 10.12938/bmfh.2019-026

Hanieh-Sadat Ejtahed, Pooneh Angoorani, Ahmad-Reza Soroush, Shirin Hasani-Ranjbar, Seyed-Davar Siadat, Bagher Larijani

{"title":"Gut microbiota-derived metabolites in obesity: a systematic review.","authors":"Hanieh-Sadat Ejtahed, Pooneh Angoorani, Ahmad-Reza Soroush, Shirin Hasani-Ranjbar, Seyed-Davar Siadat, Bagher Larijani","doi":"10.12938/bmfh.2019-026","DOIUrl":"https://doi.org/10.12938/bmfh.2019-026","url":null,"abstract":"Recent evidence suggests that gut microbiota-derived metabolites affect many biological processes of the host, including appetite control and weight management. Dysbiosis of the gut microbiome in obesity influences the metabolism and excretion of gut microbiota byproducts and consequently affects the physiology of the host. Since identification of the gut microbiota-host co-metabolites is essential for clarifying the interactions between the intestinal flora and the host, we conducted this systematic review to summarize all human studies that characterized the gut microbiota-related metabolites in overweight and obese individuals. A comprehensive search of the PubMed, Web of Science, and Scopus databases yielded 2,137 articles documented up to July 2018. After screening abstracts and full texts, 12 articles that used different biosamples and methodologies of metabolic profiling and fecal microbiota analysis were included. Amino acids and byproducts of amino acids, lipids and lipid-like metabolites, bile acids derivatives, and other metabolites derived from degradation of carnitine, choline, polyphenols, and purines are among the gut microbiota-derived metabolites which showed alterations in obesity. These metabolites play an important role in metabolic complications of obesity, including insulin resistance, hyperglycemia, and dyslipidemia. The results of this study could be useful in development of therapeutic strategies with the aim of modulating gut microbiota and consequently the metabolic profile in obesity.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"39 3","pages":"65-76"},"PeriodicalIF":3.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.12938/bmfh.2019-026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38247859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37