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A comprehensive search of the PubMed, Web of Science, and Scopus databases yielded 2,137 articles documented up to July 2018. After screening abstracts and full texts, 12 articles that used different biosamples and methodologies of metabolic profiling and fecal microbiota analysis were included. Amino acids and byproducts of amino acids, lipids and lipid-like metabolites, bile acids derivatives, and other metabolites derived from degradation of carnitine, choline, polyphenols, and purines are among the gut microbiota-derived metabolites which showed alterations in obesity. These metabolites play an important role in metabolic complications of obesity, including insulin resistance, hyperglycemia, and dyslipidemia. 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引用次数: 37
摘要
最近的证据表明,肠道微生物衍生的代谢物影响宿主的许多生物过程,包括食欲控制和体重管理。肥胖患者肠道菌群失调会影响肠道菌群副产物的代谢和排泄,从而影响宿主的生理机能。由于肠道菌群-宿主共代谢物的鉴定对于阐明肠道菌群与宿主之间的相互作用至关重要,因此我们进行了本系统综述,总结了超重和肥胖个体中肠道菌群相关代谢物的所有人类研究。对PubMed、Web of Science和Scopus数据库的全面搜索得出了截至2018年7月的2137篇文献。筛选摘要和全文后,纳入了12篇使用不同生物样本和方法进行代谢分析和粪便微生物群分析的文章。氨基酸和氨基酸的副产物、脂质和类脂代谢产物、胆汁酸衍生物,以及由肉毒碱、胆碱、多酚和嘌呤降解产生的其他代谢产物,都是肠道微生物衍生的代谢产物,在肥胖中表现出改变。这些代谢物在肥胖的代谢并发症中起重要作用,包括胰岛素抵抗、高血糖和血脂异常。这项研究的结果可能有助于制定治疗策略,以调节肠道微生物群,从而调节肥胖的代谢谱。
Gut microbiota-derived metabolites in obesity: a systematic review.
Recent evidence suggests that gut microbiota-derived metabolites affect many biological processes of the host, including appetite control and weight management. Dysbiosis of the gut microbiome in obesity influences the metabolism and excretion of gut microbiota byproducts and consequently affects the physiology of the host. Since identification of the gut microbiota-host co-metabolites is essential for clarifying the interactions between the intestinal flora and the host, we conducted this systematic review to summarize all human studies that characterized the gut microbiota-related metabolites in overweight and obese individuals. A comprehensive search of the PubMed, Web of Science, and Scopus databases yielded 2,137 articles documented up to July 2018. After screening abstracts and full texts, 12 articles that used different biosamples and methodologies of metabolic profiling and fecal microbiota analysis were included. Amino acids and byproducts of amino acids, lipids and lipid-like metabolites, bile acids derivatives, and other metabolites derived from degradation of carnitine, choline, polyphenols, and purines are among the gut microbiota-derived metabolites which showed alterations in obesity. These metabolites play an important role in metabolic complications of obesity, including insulin resistance, hyperglycemia, and dyslipidemia. The results of this study could be useful in development of therapeutic strategies with the aim of modulating gut microbiota and consequently the metabolic profile in obesity.
期刊介绍:
Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.