ASAIO Journal最新文献_第6页

Fluorescent Imaging-Guided Ligation of Lymphatic Leaks Following Decannulation From Extracorporeal Membrane Oxygenation. 体外膜氧合脱管后淋巴渗漏的荧光成像引导结扎。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-12 DOI: 10.1097/MAT.0000000000002478

Hamzah Almadani, Youssef Aref, Zachary Brennan, Andrew Cantor, Tyler Gunn, Philip S Brazio

{"title":"Fluorescent Imaging-Guided Ligation of Lymphatic Leaks Following Decannulation From Extracorporeal Membrane Oxygenation.","authors":"Hamzah Almadani, Youssef Aref, Zachary Brennan, Andrew Cantor, Tyler Gunn, Philip S Brazio","doi":"10.1097/MAT.0000000000002478","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002478","url":null,"abstract":"Lymphocele is a known complication of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). We present a novel application of fluorescent lymphatic imaging for the highly selective treatment of lymphatic leaks after VA-ECMO and describe patient outcomes at our institution. A retrospective review of patients who underwent lymphatic ligation following VA-ECMO from 2022 to 2024 was performed. Fluorescent imaging and intradermal indocyanine green injection were used to identify and ligate lymphatic leaks within the debrided wound bed. Ten patients with a mean age of 48.3 years were included. The mean number of lymphatics ligated was 5. Mean days from decannulation to ligation and from ligation to drain removal were 18.4 and 22.2, respectively. There was a significant decrease in drain output immediately following ligation (197.4 ml/day vs. 64.2 ml/day; p = 0.016). A shorter time from decannulation to ligation was significantly correlated with a decrease in drain output. A higher drain fluid lymphocyte percentage was significantly correlated with a shorter time to drain removal. Fluorescent imaging-guided lymphatic ligation is an effective method for treating lymphatic leak after decannulation from VA-ECMO. Drain fluid analysis and early consultation with plastic surgery should be encouraged in the event of high-output lymphocele.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Therapeutic Drug Monitoring to Personalize Antifungals for Blastomycosis in Pediatric Patients on Extracorporeal Membrane Oxygenation: A Case Series. 应用治疗性药物监测个体化治疗体外膜氧合治疗的儿童芽孢菌病：一个病例系列。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-12 DOI: 10.1097/MAT.0000000000002480

Rana Khafagy, Erin Chung, Anne-Marie Guerguerian, Cory Anderson, Elaine Gilfoyle, Mark Todd, Sandra Pong, Mariella Vargas-Gutierrez, Gail Annich

{"title":"Use of Therapeutic Drug Monitoring to Personalize Antifungals for Blastomycosis in Pediatric Patients on Extracorporeal Membrane Oxygenation: A Case Series.","authors":"Rana Khafagy, Erin Chung, Anne-Marie Guerguerian, Cory Anderson, Elaine Gilfoyle, Mark Todd, Sandra Pong, Mariella Vargas-Gutierrez, Gail Annich","doi":"10.1097/MAT.0000000000002480","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002480","url":null,"abstract":"Amphotericin B and posaconazole are used in the treatment of pulmonary blastomycosis. Previous reports found inadequate treatment to both antifungals due to potential sequestration in extracorporeal membrane oxygenation (ECMO). There is a lack of evidence supporting routine use of therapeutic drug monitoring (TDM) with these agents. We report amphotericin B and posaconazole TDM in two separate cases of patients with pulmonary blastomycosis and on ECMO. Plasma concentrations were collected pre- and post-ECMO membranes and used to calculate pharmacokinetic and pharmacodynamic parameters. Drug sequestration within ECMO was not evident in our cases. As such, we speculate the drugs may have saturated the circuits over time. TDM of amphotericin B and posaconazole may be beneficial in pediatric patients on ECMO, especially near initiation of therapy or after a circuit change. Further studies are warranted to evaluate the relationship between plasma concentrations of these antifungals and efficacy and safety outcomes.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing the Chill: A Critical Perspective on SherpaPak Versus Ice Storage in Heart Transplantation. 重新评估寒冷：心脏移植中SherpaPak与冰储存的关键观点。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-12 DOI: 10.1097/MAT.0000000000002481

Ibrahim Nagmeldin Hassan

引用次数: 0

Enhancing Survival Prediction After Venoarterial Extracorporeal Membrane Oxygenation Using Machine Learning. 利用机器学习增强静脉体外膜氧合后的生存预测。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-02 DOI: 10.1097/MAT.0000000000002475

Albert Leng, Preetham Bachina, Olivia Liu, Benjamin Shou, Charles Racz, David A Giliver, Ilya Shpitser, Glenn J R Whitman, Sung-Min Cho

{"title":"Enhancing Survival Prediction After Venoarterial Extracorporeal Membrane Oxygenation Using Machine Learning.","authors":"Albert Leng, Preetham Bachina, Olivia Liu, Benjamin Shou, Charles Racz, David A Giliver, Ilya Shpitser, Glenn J R Whitman, Sung-Min Cho","doi":"10.1097/MAT.0000000000002475","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002475","url":null,"abstract":"In-hospital mortality after venoarterial extracorporeal membrane oxygenation (VA-ECMO) remains high. This study compared the performance of the Survival after Venoarterial ECMO (SAVE) score with machine learning (ML) models incorporating rich electronic medical record data to evaluate survival for patients on VA-ECMO support. We retrospectively reviewed adults undergoing VA-ECMO (2016-2022) at a single tertiary care center. The CatBoost algorithm was trained using leave-one-out cross-validation (LOOCV) on 74 extracted vital signs, laboratory values, and ventilator settings. Shapley Additive Explanations (SHAP) was used to identify key predictive features for logistic regression. Overall, 194 VA-ECMO patients (median age = 58 years, 36.6% female) were included, with 133 (69%) experiencing mortality. The SAVE score was compared to two predictive models: a pre-ECMO model (≤ 24 hours before cannulation) and an on-ECMO model (including up to the first 48 hours of ECMO). The LOOCV area under the receiver-operator characteristics curves (AUC) for the SAVE score, pre-ECMO, and on-ECMO models was 0.73, 0.77, and 0.83, respectively. Logistic regressions using ML-identified variables showed stepwise AUC improvements: 0.82 (pre-ECMO), 0.86 (on-ECMO), and 0.89 (combined). A novel, interpretable ML model predicted survival for VA-ECMO patients with accuracy comparable to the SAVE score. Incorporating on-ECMO variables significantly increased predictive performance and revealed novel variables associated with survival.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Practice With Preprimed Extracorporeal Membrane Oxygenation: Safety, Sterility, and Functionality. 体外膜充氧的临床实践：安全性、无菌性和功能性。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-01 Epub Date: 2024-12-16 DOI: 10.1097/MAT.0000000000002361

Mauro Renghini, Debora Maddinelli, Anna Papeo, Carmine Puglia, Andrea Montisci, Sergio Cattaneo, Stefano Benussi

{"title":"Clinical Practice With Preprimed Extracorporeal Membrane Oxygenation: Safety, Sterility, and Functionality.","authors":"Mauro Renghini, Debora Maddinelli, Anna Papeo, Carmine Puglia, Andrea Montisci, Sergio Cattaneo, Stefano Benussi","doi":"10.1097/MAT.0000000000002361","DOIUrl":"10.1097/MAT.0000000000002361","url":null,"abstract":"This 5 year retrospective study presents the clinical experience with preprimed extracorporeal membrane oxygenation (ECMO) circuits used in a Single Hub Center Hospital, focusing on sterility, functionality, and safety. The ECMO program has been active since 2019, with a total of 223 circuits managed. Our preassembled and preprimed ECMO circuits were stored in a sterile environment and continuously circulated until implantation. Sterility and functionality testing was performed at the end of circuit preparation, every 7 days, and before implantation. Our results show that only 2 (0.3%) of the 570 samples tested positive for bacteria, and all implanted devices demonstrated satisfactory gas transfer performance. None of the ECMO devices demonstrated any loss of early functionality after implantation. The longest storage period of a preprimed circuit was 73 days, with no positive culture results. Our study highlights the importance of preassembled and preprimed ECMO circuits in improving clinical practice in emergency situations, highlighting their safety and potential to improve clinical practice. Furthermore, our findings suggest that standardizing guidelines for prepriming and storage of ECMO circuits can help minimize the risk of contamination.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"454-460"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Smart Computational Tool for Personalized Coronary Blood Flow Settings During Normothermic Ex Situ Heart Perfusion. 一个智能的计算工具，个性化冠状动脉血流设置在常温非原位心脏灌注。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-01 Epub Date: 2025-02-20 DOI: 10.1097/MAT.0000000000002394

Jorik H Amesz, Niki L Lupgens, Dirk J Duncker, Lisa E Sluijter-Rozendaal, Dwight Dumay, Olivier C Manintveld, Yannick J H J Taverne

{"title":"A Smart Computational Tool for Personalized Coronary Blood Flow Settings During Normothermic Ex Situ Heart Perfusion.","authors":"Jorik H Amesz, Niki L Lupgens, Dirk J Duncker, Lisa E Sluijter-Rozendaal, Dwight Dumay, Olivier C Manintveld, Yannick J H J Taverne","doi":"10.1097/MAT.0000000000002394","DOIUrl":"10.1097/MAT.0000000000002394","url":null,"abstract":"Myocardial edema significantly develops during current subnormothermic ex situ heart perfusion (ESHP) procedures, resulting in myocardial function decline during prolonged perfusion. A relatively high coronary blood flow (CBF) during ESHP is thought to be responsible for this high degree of myocardial edema formation. In this study, we present a novel tool to calculate CBF based on individual donor (sex and body weight) and perfusate (hemoglobin concentration, oxygen saturation, partial pressure of oxygen [PO 2 ]) characteristics. The tool continuously evaluates the balance between myocardial oxygen consumption (MVO 2 ) and delivery to facilitate adequate and preventing excess perfusion. Taking this personalized approach, the CBF can potentially be lowered while still providing sufficient oxygen to the donor heart. Furthermore, the tool automatically calculates MVO 2 , ΔPO 2 , and coronary vascular resistance during ESHP, which aids in the qualitative assessment of the heart before transplantation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e90-e93"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventricular Assist Device Implantation in a Patient Congenitally Corrected Transposition of the Great Arteries With I, D, D. 为一名患有 I、D、D 先天性大动脉转位的患者植入心室辅助装置

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-01 Epub Date: 2025-02-28 DOI: 10.1097/MAT.0000000000002388

Yongfeng Sun, Yuehang Yang, Jing Zhang, Jiawei Shi, Cheng Zhou

{"title":"Ventricular Assist Device Implantation in a Patient Congenitally Corrected Transposition of the Great Arteries With I, D, D.","authors":"Yongfeng Sun, Yuehang Yang, Jing Zhang, Jiawei Shi, Cheng Zhou","doi":"10.1097/MAT.0000000000002388","DOIUrl":"10.1097/MAT.0000000000002388","url":null,"abstract":"Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart anomaly that often leads to systemic heart failure, necessitating mechanical circulatory support or transplantation. We report a case of a 54 year old male diagnosed with dextrocardia and ccTGA (I, D, D), who had been suffering from congestive heart failure for over 7 years. Despite receiving intensive treatment, his condition deteriorated. Preoperative evaluation revealed significant systemic right ventricular dysfunction with severe valvular regurgitation and pulmonary hypertension. The surgical approach included tricuspid and aortic bioprosthetic valve replacement, mitral valve annuloplasty, and right thoracic ventricular assist device (VAD) implantation. The patient recovered well postoperatively and was discharged on postoperative day 39 with New York Heart Association (NYHA) class I. This case demonstrates the feasibility of using VAD in right heart ccTGA as a bridge to transplantation or destination therapy, emphasizing the importance of meticulous preoperative planning and intraoperative management for successful outcomes.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e97-e99"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Intervention for Outflow Graft Obstruction in Patients With Magnetically Levitated Centrifugal-Flow Left Ventricular Assist Devices. 采用磁悬浮离心流左心室辅助装置患者流出部移植物梗阻的手术干预。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-01 Epub Date: 2025-03-06 DOI: 10.1097/MAT.0000000000002412

Krish C Dewan, Alejandro Alvarez Lobo, Jacob N Schroder, Jeffrey E Keenan, Adam D DeVore, Stuart D Russell, Carmelo A Milano

{"title":"Surgical Intervention for Outflow Graft Obstruction in Patients With Magnetically Levitated Centrifugal-Flow Left Ventricular Assist Devices.","authors":"Krish C Dewan, Alejandro Alvarez Lobo, Jacob N Schroder, Jeffrey E Keenan, Adam D DeVore, Stuart D Russell, Carmelo A Milano","doi":"10.1097/MAT.0000000000002412","DOIUrl":"10.1097/MAT.0000000000002412","url":null,"abstract":"Outflow graft obstruction (OGO) is an under-reported but severe complication after insertion of magnetically levitated centrifugal-flow left ventricular assist devices (LVADs). The optimal treatment and long-term outcomes have not been well-described. We report a retrospective single high-volume center's experience with surgical exploration for OGO from June 2019 to October 2023. Outflow graft obstruction was identified in 19 LVAD recipients from a total experience of 550 LVAD implants (3.3%). Median time of LVAD support to development of OGO was 32.5 months (interquartile range [IQR], 28-47.5). Low-flow alarms were the most common presentation, followed by dyspnea on exertion, and syncope. Computed tomography angiography (CTA) and echocardiography were the most common diagnostic modalities. Aortic valve opening with every beat and worsened mitral insufficiency were both more common at presentation compared to prior echocardiographic studies. Surgical excision of the bend relief (BR) and evacuation of proteinaceous material between the BR and the outflow graft immediately improved hemodynamics and LVAD function. There were no in-hospital mortalities, and all patients were discharged home after a median length of stay of 9 days (IQR, 10-21). All but four patients were alive at median follow-up 21 months. Thirteen of the 19 patients were readmitted a total of 50 times, none for recurrent OGO.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"437-444"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Different Membranes for Continuous Renal Replacement Therapies: An In Vitro Study. 连续肾替代治疗中不同膜的比较：一项体外研究。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-01 Epub Date: 2025-02-05 DOI: 10.1097/MAT.0000000000002387

Benjamin Malard, Michael Hulko, Julia Koch, Rose Speidel, Dominique Pouchoulin, Jorge Echeverri, Lenar Yessayan

{"title":"Comparison of Different Membranes for Continuous Renal Replacement Therapies: An In Vitro Study.","authors":"Benjamin Malard, Michael Hulko, Julia Koch, Rose Speidel, Dominique Pouchoulin, Jorge Echeverri, Lenar Yessayan","doi":"10.1097/MAT.0000000000002387","DOIUrl":"10.1097/MAT.0000000000002387","url":null,"abstract":"Inflammatory mediators play a major role in the development and progression of acute kidney injury (AKI). Continuous renal replacement therapy (CRRT) removes these mediators from the blood using AN69-M, AN69-ST, and HF1400 filters to target low and middle-molecular weight molecules. We characterized the in vitro removal performance of each filter in a 72 hour simulated CRRT procedure. Urea clearance with AN69-M and AN69-ST remained stable (52.4 and 51.2 ml/minute, respectively) but decreased with HF1400 (47.0 ml/minute; p < 0.001). Vancomycin clearance remained stable for AN69 filters but decreased for HF1400. Interleukin (IL)-8 was removed primarily via adsorption with the AN69 filters (92.2 and 91.2 ml/minute for AN69-M and AN69-ST, respectively), but clearance was significantly lower with HF1400 (8.4 ml/minute). Tumor necrosis factor (TNF)-α clearance was higher with AN69-ST compared with AN69-M or HF1400 (10.3, 1.8, and 2.3 ml/minute, respectively). β 2 -microglobulin clearance was higher with both AN69-based filters. The hydrogel water repartition of AN69 filters was different, with a higher percentage of bound water in AN69-ST versus AN69-M (30.5% ± 0.2% and 19.3% ± 1.5%, respectively; p < 0.05). These results suggest that clearance profiles of CRRT filters differ according to their properties; further investigation is needed to translate this into clinical improvements.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"510-518"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation. 静脉-静脉体外膜氧合右室损伤的定义和处理。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-01 Epub Date: 2025-01-09 DOI: 10.1097/MAT.0000000000002369

Siddharth Pawan Dugar, Ryota Sato, Matthew Charlton, Daisuke Hasegawa, Marta Velia Antonini, Prashant Nasa, Hakeem Yusuff, Marcus J Schultz, Mary Pat Harnegie, Kollengode Ramanathan, Kiran Shekar, Matthieu Schmidt, Vasileios Zochios, Abhijit Duggal

{"title":"Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation.","authors":"Siddharth Pawan Dugar, Ryota Sato, Matthew Charlton, Daisuke Hasegawa, Marta Velia Antonini, Prashant Nasa, Hakeem Yusuff, Marcus J Schultz, Mary Pat Harnegie, Kollengode Ramanathan, Kiran Shekar, Matthieu Schmidt, Vasileios Zochios, Abhijit Duggal","doi":"10.1097/MAT.0000000000002369","DOIUrl":"10.1097/MAT.0000000000002369","url":null,"abstract":"Right ventricular injury (RVI) in respiratory failure receiving veno-venous extracorporeal membrane oxygenation (VV ECMO) is associated with significant mortality. A scoping review is necessary to map the current literature and guide future research regarding the definition and management of RVI in patients receiving VV ECMO. We searched for relevant publications on RVI in patients receiving VV ECMO in Medline, EMBASE, and Web of Science. Of 1,868 citations screened, 30 studies reported on RVI (inclusive of right ventricular dilation, right ventricular dysfunction, and right ventricular failure) during VV ECMO. Twenty-three studies reported on the definition of RVI including echocardiographic indices of RV function and dimensions, whereas 13 studies reported on the management of RVI, including veno-pulmonary (VP) ECMO, veno-arterial (VA) ECMO, positive inotropic agents, pulmonary vasodilators, ultra-lung-protective ventilation (Ultra-LPV), and optimization of positive end-expiratory pressure (PEEP). The definitions of RVI in patients receiving VV ECMO used in the literature are heterogeneous. Despite the high incidence of RVI during VV ECMO support and its strong association with mortality, studies investigating therapeutic strategies for RVI are also lacking. To fill the existing knowledge gaps, a consensus on the definition of RVI and research investigating RV-targeted therapies during VV ECMO is urgently warranted.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"482-491"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0