ASAIO Journal最新文献_第6页

Preliminary Long-Term Biocompatibility Assessment of Penn State University Child Pump. 宾州州立大学儿童泵的初步长期生物相容性评估。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2024-10-11 DOI: 10.1097/MAT.0000000000002327

Choon-Sik Jhun, Joseph B Clark, Javier I Gentile, Joshua P Cysyk, Karl Bohnenberger, Christopher M Scheib, Jenelle Izer, Matthew Lanza, Mindy Tillinger, Heidi Flory, Eric Yeager, William J Weiss, Gerson Rosenberg

引用次数: 0

Is Tidal Volume Another Piece of the "Rest Setting on ECMO" Puzzle? 潮气量是“ECMO休息设置”之谜的另一块吗？

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-01-16 DOI: 10.1097/MAT.0000000000002379

Sajini Ramakrishnan, Hari Krishnan Kanthimathinathan

引用次数: 0

Understanding Platelet Activation in the Aeson Bioprosthetic Total Artificial Heart: Insights From Aspirin Treatment and Outcomes. 了解 Aeson 生物人工全人工心脏中的血小板活化：阿司匹林治疗和结果的启示。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-02-28 DOI: 10.1097/MAT.0000000000002403

David M Smadja, Joseph Roux de Bezieux, Christophe Peronino, Léa Jilet, Peter Ivak, Yuri Pya, Aurélien Philippe, Christian Latremouille, Finn Gustafsson, Faiz Z Ramjankhan, Jean Christian Roussel, Marie Courbebaisse, Béatrice Parfait, David Lebeaux, Gérard Friedlander, André Vincentelli, Erwan Flecher, Pascale Gaussem, Piet Jansen, Ivan Netuka

{"title":"Understanding Platelet Activation in the Aeson Bioprosthetic Total Artificial Heart: Insights From Aspirin Treatment and Outcomes.","authors":"David M Smadja, Joseph Roux de Bezieux, Christophe Peronino, Léa Jilet, Peter Ivak, Yuri Pya, Aurélien Philippe, Christian Latremouille, Finn Gustafsson, Faiz Z Ramjankhan, Jean Christian Roussel, Marie Courbebaisse, Béatrice Parfait, David Lebeaux, Gérard Friedlander, André Vincentelli, Erwan Flecher, Pascale Gaussem, Piet Jansen, Ivan Netuka","doi":"10.1097/MAT.0000000000002403","DOIUrl":"10.1097/MAT.0000000000002403","url":null,"abstract":"This study aimed to assess platelet activation following implantation of the Aeson bioprosthetic total artificial heart (A-TAH). We monitored plasma levels of platelet activation markers in patients receiving A-TAH support (n = 16) throughout the follow-up period. Before implantation, soluble CD40 ligand (sCD40L) levels averaged 3,909.06 pg/ml (standard deviation [SD] = 3,772.37), remaining stable postimplantation at 3,964.56 pg/ml (SD = 2,198.85) during months 1-3 and at 3,519.27 pg/ml (SD = 1,647.04) during months 3-6. Similarly, P-selectin (sP-sel) levels were 35,235.36 pg/ml (SD = 14,940.47) before implantation, stabilizing to 33,158.96 pg/ml (SD = 9,023.11) (1-3 months) and 31,022.58 pg/ml (SD = 9,249.95) (3-6 months). Preimplantation platelet factor 4 (PF4) measured 2,593.47 ng/ml (SD = 2,167.85), remaining consistent at 2,136.10 ng/ml (SD = 1,264.47) (1-3 months) and 1,991.26 ng/ml (SD = 1,234.16) (3-6 months). Levels of neutrophil-activating peptide 2 (NAP2) were also steady, measuring 785.63 ng/ml (SD = 605.26) preimplantation, 935.10 ng/ml (SD = 517.73) at 1-3 months, and 907.21 ng/ml (SD = 501.96) at 3-6 months postimplantation. Importantly, neither aspirin nor heparin treatment affected these platelet biomarker levels. No correlation was observed between platelet activation marker levels and clinical outcomes such as pericardial effusion, nor with the timing of aspirin initiation and drain removal. Our findings confirm that A-TAH does not trigger platelet activation. The lack of association between aspirin, platelet activation, and clinical outcomes suggests the possibility of discontinuing antiplatelet therapy following A-TAH implantation in the future.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"701-710"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodynamics of Veno-Pulmonary Extracorporeal Membrane Oxygenation With Varying Right Ventricular Function in a Mock Circulatory Loop. 模拟循环循环中右心室功能变化的静脉-肺体外膜氧合的血流动力学。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-03-11 DOI: 10.1097/MAT.0000000000002410

Prashant Chand, Hakeem Yusuff, Vasileios Zochios, Avishka Wickramarachchi, Christopher Joyce, Shaun Gregory, Andrew Stephens, Kiran Shekar

{"title":"Hemodynamics of Veno-Pulmonary Extracorporeal Membrane Oxygenation With Varying Right Ventricular Function in a Mock Circulatory Loop.","authors":"Prashant Chand, Hakeem Yusuff, Vasileios Zochios, Avishka Wickramarachchi, Christopher Joyce, Shaun Gregory, Andrew Stephens, Kiran Shekar","doi":"10.1097/MAT.0000000000002410","DOIUrl":"10.1097/MAT.0000000000002410","url":null,"abstract":"Veno-pulmonary extracorporeal membrane oxygenation (VP ECMO) is an emerging mechanical support therapy for patients with right ventricular (RV) injury. This study aimed to assess the hemodynamic impact of VP ECMO using a mock circulatory loop (MCL) to simulate patients with varying levels of RV injury and pulmonary vascular resistance (PVR). Right ventricular injury was simulated by changing the end-systolic pressure-volume relationship (47.5-100% of healthy RV), in combination with different PVR states (100-600 dyne·s·cm -5 ). Veno-pulmonary extracorporeal membrane oxygenation was introduced into the MCL circuit from 0 to 5 L/min at 1 L/min intervals. We demonstrated that the effect of VP ECMO support on pulmonary and systemic hemodynamics may vary significantly depending on RV function and RV afterload. A common observation across all cases was that high ECMO flow rates increased mean pulmonary arterial and left atrial pressure and reduced pulmonary artery pulsatility significantly. The absolute value of these parameters depended highly on RV function and corresponding PVR state. The study highlights the importance of considering RV injury severity and corresponding afterload when using VP ECMO to maintain cardiorespiratory stability and prevent pulmonary vasculature damage or hemorrhage. Further research is needed to establish the safe and effective use of VP ECMO in managing cardiac or respiratory failure.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"727-735"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Preoperative Right Ventricular Dysfunction and Ventricular Arrhythmias on Left Ventricular Assist Device Outcomes. 术前右室功能障碍和室性心律失常对左室辅助装置效果的影响。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-02-20 DOI: 10.1097/MAT.0000000000002402

Douglas Hall, Rahul A Chhana, Bin Q Yang, Elena Deych, Christopher T Sparrow, Praveen Rao, Michael E Nassif, Shane J LaRue, Joel D Schilling

{"title":"The Impact of Preoperative Right Ventricular Dysfunction and Ventricular Arrhythmias on Left Ventricular Assist Device Outcomes.","authors":"Douglas Hall, Rahul A Chhana, Bin Q Yang, Elena Deych, Christopher T Sparrow, Praveen Rao, Michael E Nassif, Shane J LaRue, Joel D Schilling","doi":"10.1097/MAT.0000000000002402","DOIUrl":"10.1097/MAT.0000000000002402","url":null,"abstract":"Ventricular arrhythmias (VA) are common in patients being evaluated for left ventricular assist devices (LVADs) but the impact of comorbid right ventricular dysfunction (RVD) on outcomes after LVAD is not known. We performed a single-center, retrospective cohort study of patients undergoing LVAD implantation from 2005 to 2021. Patients were stratified by VA history before LVAD into no VA, low burden VA (LBVA), or clinically significant VA (CSVA) groups. Right ventricular function was assessed by baseline echo. Time-to-event analyses were used with a primary outcome of all-cause mortality. Secondary outcomes were implantable cardioverter-defibrillator (ICD) shock, rehospitalization, and postoperative complications related to RV failure. A total of 761 patients were included, of which 442 (58%) had no VA, 120 (16%) had LBVA, and 199 (26%) had CSVA. The mean age was 57 and 584 (77%) of patients were male. Within the CSVA group, mortality was higher in those with baseline RVD (hazard ratio [HR] = 1.6, confidence interval [CI] = 1.1-2.5). Clinically significant VA and renal dysfunction were associated with mortality on Cox proportional hazards modeling. Implantable cardioverter-defibrillator shocks after LVAD were more common in those with LBVA or CSVA. There was no difference in 6-month rehospitalization between groups. Patients with a history of CSVA undergoing LVAD implantation are at increased risk for mortality and this risk is predominantly seen in those with comorbid RVD.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"736-743"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steroid Utilization for Pediatric Ventricular Assist Device-Associated Inflammation and Association With Outcomes. 小儿心室辅助装置相关炎症的类固醇使用及其与预后的关系。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-03-19 DOI: 10.1097/MAT.0000000000002416

Ashish A Ankola, Hari P Tunuguntla, Kyle D Hope, Joseph A Spinner, Swati Choudhry, Iki Adachi, Kriti Puri

{"title":"Steroid Utilization for Pediatric Ventricular Assist Device-Associated Inflammation and Association With Outcomes.","authors":"Ashish A Ankola, Hari P Tunuguntla, Kyle D Hope, Joseph A Spinner, Swati Choudhry, Iki Adachi, Kriti Puri","doi":"10.1097/MAT.0000000000002416","DOIUrl":"10.1097/MAT.0000000000002416","url":null,"abstract":"The impact of methylprednisolone (MP) on ventricular assist device (VAD)-associated inflammation in children and its association with outcomes remains unclear. We report this single-center retrospective study of children less than 21 years old supported with a VAD from February 2018 to December 2022. Methylprednisolone utilization, serial laboratory markers of hemolysis, inflammation, anticoagulation, and VAD adverse outcomes were analyzed. Sixty-eight patients (47% male, median age 3.2 years, 54% pulsatile flow) were included. Thirty-three patients (49%) received MP during VAD support, starting at a median 9 days post-implant (interquartile range [IQR]: 7-14), and for a median of 4 days (IQR: 3-5). Post-MP, there was a significant reduction in c-reactive protein (CRP) (12.4-3.2 mg/dl, p < 0.001) and fibrinogen (592-325 mg/dl, p < 0.001). Patients receiving MP had a higher daily rate of decline of fibrinogen ( p = 0.024) and higher bivalirudin dose ( p = 0.013) in the 2nd week post-implant. Methylprednisolone utilization was associated with higher proportion of stroke ( p = 0.023), infection ( p = 0.010), and pump thrombosis ( p = 0.023). Methylprednisolone is used frequently during pediatric VAD support and reduces inflammatory markers. Infectious and thrombotic complications were more common in the cohort receiving MP, and larger studies are needed to investigate this further.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"752-759"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Multifunction Oxygenator With a Dual-Chamber Gas Exchanger to Reduce Dependence on Oxygen Supply. 一种新型多功能氧合器与双室气体交换器以减少对氧气供应的依赖。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-02-19 DOI: 10.1097/MAT.0000000000002396

Dong Han, Jiafeng Zhang, Aakash Shah, Bartley P Griffith, Zhongjun J Wu

{"title":"A New Multifunction Oxygenator With a Dual-Chamber Gas Exchanger to Reduce Dependence on Oxygen Supply.","authors":"Dong Han, Jiafeng Zhang, Aakash Shah, Bartley P Griffith, Zhongjun J Wu","doi":"10.1097/MAT.0000000000002396","DOIUrl":"10.1097/MAT.0000000000002396","url":null,"abstract":"Although extracorporeal membrane oxygenation (ECMO) systems have been used to provide temporary support for patients with severe respiratory or cardiac failure, they are often bedridden, in part because of their bulky size which relies solely on an unlimited source of wall oxygen. However, there is an unmet clinical need for ambulatory ECMO which necessitates downsizing the ECMO system. We sought to develop a new oxygenator to reduce the dependence on the oxygen supply source. The proposed oxygenator features a dual-chamber gas exchangers, with one chamber primarily responsible for carbon dioxide removal using ambient air and a subsequent chamber primarily responsible for oxygen transfer using pure oxygen. Computational fluid dynamics was used to analyze the blood flow field to avoid adverse stagnation and optimize gas exchange performance. Bovine blood was used for in vitro gas transfer test. This new oxygenator demonstrated the capability to provide adequate respiratory support (both carbon dioxide removal and oxygen transfer) to adult patients at blood rate of 4-6 L/min with an oxygen supply of only 2 L/min. The reduced use of oxygen with this new oxygenator may pave the way for the development of potable ECMO systems.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"719-726"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Venting About Left Ventricular Unloading. 关于左心室卸载的通气。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-01-16 DOI: 10.1097/MAT.0000000000002380

Keshava Rajagopal

引用次数: 0

Percutaneous Assessment and Intervention of Outflow Graft Stenosis in Left Ventricular Assist Device Patients-A Cohort Study. 左心室辅助装置患者流出部移植物狭窄的经皮评估与干预——一项队列研究。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-01 Epub Date: 2025-04-03 DOI: 10.1097/MAT.0000000000002417

Claudio A Bravo, Fanette Chassagne, Alberto Aliseda, Jennifer A Beckman, Song Li, Claudius Mahr

{"title":"Percutaneous Assessment and Intervention of Outflow Graft Stenosis in Left Ventricular Assist Device Patients-A Cohort Study.","authors":"Claudio A Bravo, Fanette Chassagne, Alberto Aliseda, Jennifer A Beckman, Song Li, Claudius Mahr","doi":"10.1097/MAT.0000000000002417","DOIUrl":"10.1097/MAT.0000000000002417","url":null,"abstract":"Despite progress in understanding and managing left ventricular assist device (LVAD) complications, outflow graft (OG) stenosis remains inadequately characterized. We described patients who underwent invasive percutaneous OG studies. We used a 10 and 14 mm OG three-dimensional (3D) reconstruction and computational fluid dynamics (CFD) analysis to examine the impact of OG stenosis on flow dynamics. Of the 21 LVAD patients who underwent invasive OG study (median age: 62.6 years, 81% male, 3 HeartMate 3 [HM3], 15 HeartWare [HVAD], and 3 HeartMate II [HMII]), 9 (43%) underwent OG stenting (0 HM3, 7 HVAD, and 2 HMII). Of these nine patients, two had stroke, and three expired post-OG intervention. Computational fluid dynamics analysis showed that with increasing degrees of OG stenosis, there was a rise in pressure gradient across the stenotic area, wall shear stress at the stenotic area, aortic wall shear stress, aortic root recirculation, and chaotic flow. These negative changes were more pronounced for the smaller OG. In conclusion, in our experience, the invasive hemodynamics study and OG stenting, when indicated, are safe and effective. Interestingly, the smaller OG diameter showed a worse hemodynamic response to stenosis. Further research on OG stenosis is needed to define best practices for this LVAD complication.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"711-718"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Critical Hematology Oncology Referral Pathway for Extracorporeal Life Support: Standardized Evaluation and Transfer Can Improve Survival. 体外生命支持的儿科危重血液学肿瘤学转诊途径：标准化评估和转移可以提高生存率。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-27 DOI: 10.1097/MAT.0000000000002542

Hitesh S Sandhu, Kimberly Fan, Samir Shah, Xiaomeng Yuan, Laurel Metzler, Jennifer McArthur, Dai Kimura, Melissa Hines, Caitlin Hurley, Akshay Sharma, Katy Rower, Haitao Pan, Jeffery Brown, R Ray Morrison, Saad Ghafoor

{"title":"Pediatric Critical Hematology Oncology Referral Pathway for Extracorporeal Life Support: Standardized Evaluation and Transfer Can Improve Survival.","authors":"Hitesh S Sandhu, Kimberly Fan, Samir Shah, Xiaomeng Yuan, Laurel Metzler, Jennifer McArthur, Dai Kimura, Melissa Hines, Caitlin Hurley, Akshay Sharma, Katy Rower, Haitao Pan, Jeffery Brown, R Ray Morrison, Saad Ghafoor","doi":"10.1097/MAT.0000000000002542","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002542","url":null,"abstract":"Over the last decade, extracorporeal life support (ECLS) use for patients with a hematologic or oncologic diagnosis or who have undergone hematopoietic cell transplant has increased, with steadily improving outcomes. To standardize our approach to early evaluation and identification of ECLS candidates, we developed the Critical Hematology Oncology Referral Pathway for Extracorporeal Life Support (CHORPE). We performed a retrospective chart review of patients transferred between two pediatric hospitals for ECLS evaluation. Forty-six patients were transferred for ECLS evaluation: 17 pre-CHORPE, 28 post-CHORPE implementation, and 1 index patient between January 2010 and December 2021. Six were placed on ECLS in the preprocess group; three survived decannulation, but none survived to hospital discharge. In the post-process group, nine were placed on ECLS, with six surviving to decannulation and transfer back to the referring hospital (odds ratios [OR] = 24, p = 0.01) and five surviving to hospital discharge (OR = 15.9, p = 0.03). In the post-process group, there were fewer complications during transfer (p = 0.0228), and clinical improvement was the reason for not going on ECLS (p = 0.0120). A standardized approach to ECLS candidacy evaluation, early identification, and safe transfer with continuity of care is associated with improved survival after ECLS.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0