ASAIO Journal最新文献

{"title":"A Novel Trans-Septal Cannula for Wearable Extracorporeal Membrane Oxygenation: In Vitro Hemodynamic Evaluation and Placement Feasibility.","authors":"Justin Issard, Yohann Vincent, Yuya Nobori, Sixtine Fleurot, Elie Fadel, Fabrice Antigny, Philippe Brenot, Laure Aubrège, Sebastien Hascoët, Olaf Mercier","doi":"10.1097/MAT.0000000000002721","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002721","url":null,"abstract":"<p><p>Extracorporeal membrane oxygenation (ECMO) supports patients with end-stage heart and lung disease awaiting transplantation. In pulmonary hypertension, veno-arterial ECMO (VA-ECMO) is common but linked to vascular complications and limited mobility, hindering pre-transplant rehabilitation. To overcome these challenges, we developed the BioArt-Lung (BAL) cannula-a trans-septal, dual-lumen, self-expanding device enabling cardiopulmonary support through single venous access, avoiding groin cannulation. Bench tests compared BAL with three dual-lumen cannulas, assessing pressures and transluminal flow using water and blood analogs at 0° and 120° angulation. Placement feasibility was evaluated on a three-dimensional (3D)-printed heart model, and right atrial unloading was tested via inferior vena cava perfusion. Pressure and flow remained consistent across fluids and angulations (p = ns). BioArtificial Lung exhibited significantly less admission lumen depression than Avalon 27Fr (p < 0.0001). Trans-septal insertion was smooth, and complete right atrial unloading occurred at 2 L/min flow. BioArtificial Lung demonstrated effective hemodynamics and feasible trans-septal placement via superior vena cava access. These results support further in vivo studies to assess biocompatibility and long-term outcome.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygenated Dialysate for Gas Exchange in the RenOx: Unaddressed Electrolyte and Hemocompatibility Considerations.","authors":"Muhammad Rafay Shahzad Cheema","doi":"10.1097/MAT.0000000000002728","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002728","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Artery Pulsatility Index Response to Vasodilator Challenge Predicts Early Right Ventricular Failure After Left Ventricular Assist Device.","authors":"Giulio Cacioli, Guglielmo Gallone, Alessandro Verde, Enzo Tejada, Mailen Konicoff, Michele Ciabatti, Gianluca Marcelli, Carles Díez-López, Nicolina Conti, Vito Piazza, Aldo Cannata, Stefano Pidello, Fabio Sbaraglia, Maria Monteagudo Vela, Antonio Spitaleri, Marina Comisso, Claudio Francesco Bruno, Paola Lilla Della Monica, José Carlos Sánchez-Salado, Simone Frea, Claudia Raineri, Claudio Francesco Russo, Andrew Morley-Smith, Andrea Garascia, Mauro Rinaldi, Luca Baldetti, Giampaolo Luzi, José González-Costello, Fernando Riesgo Gil, Ryan James Tedford, Antonio Loforte, Gaetano Maria De Ferrari","doi":"10.1097/MAT.0000000000002691","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002691","url":null,"abstract":"<p><p>Vasodilator challenge during right heart catheterization (RHC), by improving right ventricular (RV) loading conditions, could provide an assessment of RV functional reserve. We hypothesized that a dynamic evaluation of RV function with sodium nitroprusside (NTP) infusion could enhance conventional risk stratification for post-left ventricular assist device (LVAD) early RV failure (RVF). We performed an observational retrospective multicenter study including consecutive LVAD recipients undergoing vasodilator challenge within 3 months from surgery. We evaluated the association of clinical, echocardiographic, and hemodynamic data at baseline and after NTP infusion with post-LVAD early RVF. Of 160 patients, RVF occurred in 58 (36.3%) and was associated with higher in-hospital mortality (32.8% vs . 3.9%, p < 0.001). Among baseline hemodynamics, pulmonary artery pulsatility index (PAPi) <2 was the single variable associated with RVF ( p = 0.038). In a multivariable model adjusted for in-study outcome predictors, a blunted PAPi response to vasodilator challenge (PAPi increase <2.2) emerged as the strongest independent RVF predictor (odds ratio [OR] = 4.56, 95% confidence interval [CI] = 1.88-11.07, p = 0.001). Patients with a blunted PAPi response had an increased RVF risk both in the baseline PAPi <2 (61.9% vs . 12.5%, p = 0.022) and in the baseline PAPi ≥2 (40.2% vs . 17.5%, p = 0.004) groups. Vasodilator challenge, by unveiling RV functional reserve, could improve patient selection and optimization before LVAD implant.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Fouling on Silica Nanoparticle (SiNP)-Coated Feeding Tube After Formula Flow: Erratum.","authors":"Kagya A Amoako, Faiza Chowdhury, Santiago Andres Proano Patino, Pradyumna Iyer, Pramod Bonde","doi":"10.1097/MAT.0000000000002734","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002734","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Cannula Size Selection for Percutaneous Femoral Venoarterial Extracorporeal Membrane Oxygenation in Children and Young Adults: Solving a Goldilocks Paradox?","authors":"Catalina Vargas-Acevedo, Natalie Soszyn, Ernesto Mejia, Jenny E Zablah, Robert Hyslop, Shannon Buckvold, Gareth J Morgan","doi":"10.1097/MAT.0000000000002511","DOIUrl":"10.1097/MAT.0000000000002511","url":null,"abstract":"<p><p>The correct arterial cannula size for percutaneous femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) cannulation is imperative for adequate circulatory support. We aimed to describe the relationship between cannula size, predicted arterial size, and vascular complications. Here, we present a single-center cohort of patients who underwent percutaneous femoral VA-ECMO cannulation. A formula using height and body mass index was used to predict the estimated common femoral artery (CFA) diameter and compared it to the cannula size used. The primary endpoint was major vascular complications. Receiver Operating Characteristic (ROC) curve was used to determine the cutoff point for significant cannula size discrepancy (≥2.7 Fr greater than predicted). Twenty-five patients were included, with a median predicted CFA diameter of 5.4mm (16.2 Fr), 1.9 Fr lower than the chosen cannula. Eight patients (32%) had a significant cannula discrepancy with more vascular complications ( p = 0.039). ROC analysis confirmed a moderate correlation between cannula discrepancy and major vascular complications (area under the curve [AUC] 0.640, sensitivity of 67%; specificity of 84%) and overall vascular complications (AUC 0.662, sensitivity of 63%; specificity of 88%). Thus, the use of arterial cannulas for percutaneous VA-ECMO that are ≥2.7 Fr larger than the estimated CFA appears to be related to a higher risk of overall vascular complications. The estimated arterial diameter should be considered when selecting the arterial cannula size. https://links.lww.com/ASAIO/B590.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"433-438"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging in Left Ventricular Assist Device Outpatients: Exposure Misclassification and Heterogeneous Bleeding Risk.","authors":"Parsa Jahangiri, Kadir Caliskan","doi":"10.1097/MAT.0000000000002683","DOIUrl":"10.1097/MAT.0000000000002683","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e83"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent Imaging-Guided Ligation of Lymphatic Leaks Following Decannulation From Extracorporeal Membrane Oxygenation.","authors":"Hamzah Almadani, Youssef Aref, Zachary Brennan, Andrew Cantor, Tyler Gunn, Philip S Brazio","doi":"10.1097/MAT.0000000000002478","DOIUrl":"10.1097/MAT.0000000000002478","url":null,"abstract":"<p><p>Lymphocele is a known complication of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). We present a novel application of fluorescent lymphatic imaging for the highly selective treatment of lymphatic leaks after VA-ECMO and describe patient outcomes at our institution. A retrospective review of patients who underwent lymphatic ligation following VA-ECMO from 2022 to 2024 was performed. Fluorescent imaging and intradermal indocyanine green injection were used to identify and ligate lymphatic leaks within the debrided wound bed. Ten patients with a mean age of 48.3 years were included. The mean number of lymphatics ligated was 5. Mean days from decannulation to ligation and from ligation to drain removal were 18.4 and 22.2, respectively. There was a significant decrease in drain output immediately following ligation (197.4 ml/day vs. 64.2 ml/day; p = 0.016). A shorter time from decannulation to ligation was significantly correlated with a decrease in drain output. A higher drain fluid lymphocyte percentage was significantly correlated with a shorter time to drain removal. Fluorescent imaging-guided lymphatic ligation is an effective method for treating lymphatic leak after decannulation from VA-ECMO. Drain fluid analysis and early consultation with plastic surgery should be encouraged in the event of high-output lymphocele.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"384-389"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational and Experimental Assessment of Shear-Induced Blood Trauma by HeartMate II, HeartMate 3, and BrioVAD.","authors":"Anik Tarafder, Dong Han, Bartley P Griffith, Zhongjun J Wu","doi":"10.1097/MAT.0000000000002487","DOIUrl":"10.1097/MAT.0000000000002487","url":null,"abstract":"<p><p>Although durable mechanical circulatory support (MCS) has been promising in supporting advanced heart failure patients, device hemocompatibility-related complications remain a major concern compared with heart transplantation. We investigated the blood damage potential of the three most recent clinically available, implantable MCS devices and compared their biocompatibility performance. One axial pump (HeartMate II) and two centrifugal pumps (HeartMate 3 and BrioVAD) were chosen for this study. In vitro experiments with healthy human blood and computational fluid dynamics simulations were performed to compare high-mechanical shear-induced blood trauma in these devices. Regions of higher shear stresses were identified. Power-law relations between shear stress and blood damage were implemented to assess hemolysis, platelet activation, and platelet receptor shedding of key functional receptors (glycoprotein [GP] Ibα, and GPVI) caused by these devices. HeartMate II caused the most severe blood trauma among these three devices, producing an order of magnitude larger values for hemolysis and platelet activation compared with HeartMate 3 and BrioVAD. Also, HeartMate II consistently exhibited the highest levels of receptor shedding, approximately double those caused by the HeartMate 3 and BrioVAD. The HeartMate 3 and BrioVAD centrifugal pumps showed similar performance in terms of blood damage.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"390-397"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter: \"Bridging in Left Ventricular Assist Device Patients\".","authors":"Eleonora Camilleri, Robin P W Roovers, Eva Janssen, Jurjen F Krommenhoek, Frederikus A Klok, Meindert Palmen, J Wouter Jukema, Nienke van Rein, Laurens F Tops","doi":"10.1097/MAT.0000000000002684","DOIUrl":"10.1097/MAT.0000000000002684","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e84"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Extracorporeal Life Support in a Patient With Left Ventricular Assist Device and Electrical Storm: A Case Report.","authors":"Joseph Michael Brewer, Obaid Ashraf, Jordan Phillips, Robert Schoaps, Laura V Swant, Mircea R Mihu","doi":"10.1097/MAT.0000000000002591","DOIUrl":"10.1097/MAT.0000000000002591","url":null,"abstract":"<p><p>Left ventricular assist device (LVAD)-supported patients experiencing electrical storm (ES) and cardiac arrest present unique management challenges. Venoarterial (VA) extracorporeal membrane oxygenation (ECMO) is commonly used for extracorporeal cardiopulmonary resuscitation (ECPR), but its application in LVAD-supported patients presents hemodynamic complexities. Alternative ECMO modes, including venopulmonary (VP) and hybrid venoarteriopulmonary (VAP) ECMO, may provide tailored circulatory and respiratory support in select cases. This case report describes a patient with a newly implanted LVAD who developed ES, refractory right ventricular failure, and cardiac arrest. The patient underwent staged ECMO support, transitioning from VA ECMO for ECPR to hybrid VAP ECMO and ultimately to VP ECMO, based on evolving hemodynamic needs.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e77-e80"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}