ASAIO Journal最新文献_第2页

Association Between Red Blood Cells Transfusion and 1 Year Mortality in Patients on Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock. 心源性休克经静脉体外膜氧合治疗患者输血与1年死亡率的关系。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-04-02 DOI: 10.1097/MAT.0000000000002424

Mathilde Brouland, Antoine Kimmoun, Clément Delmas, Kevin Duarte, Nicolas Girerd, Fanny Vardon-Bounes, Thomas Klein

{"title":"Association Between Red Blood Cells Transfusion and 1 Year Mortality in Patients on Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock.","authors":"Mathilde Brouland, Antoine Kimmoun, Clément Delmas, Kevin Duarte, Nicolas Girerd, Fanny Vardon-Bounes, Thomas Klein","doi":"10.1097/MAT.0000000000002424","DOIUrl":"10.1097/MAT.0000000000002424","url":null,"abstract":"In patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock, red blood cell (RBC) transfusion is often necessary, but its impact on long-term mortality remains unclear. This multicenter retrospective cohort study aimed to assess the association between RBC transfusion and 1 year mortality in patients on VA-ECMO. Data were collected from two French intensive care units (ICUs) between January 1 st , 2016, and December 31 st , 2021. Adults with cardiogenic shock supported by VA-ECMO were included, while those under 18, with ECMO duration <24 hours, or cardiac arrest before or during implantation were excluded. Among 190 patients (71% male, median age 60 years), the median VA-ECMO duration was 8 days. One year mortality was 54%. Red blood cell transfusions were administered to 83% of patients, with a median of six packs. Multivariable analysis showed no significant association between RBC transfusion and 1 year mortality across various transfusion metrics, including transfusion status, total units, and daily packs (all p > 0.05). Subgroup analyses confirmed this consistent pattern. Although RBC transfusion is frequent in VA-ECMO-supported patients, this study found no significant association with 1 year survival. Given the risks of transfusion, a cautious approach is recommended. Further studies are needed to refine transfusion strategies for this high-risk population.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"833-840"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endostatin and Cystatin C as Predictors of 1 Month Renal Function Change in Patients With Left Ventricular Assist Device Support. 内皮抑素和胱抑素C作为左心室辅助装置支持患者1个月肾功能变化的预测因子。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-03-10 DOI: 10.1097/MAT.0000000000002414

Shiyi Li, Katherine V Nordick, Iván Murrieta-Álvarez, Ismael Garcia, Randall P Kirby, Rishav Bhattacharya, Alexis E Shafii, Samiran Ghosh, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao, Carl P Walther, Nandan K Mondal

{"title":"Endostatin and Cystatin C as Predictors of 1 Month Renal Function Change in Patients With Left Ventricular Assist Device Support.","authors":"Shiyi Li, Katherine V Nordick, Iván Murrieta-Álvarez, Ismael Garcia, Randall P Kirby, Rishav Bhattacharya, Alexis E Shafii, Samiran Ghosh, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao, Carl P Walther, Nandan K Mondal","doi":"10.1097/MAT.0000000000002414","DOIUrl":"10.1097/MAT.0000000000002414","url":null,"abstract":"First-month renal function trajectories after left ventricular assist device (LVAD) implantation vary widely. Lack of renal function improvement (RFI) and postoperative acute kidney injury (AKI) are associated with increased mortality. This study evaluates plasma levels of endostatin and cystatin C as predictors of RFI and AKI 1 month post-LVAD implantation. We prospectively enrolled 52 advanced heart failure patients undergoing LVAD implantation. Blood samples were collected pre-implant and at 1, 2, 3, and 4 weeks post-implant. Plasma levels of endostatin and cystatin C were measured. Among 52 patients, 24 (46.2%) achieved RFI, whereas 28 (53.8%) did not. Of the non-RFI group, 15 (53.6%) developed AKI within the first month. Baseline endostatin was highly significant in predicting RFI ( p = 0.012), followed by cystatin C ( p = 0.045). The patients without RFI were considered high-risk patients for postoperative AKI. We noticed distinct trajectories for postoperative 1 week cystatin C value, not endostatin, between AKI and no-AKI patients. Postoperative 1 week level of cystatin C is identified as a good biomarker for postoperative AKI prediction in these high-risk group patients. Baseline endostatin levels can help identify patients with reduced renal adaptive capacity. For patients with high pre-implant plasma endostatin values, monitoring circulating postoperative 1 week cystatin C allows physicians to detect AKI early.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"785-794"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing the Chill: A Critical Perspective on SherpaPak Versus Ice Storage in Heart Transplantation. 重新评估寒冷：心脏移植中SherpaPak与冰储存的关键观点。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-06-12 DOI: 10.1097/MAT.0000000000002481

Ibrahim Nagmeldin Hassan

引用次数: 0

Reply Letter to "Reassessing the Chill: A Critical Perspective on SherpaPak Versus Ice Storage in Heart Transplantation". 对“重新评估寒冷：SherpaPak与冰储存在心脏移植中的关键观点”的回复。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1097/MAT.0000000000002488

Tarun Dalia, Hassan Farhoud, Andrija Vidic

引用次数: 0

Anticoagulate the Circuit, Not the Patient: Nitric Oxide Reduces Thrombus Formation During Extracorporeal Carbon Dioxide Removal. 抗凝电路，而不是病人：一氧化氮减少体外二氧化碳去除过程中的血栓形成。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-06-19 DOI: 10.1097/MAT.0000000000002490

Teryn R Roberts, Yanyi Zang, George T Harea, Daniel S Wendorff, Brendan M Beely, Leopoldo C Cancio, Andrea Selkow Wallish, Tracey V Wick, Melissa M Reynolds, Andriy I Batchinsky

{"title":"Anticoagulate the Circuit, Not the Patient: Nitric Oxide Reduces Thrombus Formation During Extracorporeal Carbon Dioxide Removal.","authors":"Teryn R Roberts, Yanyi Zang, George T Harea, Daniel S Wendorff, Brendan M Beely, Leopoldo C Cancio, Andrea Selkow Wallish, Tracey V Wick, Melissa M Reynolds, Andriy I Batchinsky","doi":"10.1097/MAT.0000000000002490","DOIUrl":"10.1097/MAT.0000000000002490","url":null,"abstract":"Solutions to reduce the need for systemic anticoagulation during extracorporeal life support would improve safety and utility. The study objective was to evaluate the safety and efficacy of a nitric oxide-generating extracorporeal carbon dioxide removal (ECCO 2 R) system without systemic anticoagulation in a translational swine model. We hypothesized that nitric oxide reduces circuit thrombosis, without untoward systemic effects. Anesthetized, mechanically ventilated swine (50-60 kg) received bicaval jugular cannulation for 72 hour venovenous ECCO 2 R. Control (n = 6) received a standard ECCO 2 R device with systemic heparinization. Treatment (n = 6) received the same device, but with nitric oxide-generating circuitry and 80 ppm nitric oxide added to sweep gas, without systemic heparinization. No between-group differences in vitals, ventilator settings, blood gases, extracorporeal gas exchange, or fluid balance occurred. In both groups, ECCO 2 R enabled reduction in tidal volume. Oxygenator thrombus area, quantified following dissection and imaging, was reduced in treatment (10.2 ± 1.2%) versus control (15.2 ± 1.6%) ( p = 0.03). One control oxygenator occluded. No nitric oxide-related adverse effects were observed, including methemoglobinemia. Nitric oxide-enhanced ECCO 2 R enabled 72 hours of support without systemic anticoagulation, and without altering oxygenator performance or causing untoward systemic effects. Future studies are needed to investigate efficacy in subjects with underlying coagulopathy and/or contraindications for systemic anticoagulation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"849-860"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging to Heart Transplantation With Intraaortic Balloon Pump Versus Impella 5.5. 主动脉内球囊泵与Impella 5.5的心脏移植桥接。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-04-02 DOI: 10.1097/MAT.0000000000002432

Spencer E Kim, Max Shin, Amit Iyengar, Noah Weingarten, Dun Jin, Rachel Wilson, Michaela Asher, Omar Toubat, Pavan Atluri

{"title":"Bridging to Heart Transplantation With Intraaortic Balloon Pump Versus Impella 5.5.","authors":"Spencer E Kim, Max Shin, Amit Iyengar, Noah Weingarten, Dun Jin, Rachel Wilson, Michaela Asher, Omar Toubat, Pavan Atluri","doi":"10.1097/MAT.0000000000002432","DOIUrl":"10.1097/MAT.0000000000002432","url":null,"abstract":"In this study, we compare the clinical characteristics and courses of patients directly bridged to heart transplant with intraaortic balloon pump (IABP) versus Impella 5.5. We performed a retrospective cohort study of single-center institutional data including all adult patients at our institution bridged to transplant with either IABP or Impella 5.5 support between October 18, 2018, and May 31, 2023. Ninety-one heart transplant recipients were included in this study, of whom 54 (59%) were bridged on IABP and 37 (41%) were bridged on Impella 5.5. Patients supported with Impella 5.5 had comparable baseline characteristics compared to those bridged on IABP (all p > 0.05). However, Impella 5.5 patients had lower vasoactive inotropic scores during their temporary mechanical circulatory support (MCS) period than those bridged on IABP (all p < 0.05). Duration of MCS and post-transplant intensive care unit (ICU) length of stay were longer for Impella 5.5 patients (all p < 0.05), but rates of complications after transplant were comparable (all p > 0.05). Survival at 1 year post-transplant was significantly greater for the Impella 5.5 group (100% vs. 87%; p = 0.039). Given the increased use of MCS as a bridge to transplant, this project has important implications for preoperative management of waitlist patients.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"800-806"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized Clinical Trials on Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock: Why Are They All Negative? 心源性休克静脉体外膜氧合的随机临床试验：为什么都是阴性的？

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2024-09-20 DOI: 10.1097/MAT.0000000000002316

Maya Guglin

引用次数: 0

Open Direct Beating-Heart Atrioseptostomy: Left Heart Unloading Under Extracorporeal Life Support. 开放式直接搏动-心脏房隔造口术：体外生命支持下左心卸载。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-06-26 DOI: 10.1097/MAT.0000000000002492

Calixte de La Bourdonnaye, Xavier Beneux, Guillaume Leurent, Erwan Flecher, Amedeo Anselmi

引用次数: 0

Candidate Biomarkers YES1, Troponin I, Lactate, and Ammonia for Evaluation of Cardiac Function Post Hypothermic Oxygenated Perfusion. 候选生物标志物YES1、肌钙蛋白I、乳酸和氨用于评估低温氧灌注后心功能。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-10-01 Epub Date: 2025-03-25 DOI: 10.1097/MAT.0000000000002419

Elisa M Ballan, Mats T Vervoorn, Selma E Kaffka Genaamd Dengler, Judith Marsman, Mudit Mishra, Ilona M L J van Ginneken, Petra van der Kraak, Annelotte Vos, Saskia C A de Jager, Joost P G Sluijter, Pieter A Doevendans, Michal Mokry, Niels P van der Kaaij

{"title":"Candidate Biomarkers YES1, Troponin I, Lactate, and Ammonia for Evaluation of Cardiac Function Post Hypothermic Oxygenated Perfusion.","authors":"Elisa M Ballan, Mats T Vervoorn, Selma E Kaffka Genaamd Dengler, Judith Marsman, Mudit Mishra, Ilona M L J van Ginneken, Petra van der Kraak, Annelotte Vos, Saskia C A de Jager, Joost P G Sluijter, Pieter A Doevendans, Michal Mokry, Niels P van der Kaaij","doi":"10.1097/MAT.0000000000002419","DOIUrl":"10.1097/MAT.0000000000002419","url":null,"abstract":"Hypothermic oxygenated perfusion (HOPE) is a promising method for donor heart preservation, but the hypothermic conditions reduce metabolic activity, making cardiac evaluation challenging, and necessitating prognostic biomarkers to monitor graft quality. This study aims to identify biomarkers during HOPE that predict cardiac function. Seven porcine slaughterhouse hearts underwent 4 hours of HOPE followed by 4 hours of normothermic machine perfusion (NMP) with continuous functional assessment, including measurements of cardiac output (CO), cardiac index (CI), coronary flow (CF), coronary flow index (CFI), left ventricular pressure (LVP), left atrial pressure (LAP), and mean aortic pressure (MAP). Perfusate samples collected at baseline and after 4 hours of HOPE were analyzed for damage markers. Correlations were found between ammonia and CI ( r = 0.86), troponin I and CI ( r = 0.79), and lactate and CFI ( r = -0.81). Mitochondrial and nuclear cell-free DNA decreased during HOPE but did not correlate with function. Olink data indicated that tyrosine-protein kinase Yes (YES1) was negatively correlated with CI ( r = -0.86), CF ( r = -0.79), and CFI ( r = -0.86). These findings suggest YES1, troponin I, ammonia, and lactate as potential prognostic biomarkers during HOPE that may predict cardiac function post-reperfusion, warranting further research to validate their translational potential.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"823-832"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ELSO 2025 NARRATIVE GUIDELINE ON PREGNANT AND PERIPARTUM EXTRACORPOREAL MEMBRANE OXYGENATION. Elso 2025孕妇和围产期体外膜氧合叙事指南。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-24 DOI: 10.1097/MAT.0000000000002556

Erika R O'Neil, Ahmed Labib Shehatta, Cara Agerstrand, Caroline Sampson, Farah Siddiqui, Priya Nair, Alexandra L Schou, Javier Kattan, Emily E Naoum, Marc Anders, Kollengode Ramanathan, Matteo Di Nardo

引用次数: 0