ASAIO Journal最新文献

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Mistakes Are There to Learn From When and How to Measure. 从错误中吸取教训,何时以及如何衡量。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-09 DOI: 10.1097/MAT.0000000000002506
Joachim Kron, Susanne Kron
{"title":"Mistakes Are There to Learn From When and How to Measure.","authors":"Joachim Kron, Susanne Kron","doi":"10.1097/MAT.0000000000002506","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002506","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet Dynamics During Impella Use: A Time-Series Analysis by Model and Treatment Method. 血小板动力学在叶轮使用:一个时间序列分析的模型和处理方法。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-08 DOI: 10.1097/MAT.0000000000002498
Ikuko Shibasaki, Yasuo Haruyama, Suguru Hirose, Yusuke Takei, Shigeru Toyoda, Hirotsugu Fukuda
{"title":"Platelet Dynamics During Impella Use: A Time-Series Analysis by Model and Treatment Method.","authors":"Ikuko Shibasaki, Yasuo Haruyama, Suguru Hirose, Yusuke Takei, Shigeru Toyoda, Hirotsugu Fukuda","doi":"10.1097/MAT.0000000000002498","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002498","url":null,"abstract":"<p><p>Mechanical circulatory support is the standard treatment for refractory cardiogenic shock. However, Impella-induced thrombocytopenia is an established complication, and data on its incidence and characteristics remain limited. This study compared thrombocytopenia progression between patients who received different Impella devices (2.5/CP and 5.0/5.5) using Impella-alone or ECpella strategies. ECpella was defined as Impella combined with venoarterial extracorporeal membrane oxygenation. Secondary analyses were conducted to evaluate factors influencing complications and mortality. Between April 2018 and December 2024, 35 patients received Impella 2.5/CP alone, 67 received ECpella (2.5/CP was used), six received Impella 5.0/5.5 alone, and 13 received ECpella (5.0/5.5 was used). Platelet counts decreased significantly over time in the Impella 2.5/CP subgroups, with a greater reduction observed in the ECpella subgroup. Significant platelet count reduction was observed in only the ECpella subgroup of the Impella 5.0/5.5 group. A haptoglobin level of <10 mg/dl was more commonly noted in the Impella-alone subgroup of the Impella 2.5/CP group and in the ECpella subgroup of the Impella 5.0/5.5 group. The platelet count on day 3 post-implantation was associated with 1 year survival in the Impella 2.5/CP group (hazard ratio: 1.174, 95% confidence interval: 1.033-1.333, p = 0.014). These findings warrant validation in larger prospective studies.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Profile and Neurological Outcomes of Pediatric Patients Supported on Venoarterial Extracorporeal Mechanical Oxygenation in a Cardiorespiratory Pediatric Intensive Care Unit: A Single-Center Study. 一项单中心研究:在心肺儿科重症监护病房接受静脉体外机械氧合的儿科患者的临床概况和神经系统预后
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-02 DOI: 10.1097/MAT.0000000000002499
Swathy Subhash, Naila Ismayilova, Thomas Semple, Andreas Hoschtitzky, Amy Chan-Dominy, Diane Frall, Christopher Sparkes, Jennifer McGuckian, Kerry Engelbrecht, Lucy Hodge, Angela Aramburo, Lidia Casanueva, Abhishek Narayanan, Ajay Desai, Sandra Gala-Peralta
{"title":"Clinical Profile and Neurological Outcomes of Pediatric Patients Supported on Venoarterial Extracorporeal Mechanical Oxygenation in a Cardiorespiratory Pediatric Intensive Care Unit: A Single-Center Study.","authors":"Swathy Subhash, Naila Ismayilova, Thomas Semple, Andreas Hoschtitzky, Amy Chan-Dominy, Diane Frall, Christopher Sparkes, Jennifer McGuckian, Kerry Engelbrecht, Lucy Hodge, Angela Aramburo, Lidia Casanueva, Abhishek Narayanan, Ajay Desai, Sandra Gala-Peralta","doi":"10.1097/MAT.0000000000002499","DOIUrl":"10.1097/MAT.0000000000002499","url":null,"abstract":"<p><p>Extracorporeal membrane oxygenation (ECMO) has become a standard therapy in extremely sick patients for various indications. This rising use of ECMO warrants careful consideration of its neurological effects. Our single-center retrospective study, conducted between January 2016 and December 2022, on children ≤16 years, aimed to identify clinical and biochemical parameters associated with adverse neurological complications (ANC) on venoarterial ECMO (VA-ECMO), and its impact on their morbidity and mortality. Of 91 VA-ECMO runs analyzed, 37% were extracorporeal cardiopulmonary resuscitation (ECPR) recipients. Adverse neurological complications were diagnosed in 26% of patients during their ECMO run, and in 21% post-decannulation, for a total of 47% of the cohort. Overall, neck cannulation ( p = 0.049), lower pre-ECMO pH ( p = 0.018), higher pre-ECMO lactate ( p < 0.001), delayed lactate clearance ( p = 0.002), and progressive multiorgan dysfunction ( p = 0.018) was associated with ANC. The absence of ANC conferred better survival to decannulation and quality of function status. Sub-analysis on ECPR recipients noted that longer time to cannulation ( p = 0.023), lower pre-ECMO pH ( p = 0.006), higher pre-ECMO lactate ( p = 0.006), and delayed lactate clearance ( p = 0.024) had higher ANC. At hospital discharge, 78.6% of survivors, including 91% of ECPR survivors had favorable neurological outcomes. Point-of-care testing combined with standard neuromonitoring may help identify and prognosticate ECMO recipients.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical Aspects and Long-Term Outcomes of Additional Surgical Repair During Heart Transplantation in Adult Congenital Heart Disease. 成人先天性心脏病心脏移植过程中额外手术修复的解剖学方面和长期结果。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-11-25 DOI: 10.1097/MAT.0000000000002353
Nicola Pradegan, Claudia Cattapan, Chiara Tessari, Giuseppe Toscano, Augusto D'Onofrio, Vincenzo Tarzia, Antonio Gambino, Marny Fedrigo, Vladimiro L Vida, Annalisa Angelini, Gino Gerosa
{"title":"Anatomical Aspects and Long-Term Outcomes of Additional Surgical Repair During Heart Transplantation in Adult Congenital Heart Disease.","authors":"Nicola Pradegan, Claudia Cattapan, Chiara Tessari, Giuseppe Toscano, Augusto D'Onofrio, Vincenzo Tarzia, Antonio Gambino, Marny Fedrigo, Vladimiro L Vida, Annalisa Angelini, Gino Gerosa","doi":"10.1097/MAT.0000000000002353","DOIUrl":"10.1097/MAT.0000000000002353","url":null,"abstract":"<p><p>Adult patients with congenital heart disease (ACHD) requiring heart transplantation (HT) usually show complex anatomies, posing surgical challenges. Consequently, we analyzed technical aspects and early and long-term outcomes of additional surgical repairs during HT in ACHD. Forty patients were identified (23 males, median age: 38 years, interquartile range [IQR]: 26-50). Of these, 17 (42.5%) required additional surgical repair (7 systemic veins repair, 13 pulmonary arteries repair). These procedures were more associated with univentricular physiology ( p < 0.001) and prior Fontan palliation ( p < 0.001). Eight (20.0%) experienced 30 day mortality. At a median follow-up of 5.6 (IQR: 2.0-11.9) years, 5 (12.5%) patients died. Additional surgical repair did not affect postoperative 30 day and long-term follow-up mortality ( p = 0.451 and p = 0.330, respectively).</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e107-e109"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Left Ventricular Size on Outcomes Following HeartMate 3 Left Ventricular Assist Device Implantation: Analysis of the European Registry for Patients With Mechanical Circulatory Support (EUROMACS). 心脏伴侣3型左心室辅助装置植入后左心室大小对结果的影响:欧洲机械循环支持(EUROMACS)患者登记的分析
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-12-31 DOI: 10.1097/MAT.0000000000002370
Gaik Nersesian, Abhishek Jaiswal, Julia Stein, Ashwin Pillai, Theo M M H de By, Evgenij Potapov, David A Baran
{"title":"Impact of Left Ventricular Size on Outcomes Following HeartMate 3 Left Ventricular Assist Device Implantation: Analysis of the European Registry for Patients With Mechanical Circulatory Support (EUROMACS).","authors":"Gaik Nersesian, Abhishek Jaiswal, Julia Stein, Ashwin Pillai, Theo M M H de By, Evgenij Potapov, David A Baran","doi":"10.1097/MAT.0000000000002370","DOIUrl":"10.1097/MAT.0000000000002370","url":null,"abstract":"<p><p>We investigated the association of preimplant left ventricular end-diastolic diameter (LVEDD) with outcomes after HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. Patients from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) registry who underwent HM3 implantation from August 2014 to February 2023 (n = 834) were analyzed according to preoperative LVEDD: less than or equal to 65 (n = 251), 65-80 (n = 441), and greater than or equal to 80 mm (n = 142). The mean age was 54.4 ± 12.4 years, body surface area (BSA) 2.0 ± 0.23 m 2 , body mass index (BMI) 27.3 ± 5.0 kg/m 2 ; 87.9% were male and 40% had ischemic cardiomyopathy. Patients with LVEDD less than or equal to 65 mm were older (56.1 ± 11.0 vs . 53.8 ± 13.0 vs . 53.0 ± 12.3 years; p = 0.015), more female (17.9% vs . 11.6% vs . 4.9%; p < 0.001), smaller BSA (1.95 ± 2.03 vs . 2.01 ± 0.22 vs . 2.08 ± 0.22 m 2 ; p < 0.01) and lower BMI (26.6 ± 4.8 vs . 27.4 ± 5.1 vs . 28.2 ± 5.0; p = 0.01) compared to LVEDD 65-80 and greater than or equal to 80 mm, respectively. One year survival was associated with increasing LVEDD (75.7% vs . 84.6% vs . 89.5%; p = 0.003). Patients with LVEDD less than or equal to 65 mm had a higher risk of postoperative right heart failure (14.7% vs .10.4% vs . 6.8%; p = 0.03), the risk for postoperative stroke was similar (10% vs . 12.8% vs . 9.5%; p = 0.4). A small left ventricular (LV) size (LVEDD ≤ 65 mm) was associated with an increase in postoperative right heart failure and unadjusted 1 year mortality in adults who underwent HM3 LVAD implantation.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"552-559"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clearance of Amlodipine, Fentanyl, Fluconazole, Methylprednisolone, and Midazolam by Continuous Renal Replacement Circuits. 持续肾替代循环对氨氯地平、芬太尼、氟康唑、甲基强的松龙和咪达唑仑的清除作用。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2025-04-09 DOI: 10.1097/MAT.0000000000002422
Autumn M McKnite, Carina E Imburgia, Danielle J Green, J Porter Hunt, Rachel E Hudson, Aviva J Whelan, Cheryl L Mathis, Walter E Kelley, Joseph E Rower, Christopher A Reilly, Kevin M Watt
{"title":"Clearance of Amlodipine, Fentanyl, Fluconazole, Methylprednisolone, and Midazolam by Continuous Renal Replacement Circuits.","authors":"Autumn M McKnite, Carina E Imburgia, Danielle J Green, J Porter Hunt, Rachel E Hudson, Aviva J Whelan, Cheryl L Mathis, Walter E Kelley, Joseph E Rower, Christopher A Reilly, Kevin M Watt","doi":"10.1097/MAT.0000000000002422","DOIUrl":"10.1097/MAT.0000000000002422","url":null,"abstract":"<p><p>Critically ill pediatric patients on continuous renal replacement therapy (CRRT) have high mortality rates ranging from 30% to 70%, due in part to altered drug exposure from drug-CRRT circuit interactions. Drug loss within CRRT circuits can occur through both clearance by the hemofilter and adsorption to circuit components. Although these interactions are known to exist, their impact on the pharmacokinetics of most drugs is unknown, resulting in limited drug dosing guidance and increased risk for suboptimal drug exposure. In this study, we administered amlodipine, fentanyl, fluconazole, methylprednisolone, and midazolam individually and in combination with ex vivo , closed-loop, blood-primed CRRT circuits to quantify drug-circuit interactions. Circuits were dosed to drug-specific therapeutic concentrations, and drug concentrations in both plasma and effluent were measured over time. For all drugs administered individually, variable extraction by the CRRT circuit was observed (mean plasma recovery 0.4-49%). For drugs coadministered into a circuit, significant decreases in extraction and increases in drug recovery (2.5-109%) were found, suggesting dosing adjustments may be needed. This study highlights the need for additional studies of drug coadministration within CRRT circuits to describe complex drug-circuit and drug-drug interactions to provide dosing guidance in pediatric CRRT patients.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"603-610"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative Intravenous Administration in Renal Transplantation: A Meta-Analysis of Randomized Controlled Trials. 肾移植术中静脉给药:随机对照试验的荟萃分析。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-01 DOI: 10.1097/MAT.0000000000002500
Li-Yen Chang, El-Wui Loh, Ka-Wai Tam
{"title":"Intraoperative Intravenous Administration in Renal Transplantation: A Meta-Analysis of Randomized Controlled Trials.","authors":"Li-Yen Chang, El-Wui Loh, Ka-Wai Tam","doi":"10.1097/MAT.0000000000002500","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002500","url":null,"abstract":"<p><p>The effects of intraoperative intravenous (IV) fluids choices on kidney function during renal transplantation remain unclear. This meta-analysis compared the effectiveness of normal saline with that of alternative colloids and crystalloids in end-stage renal disease (ESRD) patients who underwent renal transplantation. We searched PubMed, Embase, and Cochrane Library to April 2025. Randomized control trials comparing normal saline with IV fluids were included. The primary outcome was delayed graft function. Secondary outcomes were total fluid volume, renal function, and perioperative ion change. Sixteen trials were analyzed with random-effects model. The pooled results for delayed graft function revealed that Plasma-Lyte was associated with a significantly lower incidence rate (risk ratio = 0.82, 95% confidence interval [CI] = 0.69-0.96) than normal saline. Serum creatinine levels on day 7 revealed that lactated Ringers (mean difference [MD] = -0.08, 95% CI = -0.15 to -0.01) and sodium bicarbonate (MD = -0.21, 95% CI = -0.41 to -0.01) groups had significantly lower creatinine levels than did the normal saline group. In conclusion, Plasma-Lyte led to a more favorable short-term graft function and perioperative ion status, which may be considered a practical option in ESRD patients undergoing kidney transplantation. Prospective controlled studies are warranted to corroborate these findings.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Over 100 Fontan Patients on Systemic Ventricular Assist Device Support: An ACTION Update. 超过100名Fontan患者接受系统心室辅助装置支持:ACTION更新。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-12-26 DOI: 10.1097/MAT.0000000000002367
Sharon Chen, Kathleen E Simpson
{"title":"Over 100 Fontan Patients on Systemic Ventricular Assist Device Support: An ACTION Update.","authors":"Sharon Chen, Kathleen E Simpson","doi":"10.1097/MAT.0000000000002367","DOIUrl":"10.1097/MAT.0000000000002367","url":null,"abstract":"<p><p>As the Fontan population grows, understanding successful strategies for ventricular assist device (VAD) support of the failing Fontan circulation is needed. We performed a retrospective analysis of patients with Fontan circulation and systemic VAD support in the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) registry. Competing outcomes and Kaplan-Meier estimated survival methods were used. Between January 2012 and December 2022, 106 Fontan patients underwent VAD implant (median age 10 years, 20% age ≥18 years). At time of implant, 58% were on greater than or equal to 2 inotropes, 26% on extracorporeal membrane oxygenation (ECMO), and 41% intubated. Since 2018, there have been more patients implanted at INTERMACS profile 1 or 2 (88% vs . 71%, p = 0.02) and on inotropic support (95% vs . 76%, p = 0.01). Median duration of VAD support was 113 (interquartile range (IQR): 43-266) days. At 12 months post-VAD implant, 53% were transplanted, 27% were alive on device, 2% had successful recovery, and 18% had died. Overall, 75% experienced greater than or equal to 1 adverse event, with bleeding, infection, and neurologic dysfunction most common. Despite high acuity at the time of VAD implant and high rate of adverse events, the majority of Fontan patients were transplanted or still alive on device at 12 months post-VAD implant.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"588-595"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age Differences in Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock: Trends in Application and Outcome From the Chinese Extracorporeal Life Support Registry. 心源性休克的静脉体外膜氧合治疗的年龄差异:来自中国体外生命支持登记的应用趋势和结果。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2025-02-25 DOI: 10.1097/MAT.0000000000002404
Kexin Wang, Liangshan Wang, Jiawang Ma, Haixiu Xie, Xing Hao, Zhongtao Du, Chenglong Li, Hong Wang, Xiaotong Hou
{"title":"Age Differences in Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock: Trends in Application and Outcome From the Chinese Extracorporeal Life Support Registry.","authors":"Kexin Wang, Liangshan Wang, Jiawang Ma, Haixiu Xie, Xing Hao, Zhongtao Du, Chenglong Li, Hong Wang, Xiaotong Hou","doi":"10.1097/MAT.0000000000002404","DOIUrl":"10.1097/MAT.0000000000002404","url":null,"abstract":"<p><p>Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used for cardiogenic shock (CS) in adults, with age-influencing outcomes. Data from the Chinese Extracorporeal Life Support (CSECLS) Organization registry (January 2017-July 2023) were analyzed to assess in-hospital mortality in VA-ECMO for CS. Patients ≤65 years were categorized as young, and those >65 as elder. The primary outcome was in-hospital mortality, with secondary outcomes including ECMO weaning, 30 day survival, and complications. Of 5,127 patients, the young group (73.4%) had a median age of 51.0 (40.0-58.0) years, and the elder group (26.6%) had a median age of 71.0 (68.0-75.0) years. The in-hospital mortality was lower in the younger group (45.1%) compared with the elder group (52.6%, p < 0.001). The young group also had higher ECMO weaning rates (79.4% vs . 74.8%, p < 0.001) and 30 day survival (59.1% vs . 51.3%, p < 0.001). Bleeding, renal, and pulmonary complications were more frequent in young patients, though not statistically significant. Young patients undergoing VA-ECMO for CS generally have better outcomes than older patients, though careful selection is crucial to manage complications.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"579-587"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and Risk Factors of Cannula-Associated Deep Vein Thrombosis After Extracorporeal Life Support in Adult Critically Ill Patients. 成人危重患者体外生命支持后套管相关深静脉血栓的发生率及危险因素分析。
IF 3.1 3区 医学
ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2025-03-06 DOI: 10.1097/MAT.0000000000002405
Sayed Abdulmotaleb Almoosawy, Joud Albalool, Ahmad Alenezi, Anwar Murad, Sarah Buabbas, Abdulaziz Almutawa, Kefaya Abdulmalek, Abdulrahman Al-Fares
{"title":"Incidence and Risk Factors of Cannula-Associated Deep Vein Thrombosis After Extracorporeal Life Support in Adult Critically Ill Patients.","authors":"Sayed Abdulmotaleb Almoosawy, Joud Albalool, Ahmad Alenezi, Anwar Murad, Sarah Buabbas, Abdulaziz Almutawa, Kefaya Abdulmalek, Abdulrahman Al-Fares","doi":"10.1097/MAT.0000000000002405","DOIUrl":"10.1097/MAT.0000000000002405","url":null,"abstract":"<p><p>Cannula-associated deep vein thrombosis (CaDVT) following decannulation from extracorporeal life support (ECLS) is a commonly reported complication with several associated risk factors. This study investigated the incidence and risk factors of CaDVT after ECLS decannulation from a nationwide registry. We analyzed consecutive patients who were successfully decannulated from ECLS and screened for CaDVT from two medical-surgical intensive care units (ICU) in Kuwait between 2016 and 2023. The incidence of CaDVT was assessed and correlated with risk factors such as baseline characteristics, ECLS mode and duration, and cannula sizes. Length of stay (LOS) in the ICU, along with ICU and in-hospital mortality were reported. Of 403 patients supported with ECLS, 144 underwent postdecannulation ultrasound. Cannula-associated deep vein thrombosis occurred in 94 (65%) patients. Venovenous ECLS (V-V ECLS) was the only independent risk factor associated with post-ECLS CaDVT (odds ratio [OR]: 4.78; 95% confidence interval [CI]: 1.18-19.4). Length of stay in the ICU and mortality were similar between patients with and without CaDVT. Cannula-associated deep vein thrombosis is a frequent complication of ECLS, occurring in more than half of patients. The use of V-V ECLS appears to be an independent risk factor for the development of post-ECLS CaDVT. Further efforts are needed to develop formal recommendations for screening and managing CaDVT post-ECLS.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"596-602"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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