ASAIO Journal最新文献_第3页

Artificial Placenta and Artificial Womb Technologies for Lung and Kidney Failure: A Holistic Perspective. 人工胎盘和人工子宫技术治疗肺和肾衰竭：整体视角。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1097/MAT.0000000000002443

Danny J M van Galen, Ana Martins Costa, Franziska Siche-Pantel, Ruth Kemper, Niels Rochow, Maria Brandani, Frank R Halfwerk, Jutta Arens

{"title":"Artificial Placenta and Artificial Womb Technologies for Lung and Kidney Failure: A Holistic Perspective.","authors":"Danny J M van Galen, Ana Martins Costa, Franziska Siche-Pantel, Ruth Kemper, Niels Rochow, Maria Brandani, Frank R Halfwerk, Jutta Arens","doi":"10.1097/MAT.0000000000002443","DOIUrl":"10.1097/MAT.0000000000002443","url":null,"abstract":"Preterm birth remains the leading cause of mortality among neonates. Despite improvements in neonatal intensive care over the years, current treatments for lung and kidney failure are highly invasive, associated with lifelong disability, and limit family integration. Artificial womb and artificial placenta technologies offer a promising alternative by providing more tailored and less invasive neonatal care. Although these technologies share some similarities, artificial womb and artificial placenta technologies differ significantly in terms of treatment initiation, treatment environment, and the potential to support family-centered care. Moreover, even though acute kidney injury is common in neonatal extracorporeal membrane oxygenation (ECMO) patients, current artificial placenta and artificial womb devices lack renal support functionality. Most artificial womb and artificial placenta studies focus on the technical feasibility of these technologies based on in-vivo animal tests. However, translation toward envisioned use of these devices in preterm neonates remains mostly underexposed. A comprehensive stakeholder analysis, including parents and caregivers, is critical to the development of socially acceptable artificial placenta and artificial womb systems. This state-of-the-art review provides an overview of conventional neonatal lung and kidney treatments, delineates the differences between artificial womb and placenta technologies, and addresses the technological and ethical challenges in advancing these technologies toward potential clinical implementation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"519-527"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations on Enhancing Venoarterial-Extracorporeal Membrane Oxygenation Via Transapical Cannulation and Minimally Invasive Techniques. 经根尖插管和微创技术增强静脉-体外膜氧合的思考。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-11-22 DOI: 10.1097/MAT.0000000000002354

Ignazio Condello

引用次数: 0

First-Day Platelet Count Is Associated With In-Hospital Mortality in Adult Postcardiotomy Extracorporeal Membrane Oxygenation. 第一天血小板计数与成人心脏切开术后体外膜氧合的住院死亡率相关

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2025-02-13 DOI: 10.1097/MAT.0000000000002393

Jing Wang, Sizhe Gao, Tianlong Wang, Han Zhang, Luyu Bian, Shujie Yan, Bingyang Ji

{"title":"First-Day Platelet Count Is Associated With In-Hospital Mortality in Adult Postcardiotomy Extracorporeal Membrane Oxygenation.","authors":"Jing Wang, Sizhe Gao, Tianlong Wang, Han Zhang, Luyu Bian, Shujie Yan, Bingyang Ji","doi":"10.1097/MAT.0000000000002393","DOIUrl":"10.1097/MAT.0000000000002393","url":null,"abstract":"To investigate the relationship between platelet counts within the first 24 hours of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support and in-hospital mortality in postcardiotomy ECMO patients. Adult patients undergoing postcardiotomy V-A ECMO from 2017 to 2021 were included and divided into survivors and non-survivors. Logistic regression evaluated the association between the first-day platelet counts and in-hospital mortality. Spearman's correlation assessed the correlations between clinical factors and the platelet hourly % decrease within 24 hours of ECMO support. The study included 72 patients, with an in-hospital mortality of 51.4%. For every 10 ×10 9 /L decrease in the lowest platelet count at 0-24, 0-12, and 12-24 hours of ECMO support, the odds of in-hospital mortality increased by 21.7% (adjusted odds ratios [aOR], 1.217; 95% confidence intervals [CI], 1.045-1.358), 20.6% (aOR, 1.206; 95% CI, 1.058-1.332), and 17.4% (aOR, 1.174; 95% CI, 1.034-1.294), respectively. Platelet hourly % decrease was positively correlated with peak lactate, alanine aminotransferase, D-dimer, fibrinogen degradation products, and ECMO flow rate variation. In postcardiotomy V-A ECMO patients, platelet counts within the first 24 hours of ECMO support are independently associated with higher in-hospital mortality. Potential factors related to decreasing rate of platelet count included thrombosis, ECMO flow fluctuation, tissue ischemia, and hypoxia.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"544-551"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Accuracy of HeartMate 3 Risk Score After the Heart Transplant Allocation Change. 心脏移植分配变化后 HeartMate 3 风险评分的预测准确性。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-11-05 DOI: 10.1097/MAT.0000000000002343

Justin D Vincent, Alyssa Ramsay, David S Lambert, Elena Deych, Ana María Pico, Erin Coglianese, Justin M Vader, Bin Q Yang

引用次数: 0

Bridge to Heart Transplant With Temporary Mechanical Circulatory Support: Trends and Outcomes in the 2018 Allocation Policy Era. 临时机械循环支持心脏移植的桥梁：2018年分配政策时代的趋势和结果。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-12-04 DOI: 10.1097/MAT.0000000000002352

Ander Dorken-Gallastegi, Yeahwa Hong, Nicholas R Hess, Luke A Ziegler, Mohamed Abdullah, Nidhi Iyanna, Raj Ramanan, Gavin W Hickey, Mary E Keebler, David J Kaczorowski

{"title":"Bridge to Heart Transplant With Temporary Mechanical Circulatory Support: Trends and Outcomes in the 2018 Allocation Policy Era.","authors":"Ander Dorken-Gallastegi, Yeahwa Hong, Nicholas R Hess, Luke A Ziegler, Mohamed Abdullah, Nidhi Iyanna, Raj Ramanan, Gavin W Hickey, Mary E Keebler, David J Kaczorowski","doi":"10.1097/MAT.0000000000002352","DOIUrl":"10.1097/MAT.0000000000002352","url":null,"abstract":"The United Network for Organ Sharing (UNOS) 2018 heart allocation policy prioritizes patients receiving temporary mechanical circulatory support (tMCS) given the high waitlist mortality rate of this group. This study evaluates national trends and waitlist outcomes for patients receiving tMCS under the UNOS 2018 allocation policy. Adult patients waitlisted for isolated heart transplantation were included using the UNOS database. The prevalence of tMCS, 90 day waitlist mortality, 90 day incidence of transplantation, and posttransplant 1 year mortality were analyzed. A total of 27,343 patients were waitlisted during the study period (pre-policy change: 13,004 vs . post-policy change: 14,339). The prevalence of tMCS increased from 7.4% (n: 956) to 22.4% (n: 3,186) after the policy change ( p < 0.001). The use of Impella increased proportionally among tMCS modalities. Patients on tMCS had lower adjusted odds of waitlist mortality ( p < 0.001), higher adjusted incidence of transplantation ( p < 0.001), and similar posttransplant mortality ( p = 0.10) under the 2018 policy. Patients on extracorporeal membrane oxygenation (ECMO) support had the highest odds of 90 day waitlist mortality ( p < 0.05) but also the highest incidence of transplantation in the post-policy change cohort ( p < 0.05). In conclusion, the use of tMCS as bridge to heart transplantation increased threefolds and is associated with lower waitlist mortality and higher incidence of transplantation following the UNOS 2018 allocation policy change.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"571-578"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Extracorporeal Membrane Oxygenation in Restrictive and Hypertrophic Cardiomyopathy: A Single Center Experience. 限制性和肥厚性心肌病的儿科体外膜氧合：单中心经验。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-10-08 DOI: 10.1097/MAT.0000000000002322

Diana L Geisser, Bryan D Siegel, Ryan L Kobayashi, Christina J VanderPluym, Francis Fynn-Thompson, Ravi R Thiagarajan, Katie M Moynihan

{"title":"Pediatric Extracorporeal Membrane Oxygenation in Restrictive and Hypertrophic Cardiomyopathy: A Single Center Experience.","authors":"Diana L Geisser, Bryan D Siegel, Ryan L Kobayashi, Christina J VanderPluym, Francis Fynn-Thompson, Ravi R Thiagarajan, Katie M Moynihan","doi":"10.1097/MAT.0000000000002322","DOIUrl":"10.1097/MAT.0000000000002322","url":null,"abstract":"Patients with restrictive cardiomyopathy (RCM) and hypertrophic cardiomyopathy (HCM) were previously considered poor candidates for mechanical circulatory support due to technical limitations related to restrictive ventricular physiology and small ventricular size, limiting the ability to provide adequate flows and decompress the heart. Literature examining use of extracorporeal membrane oxygenation (ECMO) in this population consists of a single case series reporting no survivors. We report our experience providing ECMO in children with RCM or HCM at a large pediatric quaternary cardiac center. Between 2012 and 2022, five patients (four RCM, one HCM) were supported with seven ECMO runs. All patients were cannulated to ECMO with ongoing cardiopulmonary resuscitation. Four patients survived decannulation from ECMO (median support time 209 hr, interquartile range [IQR]: 48-265), of which three (60%) survived to hospital discharge after transitioning to a ventricular assist device (VAD) and undergoing orthotopic heart transplant (OHT). Two remain alive at long-term follow-up with normal or mildly impaired functional status. These findings suggest that while RCM and HCM have traditionally been considered contraindications to ECMO due to adverse outcomes, this population may be successfully supported with ECMO with survival comparable to international registry outcomes in select centers where VAD as a bridge to OHT is available.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e110-e114"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Neutrophil-to-Lymphocyte Ratio During Venoarterial Extracorporeal Membrane Oxygenation. 静脉体外膜氧合过程中中性粒细胞与淋巴细胞比值的变化。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2025-01-16 DOI: 10.1097/MAT.0000000000002376

Jose I Nunez, Mayuko Uehara, Snehal R Patel, Stephen J Forest, Yogita Rochlani, Shivank Madan, Daniel B Sims, Nicholas Mellas, Justin E Ashley, Marjan Rahmanian, Anthony Carlese, Daniel J Goldstein, Ulrich P Jorde, Omar Saeed

{"title":"Changes in Neutrophil-to-Lymphocyte Ratio During Venoarterial Extracorporeal Membrane Oxygenation.","authors":"Jose I Nunez, Mayuko Uehara, Snehal R Patel, Stephen J Forest, Yogita Rochlani, Shivank Madan, Daniel B Sims, Nicholas Mellas, Justin E Ashley, Marjan Rahmanian, Anthony Carlese, Daniel J Goldstein, Ulrich P Jorde, Omar Saeed","doi":"10.1097/MAT.0000000000002376","DOIUrl":"10.1097/MAT.0000000000002376","url":null,"abstract":"Mortality remains elevated during venoarterial extracorporeal membrane oxygenation support (VA-ECMO) for cardiogenic shock and the role of inflammation is uncertain. By using the neutrophil-to-lymphocyte ratio (NLR), we investigated inflammatory dynamics during VA-ECMO and their relation to clinical outcomes. A single-center, retrospective cohort study was conducted. Patients receiving steroids or on-device support for less than 48 hours were excluded. Patients were grouped as those who did and did not have a persistent rise in NLR during the 24-48 hour interval after VA-ECMO placement. Overall, 253 patients comprised the study cohort. In-hospital mortality was 56%. Neutrophil-to-lymphocyte ratio was higher at 24 hours after VA-ECMO placement compared to pre-ECMO (Δ4.36, interquartile range [IQR]: -0.23 to 8.61, p < 0.001). Persistent increase in NLR during the 24-48 hour interval after VA-ECMO placement was associated with higher in-hospital mortality (adjusted hazard ratio [aHR]: 1.51, 95% confidence interval [CI]: 1.02-2.25, p = 0.04). The magnitude of this rise in NLR was incrementally related to greater in-hospital mortality (Δ0-5: 72%, aHR: 1.61, 95% CI: 1.03-2.54, p = 0.039; Δ>5: 79%, aHR: 1.64, 95% CI: 1.03-2.63, p = 0.037) in comparison 52%, for those with a drop in NLR. Venoarterial extracorporeal membrane oxygenation exacerbates inflammation, as evident by a rise in NLR, which is progressively higher in nonsurvivors.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"528-535"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left Ventricular Unloading With Surgically Implanted Microaxial Flow Pump in Patients on Venoarterial Membrane Oxygenation. 手术植入微轴流泵对静脉动脉膜氧合患者左心室负荷的影响。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-12-18 DOI: 10.1097/MAT.0000000000002364

Pia Lanmüller, Nils Hinrichs, Gaik Nersesian, Daniel Lewin, Ben O'Brien, Volkmar Falk, Evgenij Potapov, Christoph Starck, Sascha Ott

{"title":"Left Ventricular Unloading With Surgically Implanted Microaxial Flow Pump in Patients on Venoarterial Membrane Oxygenation.","authors":"Pia Lanmüller, Nils Hinrichs, Gaik Nersesian, Daniel Lewin, Ben O'Brien, Volkmar Falk, Evgenij Potapov, Christoph Starck, Sascha Ott","doi":"10.1097/MAT.0000000000002364","DOIUrl":"10.1097/MAT.0000000000002364","url":null,"abstract":"Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is applied for the treatment of cardiogenic shock. Concomitant left ventricular unloading (LVU) with a microaxial flow pump (mAFP) enables myocardial and pulmonary recovery and may overcome some of the limitations of VA-ECMO. The study included 145 cardiogenic shock patients, 89 (61.4%) of whom were treated with VA-ECMO alone (ECMO group), whereas 56 (38.6%) received LVU with a surgically implanted mAFP on top of VA-ECMO (ECMELLA group). After 2:1 propensity score matching, 30 day and 1 year survival was similar between the groups ( p = 0.62 and 0.68, respectively). In the subgroup analysis, patients who received mAFP in the first 2 hours after VA-ECMO implantation had an improved 30 day (hazard ratio [HR]: 0.45 [95% confidence interval {CI}: 0.23-0.88], p = 0.02) and 1 year survival (HR: 0.52 [95% CI: 0.28-0.97], p = 0.04). The rate of limb ischemia, hemorrhage, and renal replacement therapy were comparable between the propensity score-matched cohorts. Early LVU with a surgically implanted mAFP in patients on VA-ECMO improved short-and long-term survival.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"536-543"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Dynamic Organ Storage System Enhances Liver Graft Function in a Porcine Donation After Circulatory Death Model. 新型动态器官储存系统增强猪循环死亡模型捐献肝移植功能。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-07-01 Epub Date: 2024-12-18 DOI: 10.1097/MAT.0000000000002365

Yutaka Shishido, Kaitlyn M Tracy, Mark Petrovic, TiOluwanimi Adesanya, Avery K Fortier, Kimya Raietparvar, Gabriella A Glomp, Elizabeth Simonds, Timothy R Harris, Victoria Simon, William D Tucker, Brandon Petree, Michael Cortelli, Nancy L Cardwell, Christian Crannell, Jiancong Liang, Alexandria C Murphy, Blanche L Fields, Melanie McReynolds, Caitlin T Demarest, Rei Ukita, Michael Rizzari, Martin Montenovo, Joseph F Magliocca, Seth J Karp, M Ameen Rauf, Ashish S Shah, Matthew Bacchetta

{"title":"Novel Dynamic Organ Storage System Enhances Liver Graft Function in a Porcine Donation After Circulatory Death Model.","authors":"Yutaka Shishido, Kaitlyn M Tracy, Mark Petrovic, TiOluwanimi Adesanya, Avery K Fortier, Kimya Raietparvar, Gabriella A Glomp, Elizabeth Simonds, Timothy R Harris, Victoria Simon, William D Tucker, Brandon Petree, Michael Cortelli, Nancy L Cardwell, Christian Crannell, Jiancong Liang, Alexandria C Murphy, Blanche L Fields, Melanie McReynolds, Caitlin T Demarest, Rei Ukita, Michael Rizzari, Martin Montenovo, Joseph F Magliocca, Seth J Karp, M Ameen Rauf, Ashish S Shah, Matthew Bacchetta","doi":"10.1097/MAT.0000000000002365","DOIUrl":"10.1097/MAT.0000000000002365","url":null,"abstract":"Donation after circulatory death (DCD) livers face increased risks of critical complications when preserved with static cold storage (SCS). Although machine perfusion (MP) may mitigate these risks, its cost and logistical complexity limit widespread application. We developed the Dynamic Organ Storage System (DOSS), which delivers oxygenated perfusate at 10°C with minimal electrical power requirement and allows real-time effluent sampling in a portable cooler. In a porcine DCD model, livers were preserved using DOSS or SCS for 10 hours and evaluated with 4 hours of normothermic MP, with n = 5 per group. After 4 hours of normothermic MP, the DOSS group demonstrated significantly lower perfusate lactate ( p = 0.023), increased perfusate fibrinogen ( p = 0.005), higher oxygen consumption ( p = 0.018), greater bile production ( p = 0.013), higher bile bicarbonate levels ( p = 0.035) and bile/perfusate sodium ratio ( p = 0.002), and lower hepatic arterial resistance after phenylephrine administration ( p = 0.018). Histological analysis showed lower apoptotic markers in DOSS-preserved livers, with fewer cleaved caspase-3 ( p = 0.039) and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL; p = 0.009) positive cells. These findings suggest that DOSS can enhance DCD allograft function during transport, offering potential clinical benefits and contributing to the expansion of the donor pool.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"560-570"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodynamic Considerations of Distal Perfusion Catheters With Venoarterial Extracorporeal Membrane Oxygenation: A Dynamic Mock Loop Study. 远端灌注导管与静脉体外膜氧合的血流动力学考虑：动态模拟环研究。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-06-27 DOI: 10.1097/MAT.0000000000002494

Joshua G Crane, Gretel Monreal, Steven C Koenig, Mark S Slaughter

{"title":"Hemodynamic Considerations of Distal Perfusion Catheters With Venoarterial Extracorporeal Membrane Oxygenation: A Dynamic Mock Loop Study.","authors":"Joshua G Crane, Gretel Monreal, Steven C Koenig, Mark S Slaughter","doi":"10.1097/MAT.0000000000002494","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002494","url":null,"abstract":"There are conflicting clinical data on whether the use of a distal perfusion catheter (DPC) is beneficial for reducing the risk of limb ischemia in peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) patients. We investigated the hemodynamic effects of arterial cannula size, use of and size of a DPC, and ECMO flow (pump speed) on femoral artery hemodynamics in an adult peripheral VA-ECMO dynamic mock loop. The mock loop was tuned to heart failure conditions (cardiac output 3 L/min, arterial pressure 50 mm Hg, venous pressure 20 mm Hg). Three arterial cannulae (15Fr, 17Fr, 19Fr; right iliac) were each integrated into the loop with/without DPC (none, 5Fr, 8Fr; right superficial femoral artery [RSFA]), creating nine configurations tested. Hemodynamic pressures and flows were recorded over a range of pump speeds generating 0-3.5 L/min ECMO flow. The right femoral arteries demonstrated reduced flow, pressure, and pulsatility compared with the left across all cannula configurations and which worsened with increasing arterial cannula size and ECMO flow. Impaired right femoral hemodynamics were not improved with the use or size of DPC, suggesting that the increased resistance created by the presence of the arterial cannula and the DPC may be too great to overcome, thereby offsetting any potential flow benefits provided by the DPC.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0