ASAIO Journal最新文献

筛选
英文 中文
Evolution of Gastrointestinal Bleeding in Patients Supported With Continuous-Flow Left Ventricular Assist Devices. 连续流左心室辅助装置支持下患者胃肠道出血的演变。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2025-10-31 DOI: 10.1097/MAT.0000000000002597
Anh Nguyen, Andrew Civitello, Alexis Shafii, Gabriel Loor, Subhasis Chatterjee, O Howard Frazier, Kenneth Liao
{"title":"Evolution of Gastrointestinal Bleeding in Patients Supported With Continuous-Flow Left Ventricular Assist Devices.","authors":"Anh Nguyen, Andrew Civitello, Alexis Shafii, Gabriel Loor, Subhasis Chatterjee, O Howard Frazier, Kenneth Liao","doi":"10.1097/MAT.0000000000002597","DOIUrl":"10.1097/MAT.0000000000002597","url":null,"abstract":"<p><p>We assessed characteristics and risk factors of gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVAD) in our institutional Intermacs database (2008-2023). Patient characteristics were reported as frequencies/proportions for categorical variables and as median/interquartile range (IQR) for continuous variables. Multivariable Cox proportional hazards regression identified GI bleeding risk factors. Among 1,030 CF-LVADs implanted, the median age was 58.5 years (IQR: 50.4-65.4), and 79.4% were male. Pre-implant Intermacs profile less than or equal to 3 was seen in 80.6%. Axial-flow LVADs were used in 55.2%, partially magnetically levitated centrifugal-flow in 30.7%, and fully magnetically levitated centrifugal-flow in 14.1%. GI bleeding occurred in 37.5% (13.9 per 100 person-years), with 65.3% rebleeding. Bleeding sources: 54.4% upper GI, 21.8% lower GI, and 23.8% unknown. The median time from LVAD implant to first GI bleeding was 5 months (IQR: 1-19); to any GI bleeding was 11 months (IQR: 2-31). Patients older than 50 years were three times more likely to develop GI bleeding (hazard ratio [HR]: 3.15, p < 0.001). Fully magnetically levitated centrifugal-flow LVADs reduced GI bleeding risk by four times compared to axial-flow LVADs (HR: 0.26, p < 0.001). Coronary artery disease (HR: 1.49, p = 0.022) and chronic kidney disease (HR: 1.91, p = 0.001) nearly double the risk of GI bleeding.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e222-e227"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes Comparison of Venoarterial Extracorporeal Life Support With Acute Decompensated Heart Failure Versus Acute Myocardial Infarction. 急性失代偿性心力衰竭与急性心肌梗死患者静脉体外生命支持的结果比较。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2025-11-11 DOI: 10.1097/MAT.0000000000002599
Yuichiro Kitada, Guillermo Almodovar-Cruz, Yangling Zhao, Paul Kurlansky, Mitchel Drew, Adham Elmously, Amirali Masoumi, Adhil A Yunis, Justin Fried, Koji Takeda
{"title":"Outcomes Comparison of Venoarterial Extracorporeal Life Support With Acute Decompensated Heart Failure Versus Acute Myocardial Infarction.","authors":"Yuichiro Kitada, Guillermo Almodovar-Cruz, Yangling Zhao, Paul Kurlansky, Mitchel Drew, Adham Elmously, Amirali Masoumi, Adhil A Yunis, Justin Fried, Koji Takeda","doi":"10.1097/MAT.0000000000002599","DOIUrl":"10.1097/MAT.0000000000002599","url":null,"abstract":"<p><p>Acute decompensated heart failure (ADHF) and acute myocardial infarction (AMI) are major etiologies of cardiogenic shock with distinct pathophysiology. This study reported the outcomes of venoarterial extracorporeal life support (V-A ECLS) between ADHF cardiogenic shock (ADHF-CS) and AMI cardiogenic shock (AMI-CS), including 233 patients. Outcomes were compared between patients with ADHF-CS and AMI-CS. Additionally, we classified each study cohort into two groups based on the date of cannulation to V-A ECLS before and after the United Network for Organ Sharing (UNOS) policy change and compared outcomes. There were 107 ADHF-CS patients and 126 AMI-CS patients. A Kaplan-Meier 1 year survival probability of ADHF-CS group was 51.8%, while the AMI-CS group had a 1 year survival probability of 29.2% ( p = 0.001). However, the difference in 1 year survival is no longer observed after inverse probability of treatment weighting (IPTW) (37.5% vs . 27.0%, p = 0.28). Regarding myocardial recovery and bridging modality, bridge to recovery or ventricular assist device rate was similar between groups, whereas bridge to transplant rate was significantly higher in the ADHF-CS than AMI-CS after IPTW (3.5% vs. 0.0%, p = 0.010). This trend became particularly evident following the change in the UNOS allocation system.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e228-e234"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145487456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parallel Dual-Lumen Venovenous Extracorporeal Membrane Oxygenation Following Extracorporeal Cardiopulmonary Resuscitation. 体外心肺复苏后平行双腔静脉-静脉体外膜氧合。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2026-04-09 DOI: 10.1097/MAT.0000000000002704
Elliott Worku, Sridevi Shetty, Paul Forrest, Paul Torzillo, Richard Totaro
{"title":"Parallel Dual-Lumen Venovenous Extracorporeal Membrane Oxygenation Following Extracorporeal Cardiopulmonary Resuscitation.","authors":"Elliott Worku, Sridevi Shetty, Paul Forrest, Paul Torzillo, Richard Totaro","doi":"10.1097/MAT.0000000000002704","DOIUrl":"10.1097/MAT.0000000000002704","url":null,"abstract":"<p><p>Differential oxygenation may complicate extracorporeal cardiopulmonary resuscitation (ECPR) either due to the initial pathology or subsequent lung injury. The dual circulation phenomenon inherent to peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) risks poorly oxygenated blood preferentially supplying the cerebral circulation. This may be deleterious to neurological outcomes and survival in this cohort. We describe two novel cases of parallel VV-ECMO support following ECPR, using a dual-lumen bicaval cannula to salvage severe differential hypoxemia. Decannulation of arterial support occurred at 4 and 7 days, respectively, with initial reconfiguration to high-flow VV-ECMO. This unique approach offers an attractive alternative to hybrid VAVECMO and may provide a necessary escalation following successful ECPR to facilitate neuroprotection.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e260-e267"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventive Strategies for Driveline Infections in Ventricular Assist Devices: A Systematic Review. 心室辅助装置传动系统感染的预防策略:系统综述。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2026-08-03 DOI: 10.1097/MAT.0000000000002800
Simone Amato, Francesco Limonti, Andrea Battisti, Antonio Cartolano, Angela Lappa, Emilio D'Avino, Guglielmo Imbriaco
{"title":"Preventive Strategies for Driveline Infections in Ventricular Assist Devices: A Systematic Review.","authors":"Simone Amato, Francesco Limonti, Andrea Battisti, Antonio Cartolano, Angela Lappa, Emilio D'Avino, Guglielmo Imbriaco","doi":"10.1097/MAT.0000000000002800","DOIUrl":"10.1097/MAT.0000000000002800","url":null,"abstract":"<p><p>Driveline infection (DLI) is the most frequent infectious complication in patients supported with ventricular assist devices (VADs) and remains a major cause of morbidity and rehospitalization. This systematic review aimed to synthesize the available evidence on preventive strategies to reduce the incidence of DLI in adult VAD recipients. A systematic search of MEDLINE/PubMed, Scopus, CINAHL, Web of Science, the Cochrane Library, and APA PsycInfo up to April 1, 2026, followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Eleven observational studies were included. The infection prevention strategies evaluated included modifications to surgical tunneling, driveline stabilization techniques, standardized exit-site care protocols, antiseptic and dressing management, negative pressure wound therapy, and antibiotic prophylaxis. Surgical routing optimization, mechanical stabilization, and standardized exit-site care protocols were most consistently associated with reduced DLI incidence. In contrast, adjunctive interventions such as negative pressure wound therapy and prolonged antibiotic prophylaxis showed limited or inconsistent benefit. Current evidence remains limited to observational studies, highlighting the need for prospective and controlled research to establish standardized preventive strategies.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"721-732"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Low-Profile Full-Flow Percutaneous Ventricular Assist Device. 一种新型低轮廓全流量经皮心室辅助装置。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2025-10-03 DOI: 10.1097/MAT.0000000000002564
Martin C Cook, Sara Inglis, Jordon Honeck, Atta Behfar, Sukumaran T Thambar
{"title":"A Novel Low-Profile Full-Flow Percutaneous Ventricular Assist Device.","authors":"Martin C Cook, Sara Inglis, Jordon Honeck, Atta Behfar, Sukumaran T Thambar","doi":"10.1097/MAT.0000000000002564","DOIUrl":"10.1097/MAT.0000000000002564","url":null,"abstract":"<p><p>Percutaneous ventricular assist devices (pVAD) decrease mortality in cardiogenic shock (CS) patients, but at a high adverse event rate. Novel pVADs need to improve cardiac power output (CPO) to improve efficacy and reduce profile to reduce adverse events. Venstramedical has developed an impeller with nitinol and polymer which can collapse for low-profile insertion and expand in the body to provide optimal CPO. We have also developed a unique 9 French (9Fr) delivery system. In vitro and in vivo testing have been performed to develop this device. Head-flow (HQ) tests generate 5.0 L/min with a pressure differential of 80 mm Hg and 7.0 L/min against 60 mm Hg. Durability testing demonstrated continuous operation of up to 20 days. In the acute healthy ovine model, we demonstrated full flow (7-9 L against 60-80 mm Hg), transcatheter 9Fr delivery, retrieval of the device, and resting of the native heart during pumping. In a CS animal, we demonstrated survival and resting of the native heart during the acute study with decreased stroke work (SW), decreased stroke volume (SV), while total cardiac output was up to 7 L/min and maintaining adequate pressure with low hemolysis. We also demonstrated multiday functioning of the device in a healthy ovine model with good CO and low hemolysis.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"733-739"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal Angina Index as a Predictor of Renal Injury Progression in Patients on Extracorporeal Membrane Oxygenation Support: The DREAMS Study. 肾性心绞痛指数作为体外膜氧合支持患者肾损伤进展的预测因子:DREAMS研究。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2025-10-31 DOI: 10.1097/MAT.0000000000002589
Michel Perez-Garzon, Henry Robayo-Amortegui, Alejandro Quintero-Altare, Sergio Linares-Peña, Lina Lasso-Ossa, Claudia Poveda-Henao, Alex Forero-Delgadillo
{"title":"Renal Angina Index as a Predictor of Renal Injury Progression in Patients on Extracorporeal Membrane Oxygenation Support: The DREAMS Study.","authors":"Michel Perez-Garzon, Henry Robayo-Amortegui, Alejandro Quintero-Altare, Sergio Linares-Peña, Lina Lasso-Ossa, Claudia Poveda-Henao, Alex Forero-Delgadillo","doi":"10.1097/MAT.0000000000002589","DOIUrl":"10.1097/MAT.0000000000002589","url":null,"abstract":"<p><p>This retrospective cohort study evaluates the validity of the Renal Angina Index (RAI) in predicting acute kidney injury (AKI) in 272 patients receiving extracorporeal membrane oxygenation (ECMO) support. The findings show that 56.9% of patients present with renal angina. This condition is significantly associated with the use of vasoactive agents like norepinephrine (odds ratios [OR]: 4.54; 95% confidence interval [CI], 2.42-8.53; p < 0.001), oxygen debt (OR: 1.15; 95% CI, 1.03-1.07; p < 0.001), veno-arterial extracorporeal membrane oxygenation (VA-ECMO) therapy (OR: 3.99; 95% CI, 2.14-7.40; p < 0.001), and pre-ECMO potassium levels (OR: 3.14; 95% CI, 2.05-4.82; p < 0.001). Ultimately, 81.9% of patients develop AKI, 50.3% require renal replacement therapy (RRT), and 41.3% die. The RAI demonstrates a good predictive ability for developing AKI, with an area under the receiver operating characteristic curve (AUROC) of 0.756 (95% CI, 0.70-0.80). Its performance is moderate for predicting AKI severity progression (AUROC: 0.604) and the need for RRT (AUROC: 0.615). The authors conclude that RAI is a reliable and practical early clinical tool to identify ECMO patients at high risk for AKI and its complications.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e214-e221"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Cardiac Resynchronization Therapy in Patients With Left Ventricular Assist Device. 心脏再同步化治疗对左心室辅助装置患者的影响。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2025-10-27 DOI: 10.1097/MAT.0000000000002584
Miloud Cherbi, Vincent Galand, Erwan Flecher, Pierre Groussin, Philippe Maury, Clément Delmas, Raphael Martins
{"title":"Influence of Cardiac Resynchronization Therapy in Patients With Left Ventricular Assist Device.","authors":"Miloud Cherbi, Vincent Galand, Erwan Flecher, Pierre Groussin, Philippe Maury, Clément Delmas, Raphael Martins","doi":"10.1097/MAT.0000000000002584","DOIUrl":"10.1097/MAT.0000000000002584","url":null,"abstract":"<p><p>A significant number of patients with left ventricular assist devices (LVAD) are also treated with cardiac resynchronization therapy (CRT). However, the effects of CRT on LVAD-recipient survival and ventricular arrhythmias (VAs) remain uncertain. To address this issue, we analyzed patients from the multicenter ASSIST-ICD registry using a 1:1 propensity score-matched cohort to evaluate the association between CRT and all-cause mortality. Secondary outcomes included cardiovascular/noncardiovascular mortality, and early (≤30 days postimplant) or late VAs. Among 652 LVAD recipients, 198 patients (30.4%) had CRT before LVAD implantation, followed for a median duration of 9.1 months (2.5-22.1). Cardiac resynchronization therapy patients were older with higher rates of atrial fibrillation, history of VAs, ischemic cardiomyopathy, and longer heart failure duration. After propensity matching, CRT use was not associated with improved survival (hazard ratio [HR]: 1.31 [0.94-1.82]), cardiovascular mortality (HR: 1.14 [0.68-1.90]), noncardiovascular mortality (HR: 0.88 [0.56-1.40]), or incidence of early (odds ratio [OR]: 0.71 [0.43-1.16]) or late (OR: 1.24 [0.73-2.11]) VAs. However, 27 CRT patients (13.6%) experienced device-related complications. These findings suggest that concomitant CRT with LVAD is not associated with survival benefit, despite notable device-related complications, warranting future randomized trials to clarify the clinical impact of pre-existing CRT in LVAD patients.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"757-764"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Prevention of Aortic Root Thrombosis Following Left Ventricular Assist Device Implantation Using Outflow Graft-Aortic Root Bypass. 流出体移植物-主动脉根部旁路移植术成功预防左心室辅助装置植入后主动脉根部血栓形成。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2026-01-30 DOI: 10.1097/MAT.0000000000002662
Hironobu Sakurai, Kota Suzuki, Kohei Tonai, Takuma Sato, Takuya Watanabe, Yasumasa Tsukamoto, Satsuki Fukushima
{"title":"Successful Prevention of Aortic Root Thrombosis Following Left Ventricular Assist Device Implantation Using Outflow Graft-Aortic Root Bypass.","authors":"Hironobu Sakurai, Kota Suzuki, Kohei Tonai, Takuma Sato, Takuya Watanabe, Yasumasa Tsukamoto, Satsuki Fukushima","doi":"10.1097/MAT.0000000000002662","DOIUrl":"10.1097/MAT.0000000000002662","url":null,"abstract":"<p><p>Aortic root thrombosis is a rare but potentially fatal complication associated with left ventricular assist device usage, potentially causing myocardial infarction and right heart failure. A patient with aortic root thrombosis causing left main trunk occlusion early following HeartMate 3 implantation was successfully treated with surgical thrombectomy and a novel outflow graft-aortic root bypass. A 59 year old man with dilated cardiomyopathy and deteriorating heart failure underwent HeartMate 3 implantation and aortic valve repair for advanced circulatory support. Chest pain and reduced left ventricular assist device flow were noted on postoperative day 6. Left coronary cusp thrombosis occluded the left main trunk, causing myocardial infarction. Following emergency percutaneous coronary intervention, surgical thrombectomy was performed, accompanied by an outflow graft-aortic root bypass using a saphenous vein graft to relieve blood stasis in the aortic root for recurrence prevention. Postoperative computed tomography indicated graft patency and no thrombus recurrence. Computational fluid dynamics analysis showed altered flow velocity and wall shear stress within the aortic root, suggesting thrombosis prevention by the bypass. This case highlights a potential role of outflow graft-aortic bypass for recurrent aortic root thrombosis prevention. Additional studies are required to assess effects on clinical outcomes.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e256-e259"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marginal Band Collapsing: Structural Insights Into Shear-Induced Platelet Activation Relevant to Circulatory Assist Devices. 边缘带塌陷:与循环辅助装置相关的剪切诱导血小板激活的结构见解。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2026-01-30 DOI: 10.1097/MAT.0000000000002666
Randy Perez, Kevin Ho, John Vandenberge, Nancy Kim, Douglas Tran, Dong Han, Wenji Sun, Shigang Wang, Bartley P Griffith, Zhongjun J Wu
{"title":"Marginal Band Collapsing: Structural Insights Into Shear-Induced Platelet Activation Relevant to Circulatory Assist Devices.","authors":"Randy Perez, Kevin Ho, John Vandenberge, Nancy Kim, Douglas Tran, Dong Han, Wenji Sun, Shigang Wang, Bartley P Griffith, Zhongjun J Wu","doi":"10.1097/MAT.0000000000002666","DOIUrl":"10.1097/MAT.0000000000002666","url":null,"abstract":"<p><p>Shear-induced platelet activation and receptor shedding in mechanical circulatory support (MCS) paradoxically increase risks of thrombosis and bleeding. Although flow cytometry commonly assesses platelet activation and receptor expression, correlations with structural changes remain poorly defined. Recent studies emphasize the role of the marginal band (MB) in platelet morphological transitions during activation. This study investigated MB alteration in shear-induced activated platelets and its relationship with flow cytometric markers. Human blood was circulated in a circulatory loop with an MCS device for 4 hours. Under three operating conditions from 75 to 350 mm Hg pressure head, platelet activation (PAC-1 and P-selectin) and glycoprotein (GP) receptor shedding (GPIbα, GPVI, GPIIb/IIIa) were quantified by flow cytometry, and the MB collapse state was microscopically examined and classified. Results demonstrated that platelet activation, receptor shedding, and MB collapse progressively increased with increasing pressure head in the loop. Marginal band collapse correlated strongly with platelet activation, but less with platelet receptor shedding. Marginal band collapse varied significantly among the population of activated platelets, highlighting the complex, heterogeneous response of platelets to shear stresses generated in the loop. The study suggested that the MB collapse can be used as an effective assay to examine platelet activation caused by MCS devices.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"765-773"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to Move Beyond the Legacy of Lactate Dehydrogenase? Assessing the Role of Routine Lactate Dehydrogenase Monitoring in HeartMate 3 Patients. 是时候超越乳酸脱氢酶的遗产了?评估常规乳酸脱氢酶监测在心脏伴侣3号患者中的作用。
IF 2.2 3区 医学
ASAIO Journal Pub Date : 2026-09-01 Epub Date: 2026-03-10 DOI: 10.1097/MAT.0000000000002697
Cyrus Khalily, Alvina Karam, Alex M Parker, Juan R Vilaro, Juan M Aranda, Mustafa M Ahmed
{"title":"Time to Move Beyond the Legacy of Lactate Dehydrogenase? Assessing the Role of Routine Lactate Dehydrogenase Monitoring in HeartMate 3 Patients.","authors":"Cyrus Khalily, Alvina Karam, Alex M Parker, Juan R Vilaro, Juan M Aranda, Mustafa M Ahmed","doi":"10.1097/MAT.0000000000002697","DOIUrl":"10.1097/MAT.0000000000002697","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e254-e255"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书