ASAIO JournalPub Date : 2025-01-29DOI: 10.1097/MAT.0000000000002368
Shivalika Khanduja, Jin K Kang, Ifeanyi D Chinedozi, Zachary Darby, Jiah Kim, Glenn Whitman, Sung-Min Cho
{"title":"Ultra-Low-Field Portable Brain Magnetic Resonance Imaging in Patients With Cardiac Devices: Current Evidence and Future Directions.","authors":"Shivalika Khanduja, Jin K Kang, Ifeanyi D Chinedozi, Zachary Darby, Jiah Kim, Glenn Whitman, Sung-Min Cho","doi":"10.1097/MAT.0000000000002368","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002368","url":null,"abstract":"<p><p>The use of cardiac devices, including mechanical circulatory support (MCS), cardiac implantable electronic devices (CIEDs), and pacing wires, has increased and significantly improved survival in patients with severe cardiac failure. However, these devices are frequently associated with acute brain injuries (ABIs) including ischemic strokes, intracranial hemorrhages, seizures, and hypoxic-ischemic brain injury which contribute substantially to morbidity and mortality. Computed tomography (CT) and magnetic resonance imaging (MRI), the standard imaging modalities for ABI diagnosis, can pose significant challenges in this patient population due to the risks associated with patient transportation and the incompatibility of ferromagnetic components of certain cardiac devices with high magnetic field of the MRI. This review discusses the application of Ultralow-field portable MRI (ULF-pMRI), which operates at much lower magnetic field (0.064 T), with the potential to allow safe bedside imaging of critically ill patients. In this review, we detail the clinical studies and research findings defining the safety, feasibility, and diagnostic utility of ULF-pMRI in detecting ABI in the critically ill. We further discuss the potential broader applications of ULF-pMRI, as a standard diagnostic tool for neurocritical care in patients with cardiac devices. The integration of such technology into current practice promises to enhance diagnostic accuracy, improve patient outcomes, and optimize healthcare resources.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ASAIO JournalPub Date : 2025-01-28DOI: 10.1097/MAT.0000000000002375
Stephen Ramsey, Ahmed Labib Shehatta, Kollengode Ramanathan, Kiran Shekar, Daniel Brodie, Rodrigo Diaz, Abigail Roberts, Sherene Cruz, Carol Hodgson, Bishoy Zakhary, Daniel Herr, Raj Ramanan, Lars Broman, Jordi Riera, Erika O'Neil, Giles Peek
{"title":"Extracorporeal Life Support Organization 2024 Guideline for Early Rehabilitation or Mobilization of Adult Patients on Extracorporeal Membrane Oxygenation.","authors":"Stephen Ramsey, Ahmed Labib Shehatta, Kollengode Ramanathan, Kiran Shekar, Daniel Brodie, Rodrigo Diaz, Abigail Roberts, Sherene Cruz, Carol Hodgson, Bishoy Zakhary, Daniel Herr, Raj Ramanan, Lars Broman, Jordi Riera, Erika O'Neil, Giles Peek","doi":"10.1097/MAT.0000000000002375","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002375","url":null,"abstract":"<p><strong>Disclaimer: </strong>This Extracorporeal Life Support Organization guideline describes early rehabilitation or mobilization of patients on extracorporeal membrane oxygenation (ECMO). The guideline describes useful and safe practices put together by an international interprofessional team with extensive experience in the field of ECMO and ECMO rehabilitation or mobilization. The guideline is not intended to define the delivery of care or substitute sound clinical judgment. The guideline is subject to regular revision as new scientific evidence becomes available.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ASAIO JournalPub Date : 2025-01-27DOI: 10.1097/MAT.0000000000002353
Nicola Pradegan, Claudia Cattapan, Chiara Tessari, Giuseppe Toscano, Augusto D'Onofrio, Vincenzo Tarzia, Antonio Gambino, Marny Fedrigo, Vladimiro L Vida, Annalisa Angelini, Gino Gerosa
{"title":"Anatomical Aspects and Long-Term Outcomes of Additional Surgical Repair During Heart Transplantation in Adult Congenital Heart Disease.","authors":"Nicola Pradegan, Claudia Cattapan, Chiara Tessari, Giuseppe Toscano, Augusto D'Onofrio, Vincenzo Tarzia, Antonio Gambino, Marny Fedrigo, Vladimiro L Vida, Annalisa Angelini, Gino Gerosa","doi":"10.1097/MAT.0000000000002353","DOIUrl":"10.1097/MAT.0000000000002353","url":null,"abstract":"<p><p>Adult patients with congenital heart disease (ACHD) requiring heart transplantation (HT) usually show complex anatomies, posing surgical challenges. Consequently, we analyzed technical aspects and early and long-term outcomes of additional surgical repairs during HT in ACHD. Forty patients were identified (23 males, median age: 38 years, interquartile range [IQR]: 26-50). Of these, 17 (42.5%) required additional surgical repair (7 systemic veins repair, 13 pulmonary arteries repair). These procedures were more associated with univentricular physiology ( p < 0.001) and prior Fontan palliation ( p < 0.001). Eight (20.0%) experienced 30 day mortality. At a median follow-up of 5.6 (IQR: 2.0-11.9) years, 5 (12.5%) patients died. Additional surgical repair did not affect postoperative 30 day and long-term follow-up mortality ( p = 0.451 and p = 0.330, respectively).</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ASAIO JournalPub Date : 2025-01-22DOI: 10.1097/MAT.0000000000002378
Benjamin Wang, Jimmy Zheng, Madeline D Silva, Zhuo Shi, Jared Fong, Calvin Diep, William Hiesinger, Karim Sallam
{"title":"Alteplase Purge Solution for Impella 5.5 Ventricular Assist Device Purge System Occlusion: Case Report and Review of the Literature.","authors":"Benjamin Wang, Jimmy Zheng, Madeline D Silva, Zhuo Shi, Jared Fong, Calvin Diep, William Hiesinger, Karim Sallam","doi":"10.1097/MAT.0000000000002378","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002378","url":null,"abstract":"<p><p>The use of an alteplase (Activase) purge solution to address Impella ventricular assist device \"thrombosis\" or \"purge system occlusion\" has been mainly documented with earlier generation Impella devices (CP, 2.5, 5.0). Here, we report the use of an alteplase purge solution to manage Impella 5.5 purge system occlusion in a 31-year-old male admitted to the cardiac care unit in cardiogenic shock and listed for a heart transplant. Throughout the purge system occlusion, the patient demonstrated hemodynamic stability and overall pump flow and cardiac output were preserved. Initially, there was a lack of response in purge flow and pressure observed at the lower concentration of alteplase purge solution (0.04 mg/ml), yet after using the alteplase 4 mg/50 ml purge (0.08 mg/ml) solution concentration, a response was seen. No bleeding or hemodynamic complications were observed. In addition, a suggested management workflow and review of the case reports and case series published to date regarding Impella purge system occlusion is included in this article.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ASAIO JournalPub Date : 2025-01-16DOI: 10.1097/MAT.0000000000002381
Kaspar F Bachmann, David Berger
{"title":"Estimation of Cardiac Output Under Venovenous Extracorporeal Membrane Oxygenation: Comparing Thermodilution Methods to 3D Echocardiography.","authors":"Kaspar F Bachmann, David Berger","doi":"10.1097/MAT.0000000000002381","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002381","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ASAIO JournalPub Date : 2025-01-16DOI: 10.1097/MAT.0000000000002376
Jose I Nunez, Mayuko Uehara, Snehal R Patel, Stephen J Forest, Yogita Rochlani, Shivank Madan, Daniel B Sims, Nicholas Mellas, Justin E Ashley, Marjan Rahmanian, Anthony Carlese, Daniel J Goldstein, Ulrich P Jorde, Omar Saeed
{"title":"Changes in Neutrophil-to-Lymphocyte Ratio During Venoarterial Extracorporeal Membrane Oxygenation.","authors":"Jose I Nunez, Mayuko Uehara, Snehal R Patel, Stephen J Forest, Yogita Rochlani, Shivank Madan, Daniel B Sims, Nicholas Mellas, Justin E Ashley, Marjan Rahmanian, Anthony Carlese, Daniel J Goldstein, Ulrich P Jorde, Omar Saeed","doi":"10.1097/MAT.0000000000002376","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002376","url":null,"abstract":"<p><p>Mortality remains elevated during venoarterial extracorporeal membrane oxygenation support (VA-ECMO) for cardiogenic shock and the role of inflammation is uncertain. By using the neutrophil-to-lymphocyte ratio (NLR), we investigated inflammatory dynamics during VA-ECMO and their relation to clinical outcomes. A single-center, retrospective cohort study was conducted. Patients receiving steroids or on-device support for less than 48 hours were excluded. Patients were grouped as those who did and did not have a persistent rise in NLR during the 24-48 hour interval after VA-ECMO placement. Overall, 253 patients comprised the study cohort. In-hospital mortality was 56%. Neutrophil-to-lymphocyte ratio was higher at 24 hours after VA-ECMO placement compared to pre-ECMO (Δ4.36, interquartile range [IQR]: -0.23 to 8.61, p < 0.001). Persistent increase in NLR during the 24-48 hour interval after VA-ECMO placement was associated with higher in-hospital mortality (adjusted hazard ratio [aHR]: 1.51, 95% confidence interval [CI]: 1.02-2.25, p = 0.04). The magnitude of this rise in NLR was incrementally related to greater in-hospital mortality (Δ0-5: 72%, aHR: 1.61, 95% CI: 1.03-2.54, p = 0.039; Δ>5: 79%, aHR: 1.64, 95% CI: 1.03-2.63, p = 0.037) in comparison 52%, for those with a drop in NLR. Venoarterial extracorporeal membrane oxygenation exacerbates inflammation, as evident by a rise in NLR, which is progressively higher in nonsurvivors.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ASAIO JournalPub Date : 2025-01-16DOI: 10.1097/MAT.0000000000002380
Keshava Rajagopal
{"title":"Venting About Left Ventricular Unloading.","authors":"Keshava Rajagopal","doi":"10.1097/MAT.0000000000002380","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002380","url":null,"abstract":"","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ASAIO JournalPub Date : 2025-01-10DOI: 10.1097/MAT.0000000000002374
Lesley Pepin, HoanVu Nguyen, Stephanie Kilgore, George Sam Wang, John S Kim
{"title":"Venoarterial Extracorporeal Membrane Oxygenation for Support of Vasodilatory Shock in Children Due to Toxicological Ingestions.","authors":"Lesley Pepin, HoanVu Nguyen, Stephanie Kilgore, George Sam Wang, John S Kim","doi":"10.1097/MAT.0000000000002374","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002374","url":null,"abstract":"<p><p>Venoarterial extracorporeal membrane oxygenation (VA ECMO) may provide temporary hemodynamic support for patients with severe vasodilatory shock due to toxicologic ingestion. In a series of 10 cases of children less than 18 years of age who received VA ECMO support for toxicologic-induced vasodilatory shock, there were eight survivors and two nonsurvivors who died of significant neurologic injury. Upon initiation of ECMO support, survivors had decline in Vasoactive-Inotrope Scores (VIS). With the exception of one survivor who had a VIS range of 5-10, the seven remaining survivors had reduction in VIS by half at a median of 5.3 (interquartile range [IQR]: 3.7-12) hours. Nonsurvivors demonstrated no VIS reduction on ECMO before death. Six of 10 patients received continuous renal replacement therapy (CRRT) while on ECMO and potentially had augmentation of toxin clearance or treatment of severe acidosis as a result. Of the eight survivors, four patients had ECMO-related bleeding or thrombotic complications (three patients with stroke and one patient with extremity compartment syndrome). Venoarterial extracorporeal membrane oxygenation, with and without CRRT, may have potential utility and benefit in supporting poisoned patients with vasodilatory shock.</p>","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}