ASAIO Journal最新文献_第3页

Effects of Inadvertent Left Atrial Return During Venovenous Extracorporeal Membrane Oxygenation: The Veno-Left Atrial Case Series. 静脉-静脉体外膜氧合过程中无意左心房返流的影响：静脉-左心房病例系列。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-23 DOI: 10.1097/MAT.0000000000002562

Jessica Guevara-Chaux, Pau Torrella, Eduard Argudo, María Vidal, Elisabet Gallart, Ricard Ferrer, Jordi Riera

{"title":"Effects of Inadvertent Left Atrial Return During Venovenous Extracorporeal Membrane Oxygenation: The Veno-Left Atrial Case Series.","authors":"Jessica Guevara-Chaux, Pau Torrella, Eduard Argudo, María Vidal, Elisabet Gallart, Ricard Ferrer, Jordi Riera","doi":"10.1097/MAT.0000000000002562","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002562","url":null,"abstract":"Venovenous extracorporeal membrane oxygenation (V-V ECMO) is a life-saving organ support for patients with severe respiratory failure. One of the possible complications involves cannula positioning, but the literature has largely focused on recirculation. We report five cases, from a cohort of 320 patients treated at a high-volume ECMO center, in which the tip of the long, non-multiperforated return cannula in a femoro-femoral V-V ECMO configuration inadvertently crossed the interatrial septum. This resulted in a veno-left atrial (V-LA) configuration with a massive right-to-left shunt of hyperoxygenated blood. The malposition was not clinically evident during the ECMO run and only became apparent during weaning attempts, when abrupt desaturation occurred. In retrospect, all patients exhibited strikingly high arterial partial pressure of oxygen (PaO₂) levels, absent recirculation, low sweep gas requirements, and excellent exercise tolerance-features that may help raise clinical suspicion. All cases were ultimately resolved by cannula repositioning, and no interatrial defect was identified in follow-up among the four survivors. Inadvertent V-LA ECMO is a rare but underrecognized complication. Early recognition is essential to avoid misinterpreting this phenomenon as treatment failure during weaning. Although it carries potential risks, such as systemic embolism or left atrial overload, it may also confer physiological benefits in selected clinical scenarios.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Methodological Issues of Meta-Analysis May Affect Clinical Practice. 荟萃分析的方法学问题可能影响临床实践。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-22 DOI: 10.1097/MAT.0000000000002548

Yuqian Zheng, Tiangang Zhou, Guoying Wang

引用次数: 0

Hemodynamic Ramp Test in Cardiogenic Shock Supported by Microaxial Flow Pump: Protocol Description, Feasibility, and Hemodynamic Response. 由微轴流泵支持的心源性休克的血流动力学斜坡试验：方案描述、可行性和血流动力学反应。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-22 DOI: 10.1097/MAT.0000000000002555

Yuki Ikeda, Saeko Iikura, Shohei Nakahara, Yu Takigami, Yuko Eda, Yuichiro Iida, Takeru Nabeta, Shunsuke Ishii, Nobuhiro Sato, Junya Ako

{"title":"Hemodynamic Ramp Test in Cardiogenic Shock Supported by Microaxial Flow Pump: Protocol Description, Feasibility, and Hemodynamic Response.","authors":"Yuki Ikeda, Saeko Iikura, Shohei Nakahara, Yu Takigami, Yuko Eda, Yuichiro Iida, Takeru Nabeta, Shunsuke Ishii, Nobuhiro Sato, Junya Ako","doi":"10.1097/MAT.0000000000002555","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002555","url":null,"abstract":"Evidence-based protocols for microaxial flow pump (MAFP) weaning remain limited. This study aimed to standardize the ramp test for MAFP and evaluate its feasibility and associated hemodynamic trajectories. In this single-center prospective study, we developed and implemented an Impella ramp test in 54 cardiogenic shock patients who met pretest stability criteria. Forty-six patients (85%) completed the full protocol, while the test was terminated in eight patients according to predefined safety criteria (significant disturbances in arterial pressure or pulmonary artery wedge pressure [PAWP], or sustained arrhythmias), with prompt recovery observed upon returning to the baseline P-level. Under continuous hemodynamic monitoring via a pulmonary artery catheter, the Impella P-level was reduced stepwise from P8 to P2 at 5 minute intervals, while systemic arterial pulse pressure (SAPP), cardiac power output (CPO), and PAWP were recorded. In the overall cohort, SAPP increased by 12.2 mm Hg, CPO decreased by 0.09 W, and PAWP increased by 2.5 mm Hg. Patients supported with Impella 5.5 experienced a greater reduction in flow (-2.8 vs. -1.4 L/minute) and more pronounced hemodynamic changes compared to those with Impella CP. The Impella ramp test is feasible and safe, providing quantitative hemodynamic insights that may inform individualized clinical decision-making and MAFP weaning strategies.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catheter-Directed Bivalirudin for Local Anticoagulation and Clot Dissolution in Children Requiring Mechanical Circulatory Support. 导管导向比伐鲁定用于需要机械循环支持的儿童局部抗凝和凝块溶解。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-17 DOI: 10.1097/MAT.0000000000002560

Nadia Chaudhry-Waterman, Timothy Q Schardt, Rhynn M Soderstrom, Beth B Warren, Shannon Buckvold, Gareth Morgan, John S Kim

{"title":"Catheter-Directed Bivalirudin for Local Anticoagulation and Clot Dissolution in Children Requiring Mechanical Circulatory Support.","authors":"Nadia Chaudhry-Waterman, Timothy Q Schardt, Rhynn M Soderstrom, Beth B Warren, Shannon Buckvold, Gareth Morgan, John S Kim","doi":"10.1097/MAT.0000000000002560","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002560","url":null,"abstract":"Bivalirudin is a direct thrombin inhibitor that inhibits both circulating thrombin and fibrin-bound thrombin, giving it the ability to not only prevent thrombus extension, but also more directly facilitate clot resolution than heparin. Although still not yet the standard of care, bivalirudin has become more frequently used for anticoagulation in patients on mechanical circulatory support. In patients who develop large or critically localized thrombosis, requiring catheter-directed therapy, alteplase remains the drug of choice. Here we describe three cases of children, all of whom were on mechanical circulatory support, who required catheter-directed thrombolysis. In each case, direct bivalirudin delivery through a lysis catheter was associated with rapid resolution of thrombosis. Although study of more patients is needed to truly assess safety and efficacy, this series demonstrates that bivalirudin may be an effective drug for thrombolysis and should be considered in patients who have experienced bleeding or other complications from catheter-directed alteplase infusion.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Cytokine Hemoadsorption Therapy in Rats During Venovenous Extracorporeal Membrane Oxygenation. 细胞因子血液吸附治疗对大鼠静脉-静脉体外膜氧合的影响。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-16 DOI: 10.1097/MAT.0000000000002553

Wenli Li, Yuansen Chen, Lichun Wang, Duo Li, Yinchang Zhang, Lailiang Ou, Yanqing Liu, Yongnan Li, Haojun Fan

{"title":"Effect of Cytokine Hemoadsorption Therapy in Rats During Venovenous Extracorporeal Membrane Oxygenation.","authors":"Wenli Li, Yuansen Chen, Lichun Wang, Duo Li, Yinchang Zhang, Lailiang Ou, Yanqing Liu, Yongnan Li, Haojun Fan","doi":"10.1097/MAT.0000000000002553","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002553","url":null,"abstract":"Cytokine hemoadsorption therapy has been proposed to reduce inflammation in patients with hyperinflammation. However, the clinical benefit of cytokine hemoadsorption therapy during venovenous extracorporeal membrane oxygenation (VV ECMO) is still unclear. The aim of the study was to evaluate the effect and mechanism of small molecular affinity ligand adsorbent (PS-Arg) for cytokine hemoadsorption in a rat model during VV ECMO. Forty-five Sprague-Dawley (SD) rats were divided into three groups: a control group, a VV ECMO group, and an ECMO combined with hemoadsorption group (VV ECMO + HA [ECMO + hemoadsorption] group), with 15 rats in each group. Each experiment was repeated at least three times. The duration of ECMO is 3 hours. After weaning, arterial blood gas analysis, serum cytokine levels, and lung injury of rats were assessed. Then, we performed histological and RNA sequencing analyses of lung tissues. Cytokine hemoadsorption therapy with PS-Arg increased the circulation volume but maintained the stability of blood gases. Polystyrene-arginine significantly reduced the serum levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), lung injury, and macrophage and neutrophil infiltration in the lung. According to the RNA sequencing results, it is associated with the downregulation of inflammation-related signaling pathways. Our findings indicate that cytokine hemoadsorption therapy reduces systemic inflammation and provides lung protection in a rat VV ECMO model by down-regulating components of inflammatory signaling pathways.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Efficacy of the Corheart 6 Left Ventricular Assist System. Corheart 6左心室辅助系统的安全性和有效性。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-15 DOI: 10.1097/MAT.0000000000002554

Zhibing Qiu, Xiaochun Song, Hongwei Shi, Xiaomin Zhang, Wen Chen, Yunzhang Wu, Xin Chen

{"title":"Safety and Efficacy of the Corheart 6 Left Ventricular Assist System.","authors":"Zhibing Qiu, Xiaochun Song, Hongwei Shi, Xiaomin Zhang, Wen Chen, Yunzhang Wu, Xin Chen","doi":"10.1097/MAT.0000000000002554","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002554","url":null,"abstract":"To assess the efficacy and safety of the Corheart 6 Left Ventricular Assist System (LVAS) in patients with end-stage heart failure. A retrospective cohort study was conducted at Nanjing First Hospital to evaluate the clinical outcomes of patients with end-stage heart failure who underwent implantation of the Corheart 6 LVAS between March 2022 and March 2024. A total of 28 patients were enrolled. The primary endpoint was a composite of survival free from disabling stroke at 6 months post-implantation. Statistical analyses were conducted to compare pre- and post-implantation outcomes. No intraoperative or 30 day postoperative mortality occurred. Survival rates were 100% at 3 months and 89.3% at 6 months, with three deaths attributed to cerebral hemorrhage, device alarm mismanagement, and systemic amyloidosis complications. Significant improvements in cardiac function were observed. Hemolysis markers remained stable. Adverse events included hemorrhagic cerebrovascular accident (3.6%), ventricular arrhythmias (25%), pulmonary infections (35.7%), driveline exit site infection (3.6%), renal failure (requiring dialysis) (7.1%), and right heart failure (3.6%). No pump thrombosis, hemolysis or device malfunction occurred. The Corheart 6 LVAS demonstrated favorable mid-term survival and cardiac functional improvement in critically ill heart failure patients, with a manageable safety profile.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive Echocardiographic Hemodynamics in Patients on Temporary Mechanical Circulatory Support: A Case Series. 临时机械循环支持患者的无创超声心动图血流动力学：一个病例系列。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-11 DOI: 10.1097/MAT.0000000000002550

Govind Pandompatam, Rohan Goswami

引用次数: 0

Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis. 体外膜氧合治疗先天性膈疝患者：登记分析。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-11 DOI: 10.1097/MAT.0000000000002551

Niklas Adrian, Lars Mikael Broman, Carmen Mesas Burgos

{"title":"Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis.","authors":"Niklas Adrian, Lars Mikael Broman, Carmen Mesas Burgos","doi":"10.1097/MAT.0000000000002551","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002551","url":null,"abstract":"Congenital diaphragmatic hernia (CDH) is a rare and severe malformation that can lead to life-threatening postnatal physiological challenges which may require lifesaving extracorporeal membrane oxygenation (ECMO) support, sometimes more than once. However, the benefits of multiple ECMO courses remain uncertain. Data on all patients with CDH supported on ECMO from 1976 to 2020 were retrieved from the Extracorporeal Life Support Organization (ELSO) Registry. Outcomes for patients with CDH undergoing more than one ECMO course were analyzed. This group was then stratified into two subgroups, \"treated before 2010\" and \"treated after 2010,\" which were analyzed separately. A total of 9,928 patients were identified. The overall survival to discharge for CDH supported with ECMO was 51.9%. Three hundred and thirty-nine patients (3.5%) were supported with ECMO more than once. The overall survival to discharge in this group was 39%. After 2010, the survival rate had increased from 34.7 (n = 213) to 46.8% (n = 126) (p = 0.018). We found that the rate of CDH patients requiring repeated ECMO support was low, and that survival rates were acceptable and improving over time.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One Size Does Not Fit All: Evidence Synthesis Methods Must Be Adapted to the Systematic Review Question. 一种方法不适合所有：证据综合方法必须适应系统评价问题。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-10 DOI: 10.1097/MAT.0000000000002549

Patrick M Wieruszewski, Hannah M Brinkman, Jamel P Ortoleva, Jacopo D'Andria Ursoleo, Erin D Wieruszewski, Troy G Seelhammer

引用次数: 0

iDECIDE-VAD-PEDIATRIC : Development of a Decision Aid to Assist Children and Their Caregivers When Considering a Ventricular Assist Device. idecide - vad -儿科：在考虑使用心室辅助装置时，开发一种辅助儿童及其护理人员决策的辅助工具。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-10 DOI: 10.1097/MAT.0000000000002552

Seth A Hollander, Jenna M Murray, John C Dykes, Toni Duganiero, Jocelyn S Thompson, Tiffany Hunter, Kari Christ, Sabena F Hussain, Daniel D Matlock, Larry A Allen, Colleen K McIlvennan

引用次数: 0