ASAIO Journal最新文献_第3页

Estimation of Absolute Blood Volume Using Online Dialysate Dilution: When and How to Measure? 使用在线透析液稀释估算绝对血容量：何时以及如何测量？

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-08-01 DOI: 10.1097/MAT.0000000000002284

Joachim Kron, Susanne Kron

引用次数: 0

Chilling Choices: Heart Transplant Outcomes Using SherpaPak With Long Ischemic Time Versus Traditional Ice Storage With Short Ischemic Time. 冷冻选择：长缺血时间的SherpaPak与短缺血时间的传统冰储存的心脏移植结果。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-12-12 DOI: 10.1097/MAT.0000000000002357

Hassan Farhoud, Zubair Shah, Tarun Dalia, Scott Silvestry, Hirak Shah, Dan Meyer, David DʼAlessandro, Andrija Vidic

{"title":"Chilling Choices: Heart Transplant Outcomes Using SherpaPak With Long Ischemic Time Versus Traditional Ice Storage With Short Ischemic Time.","authors":"Hassan Farhoud, Zubair Shah, Tarun Dalia, Scott Silvestry, Hirak Shah, Dan Meyer, David DʼAlessandro, Andrija Vidic","doi":"10.1097/MAT.0000000000002357","DOIUrl":"10.1097/MAT.0000000000002357","url":null,"abstract":"We performed a retrospective review comparing outcomes between traditional ice storage (ICE) with short ischemic times (<3 hours) to SherpaPak Cardiac Transport System (SCTS) with long ischemic times (>4 hours) using data from the GUARDIAN registry, a retrospective observational trial. To minimize baseline differences, propensity-matched (PSM) cohorts for site and era were performed. SherpaPak Cardiac Transport System travel distance was almost 10-fold greater than ICE (82 miles ICE vs . 765 miles SCTS). There was no significant difference in primary graft dysfunction (PGD) (20.8% vs. 18.2%, p = 0.58), length of stay (LOS) (24.7 vs. 24.8, p = 0.98), posttransplant mechanical circulatory support (MCS) (25.1% vs. 20.3%, p = 0.34), and 30 day survival (100% vs. 98.6%, p = 0.20). SherpaPak Cardiac Transport System showed statistically significant reduction in 24 hour inotrope scores (17.6 vs. 13.6, p = 0.007) and right ventricular (RV) dysfunction (31.1% vs. 15.7%, p = 0.002). Propensity-matched cohorts showed statistically similar rates of MCS utilization and PGD, but SCTS trended toward less RV dysfunction (26.0% vs. 16.2%, p = 0.11) and lower inotrope scores (16.5 vs. 12.9, p = 0.06) despite almost double the ischemic time. In conclusion, donor heart preservation with SCTS continues to be effective in prolonged ischemic times without sacrificing postheart transplantation clinical outcomes. This may aid in expanding donor organ geography.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"308-315"},"PeriodicalIF":3.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antepartum Extracorporeal Life Support: A Viable Way to Improve Fetal Outcomes.

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.1097/MAT.0000000000002413

Maya Guglin, Dmitry Abramov

引用次数: 0

Hemodynamic Support With the Impella 5.5 Acute Mechanical Circulatory Support Device. Impella 5.5 急性机械循环支持设备的血流动力学支持。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-10-14 DOI: 10.1097/MAT.0000000000002331

James W Schurr, Adrian Pearson, Matthew S Delfiner, Alyson Brown, Mary Frances Quinn, Yoav Karpenshif, Juan Ortega-Legaspi, Aditya Parikh, Marisa Cevasco, Joyce W Wald

{"title":"Hemodynamic Support With the Impella 5.5 Acute Mechanical Circulatory Support Device.","authors":"James W Schurr, Adrian Pearson, Matthew S Delfiner, Alyson Brown, Mary Frances Quinn, Yoav Karpenshif, Juan Ortega-Legaspi, Aditya Parikh, Marisa Cevasco, Joyce W Wald","doi":"10.1097/MAT.0000000000002331","DOIUrl":"10.1097/MAT.0000000000002331","url":null,"abstract":"The Impella 5.5 is increasingly used as a bridge to recovery or heart replacement therapies despite lack of clinical trial evidence. We report real-world outcomes and hemodynamic effects of 150 consecutive patients from a single, high-volume center. Primary outcome was incidence of recovery, durable left ventricular assist device (LVAD), or heart transplant compared with incidence of death at 90 days. Secondary outcomes included hemodynamic trends and upgrade to veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support. The composite endpoint occurred in 59.3% and death in 18.8% of patients (incidence rate ratio: 8.1 [95% confidence interval {CI}: 5.4-12.2], p < 0.001). Decreases in pulmonary artery diastolic pressure (PADP) ( p = 0.026), estimated pulmonary effective arterial elastance (Ea) ( p < 0.001), and vasoactive-inotropic score (VIS) ( p < 0.001) occurred during Impella 5.5 support. Pulmonary artery diastolic pressure correlated with estimated Ea ( p < 0.001), suggesting improved right ventricle (RV) afterload with left ventricle (LV) unloading. Veno-arterial extracorporeal membrane oxygenation upgrade occurred in 11.3% of patients who had higher baseline right atrial pressure (RAP) (16.0 [9.0-20.5] vs. 9.0 [7.0-12.0], p = 0.022), PADP (28.5 [25.0-31.0] vs. 23.0 [18.0-28.0], p = 0.011), and lower pulmonary artery pulsatility index (PAPi) (1.45 [0.82-3.45] vs. 2.5 [1.65-3.86], p = 0.029). Upgrade patients had higher repeated measures trends in RAP ( p < 0.001) and PADP ( p = 0.015). The Impella 5.5 improved hemodynamics and effectively bridged to recovery or heart replacement therapies. Co-existing RV dysfunction can be supported on Impella 5.5 with careful hemodynamic trend monitoring.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"300-307"},"PeriodicalIF":3.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyponatremia in Critically Ill Patients Due to Continuous Venovenous Hemofiltration With Diluted Sodium Citrate. 使用稀释柠檬酸钠进行持续静脉血液滤过导致的重症患者低钠血症。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-10-22 DOI: 10.1097/MAT.0000000000002330

Francesco Zadek, Beatrice Brunoni, Francesca Mulazzani, Francesco Minotti, Loredana Faraldi, Francesca Tardini, Riccardo Giudici, Stefania Paccagnini, Maria Luisa De Angelis, Roberto Fumagalli, Thomas Langer

{"title":"Hyponatremia in Critically Ill Patients Due to Continuous Venovenous Hemofiltration With Diluted Sodium Citrate.","authors":"Francesco Zadek, Beatrice Brunoni, Francesca Mulazzani, Francesco Minotti, Loredana Faraldi, Francesca Tardini, Riccardo Giudici, Stefania Paccagnini, Maria Luisa De Angelis, Roberto Fumagalli, Thomas Langer","doi":"10.1097/MAT.0000000000002330","DOIUrl":"10.1097/MAT.0000000000002330","url":null,"abstract":"Continuous venovenous hemofiltration (CVVH) is frequently performed in critically ill patients using diluted citrate for regional anticoagulation. The impact of this renal replacement strategy on plasma sodium has not been evaluated yet. Our aim was therefore to assess the period prevalence of hyponatremia (sodium <135 mmol/L) during CVVH and discuss possible underlying mechanisms. After 48 hours of treatment, 70% of the 27 oligo-anuric critically ill patients were hyponatremic, despite the use of dialysis fluid bags (Regiocit 18/0, Phoxilium by Baxter, Deerfield, IL, and Multibic K2 by Fresenius Medical Care AG & Co. KGaA, Bad Homburg, Germany) with sodium content of 140 mmol/L. Indeed, sodium decreased from 142 ± 7 to 135 ± 3 mmol/L, p < 0.001. Sodium concentrations of employed dialysis bags were confirmed using ion chromatography. However, ionized sodium of Regiocit measured with a direct-ion selective electrode (ISE) resulted lower (~118 mmol/L), suggesting the presence of sodium-to-citrate complexes. Possible mechanisms explaining the hyponatremia development could therefore include: i) plasma water dilution; ii) a reduced Gibbs-Donnan effect, given the low albumin concentration (2.6 ± 0.8 g/dl) of our critically ill patients; iii) a negative sodium balance due to the loss of sodium-to-citrate complexes across the filter. The clinical implications of the described hyponatremia and the different contributions of the hypothesized mechanisms need to be addressed in future studies.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"355-362"},"PeriodicalIF":3.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLACE: Multicenter Study for Right Ventricular Failure on Mechanical Cardiocirculatory Supports.

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/MAT.0000000000002328

Valeria Lo Coco, Michele Di Mauro, Antonio Loforte, Thomas Fux, Dominik Wiedemann, Tom Verbelen, Lars Mikael Broman, Jamila Kremer, Matteo Pozzi, Koji Takeda, Udo Boeken, Yih-Sharng Chen, Paolo Masiello, Dominik J Vogel, Jacinta J Maas, Andrea Ballotta, Federico Pappalardo, Kasia Hryniewicz, Roberto Lorusso

{"title":"PLACE: Multicenter Study for Right Ventricular Failure on Mechanical Cardiocirculatory Supports.","authors":"Valeria Lo Coco, Michele Di Mauro, Antonio Loforte, Thomas Fux, Dominik Wiedemann, Tom Verbelen, Lars Mikael Broman, Jamila Kremer, Matteo Pozzi, Koji Takeda, Udo Boeken, Yih-Sharng Chen, Paolo Masiello, Dominik J Vogel, Jacinta J Maas, Andrea Ballotta, Federico Pappalardo, Kasia Hryniewicz, Roberto Lorusso","doi":"10.1097/MAT.0000000000002328","DOIUrl":"10.1097/MAT.0000000000002328","url":null,"abstract":"Isolated acute right ventricular failure (aRVF) is associated with poor prognosis in different scenarios. In severe conditions, temporary mechanical cardiocirculatory support (tMCS) is required. PLACE is an international, retrospective, multicenter registry including 17 centers that investigated patients affected by isolated aRVF and treated with various types of tMCS from January 2000 to December 2020. The registry included 644 (69.6% males, mean age: 55 years) patients. The most frequent etiologies were post-left ventricular assist device implantation (LVAD) and postcardiotomy shock. These patients received mostly mechanical circulatory support (MCS) and veno-arterial extracorporeal membrane oxygenation. Mean tMCS duration was 9 days, weaning was achieved in 70.5% of the patients, and the major cause of death on support was multiorgan failure (50.5%). The mortality rate was 45 and 48.4% in-hospital and at 3 month follow-up, respectively. Multivariable logistic regression analysis identified age, aRVF due to acute pulmonary hypertension, bilirubin level, and oliguria or anuria at tMCS implantation as risk factors for in-hospital mortality. Conversely, aRVF after LVAD was found to be associated with a lower risk of early mortality. In-hospital and 3 months mortality occurred in less than half of the aRVF-supported subjects. Furthermore, several preimplant aspects such as age, organ function, and type of tMCS are independently associated with in-hospital and 3 month mortality.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"290-299"},"PeriodicalIF":3.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Kidney Injury and Outcomes in Infants, Children, and Adolescents, Supported With Extracorporeal Life Support for Cardiopulmonary Failure. 婴儿、儿童和青少年在体外生命支持下治疗心肺衰竭的急性肾损伤和结局。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-11-25 DOI: 10.1097/MAT.0000000000002321

Asaad G Beshish, Joshua Qian, Kasey Keane-Lerner, Paola Rodriguez Morales, Rebecca Shamah, Tawanda Zinyandu, Pranay Nayi, Joel Davis, Joshua M Rosenblum, Heather K Viamonte

{"title":"Acute Kidney Injury and Outcomes in Infants, Children, and Adolescents, Supported With Extracorporeal Life Support for Cardiopulmonary Failure.","authors":"Asaad G Beshish, Joshua Qian, Kasey Keane-Lerner, Paola Rodriguez Morales, Rebecca Shamah, Tawanda Zinyandu, Pranay Nayi, Joel Davis, Joshua M Rosenblum, Heather K Viamonte","doi":"10.1097/MAT.0000000000002321","DOIUrl":"10.1097/MAT.0000000000002321","url":null,"abstract":"In neonatal and pediatric patients who require extracorporeal life support (ECLS), 60-70% develop acute kidney injury (AKI). Acute kidney injury has been associated with increased morbidity and mortality. We sought to describe our center's experience with AKI in patients requiring ECLS and its effect on outcomes. We conducted a retrospective single-center study at an academic children's hospital. All patients 0-18 years of age who required ECLS between January 2014 and December 2019. During the study period, there were 313 ECLS runs. The majority were neonates (66.8%) and 68.7% of runs were veno-arterial. Using Kidney Disease Improving Global Outcomes (KDIGO) criteria, 227 patients (72.5%) developed stage 2 or 3 AKI. The AKI group were younger (median age: 0.9 vs . 11.7 months, p < 0.001), more likely to experience a hemorrhagic complication (46.9% vs . 31.9%, p = 0.0298), and had higher mortality rates (44.9% vs . 24.4%, p = 0.0009). Neonates who required ECLS were more likely to develop stage 2 or 3 AKI (78%) than pediatrics (63%) ( p = 0.005). Adjusting for confounders, patients who developed AKI had 2.38 times higher odds of mortality (95% confidence interval [CI]: 1.34-4.25, p = 0.003). We conclude that the majority of patients requiring ECLS develop stage 2 or 3 AKI. Those with AKI were twice as likely to die when controlling for confounding variables. Multicenter and prospective evaluation of this modifiable risk factor is imperative to improve the care of this high-risk cohort.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"339-344"},"PeriodicalIF":3.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Tidal Volume in Invasive Mechanical Ventilation and Mortality in Children With Extracorporeal Membrane Oxygenation. 体外膜肺氧合患儿有创机械通气潮气量与死亡率之间的关系

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-10-23 DOI: 10.1097/MAT.0000000000002341

Jennifer Guijarro, Jaime Fernández-Sarmiento, Lorena Acevedo, Mauricio Sarta-Mantilla, Hernando Mulett, Daniel Castro, Martha Cecilia Reyes Casas, Daniel Felipe Pardo, Carlos Miguel Santacruz, Ligia Tatiana Bernal, Laura Henao Ramírez, María Camila Gómez, Giovanni A Di Giovanna, Catalina Duque-Arango

{"title":"Association Between Tidal Volume in Invasive Mechanical Ventilation and Mortality in Children With Extracorporeal Membrane Oxygenation.","authors":"Jennifer Guijarro, Jaime Fernández-Sarmiento, Lorena Acevedo, Mauricio Sarta-Mantilla, Hernando Mulett, Daniel Castro, Martha Cecilia Reyes Casas, Daniel Felipe Pardo, Carlos Miguel Santacruz, Ligia Tatiana Bernal, Laura Henao Ramírez, María Camila Gómez, Giovanni A Di Giovanna, Catalina Duque-Arango","doi":"10.1097/MAT.0000000000002341","DOIUrl":"10.1097/MAT.0000000000002341","url":null,"abstract":"Mechanical ventilation (MV) strategies in children on extracorporeal membrane oxygenation (ECMO) have not been studied much and the ventilatory parameters to avoid greater lung damage are still unclear. Our objective was to determine the relationship between conventional tidal volume (4-8 ml/kg, CTV) versus low tidal volume (<4 ml/kg, LTV) and mortality in children with MV at the beginning of ECMO. This was a retrospective cohort study that included 101 (10.9 months interquartile range [IQR]: 6.0-24.0) children. Children with LTV had greater odds of hospital mortality (adjusted odds ratio [aOR]: 2.45; 95% confidence interval [CI]: 1.05-5.71; p = 0.03) regardless of age, reason for ECMO, and disease severity, as well as a longer duration of MV after ECMO. We found no differences between the groups in other MV settings. The CTV group required fewer fibrobronchoscopies than patients with LTV (aOR: 0.38; 95% CI: 0.15-0.99; p = 0.04). We found that a tidal volume (V T ) lower than 4 ml/kg at the onset of ECMO support in children with MV was associated with higher odds of mortality, longer post-decannulation ventilation, and a greater need for fibrobronchoscopies. Lung-protective bundles in patients with ECMO and MV should consider the V T to maintain plateau and driving pressure that avoid major lung injury caused by MV.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"332-338"},"PeriodicalIF":3.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply Letter to Editor to Daniel Schneditz. 给编辑丹尼尔-施内迪茨的回信。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-11-05 DOI: 10.1097/MAT.0000000000002336

Dilek Karacanoğlu, Benan Bayrakci

引用次数: 0

Characterization of Protein Binding on an Extracorporeal Membrane Oxygenation (ECMO) Circuit Following the Priming Procedure. 体外膜氧合（ECMO）回路在启动程序后蛋白质结合的特征。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-04-01 Epub Date: 2024-07-12 DOI: 10.1097/MAT.0000000000002273

Tengyi Cai, Samantha J Emery-Corbin, Conor McCafferty, Suelyn Van Den Helm, Natasha Letunica, Rebecca Barton, Chantal Attard, Stephen Horton, Steve Bottrell, Bradley Schultz, Graeme MacLaren, Roberto Chiletti, Derek Best, Amy Johansen, Fiona Newall, Warwick Butt, Yves d'Udekem, Laura F Dagley, Jumana M Yousef, Paul Monagle, Vera Ignjatovic

引用次数: 0