ASAIO Journal最新文献_第4页

Effect of Cytokine Hemoadsorption Therapy in Rats During Venovenous Extracorporeal Membrane Oxygenation. 细胞因子血液吸附治疗对大鼠静脉-静脉体外膜氧合的影响。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-16 DOI: 10.1097/MAT.0000000000002553

Wenli Li, Yuansen Chen, Lichun Wang, Duo Li, Yinchang Zhang, Lailiang Ou, Yanqing Liu, Yongnan Li, Haojun Fan

{"title":"Effect of Cytokine Hemoadsorption Therapy in Rats During Venovenous Extracorporeal Membrane Oxygenation.","authors":"Wenli Li, Yuansen Chen, Lichun Wang, Duo Li, Yinchang Zhang, Lailiang Ou, Yanqing Liu, Yongnan Li, Haojun Fan","doi":"10.1097/MAT.0000000000002553","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002553","url":null,"abstract":"Cytokine hemoadsorption therapy has been proposed to reduce inflammation in patients with hyperinflammation. However, the clinical benefit of cytokine hemoadsorption therapy during venovenous extracorporeal membrane oxygenation (VV ECMO) is still unclear. The aim of the study was to evaluate the effect and mechanism of small molecular affinity ligand adsorbent (PS-Arg) for cytokine hemoadsorption in a rat model during VV ECMO. Forty-five Sprague-Dawley (SD) rats were divided into three groups: a control group, a VV ECMO group, and an ECMO combined with hemoadsorption group (VV ECMO + HA [ECMO + hemoadsorption] group), with 15 rats in each group. Each experiment was repeated at least three times. The duration of ECMO is 3 hours. After weaning, arterial blood gas analysis, serum cytokine levels, and lung injury of rats were assessed. Then, we performed histological and RNA sequencing analyses of lung tissues. Cytokine hemoadsorption therapy with PS-Arg increased the circulation volume but maintained the stability of blood gases. Polystyrene-arginine significantly reduced the serum levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), lung injury, and macrophage and neutrophil infiltration in the lung. According to the RNA sequencing results, it is associated with the downregulation of inflammation-related signaling pathways. Our findings indicate that cytokine hemoadsorption therapy reduces systemic inflammation and provides lung protection in a rat VV ECMO model by down-regulating components of inflammatory signaling pathways.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Efficacy of the Corheart 6 Left Ventricular Assist System. Corheart 6左心室辅助系统的安全性和有效性。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-15 DOI: 10.1097/MAT.0000000000002554

Zhibing Qiu, Xiaochun Song, Hongwei Shi, Xiaomin Zhang, Wen Chen, Yunzhang Wu, Xin Chen

{"title":"Safety and Efficacy of the Corheart 6 Left Ventricular Assist System.","authors":"Zhibing Qiu, Xiaochun Song, Hongwei Shi, Xiaomin Zhang, Wen Chen, Yunzhang Wu, Xin Chen","doi":"10.1097/MAT.0000000000002554","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002554","url":null,"abstract":"To assess the efficacy and safety of the Corheart 6 Left Ventricular Assist System (LVAS) in patients with end-stage heart failure. A retrospective cohort study was conducted at Nanjing First Hospital to evaluate the clinical outcomes of patients with end-stage heart failure who underwent implantation of the Corheart 6 LVAS between March 2022 and March 2024. A total of 28 patients were enrolled. The primary endpoint was a composite of survival free from disabling stroke at 6 months post-implantation. Statistical analyses were conducted to compare pre- and post-implantation outcomes. No intraoperative or 30 day postoperative mortality occurred. Survival rates were 100% at 3 months and 89.3% at 6 months, with three deaths attributed to cerebral hemorrhage, device alarm mismanagement, and systemic amyloidosis complications. Significant improvements in cardiac function were observed. Hemolysis markers remained stable. Adverse events included hemorrhagic cerebrovascular accident (3.6%), ventricular arrhythmias (25%), pulmonary infections (35.7%), driveline exit site infection (3.6%), renal failure (requiring dialysis) (7.1%), and right heart failure (3.6%). No pump thrombosis, hemolysis or device malfunction occurred. The Corheart 6 LVAS demonstrated favorable mid-term survival and cardiac functional improvement in critically ill heart failure patients, with a manageable safety profile.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive Echocardiographic Hemodynamics in Patients on Temporary Mechanical Circulatory Support: A Case Series. 临时机械循环支持患者的无创超声心动图血流动力学：一个病例系列。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-11 DOI: 10.1097/MAT.0000000000002550

Govind Pandompatam, Rohan Goswami

引用次数: 0

Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis. 体外膜氧合治疗先天性膈疝患者：登记分析。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-11 DOI: 10.1097/MAT.0000000000002551

Niklas Adrian, Lars Mikael Broman, Carmen Mesas Burgos

{"title":"Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis.","authors":"Niklas Adrian, Lars Mikael Broman, Carmen Mesas Burgos","doi":"10.1097/MAT.0000000000002551","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002551","url":null,"abstract":"Congenital diaphragmatic hernia (CDH) is a rare and severe malformation that can lead to life-threatening postnatal physiological challenges which may require lifesaving extracorporeal membrane oxygenation (ECMO) support, sometimes more than once. However, the benefits of multiple ECMO courses remain uncertain. Data on all patients with CDH supported on ECMO from 1976 to 2020 were retrieved from the Extracorporeal Life Support Organization (ELSO) Registry. Outcomes for patients with CDH undergoing more than one ECMO course were analyzed. This group was then stratified into two subgroups, \"treated before 2010\" and \"treated after 2010,\" which were analyzed separately. A total of 9,928 patients were identified. The overall survival to discharge for CDH supported with ECMO was 51.9%. Three hundred and thirty-nine patients (3.5%) were supported with ECMO more than once. The overall survival to discharge in this group was 39%. After 2010, the survival rate had increased from 34.7 (n = 213) to 46.8% (n = 126) (p = 0.018). We found that the rate of CDH patients requiring repeated ECMO support was low, and that survival rates were acceptable and improving over time.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One Size Does Not Fit All: Evidence Synthesis Methods Must Be Adapted to the Systematic Review Question. 一种方法不适合所有：证据综合方法必须适应系统评价问题。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-10 DOI: 10.1097/MAT.0000000000002549

Patrick M Wieruszewski, Hannah M Brinkman, Jamel P Ortoleva, Jacopo D'Andria Ursoleo, Erin D Wieruszewski, Troy G Seelhammer

引用次数: 0

iDECIDE-VAD-PEDIATRIC : Development of a Decision Aid to Assist Children and Their Caregivers When Considering a Ventricular Assist Device. idecide - vad -儿科：在考虑使用心室辅助装置时，开发一种辅助儿童及其护理人员决策的辅助工具。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-10 DOI: 10.1097/MAT.0000000000002552

Seth A Hollander, Jenna M Murray, John C Dykes, Toni Duganiero, Jocelyn S Thompson, Tiffany Hunter, Kari Christ, Sabena F Hussain, Daniel D Matlock, Larry A Allen, Colleen K McIlvennan

引用次数: 0

Degradation of von Willebrand Factor: A Missing Link Between Shear Stress, Hemolysis, and Bleeding After Left Ventricular Assist Device Implantation. 血管性血友病因子的退化：剪应力、溶血和左心室辅助装置植入后出血之间的缺失环节。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-09 DOI: 10.1097/MAT.0000000000002534

Parsa Jahangiri, Kadir Caliskan

引用次数: 0

Outcomes of a Second Run of Extracorporeal Membrane Oxygenation in Neonates: A Propensity Score Matched Analysis of a Nationwide Registry. 新生儿第二次体外膜氧合的结果：全国登记的倾向评分匹配分析。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-09 DOI: 10.1097/MAT.0000000000002546

Humza Thobani, Muhammad Osama Khan, Timothy F Tirrell, Faraz A Khan, Saleem Islam

{"title":"Outcomes of a Second Run of Extracorporeal Membrane Oxygenation in Neonates: A Propensity Score Matched Analysis of a Nationwide Registry.","authors":"Humza Thobani, Muhammad Osama Khan, Timothy F Tirrell, Faraz A Khan, Saleem Islam","doi":"10.1097/MAT.0000000000002546","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002546","url":null,"abstract":"This study analyzed the outcomes of neonates undergoing a second run of extracorporeal membrane oxygenation (ECMO) to determine whether there is a benefit to a repeated run. We used Extracorporeal Life Support Organization data to compare neonates undergoing a single versus two runs of ECMO from 2009 to 2019. Baseline characteristics of single-run patients were compared with the first run in two-run patients to identify clinical predictors of a second run of ECMO. Furthermore, we compared overall survival outcomes and ECMO-related complications in single-run and two-run patients, with propensity score matching to adjust for baseline differences between the groups. A total of 12,292 patients undergoing 12,668 ECMO runs met criteria. Neonates requiring a second run had a shorter duration of the first ECMO run (p < 0.001) and were more likely to have had venoarterial cannulation (p < 0.001) than single-run patients. Overall, 33.8% of patients undergoing a second run survived until discharge, compared with 62.9% of patients undergoing a single run only. Propensity score matched analysis demonstrated that patients undergoing two runs were more likely to die, irrespective of underlying physiologic status or ECMO indication (odds ratio [OR] = 3.53, 95% confidence interval [CI] = 2.75-4.56). Nevertheless, nearly a third of patients undergoing two ECMO runs survived until discharge, indicating that recannulation may be beneficial in certain patient cohorts.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aeromedical Transport With Combined Extracorporeal Circulatory and Renal Support Bridging a Critically Ill Patient to Heart Transplantation. 体外循环和肾脏联合支持的航空运输架起危重病人到心脏移植的桥梁。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-09 DOI: 10.1097/MAT.0000000000002543

David Tran-Van, Natacha Almoyner, Christophe Bombert, Alexandre Arnaud, Marina Clement, Solenn Coz

引用次数: 0

Modified Park's Stitch Using Initial Systematic Cusp Alignment in Patients With Left Ventricular Assist Device. 改良Park's针在左心室辅助装置患者初始系统尖对准中的应用。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-09-09 DOI: 10.1097/MAT.0000000000002545

Tomonari Uemura, Tomo Yoshizumi, Yasunari Hayashi, Toru Kondo, Ryota Morimoto, Masato Mutsuga

{"title":"Modified Park's Stitch Using Initial Systematic Cusp Alignment in Patients With Left Ventricular Assist Device.","authors":"Tomonari Uemura, Tomo Yoshizumi, Yasunari Hayashi, Toru Kondo, Ryota Morimoto, Masato Mutsuga","doi":"10.1097/MAT.0000000000002545","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002545","url":null,"abstract":"We describe a modified Park's stitch technique incorporating systematic free margin alignment to achieve complete elimination of aortic regurgitation in patients with a left ventricular assist device. The technique involves a two-step approach: first, free margin alignment of all three cusps using single interrupted 6-0 polypropylene sutures placed at the nodules of Arantius to achieve precise coaptation, followed by conventional Park's stitch using mattress sutures with autologous pericardial pledgets for central closure. The alignment sutures remain in place to provide reinforcement. This modification addresses the central redundancy created by prolapsing or elongated cusps while maintaining the theoretical advantages of Park's stitch. In six consecutive patients (mean age, 56.5 years; 66.7% destination therapy), complete elimination of aortic insufficiency was immediately achieved with a median cross-clamp time of 30.5 min (interquartile range, 26.8-41.3 min). At follow-up (median, 8 months), five of the six patients had maintained zero regurgitation, while the remaining patient had developed only trivial regurgitation. This systematic approach to free margin alignment before Park's stitch may offer improved durability compared with conventional techniques, particularly for destination therapy patients requiring extended support.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0