ASAIO Journal最新文献_第4页

Kinetic of Vasoactive-Inotropic Score in Children on Veno-Venous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. 静脉-静脉体外膜氧合治疗急性呼吸窘迫综合征患儿血管活性-肌力评分的动态变化。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-10-01 Epub Date: 2026-06-05 DOI: 10.1097/MAT.0000000000002757

Vladimir L Cousin, Sarah Touati, Jordi Miatello, Pierre Tissières, Ramy Charbel

引用次数: 0

Clinical and Hemodynamic Effects of Impella 5.5 Therapy in Patients With Cardiogenic Shock. Impella 5.5治疗心源性休克的临床及血流动力学影响。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-10-01 Epub Date: 2026-01-21 DOI: 10.1097/MAT.0000000000002616

Gabriel Dardik, Yuji Kaku, Christine Yang, Rochelle Vayntrub, John Depaolo, Marisa Cevasco, Mauer Biscotti, Joyce Wald, Nir Uriel, Gabriel Sayer, Koji Takeda, Justin Fried

{"title":"Clinical and Hemodynamic Effects of Impella 5.5 Therapy in Patients With Cardiogenic Shock.","authors":"Gabriel Dardik, Yuji Kaku, Christine Yang, Rochelle Vayntrub, John Depaolo, Marisa Cevasco, Mauer Biscotti, Joyce Wald, Nir Uriel, Gabriel Sayer, Koji Takeda, Justin Fried","doi":"10.1097/MAT.0000000000002616","DOIUrl":"10.1097/MAT.0000000000002616","url":null,"abstract":"The Impella 5.5 is a large-bore transaortic microaxial flow pump used to treat patients with cardiogenic shock (CS). We sought to assess the hemodynamic and clinical response to Impella 5.5 in patients with CS and identify predictors of clinical deterioration. We reviewed 265 patients who underwent Impella 5.5 implantation from 2020 to 2024 at two institutions to identify patients in CS. Patients with preoperative extracorporeal life support (ECLS) were excluded and a total of 177 patients made up the final study cohort. Fifty patients (28%) deteriorated while on support and needed escalation to ECLS and/or died in-hospital, while 127 (72%) were successfully bridged to heart replacement therapy (HRT) or discharged without need for escalation of device support. Creatinine, lactate, white blood cell count, central venous pressure, and tricuspid regurgitation (TR) severity were all significantly higher in those with clinical deterioration, while pulmonary artery pulsatility index (PAPi) was lower. Rates of stroke, renal failure, and tracheostomy were significantly higher in those who deteriorated. After adjusting for age and sex, both TR and PAPi <2.5 were associated with clinical deterioration. Overall outcomes with Impella 5.5 in CS patients are encouraging; poor baseline right ventricular function appears to be a predictor of worse outcomes with Impella 5.5 in this population.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"826-831"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of an Oxygenator in the EXTra-Uterine Environment for Neonatal Development System Without Systemic Anticoagulation. 无系统抗凝的子宫外环境下新生儿发育（EXTEND）系统氧合器的评价。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-10-01 Epub Date: 2025-12-18 DOI: 10.1097/MAT.0000000000002624

Seitaro Kosaka, Urgyen Wangmo, Marina Heffelfinger, Hannah R Weisman, Maria F Varela, Maria Silena Mosquera, Vivek Patel, Michelle Ngo, Rachel S White, Brittany McGlone, Lijun Wu, Haiyan Cao, Marcus G Davey, Alan W Flake

{"title":"Evaluation of an Oxygenator in the EXTra-Uterine Environment for Neonatal Development System Without Systemic Anticoagulation.","authors":"Seitaro Kosaka, Urgyen Wangmo, Marina Heffelfinger, Hannah R Weisman, Maria F Varela, Maria Silena Mosquera, Vivek Patel, Michelle Ngo, Rachel S White, Brittany McGlone, Lijun Wu, Haiyan Cao, Marcus G Davey, Alan W Flake","doi":"10.1097/MAT.0000000000002624","DOIUrl":"10.1097/MAT.0000000000002624","url":null,"abstract":"An important goal in the development of an artificial womb is the avoidance of the use of heparin, due to the presumed risk of intracranial hemorrhage in premature infants. We developed the Experimental Oxygenator (Exp-Ox), featuring a small surface area and low priming volume, as an oxygenator to support the clinical application of the EXTra-uterine Environment for Neonatal Development (EXTEND) system. This study evaluated the durability and hemocompatibility of the Exp-Ox during prolonged use (exceeding 14 days) in premature lambs in the EXTEND system without systemic anticoagulation (heparin-free study) compared to the standard heparin-based EXTEND system (heparin study). Twelve animals (91-93 days gestational age) completed the study: six in the heparin and six in the heparin-free study. Oxygen and CO 2 transfer per weight remained stable overall in both studies, with no significant differences observed in oxygen transfer efficiency between the studies ( p = 0.61). The quantitative clot burden of the Exp-Ox on computed tomography scan images ranged from 3.91-29.94% to 1.28-11.77% in the heparin and heparin-free studies, respectively ( p = 0.15, nonsignificant difference), with no correlation to study duration or oxygen transfer efficiency. The Exp-Ox sustained function and hemocompatibility for over 14 days in the EXTEND system without systemic anticoagulation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"856-864"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Transition From University of Wisconsin to Del Nido Cardioplegia for Cardiac Allograft Preservation: The Vanderbilt Experience. 评估从威斯康辛大学过渡到德尔尼多心脏截瘫的心脏移植保存：范德比尔特的经验。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-10-01 Epub Date: 2025-12-25 DOI: 10.1097/MAT.0000000000002637

Awab Ahmad, John Trahanas, Brian Lima, Swaroop Bommareddi, Chen Chia Wang, Mark Petrovic, Kevin McGann, Stephen DeVries, Matthew Bacchetta, Ashish S Shah, Aaron M Williams

{"title":"Evaluating Transition From University of Wisconsin to Del Nido Cardioplegia for Cardiac Allograft Preservation: The Vanderbilt Experience.","authors":"Awab Ahmad, John Trahanas, Brian Lima, Swaroop Bommareddi, Chen Chia Wang, Mark Petrovic, Kevin McGann, Stephen DeVries, Matthew Bacchetta, Ashish S Shah, Aaron M Williams","doi":"10.1097/MAT.0000000000002637","DOIUrl":"10.1097/MAT.0000000000002637","url":null,"abstract":"The University of Wisconsin (UW) solution is widely used for cardiac allograft preservation. In early 2021, our center transitioned to Del Nido (DN) cardioplegia for all donors. This study evaluated whether this shift affected post-transplant outcomes. Adult, single-organ, donation after brain death heart transplants from January 2020 to December 2023 were included; congenital cases and non-ice storage techniques were excluded. Recipients were grouped by preservation solution. Interrupted time series (ITS) regression accounted for temporal bias and baseline differences, while exponential decay analysis evaluated lactate clearance. Of 203 transplants, 71 used UW and 132 used DN. Baseline characteristics were similar aside from longer ischemic times in the DN group. Unadjusted outcomes showed no significant differences in severe primary graft dysfunction (PGD), early mortality, cardiac index, or 24 hour vasoactive inotrope score (VIS). Intensive care unit and hospital stays were longer in the DN group. Lactate clearance was faster with DN (half-life 11.3 vs. 18.6 hours; p = 0.07). Interrupted time series regression showed no significant impact of DN on PGD, mortality, or morbidity scores, though VIS modestly increased ( p = 0.048), and peak lactate levels decreased ( p = 0.004). Del Nido provides comparable preservation to UW, supporting its use based on logistics and availability.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"840-847"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145826827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Bicarbonate Dialysis With or Without Extracorporeal Carbon Dioxide Removal for pH Control in a Swine Model of Acute Kidney Injury. 高碳酸氢盐透析加或不加体外二氧化碳去除对猪急性肾损伤模型pH控制的影响。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-10-01 Epub Date: 2026-05-13 DOI: 10.1097/MAT.0000000000002723

Yuri de Albuquerque Pessoa Dos Santos, Luis Carlos Maia Cardozo, Susimeire Gomes, Pedro Vitale Mendes, Bruno Adler Maccagnan Pinheiro Besen, Marcelo Park

{"title":"High Bicarbonate Dialysis With or Without Extracorporeal Carbon Dioxide Removal for pH Control in a Swine Model of Acute Kidney Injury.","authors":"Yuri de Albuquerque Pessoa Dos Santos, Luis Carlos Maia Cardozo, Susimeire Gomes, Pedro Vitale Mendes, Bruno Adler Maccagnan Pinheiro Besen, Marcelo Park","doi":"10.1097/MAT.0000000000002723","DOIUrl":"10.1097/MAT.0000000000002723","url":null,"abstract":"In acute respiratory distress syndrome (ARDS) complicated by acute kidney injury (AKI), severe acidemia may limit implementation of protective ventilation. Continuous renal replacement therapy (CRRT) may improve acid-base control either by increasing dialysate bicarbonate concentration or by combining CRRT with extracorporeal carbon dioxide removal (ECCO 2 R). We compared these strategies in a randomized experimental model. Twelve anesthetized Landrace pigs underwent surgical induction of anuric AKI followed by protocolized hypoventilation with stepwise tidal volume (Vt) reduction. Animals were assigned to CRRT with very-high bicarbonate dialysate (60 mEq/L) alone or CRRT with high bicarbonate dialysate (40 mEq/L) plus low-flow ECCO 2 R. The primary outcomes were time to vasopressor initiation and the lowest Vt achieved while maintaining arterial pH ≥7.2 during a 12 hour protocol. Both strategies corrected hypercapnic acidemia and enabled substantial Vt reduction, approximately 50% from baseline, without differences between groups at 12 hours ( p = 0.756). Time to vasopressor initiation was likewise similar (hazard ratio [HR] = 0.76, 95% confidence interval [CI] = 0.21-2.71). Cardiac output remained preserved despite increasing vasopressor requirements. In this experimental AKI model, very-high bicarbonate CRRT provided short-term pH control comparable to CRRT plus ECCO 2 R, supporting ultralow-Vt ventilation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"871-879"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Challenging the Obesity Paradox: A Multicenter Study of Body Mass Index and Mortality in Venovenous Extracorporeal Membrane Oxygenation. 致编辑的信：挑战肥胖悖论：一项多中心研究的身体质量指数和死亡率在静脉静脉体外膜氧合。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-10-01 DOI: 10.1097/MAT.0000000000002874

Chaofan Song, Yunyan Sheng, Guoying Wang

引用次数: 0

Neural Network Model for Predicting Oxygen Transfer in Membrane Oxygenators Under Variable Extracorporeal Membrane Oxygenation Conditions. 可变体外膜氧合条件下膜氧合器氧传递的神经网络预测模型。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-10-01 Epub Date: 2026-01-30 DOI: 10.1097/MAT.0000000000002667

Tsukasa Nakao, Satoshi Miyamoto, Shinichiro Ohshimo, Shinya Takahashi, Nobuaki Shime

{"title":"Neural Network Model for Predicting Oxygen Transfer in Membrane Oxygenators Under Variable Extracorporeal Membrane Oxygenation Conditions.","authors":"Tsukasa Nakao, Satoshi Miyamoto, Shinichiro Ohshimo, Shinya Takahashi, Nobuaki Shime","doi":"10.1097/MAT.0000000000002667","DOIUrl":"10.1097/MAT.0000000000002667","url":null,"abstract":"During extracorporeal membrane oxygenation (ECMO) management, early recognition and intervention are essential in cases of membrane oxygenator (MO) oxygenation failure. However, because the MO oxygen transfer (O 2 transfer) capacity is influenced by various factors, clear evaluation criteria are lacking. Theoretical O 2 transfer values provided by manufacturers are commonly used to assess MO performance; however, these values are presented only under standardized conditions. In this study, to develop an O 2 transfer model for real-world ECMO settings, we conducted perfusion experiments using bovine blood under various venous blood compositions (hemoglobin concentration and oxygen saturation) and operational conditions (blood flow and fraction of delivered oxygen). Although substantial variability was observed in the relationships between O 2 transfer and individual parameters, partial correlation analysis revealed significant associations with all factors, underscoring the need to incorporate them into the model. A multilayer feedforward neural network was employed to construct the model, achieving a high coefficient of determination ( R2 = 0.992), demonstrating excellent predictive performance. The proposed O 2 transfer model provides a framework for evaluating the oxygenation performance of MO under diverse ECMO conditions. By enabling comparison with real-time clinical data, it has the potential to support clinical decision-making and enhance the safety of ECMO management.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"832-839"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Veno-Venous Extracorporeal Membrane Oxygenation as Bridge to Patent Foramen Ovale Closure for Platypnea-Orthodeoxia Syndrome: A Case Report. 静脉-静脉体外膜氧合作为闭合卵圆孔未闭治疗肺动脉-正氧综合征1例报告。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-09-29 DOI: 10.1097/MAT.0000000000002857

Claudio Ripa, Jagan Murugachandran, Patrick A Calvert, Robert Gatherer

{"title":"Veno-Venous Extracorporeal Membrane Oxygenation as Bridge to Patent Foramen Ovale Closure for Platypnea-Orthodeoxia Syndrome: A Case Report.","authors":"Claudio Ripa, Jagan Murugachandran, Patrick A Calvert, Robert Gatherer","doi":"10.1097/MAT.0000000000002857","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002857","url":null,"abstract":"Right-to-left intracardiac shunting may complicate patent foramen ovale, with percutaneous closure being the standard treatment. We present the case of a 63 year old man admitted for percutaneous patent foramen ovale (PFO) closure due to severe right-to-left shunting. Despite treatment with diuretics and noradrenaline, he developed persistent hypoxemia with pulmonary edema. Intubation was initially avoided because of the risk of worsening shunt physiology and anticipated airway management difficulties. To optimize oxygenation while maintaining femoral access for intervention, awake veno-venous extracorporeal membrane oxygenation (ECMO) was initiated, resulting in a marked improvement in oxygenation. The patient subsequently underwent intubation, diagnostic imaging, and successful PFO closure. Extracorporeal membrane oxygenation was weaned 2 days later, and he was discharged from the intensive care unit (ICU) to the ward. This case demonstrates that awake veno-venous ECMO (V-V-ECMO) can serve as a bridging strategy in patients with PFO-related right-to-left shunting when mechanical ventilation carries substantial risks. Careful multidisciplinary evaluation is essential to weigh the potential benefits of ECMO against the risks of cannulation and shunt dynamics.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socioeconomic Disparities in Patients With Cardiogenic Shock Treated With Extracorporeal Support. 体外支持治疗心源性休克患者的社会经济差异。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-09-29 DOI: 10.1097/MAT.0000000000002864

Luiz Marcelo Almeida de Araujo, Elliot Richard Haut, Glenn J R Whitman, Sung-Min Cho

{"title":"Socioeconomic Disparities in Patients With Cardiogenic Shock Treated With Extracorporeal Support.","authors":"Luiz Marcelo Almeida de Araujo, Elliot Richard Haut, Glenn J R Whitman, Sung-Min Cho","doi":"10.1097/MAT.0000000000002864","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002864","url":null,"abstract":"Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a resource-intensive therapy that can be used in severe cardiogenic shock (CS). Socioeconomic factors are known determinants of cardiovascular outcomes, yet their association with mortality among patients receiving mechanical circulatory support remains unclear. We conducted a retrospective cohort study using the Healthcare Cost and Utilization Project National Inpatient Sample, including adult hospitalizations with CS receiving VA-ECMO between 2018 and 2022. Exposure was Zone Improvement Plan (ZIP) code-level median household income quartile. The primary outcome was in-hospital mortality. We used multivariable regression to estimate risk ratios and Cox-proportional hazards for time-to-event analyses, adjusting for confounders. The 3,032 hospitalizations were evenly distributed across income quartiles. Compared with the lowest-income quartile, the adjusted mortality risk ratio of the second (adjusted risk ratio [aRR], 0.97; 95% confidence interval [CI], 0.86-1.09) and third quartiles (aRR, 0.94; 95% CI, 0.84-1.05) had no significant difference. The highest-income quartile had a significantly lower risk of in-hospital mortality (aRR, 0.83; 95% CI, 0.74-0.94). Time-to-event analyses showed a lower adjusted hazard of death for the fourth versus first quartile (adjusted hazard ratio [aHR], 0.76; 95% CI, 0.64-0.89), whereas second and third quartiles were not significantly different. These findings suggest that disparities persist among patients receiving resource-intensive life-support therapies, highlighting the need to measure socioeconomic variables and address structural factors influencing outcomes in critical care.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative Goal-Directed Perfusion Improves Outcomes in Left Ventricular Assist Device Explant Heart Transplantation. 术中目标导向灌注改善左心室辅助装置外植心脏移植的预后。

IF 2.2 3区医学

ASAIO Journal Pub Date : 2026-09-28 DOI: 10.1097/MAT.0000000000002866

Chen Chia Wang, Mark Petrovic, Awab Ahmad, Walter Navid, Christian Eidson, Kevin McGann, John Trahanas, Swaroop Bommareddi, Tarek Absi, Eric Quintana, Aniket Rali, Kelly Schlendorf, Matthew Bacchetta, Ashish Shah, Brian Lima, Aaron M Williams

{"title":"Intraoperative Goal-Directed Perfusion Improves Outcomes in Left Ventricular Assist Device Explant Heart Transplantation.","authors":"Chen Chia Wang, Mark Petrovic, Awab Ahmad, Walter Navid, Christian Eidson, Kevin McGann, John Trahanas, Swaroop Bommareddi, Tarek Absi, Eric Quintana, Aniket Rali, Kelly Schlendorf, Matthew Bacchetta, Ashish Shah, Brian Lima, Aaron M Williams","doi":"10.1097/MAT.0000000000002866","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002866","url":null,"abstract":"Left ventricular assist device (LVAD) explant heart transplantation represents a metabolically vulnerable population with an increased risk for renal failure and mortality. Oxygen extraction ratio (O2ER), which integrates oxygen delivery and tissue oxygen demand, may provide a physiologic marker of cumulative metabolic stress during cardiopulmonary bypass (CPB). Adult LVAD-explant heart transplant recipients at a single center from October 2021 to June 2025 were analyzed using continuous perfusion data captured during CPB. Oxygen extraction ratio was calculated continuously, and cumulative oxygen extraction burden was quantified as the area above an O2ER threshold of 0.20. Patients were stratified by median O2ER burden. Among 110 patients, a higher intraoperative O2ER burden was associated with increased postoperative renal replacement therapy (odds ratio [OR], 4.16; 95% confidence interval [CI], 1.35-12.83) and increased 2-year mortality (hazard ratio [HR], 7.61; 95% CI, 1.49-38.73) after inverse probability weighting adjustment. A higher O2ER burden was also associated with a lower immediate postoperative cardiac index and increased vasoactive inotrope requirements. Donor hypertension, recipient diabetes, static storage modality, and a lower intraoperative oxygen delivery index were associated with an increased O2ER burden. These findings suggest that cumulative oxygen extraction during CPB reflects intraoperative metabolic stress and may represent a physiologically integrated perfusion target in LVAD-explant heart transplantation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0