ASAIO Journal最新文献_第10页

Antithrombotic and Antimicrobial Potential of S -Nitroso-1-Adamantanethiol-Impregnated Extracorporeal Circuit. S-亚硝基-1-金刚烷硫醇浸渍体外循环的抗血栓和抗菌潜力

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-07-22 DOI: 10.1097/MAT.0000000000002276

Orsolya Lautner-Csorba, Roopa Gorur, Terry Major, Jianfeng Wu, Partha Sheet, Joseph Hill, Minzhi Yu, Chuanwu Xi, Robert H Bartlett, Steven P Schwendeman, Gergely Lautner, Mark E Meyerhoff

{"title":"Antithrombotic and Antimicrobial Potential of S -Nitroso-1-Adamantanethiol-Impregnated Extracorporeal Circuit.","authors":"Orsolya Lautner-Csorba, Roopa Gorur, Terry Major, Jianfeng Wu, Partha Sheet, Joseph Hill, Minzhi Yu, Chuanwu Xi, Robert H Bartlett, Steven P Schwendeman, Gergely Lautner, Mark E Meyerhoff","doi":"10.1097/MAT.0000000000002276","DOIUrl":"10.1097/MAT.0000000000002276","url":null,"abstract":"This study presents the utilization of a novel, highly lipophilic nitric oxide (NO) donor molecule, S -nitroso-1-adamantanethiol (SNAT), for developing an NO-emitting polymer surface aimed at preventing thrombus formation and bacterial infection in extracorporeal circuits (ECCs). S -nitroso-1-adamantanethiol, a tertiary nitrosothiol-bearing adamantane species, was synthesized, characterized, and used to impregnate polyvinyl chloride (PVC) tubing for subsequent in vivo evaluation. The impregnation process with SNAT preserved the original mechanical strength of the PVC. In vitro assessments revealed sustained NO release from the SNAT-impregnated PVC tubing (iSNAT), surpassing or matching endothelial NO release levels for up to 42 days. The initial NO release remained stable even after 1 year of storage at -20°C. The compatibility of iSNAT with various sterilization techniques (OPA Plus, hydrogen peroxide, EtO) was tested. Acute in vivo experiments in a rabbit model demonstrated significantly reduced thrombus formation in iSNAT ECCs compared with controls, indicating the feasibility of iSNAT to mitigate coagulation system activation and potentially eliminate the need for systemic anticoagulation. Moreover, iSNAT showed substantial inhibition of microbial biofilm formation, highlighting its dual functionality. These findings underscore the promising utility of iSNAT for long-term ECC applications, offering a multifaceted approach to enhancing biocompatibility and minimizing complications.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"177-185"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impella RP Flex: Rescue for the Failing Right Ventricle After Heart Transplantation-Case Report. Impella RP Flex：心脏移植后衰竭右心室的抢救--病例报告。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-06-21 DOI: 10.1097/MAT.0000000000002253

Akanksha Agrawal, Joel Shoemaker, Swaroop Bommareddi, Ioana Dumitru

{"title":"Impella RP Flex: Rescue for the Failing Right Ventricle After Heart Transplantation-Case Report.","authors":"Akanksha Agrawal, Joel Shoemaker, Swaroop Bommareddi, Ioana Dumitru","doi":"10.1097/MAT.0000000000002253","DOIUrl":"10.1097/MAT.0000000000002253","url":null,"abstract":"Right ventricular (RV) dysfunction (RVD) after orthotopic heart transplantation (OHT) is a common cause of morbidity and mortality. Impella RP Flex was recently approved for RV support as a temporary mechanical circulatory device. We present the first case of its use in managing RVD in a patient after OHT. Here, a 40 year old male patient with familial dilated cardiomyopathy and factor V Leiden mutation presented with Society for Cardiovascular Angiography & Interventions (SCAI) stage B cardiogenic shock. Hemodynamics at admission were indicative of need for intra-aortic balloon pump (IABP) support. Hemodynamics improved and patient underwent OHT. Postoperative day (POD) 1, IABP support was changed to 1:2 and eventually removed. Hemodynamics deteriorated quickly, requiring pharmacologic RV support and diuresis, but refractory RV failure persisted. Impella RP Flex was chosen due to the patient's small size and was placed via the right internal jugular vein on POD 12. The procedure was well tolerated, with the patient ambulatory the following day (POD 13). Impella was removed on POD 25 after 13 days of support. Patient achieved normal kidney, intrinsic rhythm improved sinus rhythm, and ultimately discharged on POD 50. Impella RP flex has emerged as a promising future indication as single or biventricular support postcardiac transplantation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e33-e37"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannula-Associated Deep Vein Thrombosis Following Extracorporeal Membrane Oxygenation Decannulation: Incidence and Risk Factors. 体外膜氧封管术后的套管相关性深静脉血栓：发生率和风险因素。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-08-01 DOI: 10.1097/MAT.0000000000002289

Ngan Hoang Kim Trieu, Huy Minh Pham, Tuan Anh Mai, Dai Quang Huynh, Linh Thanh Tran, Xuan Thi Phan, Thao Thi Ngoc Pham

{"title":"Cannula-Associated Deep Vein Thrombosis Following Extracorporeal Membrane Oxygenation Decannulation: Incidence and Risk Factors.","authors":"Ngan Hoang Kim Trieu, Huy Minh Pham, Tuan Anh Mai, Dai Quang Huynh, Linh Thanh Tran, Xuan Thi Phan, Thao Thi Ngoc Pham","doi":"10.1097/MAT.0000000000002289","DOIUrl":"10.1097/MAT.0000000000002289","url":null,"abstract":"Thrombotic complications during and after extracorporeal membrane oxygenation (ECMO) are commonly observed clinically. The incidences of cannula-associated deep vein thrombosis (CaDVT) post-ECMO support have predominantly focused on Caucasian demographics. This study aims to determine the incidence and risk factors for CaDVT in Vietnamese patients following ECMO decannulation. The retrospective study from January 2019 to February 2020 observed ECMO weaning patients and screened for CaDVT using Doppler ultrasonography. Data were collected on patient demographics, ECMO parameters, and transfusion and coagulation profiles during ECMO support. Of the 82 patients successfully weaned ECMO, 89% were assessed for CaDVT. We observed a CaDVT incidence of 24.7%, and only one patient (5.6%) had a pulmonary embolism in the CaDVT group. Noteworthy is that the anticoagulation goals, transfusion during ECMO, and hospital mortality showed no significant difference between the CaDVT and non-CaDVT groups. The findings showed that the duration of ECMO support is a risk factor for CaDVT. The incidence of CaDVT following ECMO decannulation was 24.7%, and the diagnosis of CaDVT can be underestimated. Therefore, we suggest routine screening for CaDVT after cannula removal.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"164-170"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse Pressure During VA-ECMO Support and Neurologic Outcomes: Worth Getting Pumped Up About? VA-ECMO支持期间的脉压和神经预后：值得关注吗？

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1097/MAT.0000000000002363

Reza Salabat, Dmitry Abramov

引用次数: 0

Pulse Pressure and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis. 脉压与体外膜肺氧合中的急性脑损伤：体外生命支持组织登记分析。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-08-23 DOI: 10.1097/MAT.0000000000002294

Andrew Kalra, Jin Kook Kang, Christopher Wilcox, Benjamin L Shou, Patricia Brown, Peter Rycus, Marc M Anders, Akram M Zaaqoq, Daniel Brodie, Glenn J R Whitman, Sung-Min Cho

{"title":"Pulse Pressure and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis.","authors":"Andrew Kalra, Jin Kook Kang, Christopher Wilcox, Benjamin L Shou, Patricia Brown, Peter Rycus, Marc M Anders, Akram M Zaaqoq, Daniel Brodie, Glenn J R Whitman, Sung-Min Cho","doi":"10.1097/MAT.0000000000002294","DOIUrl":"10.1097/MAT.0000000000002294","url":null,"abstract":"Low pulse pressure (PP) in venoarterial-extracorporeal membrane oxygenation (VA-ECMO) is a marker of cardiac dysfunction and has been associated with acute brain injury (ABI) as continuous-flow centrifugal pump may lead to endothelial dysregulation. We retrospectively analyzed adults (≥18 years) receiving \"peripheral\" VA-ECMO for cardiogenic shock in the Extracorporeal Life Support Organization Registry (January 2018-July 2023). Acute brain injury (our primary outcome) included central nervous system (CNS) ischemia, intracranial hemorrhage, brain death, and seizures. Multivariable logistic regressions were performed to examine whether PP ≤10 mm Hg was associated with ABI. Of 9,807 peripheral VA-ECMO patients (median age = 57.4 years, 67% = male), 8,294 (85%) had PP >10 mm Hg versus 1,513 (15%) had PP ≤10 mm Hg. Patients with PP ≤10 mm Hg experienced ABI more frequently versus PP >10 mm Hg (15% versus 11%, p < 0.001). After adjustment, PP ≤10 mm Hg was independently associated with ABI (adjusted odds ratio [aOR] = 1.25, 95% confidence interval [CI] = 1.06-1.48, p = 0.01). Central nervous system ischemia and brain death were more common in patients with PP ≤10 versus PP >10 mm Hg (8% versus 6%, p = 0.008; 3% versus 1%, p < 0.001). Pulse pressure ≤10 mm Hg was associated with CNS ischemia (aOR = 1.26, 95% CI = 1.02-1.56, p = 0.03) but not intracranial hemorrhage (aOR = 1.14, 95% CI = 0.85-1.54, p = 0.38). Early low PP (≤10 mm Hg) at 24 hours of ECMO support was associated with ABI, particularly CNS ischemia, in peripheral VA-ECMO patients.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"99-108"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142043852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet Activation and Severe Bleeding During Extracorporeal Carbon Dioxide Removal in Chronic Obstructive Pulmonary Disease Patients. 慢性阻塞性肺病患者在体外二氧化碳清除过程中的血小板活化和严重出血。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-05-16 DOI: 10.1097/MAT.0000000000002241

David M Smadja, Richard Chocron, Nadia Rivet, Sofia Ortuno, Coralie L Guerin, Jean-Luc Diehl

引用次数: 0

Aortic Root Vortex Formation During Left Ventricular Assist Device Support. 左心室辅助装置支持过程中的主动脉根部涡流形成

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-08-27 DOI: 10.1097/MAT.0000000000002298

Chaztyn Pangelina, Vi Vu, Karen May-Newman

{"title":"Aortic Root Vortex Formation During Left Ventricular Assist Device Support.","authors":"Chaztyn Pangelina, Vi Vu, Karen May-Newman","doi":"10.1097/MAT.0000000000002298","DOIUrl":"10.1097/MAT.0000000000002298","url":null,"abstract":"The vortex that forms in the aortic sinus plays a vital role in optimizing blood flow. Disruption of the vortex can result in flow stagnation and activate thrombus formation in the aortic root, especially when aortic valve flow is reduced as during left ventricular assist device (LVAD) support. Our goal in this study was to visualize vortex formation in an experimental model of the aortic root as flow is progressively reduced. A mock circulatory loop that reproduces heart failure hemodynamics was combined with a HeartMate II LVAD and velocity measured in a transparent aortic root with a bioprosthetic valve. The aortic valve sinus vortices are clearly visible as counter-rotating structures in the velocity field at baseline and for all conditions with flow through the aortic valve. As LVAD speed increases, the central jet narrows but the vortices persist, disappearing only when the valve is completely closed. The vortices preserve fluid momentum and generate shear stress along the tissue surfaces which disrupts flow stasis. These features underscore the importance of maintaining \"intermittent\" aortic valve opening, as recommended for LVAD patients. This study is the first to report vortex formation in the aortic root during LVAD support, providing a motivation for further evaluation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"149-156"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Index.

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2025-02-04 DOI: 10.1097/01.mat.0001105996.77764.ea

引用次数: 0

Evaluation of the Nautilus Smart Extracorporeal Membrane Oxygenation in Patients With Hemostatic Alteration: A Case Series. 评估 Nautilus 智能体外膜氧合技术在止血功能改变患者中的应用：病例系列。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-06-14 DOI: 10.1097/MAT.0000000000002252

Mauro Renghini, Debora Maddinelli, Anna Papeo, Carmine Puglia, Andrea Montisci, Sergio Cattaneo, Stefano Benussi

{"title":"Evaluation of the Nautilus Smart Extracorporeal Membrane Oxygenation in Patients With Hemostatic Alteration: A Case Series.","authors":"Mauro Renghini, Debora Maddinelli, Anna Papeo, Carmine Puglia, Andrea Montisci, Sergio Cattaneo, Stefano Benussi","doi":"10.1097/MAT.0000000000002252","DOIUrl":"10.1097/MAT.0000000000002252","url":null,"abstract":"The intricate management of hemostatic disorders in extracorporeal membrane oxygenation (ECMO) assisted patients poses challenges, particularly when procoagulant administration is necessary. We hereby report the performance of the Nautilus* Smart ECMO Module in three patients with hemostatic disorders. We collected data from ECMO procedures with Nautilus* Smart ECMO Module and analyzed the performance: the operating pressures and resistance of the device in addition to the coagulation status of the patients. During the three procedures, partial pressure oxygen post-oxygenator (paO 2 ) stayed above 100 mm Hg and partial pressure carbon dioxide post-oxygenator (paCO 2 ) did not exceed 45 mm Hg. Membrane FiO 2 (fractional inspired O 2 ) did not exceed 75% and air flow remained within a 1:1 ratio with blood flow in veno-arterial ECMO (V-A) and within 1:2 in veno-venous ECMO (V-V). There was no evidence of excessive operating pressure for the device, with a pressure drop consistently below 28 mm Hg and a maximum peak resistance of 7 Δmm Hg/L/min. The Nautilus* Smart ECMO Module showed good performance in patients with hemostatic disorders despite the implications associated with procoagulant administration.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"e28-e32"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Cardiac Resynchronization Therapy on Ventricular Arrhythmias and Survival After Durable Left Ventricular Assist Device Implantation. 心脏再同步化疗法对持久性左心室辅助装置植入术后室性心律失常和存活率的影响

IF 3.1 3区医学

ASAIO Journal Pub Date : 2025-02-01 Epub Date: 2024-07-29 DOI: 10.1097/MAT.0000000000002279

Connor P Oates, Luke L Lawrence, Grace E Bigham, Namratha S Meda, Binaya Basyal, Sriram D Rao, Cyrus A Hadadi, Samer S Najjar, Manish H Shah, Farooq H Sheikh, Phillip H Lam

{"title":"Impact of Cardiac Resynchronization Therapy on Ventricular Arrhythmias and Survival After Durable Left Ventricular Assist Device Implantation.","authors":"Connor P Oates, Luke L Lawrence, Grace E Bigham, Namratha S Meda, Binaya Basyal, Sriram D Rao, Cyrus A Hadadi, Samer S Najjar, Manish H Shah, Farooq H Sheikh, Phillip H Lam","doi":"10.1097/MAT.0000000000002279","DOIUrl":"10.1097/MAT.0000000000002279","url":null,"abstract":"The impact of cardiac resynchronization therapy (CRT) in patients receiving durable left ventricular assist device (LVAD) implantation remains unclear and there is no consensus regarding postoperative management. We sought to determine the impact of postoperative management of CRT on clinical outcomes following LVAD implantation. A total of 789 patients underwent LVAD implantation at our institution from 2007 to 2022 including 195 patients (24.7%) with preoperative CRT. Patients with preoperative CRT were significantly older and more frequently received an LVAD as destination therapy compared to patients without preoperative CRT. After LVAD implantation, 85 patients had CRT programmed \"off\" and 74 patients had CRT programmed \"on.\" The risk of mortality was significantly increased amongst patients with preoperative CRT that was turned \"on\" following LVAD implantation compared to patients with preoperative CRT turned \"off\" following implant (subdistribution hazard ratio [sdHR] = 1.54; 1.06-2.37 95% confidence interval [CI]; p = 0.036). There was no significant difference between incidence of ventricular arrhythmias in patients with and without postoperative CRT \"on\" (35.1% vs . 48.2%; p = 0.095). Additional clinical trials are warranted to determine the best CRT programming strategy following LVAD implantation.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"157-163"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0