ASAIO Journal最新文献_第7页

Aortic Dissection in a Neonate Receiving Extracorporeal Life Support Therapy: A Case Report. 接受体外生命支持疗法的新生儿主动脉夹层：病例报告。

IF 4.2 3区医学

ASAIO Journal Pub Date : 2024-09-11 DOI: 10.1097/mat.0000000000002306

Shivanand S Medar,Arun Chopra,T K Susheel Kumar,Jaclyn McKinstry,Keith Kuenzler,Sujata B Chakravarti,Jason Fisher

引用次数: 0

A Case Report About Cardiac Arrest After Left Ventricular Assist Device Explantation. 左心室辅助装置爆炸后心脏骤停的病例报告

IF 4.2 3区医学

ASAIO Journal Pub Date : 2024-09-11 DOI: 10.1097/mat.0000000000002304

Edisson Nemer,Rami Rassam,Ann Hallberg Kristensen,Tonje Thorvaldsen,Magnus Dalén,Emil Najjar

引用次数: 0

Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure. 针对小儿心力衰竭患者的双启动系列多血流泵设计

IF 4.2 3区医学

ASAIO Journal Pub Date : 2024-09-11 DOI: 10.1097/mat.0000000000002300

Thomas C Palazzolo,Harutyun Sarkisyan,Giselle C Matlis,Jordon McGowan,Vakhtang Tchantchaleishvili,Randy M Stevens,Amy L Throckmorton

{"title":"Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure.","authors":"Thomas C Palazzolo,Harutyun Sarkisyan,Giselle C Matlis,Jordon McGowan,Vakhtang Tchantchaleishvili,Randy M Stevens,Amy L Throckmorton","doi":"10.1097/mat.0000000000002300","DOIUrl":"https://doi.org/10.1097/mat.0000000000002300","url":null,"abstract":"The translational development of pediatric ventricular assist devices (VADs) lags years behind adult device options, negatively impacting pediatric patient outcomes. To address this need, we are developing a novel, series-flow, double-blood pump VAD that integrates an axial and centrifugal pump into a single device. The axial pump is used for initial circulatory assistance in younger patients; then, an internal activation mechanism triggers the centrifugal pump to activate in line with the axial pump, providing additional pressure and flow to match pediatric patient growth cycles. Here, we focused on the design and improvement of the device flow paths through computational analysis and in vitro hydraulic testing of a prototype. We estimated pressure-flow generation, fluid scalar stresses, and blood damage levels. In vitro hydraulic tests correlated well with shear stress transport (SST) predictions, with an average deviation of 4.5% for the complex, combined flow path. All data followed expected pump performance trends. The device exceeded target levels for blood damage in the blade tip clearances, and this must be both investigated and addressed in the next design phase. These study findings establish a strong foundation for the future development of the Drexel Double-Dragon VAD.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":"12 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142179253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Heart Failure Care: Deep Learning-Based Activity Classification in Left Ventricular Assist Device Patients. 加强心衰护理：基于深度学习的左心室辅助装置患者活动分类。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2024-09-05 DOI: 10.1097/MAT.0000000000002299

Laurenz Berger, Max Haberbusch, Christoph Gross, Francesco Moscato

{"title":"Enhancing Heart Failure Care: Deep Learning-Based Activity Classification in Left Ventricular Assist Device Patients.","authors":"Laurenz Berger, Max Haberbusch, Christoph Gross, Francesco Moscato","doi":"10.1097/MAT.0000000000002299","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002299","url":null,"abstract":"Accurate activity classification is essential for the advancement of closed-loop control for left ventricular assist devices (LVADs), as it provides necessary feedback to adapt device operation to the patient's current state. Therefore, this study aims at using deep neural networks (DNNs) to precisely classify activity for these patients. Recordings from 13 LVAD patients were analyzed, including heart rate, LVAD flow, and accelerometer data, classifying activities into six states: active, inactive, lying, sitting, standing, and walking. Both binary and multiclass classifiers have been trained to distinguish between active and inactive states and to discriminate the remaining categories. The models were refined by testing several architectures, including recurrent and convolutional layers, optimized via hyperparameter search. Results demonstrate that integrating LVAD flow, heart rate, and accelerometer data leads to the highest accuracy in both binary and multiclass classification. The optimal architectures featured two and three bidirectional long short-term memory layers for binary and multiclass classifications, respectively, achieving accuracies of 91% and 84%. In this study, the potential of DNNs has been proven for providing a robust method for activity classification that is vital for the effective closed-loop control of medical devices in cardiac care.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Mortality in Adults With Calcium Channel Blocker Toxicity Receiving Extra Corporeal Membrane Oxygenation Support: An Extracorporeal Life Support Organization Registry Analysis. 接受体外膜氧合支持的钙通道阻滞剂毒性成人的死亡率预测因素：体外生命支持组织登记分析》。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2024-09-03 DOI: 10.1097/MAT.0000000000002307

Rakeshkumar Subramanian, Amelia Roebuck, Hariom Joshi, Michelle Drouin

{"title":"Predictors of Mortality in Adults With Calcium Channel Blocker Toxicity Receiving Extra Corporeal Membrane Oxygenation Support: An Extracorporeal Life Support Organization Registry Analysis.","authors":"Rakeshkumar Subramanian, Amelia Roebuck, Hariom Joshi, Michelle Drouin","doi":"10.1097/MAT.0000000000002307","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002307","url":null,"abstract":"Calcium channel blocker (CCB) toxicity presents a significant mortality risk, highlighting the need for effective treatment strategies such as extracorporeal membrane oxygenation (ECMO). This study analyzes Extracorporeal Life Support Organization (ELSO) registry data to determine the mortality rate in adults treated with ECMO for CCB toxicity and identifies clinical predictors of mortality. A retrospective analysis of the ELSO registry from January 2016 to April 2023 was conducted, focusing on adults diagnosed with CCB toxicity (ICD-10 T46.1) who received ECMO. Data collected included patient demographics, ECMO details (mode, duration, type), pre-ECMO clinical indicators (pH, lactate levels, cardiac arrest incidence), and in-hospital mortality. The analysis employed descriptive statistics to profile the patient population, with independent t-tests and chi-square tests comparing survivors to nonsurvivors. Logistic regression identified mortality predictors, integrating multiple imputations to remedy missing data, thus ensuring the analysis's integrity. The mortality rate for ECMO-treated CCB toxicity was 40.6%. Severe acidosis and the need for pre-ECMO renal replacement therapy were identified as key predictors of mortality. Further research is needed to determine if early ECMO initiation before a significant pH drop improves outcomes.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Safety in Left Ventricular Assist Device Implantation: Laparoscopic Technique for Driveline Tunneling. 提高左心室辅助装置植入术的安全性：腹腔镜 Driveline 隧道技术。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2024-09-02 DOI: 10.1097/MAT.0000000000002303

Douglas Tran, Hannah Frederick, Bartley Griffith, Aakash Shah

引用次数: 0

Percutaneous Venopulmonary Extracorporeal Membrane Oxygenation as Bridge to Lung Transplantation. 经皮静脉肺体外膜氧合作为肺移植的桥梁。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2024-09-01 Epub Date: 2024-03-06 DOI: 10.1097/MAT.0000000000002179

Asad Ali Usman, Audrey Elizabeth Spelde, Wasim Lutfi, Jacob T Gutsche, William J Vernick, Omar Toubat, Salim E Olia, Edward Cantu, Andrew Courtright, Maria M Crespo, Joshua Diamond, Mauer Biscotti, Christian A Bermudez

{"title":"Percutaneous Venopulmonary Extracorporeal Membrane Oxygenation as Bridge to Lung Transplantation.","authors":"Asad Ali Usman, Audrey Elizabeth Spelde, Wasim Lutfi, Jacob T Gutsche, William J Vernick, Omar Toubat, Salim E Olia, Edward Cantu, Andrew Courtright, Maria M Crespo, Joshua Diamond, Mauer Biscotti, Christian A Bermudez","doi":"10.1097/MAT.0000000000002179","DOIUrl":"10.1097/MAT.0000000000002179","url":null,"abstract":"Mechanical circulatory support (MCS) as a bridge to lung transplant is an infrequent but accepted pathway in patients who have refractory end-stage pulmonary failure. The American Association of Thoracic Surgeons Expert Consensus Guidelines, published in 2023, recommends venovenous (VV) extracorporeal membrane oxygenation (ECMO) as the initial configuration for those patients who have failed conventional medical therapy, including mechanical ventilation, while waiting for lung transplantation and needing MCS. Alternatively, venoarterial (VA) ECMO can be used in patients with acute right ventricular failure, hemodynamic instability, or refractory respiratory failure. With the advancement in percutaneous venopulmonary (VP) ECMO cannulation techniques, this option is becoming an attractive configuration as bridge to lung transplantation. This configuration enhances stability of the right ventricle, prevents recirculation with direct introduction of pulmonary artery oxygenation, and promotes hemodynamic stability during mobility, rehabilitation, and sedation-weaning trials before lung transplantation. Here, we present a case series of eight percutaneous VP ECMO as bridge to lung transplant with all patients mobilized, awake, and successfully transplanted with survival to hospital discharge.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"758-766"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meet the Authors. 与作者见面

IF 3.1 3区医学

ASAIO Journal Pub Date : 2024-09-01 Epub Date: 2024-08-28 DOI: 10.1097/01.mat.0001052028.16798.af

引用次数: 0

The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion. 常温离体心脏灌注过程中氧自由基清除剂的作用

IF 3.1 3区医学

ASAIO Journal Pub Date : 2024-09-01 Epub Date: 2024-03-08 DOI: 10.1097/MAT.0000000000002176

Xiao Qi, Sanaz Hatami, Sabin Bozso, Xiuhua Wang, Bruno Saleme, Jayan Nagendran, Evangelos Michelakis, Gopinath Sutendra, Darren H Freed

{"title":"The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion.","authors":"Xiao Qi, Sanaz Hatami, Sabin Bozso, Xiuhua Wang, Bruno Saleme, Jayan Nagendran, Evangelos Michelakis, Gopinath Sutendra, Darren H Freed","doi":"10.1097/MAT.0000000000002176","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002176","url":null,"abstract":"Oxidative stress occurs during ex-situ heart perfusion (ESHP) and may negatively affect functional preservation of the heart. We sought to assess the status of key antioxidant enzymes during ESHP, and the effects of augmenting these antioxidants on the attenuation of oxidative stress and improvement of myocardial and endothelial preservation in ESHP. Porcine hearts were perfused for 6 hours with oxygen-derived free-radical scavengers polyethylene glycol (PEG)-catalase or PEG-superoxide dismutase (SOD) or with naive perfusate (control). The oxidative stress-related modifications were determined in the myocardium and coronary vasculature, and contractile function, injury, and endothelial integrity were compared between the groups. The activity of key antioxidant enzymes decreased and adding catalase and SOD restored the enzyme activity. Cardiac function and endothelial integrity were preserved better with restored catalase activity. Catalase and SOD both decreased myocardial injury and catalase reduced ROS production and oxidative modification of proteins in the myocardium and coronary vasculature. The activity of antioxidant enzymes decrease in ESHP. Catalase may improve the preservation of cardiac function and endothelial integrity during ESHP. While catalase and SOD may both exert cardioprotective effects, unbalanced SOD and catalase activity may paradoxically increase the production of reactive species during ESHP.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":"70 9","pages":"741-749"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Transfusion During Extracorporeal Membrane Oxygenation: An ELSO Position Statement. 体外膜氧合过程中的输血：ELSO 立场声明。

IF 3.1 3区医学

ASAIO Journal Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI: 10.1097/MAT.0000000000002275

Kollengode Ramanathan, Giles Peek, Gennaro Martucci, Huda Al Foudri, Priya Nair, Javier Kattan, Ravi Thiagarajan, Bingwen Eugene Fan, Cara Agerstand, Graeme MacLaren, Robert Bartlett

引用次数: 0