ASAIO Journal最新文献_第8页

Reply to Caliskan et al. "Degradation of von Willebrand Factor: A Missing Link Between Shear Stress, Hemolysis, and Bleeding After Left Ventricular Assist Device Implantation". 回复Caliskan等人。血管性血友病因子的退化：剪应力、溶血和左心室辅助装置植入后出血之间的缺失环节。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-22 DOI: 10.1097/MAT.0000000000002535

Guglielmo Gallone, Daniel Lewin, Evgenij Potapov, Antonio Loforte

引用次数: 0

Vericiguat Use in Right Heart Failure Management Following Left Ventricular Assist Device Implantation: A Case Report. Vericiguat在左心室辅助装置植入后右心衰治疗中的应用：1例报告。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-22 DOI: 10.1097/MAT.0000000000002537

Tasuku Hada, Takuya Watanabe, Satsuki Fukushima, Yasumasa Tsukamoto

{"title":"Vericiguat Use in Right Heart Failure Management Following Left Ventricular Assist Device Implantation: A Case Report.","authors":"Tasuku Hada, Takuya Watanabe, Satsuki Fukushima, Yasumasa Tsukamoto","doi":"10.1097/MAT.0000000000002537","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002537","url":null,"abstract":"Right heart failure (RHF) is a major cause of mortality in patients using left ventricular assist devices (LVADs). Vericiguat, an oral soluble guanylate cyclase stimulator, has recently been used to treat chronic heart failure (HF) with a reduced ejection fraction (EF) and is expected to improve RHF owing to its pulmonary vasodilatory and inotropic properties in patients with an LVAD. A 62 year old woman with advanced HF due to cardiac sarcoidosis was transferred to our center with HF recurrence and left ventricular (LV) thrombosis. Since her status became inotropic-dependent post-thrombectomy, an LVAD was implanted. Right heart catheterization before LVAD implantation suggested combined pre- and post-capillary pulmonary hypertension. Postoperative RHF requiring a temporary right VAD (RVAD) was noted. Despite the administration of oral inotropes and pulmonary artery vasodilators, including pimobendan and sildenafil, the low cardiac output associated with RHF persisted post-RVAD withdrawal. Upon the addition of vericiguat, her cardiac output increased and RHF improved; moreover, the interventricular septal position was optimized. Treatment strategies for RHF after LVAD implantation are limited; therefore, vericiguat may be an additional therapeutic option for RHF in patients with an LVAD.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Impact of Cannula Size on Pump Operation and Hemodynamics in an In Silico Clinical Trial. 在一项计算机临床试验中探讨导管大小对泵操作和血流动力学的影响。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-14 DOI: 10.1097/MAT.0000000000002529

Lars Fischer, Jan-Niklas Thiel, Christopher Blum, Ulrich Steinseifer, Ifan Yen, Po-Lin Hsu, Michael Neidlin

{"title":"Investigating the Impact of Cannula Size on Pump Operation and Hemodynamics in an In Silico Clinical Trial.","authors":"Lars Fischer, Jan-Niklas Thiel, Christopher Blum, Ulrich Steinseifer, Ifan Yen, Po-Lin Hsu, Michael Neidlin","doi":"10.1097/MAT.0000000000002529","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002529","url":null,"abstract":"Veno-arterial extracorporeal membrane oxygenation (V‑A ECMO) is a critical care therapy for patients with severe cardiorespiratory failure, and it is associated with high in‑hospital mortality rates. Causes are the complex device-patient interaction and the choice of individual ECMO circuit components: oxygenator, pump, and cannulas. To evaluate the impact of cannulas sizes and pump selection on device-induced hemolysis, circuit operation conditions and patient hemodynamics, an in silico clinical trial combining lumped parameter modeling, computational fluid dynamics, laboratory, and clinical data, was performed. Two cannula configurations (small: 19 Fr and 15 Fr, large: 29 Fr and 23 Fr) alongside three pumps (Rotaflow, DP3, and Revolution) were tested each on a virtual patient cohort consisting of 30 V‑A ECMO patients. Small cannulas led to increased circuit resistances requiring higher pump speeds and yielding elevated hemolysis levels when compared to large cannulas. The pumps had hemolytic risks, however appropriate cannula selection enabled comparable blood damage potential across all pumps. No noticeable differences in patient hemodynamics were observed between the two cannula configurations. Our findings highlight the importance of cannula selection on ECMO performance. Low circuit resistance was revealed to be a crucial factor for a hemoprotective ECMO therapy.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex Vivo Hydrodynamic Assessment of Expanded Polytetrafluoroethylene Trileaflet Pulmonary Valves. 膨化聚四氟乙烯三叶肺瓣膜的体外水动力学评价。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-13 DOI: 10.1097/MAT.0000000000002521

Muhammad Aanish Raees, Spencer Hogue, Alan O'Donnell, James F Cnota, David L S Morales, David G Lehenbauer, Farhan Zafar, James A Quintessenza, James S Tweddell, Awais Ashfaq

{"title":"Ex Vivo Hydrodynamic Assessment of Expanded Polytetrafluoroethylene Trileaflet Pulmonary Valves.","authors":"Muhammad Aanish Raees, Spencer Hogue, Alan O'Donnell, James F Cnota, David L S Morales, David G Lehenbauer, Farhan Zafar, James A Quintessenza, James S Tweddell, Awais Ashfaq","doi":"10.1097/MAT.0000000000002521","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002521","url":null,"abstract":"Handmade trileaflet valves using expanded polytetrafluorethylene (ePTFE) have been considered a viable option for pulmonary valve replacement. Studies have performed ex vivo testing of adult sized valves, data on pediatric-sized ePTFE valves is limited. Our aim was to evaluate pediatric-sized ePTFE valves and ovine tissue valves as comparison to assess performance. Trileaflet valves were constructed using 0.1 mm ePTFE Gore-Tex membrane ranging from 14 to 20 mm in size and sutured into Hemashield conduits. Ovine pulmonary valves were harvested and ranged from 14 to 20 mm. Valves were tested under pediatric pulmonary conditions using a hydrodynamic tester. Regurgitation fraction (RF%), closing volume (CV%), closing volume duration (CVd, second), effective orifice area (EOA, cm2), and peak pressure (PMax, mm Hg), and mean pressure (PMean, mm Hg) were measured. All valves reached goal cardiac output with mild regurgitation. Ovine pulmonary valves had significantly lower RF% than ePTFE valves (14 mm: 4.1 vs. 9.4%; 16 mm: 5.6 vs. 13.8%; 18 mm: 3.5 vs. 9.8%; 20 mm: 5.4% vs. 14.4%; p < 0.05, Table 3). Peak pressure was not significantly different between ovine versus ePTFE groups (14 mm: 37 vs. 24 mm Hg; 16 mm: 27 vs. 27 mm Hg; 18 mm: 26 vs. 27 mm Hg; 20 mm: 13 vs. 12 mm Hg). Expanded polytetrafluorethylene valves offer a viable option for pulmonary valve replacement given mild RF%, and comparable PMax. Further work is needed to understand the interplay between leaflet design and function.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-Hospital Outcomes and Readmissions in High-Risk Pulmonary Embolism Patients Requiring Extracorporeal Membrane Oxygenation Support. 需要体外膜氧合支持的高危肺栓塞患者的住院结果和再入院率

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-07 DOI: 10.1097/MAT.0000000000002523

Prakash Upreti, Umesh Bhagat, Adeel A Abbasi, Neel R Sodha, Omar N Hyder, Daniel J Levine, Shashank S Sinha, Jinnette Dawn Abbott, Saraschandra Vallabhajosyula

{"title":"In-Hospital Outcomes and Readmissions in High-Risk Pulmonary Embolism Patients Requiring Extracorporeal Membrane Oxygenation Support.","authors":"Prakash Upreti, Umesh Bhagat, Adeel A Abbasi, Neel R Sodha, Omar N Hyder, Daniel J Levine, Shashank S Sinha, Jinnette Dawn Abbott, Saraschandra Vallabhajosyula","doi":"10.1097/MAT.0000000000002523","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002523","url":null,"abstract":"There are limited data on the use of extracorporeal membrane oxygenation (ECMO) in high-risk pulmonary embolism (PE) patients. We analyzed the use of ECMO in high-risk PE patients (defined as requiring vasopressors, with cardiogenic shock, or cardiac arrest) using the National Readmission Database (2016-2020) to assess the outcomes of in-hospital mortality, hospitalization costs and length of stay (LOS). Among 130,486 patients, 1,685 (1.3%) received ECMO. The ECMO cohort was on average younger (54 vs. 65 years), male, admitted to urban hospitals, and had higher rates of multiorgan failure. The cohort receiving ECMO support received definitive PE therapies, such as thrombolysis and thrombectomy, more frequently. In-hospital mortality was similar between the cohorts with and without ECMO (46% vs. 46%). The ECMO cohort had greater LOS (20 vs. 10 days) and costs ($622,026 vs. $142,390). Extracorporeal membrane oxygenation patients had higher 30 day readmission rates (6% vs. 1%; hazard ratio 8.42; p < 0.001), with sepsis, PE, and heart failure being common causes. In 1,065 propensity matched pairs, the in-hospital mortality was comparable between the two cohorts (odds ratio: 0.90 [95% confidence interval: 0.75-1.08]; p = 0.25). In conclusion, compared to those not receiving ECMO support, ECMO-supported high-risk PE patients had similar in-hospital mortality but more frequent readmissions.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic Balloon Occlusion in Circulatory Determination of Death Donors Undergoing Abdominal Normothermic Regional Perfusion? Think High! 主动脉球囊阻塞对腹部常温区域灌注死亡供体血液循环的影响？认为高!

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-04 DOI: 10.1097/MAT.0000000000002519

Marta Velia Antonini, Emiliano Gamberini, Maria Maddalena Bitondo, Gabriele Testi, Giulia Felloni, Nicola Pannacci, Alessandro Circelli

{"title":"Aortic Balloon Occlusion in Circulatory Determination of Death Donors Undergoing Abdominal Normothermic Regional Perfusion? Think High!","authors":"Marta Velia Antonini, Emiliano Gamberini, Maria Maddalena Bitondo, Gabriele Testi, Giulia Felloni, Nicola Pannacci, Alessandro Circelli","doi":"10.1097/MAT.0000000000002519","DOIUrl":"https://doi.org/10.1097/MAT.0000000000002519","url":null,"abstract":"Normothermic regional perfusion (NRP) is a strategy of postmortem reperfusion with warm oxygenated blood of a portion of the body applied in donors undergoing circulatory determination of death (DCDDs). Normothermic regional perfusion is aimed to shorten warm ischemic time, and to restore a near physiological environment throughout surgical recovery procedure. The regionalization of perfusion is aimed to prevent cerebral reperfusion, with an ethical and legal rationale. Endovascular occlusion of the aorta, accomplished inserting a balloon catheter through the femoral artery, is frequently implemented to provide the splanchnic regionalization required during abdominal NRP (A-NRP). As evidence accumulates, NRP is increasingly used, and extended criteria and older donors are increasingly enrolled in organ procurement programs. Vascular comorbidities, particularly age-related, or vascular anatomical anomalies could be identified in a growing number of donors. We describe a strategy of endovascular balloon occlusion through the axillary artery in controlled DCDDs undergoing A-NRP. Its invasiveness, effectiveness, and resource requirement are equivalent to the conventional approach. This procedure may represent a valuable alternative when femoral vessels could not be accessed for any clinical reason, avoiding the need to rush for surgical access to provide aortic cross-clamping, delaying NRP initiation and increasing warm ischemic time.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association of Provider-Assessed Psychosocial Risk With Outcomes in Destination Therapy Left Ventricular Assist Device Patients: An Intermacs Registry Analysis. 提供者评估的心理社会风险与目的地治疗左心室辅助装置患者预后的关系：Intermacs注册分析。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-01 Epub Date: 2024-12-12 DOI: 10.1097/MAT.0000000000002358

Rebecca S Steinberg, Jeffrey Wang, Jennifer A Cowger, Alanna A Morris, Shelley A Hall, Anju Nohria, Aditi Nayak

引用次数: 0

Comment on "Changes in Neutrophil-to-Lymphocyte Ratio During Venoarterial Extracorporeal Membrane Oxygenation". 对“静脉体外膜氧合过程中中性粒细胞与淋巴细胞比值的变化”的评论。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-01 Epub Date: 2025-02-27 DOI: 10.1097/MAT.0000000000002407

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Impact of Multistage Cannula on Recirculation in Various Venovenous Extracorporeal Membrane Oxygenation Cannulation Strategies. 不同静脉-静脉体外膜氧合插管策略中多级插管对循环的影响。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-01 Epub Date: 2025-02-18 DOI: 10.1097/MAT.0000000000002384

Yong Chae Jung, Yooyoung Chong, Sung Joon Han, Sang-Jun Park, Yujin Kwak, Sang Yoon Kim, Man-Shik Shim

{"title":"Impact of Multistage Cannula on Recirculation in Various Venovenous Extracorporeal Membrane Oxygenation Cannulation Strategies.","authors":"Yong Chae Jung, Yooyoung Chong, Sung Joon Han, Sang-Jun Park, Yujin Kwak, Sang Yoon Kim, Man-Shik Shim","doi":"10.1097/MAT.0000000000002384","DOIUrl":"10.1097/MAT.0000000000002384","url":null,"abstract":"We aimed to compare recirculation of venovenous extracorporeal membrane oxygenation (V-V ECMO) administered with various cannula placements for femoro-femoral (F-F) and femoro-jugular (F-J) configurations in patients with respiratory failure. This single-center retrospective study included 58 consecutive patients who underwent V-V ECMO between January 2021 and December 2023. Ultrasonic dilution technology was used to quantify the flow of recirculation. The drain cannula placements were categorized into three positions: right atrium and superior and inferior venae cavae. The primary outcome was the difference in recirculation according to the configuration of the V-V ECMO and cannula tip placement. The secondary outcomes were the correlations between recirculation and distance between cannula tips and recirculation difference after cannula adjustment. The recirculation fractions for all types of F-J (27.18%) and F-F (29.33%) configurations were not significantly different. No significant correlation ( r = 0.14) was observed between recirculation and the distance between the drain and return cannula tips in chest radiography. The configuration and placement of the drain cannula may have limited effects on recirculation when using a multistage continuous cannula while applying V-V ECMO.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"667-674"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Loss With High-Flux and Medium Cut-Off Membranes: An Ex Vivo Comparative Analysis. 高通量和中等切断膜的蛋白质损失：离体比较分析。

IF 2.3 3区医学

ASAIO Journal Pub Date : 2025-08-01 Epub Date: 2025-06-26 DOI: 10.1097/MAT.0000000000002486

Xiaoling Wang, Nadja Grobe, Colleen Fisher, Kylie Colvin, Chih-Hu Ho, Peter Kotanko

{"title":"Protein Loss With High-Flux and Medium Cut-Off Membranes: An Ex Vivo Comparative Analysis.","authors":"Xiaoling Wang, Nadja Grobe, Colleen Fisher, Kylie Colvin, Chih-Hu Ho, Peter Kotanko","doi":"10.1097/MAT.0000000000002486","DOIUrl":"10.1097/MAT.0000000000002486","url":null,"abstract":"Removal of middle-sized uremic toxins is one goal of hemodialysis. However, dialysis membranes are nonselective, raising the specter that salutary proteins may also be removed. To better understand the spectrum of proteins filtered by medium cut-off (MCO) and high-flux membranes, we conducted quantitative analyses of proteins in ultrafiltrates. We developed an ex vivo system that allows us to concurrently compare two dialyzers under the same conditions, using the same plasma source. We used this system to study the ultrafiltrate protein loss of two high-flux (Fresenius Optiflux F180NRe, USA; Fresenius FX CorAL80, Germany) and one MCO dialyzer (Baxter Theranova 400, Germany). Ultrafiltrates underwent analysis including gel electrophoresis, quantitative proteomics using liquid chromatography-tandem mass spectrometry, and immunoassays. We identified 244 proteins and semiquantified 113 of them, all of which were more prevalent in MCO compared with high-flux ultrafiltrate (MCO/Optiflux: median 8.25-fold; MCO/CorAL: median 9.14-fold). The protein distribution in MCO ultrafiltrate was skewed toward higher molecular mass. Notably, the ultrafiltered proteins include some with putative salutary functions. In conclusion, our data consistently show a higher protein loss with MCO membrane compared with high-flux dialyzers. The extent to which biological functions are impacted by the removal of proteins warrants bioinformatic analyses and clinical studies.","PeriodicalId":8844,"journal":{"name":"ASAIO Journal","volume":" ","pages":"682-690"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0