Biochemical Society transactions最新文献_第3页

Replication associated nuclear DNA mismatch repair across kingdoms. 复制相关的核DNA错配修复跨越王国。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-07-29 DOI: 10.1042/BST20260765

Claudia P Spampinato, Julieta Giri

引用次数: 0

Escape from X-chromosome inactivation: from gene discovery to regulatory mechanisms. 逃避x染色体失活：从基因发现到调控机制。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-07-29 DOI: 10.1042/BST20250104

Caterina Simoncini, Agnese Loda

引用次数: 0

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis. 再生肝磷酸酶下调PTEN，促进肿瘤发生。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-07-29 DOI: 10.1042/BST20250538

Ahmed M Abou-Shanab, Jingmei Yu, Yunpeng Bai, Zhong-Yin Zhang

{"title":"Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.","authors":"Ahmed M Abou-Shanab, Jingmei Yu, Yunpeng Bai, Zhong-Yin Zhang","doi":"10.1042/BST20250538","DOIUrl":"10.1042/BST20250538","url":null,"abstract":"The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is one of the most frequently inactivated tumor suppressors in human cancers, serving as a critical negative regulator of phosphatidylinositol 3-kinase (PI3K)-AKT signaling. Although genetic mutation or deletion commonly underlie functional PTEN loss, accumulating evidence indicates that post-transcriptional and post-translational mechanisms also substantially contribute to PTEN suppression. Phosphatases of regenerating liver (PRLs), comprising PRL1, PRL2, and PRL3, are oncogenic phosphatases frequently overexpressed in both solid and hematological malignancies. Emerging studies reveal that PRLs can downregulate PTEN through a post-translational mechanism by direct dephosphorylation of PTEN at Tyr336, therefore promoting PTEN ubiquitination and proteasomal degradation. PRLs can also reduce PTEN expression through a post-transcriptional mechanism by dephosphorylating the inhibitory Tyr570 in JAK2, thereby activating the JAK2/STAT3-mediated miR-21 expression. These coordinated actions collectively amplify PI3K-AKT signaling, consequently promoting proliferation, survival, and metastasis. In the present review, we synthesize current knowledge of PRL structure, evolution, and functional diversity, evaluate genetic, biochemical, and organismal evidence linking PRLs to PTEN regulation, and discuss insights on PRL oncogenicity derived from experimental models. We further examine context-dependent functions of PRLs, unresolved questions regarding catalytic versus scaffold activities, and the therapeutic potential of targeting the PRL-PTEN axis. Understanding how PRLs modulate PTEN activity may reveal new strategies to restore tumor suppressor function in PTEN-deficient cancers.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"54 7","pages":"845-860"},"PeriodicalIF":4.4,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pore is a pore is a pore (or a hub?): VDAC oligomerization in mitochondrial connectivity and modulation. 一个孔是一个孔是一个孔（或枢纽？）：VDAC寡聚化在线粒体连通性和调节。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-06-24 DOI: 10.1042/BST20250480

Vito De Pinto, Giuseppe Battiato, Stefano Conti-Nibali, Salvatore Antonio Maria Cubisino

{"title":"A pore is a pore is a pore (or a hub?): VDAC oligomerization in mitochondrial connectivity and modulation.","authors":"Vito De Pinto, Giuseppe Battiato, Stefano Conti-Nibali, Salvatore Antonio Maria Cubisino","doi":"10.1042/BST20250480","DOIUrl":"10.1042/BST20250480","url":null,"abstract":"For decades, the voltage-dependent anion-selective channel (VDAC), formerly known as the mitochondrial porin, was considered a simple pore enabling nearly free permeability across the outer mitochondrial membrane. This simplified view has been progressively dismantled through the discovery of three mammalian isoforms (VDAC1, VDAC2, and VDAC3) with the gradual attribution, often serendipitous, of diverse cellular roles beyond passive metabolite exchange. Recent advances in cryo-electron microscopy have catalyzed a breakthrough in VDAC research. Three converging lines of evidence are reshaping our understanding: (a) high-resolution structures of VDAC within its native protein complexes; (b) discovery of unexpected functions, including phospholipid scrambling and regulation of outer membrane permeabilization through higher-order oligomeric assemblies; and (c) structural determination of VDAC interactions with macromolecules, as well as small-molecule modulators. Collectively, these insights have strengthened the consideration of VDAC as a multifunctional signaling hub and therapeutic target, with emerging small molecules and peptides designed to modulate gating, oligomerization, and interfering with interacting partners. The aim of this review is to summarize current structural, functional, and pharmacological advances in VDAC biology, emphasizing how oligomerization dynamics and isoform specificity orchestrate mitochondrial behavior and offering perspectives on therapeutic strategies for diseases driven by mitochondrial dysfunction.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"54 6","pages":"651-664"},"PeriodicalIF":4.4,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13234627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and function of periplasmic nitrate reductase. 质周硝酸盐还原酶的结构与功能。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-06-24 DOI: 10.1042/BST20250033

Chanakarn Mongkonpruthangkoon, Nitai C Giri, Partha Basu

引用次数: 0

Emerging roles of pterins as signaling molecules in bacteria. 翼蛋白在细菌中作为信号分子的新角色。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-06-24 DOI: 10.1042/BST20250041

Pierson Rucker, Lauren Augusta, Clay Fuqua, Kylie D Allen

{"title":"Emerging roles of pterins as signaling molecules in bacteria.","authors":"Pierson Rucker, Lauren Augusta, Clay Fuqua, Kylie D Allen","doi":"10.1042/BST20250041","DOIUrl":"10.1042/BST20250041","url":null,"abstract":"Pterins are redox-active biomolecules with well-established functions as enzymatic cofactors in all domains of life. Examples of pterin cofactors include tetrahydrofolate, an essential carrier of one-carbon units, and the molybdenum cofactor (Moco)-composed of molybdopterin bound to molybdenum or tungsten-which supports a wide range of redox reactions for diverse enzymes. Pterins also play important roles outside of enzyme active sites where they serve as antioxidants and immune system modulators. Recently, a new role for pterins in bacteria has emerged through the discovery of a pterin-dependent regulator called DcpA that modulates the cytoplasmic second messenger cyclic-di-guanylate monophosphate (c-di-GMP) levels and biofilm formation in Agrobacterium tumefaciens, a model bacterial plant pathogen. The regulatory pathway involves the PruA pteridine reductase and a periplasmic pterin-binding protein termed PruR. This review provides an overview of each of the key players in this pathway and highlights the broad distribution of the respective genes that supports the presence of similar pterin-mediated regulatory pathways in diverse bacteria. In our current model for the A. tumefaciens pathway, PruA generates a tetrahydropterin species that is released to the periplasm where it binds to PruR. The pterin-PruR complex then interacts with the periplasmic domain of DcpA to promote c-di-GMP degradation. The decreased levels of cytoplasmic c-di-GMP disfavor attachment and limit biofilm formation. The redox active nature of pterins is likely a central facet of their signaling functions, where the different redox states of a given pterin species may reflect changing environmental conditions.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"54 6","pages":"715-726"},"PeriodicalIF":4.4,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13259868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and molecular function of the BCL7 proteins. BCL7蛋白的结构和分子功能。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-06-24 DOI: 10.1042/BST20250117

Franck Martin, Elisa Bergamin

{"title":"Structure and molecular function of the BCL7 proteins.","authors":"Franck Martin, Elisa Bergamin","doi":"10.1042/BST20250117","DOIUrl":"10.1042/BST20250117","url":null,"abstract":"Initially identified through chromosomal translocations in lymphomas, the BCL7 protein family, comprising the three paralogues BCL7A, BCL7B, and BCL7C, has recently emerged as a core component of mammalian SWI/SNF ATP-dependent chromatin remodeling complexes. Although their functions remained poorly understood for many years, recent structural and biochemical studies have substantially improved our understanding of their roles. Cryo-electron microscopy studies revealed that BCL7 proteins interact with nucleosomes through a conserved N-terminal arginine anchor motif that binds the nucleosomal acidic patch and stabilize the actin-related protein module through a conserved β-hairpin motif. These findings identify BCL7 proteins as structural elements that contribute to nucleosome engagement and SWI/SNF complex integrity. Comparative analyses further suggest that key structural features of BCL7 proteins are conserved across evolution despite limited sequence similarity. In addition to their roles in chromatin remodeling, increasing evidence links BCL7 proteins to hematological malignancies, solid tumors, and developmental disorders, highlighting their emerging value as biomarkers and potential therapeutic targets. This review summarizes current knowledge on the structure, evolution, and functions of the BCL7 family and outlines future directions for elucidating their contribution to chromatin regulation and disease.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"54 6","pages":"769-780"},"PeriodicalIF":4.4,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small bites for big problems: stepwise aggregate degradation by autophagy. 小口吃大问题：通过自噬逐步累积降解。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-06-24 DOI: 10.1042/BST20250460

Mark S Hipp, Mario Mauthe

{"title":"Small bites for big problems: stepwise aggregate degradation by autophagy.","authors":"Mark S Hipp, Mario Mauthe","doi":"10.1042/BST20250460","DOIUrl":"10.1042/BST20250460","url":null,"abstract":"Protein aggregates are a pathological hallmark of diverse disorders, including many neurodegenerative diseases, but also cardiometabolic disease and cancer. While the ubiquitin-proteasome system efficiently removes many soluble misfolded proteins, large or persistent assemblies often require the autophagy-lysosome pathway for their degradation. In the present mini-review, we summarize our knowledge of aggrephagy, the selective clearance of protein aggregates by autophagy, and discuss two recent manuscripts that argue that some aggregates must be primed for autophagosomal degradation, through chaperone-mediated remodeling. Aggrephagy substrates are defined by aggregate architecture, biophysical state, surface accessibility, and the physical constraints of membrane capture. These features help to explain why recruitment of selective autophagy receptors is necessary yet insufficient for clearance. Receptor clustering is required to concentrate early autophagy factors to establish initiation hubs, but successful degradation often requires upstream generation of smaller 'aggrephagy-competent' cargo units, which contain autophagy receptor clusters that successfully initiate autophagosome formation. Recent work supports a model in which larger aggregates are cleared through stepwise degradation enabled by prior remodeling steps that involve p97/VCP-driven disintegration or a chaperone module (DNAJB6-HSP70-HSP110) cooperating with the proteasomal 19S regulatory particle.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"54 6","pages":"803-814"},"PeriodicalIF":4.4,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty acid esters of hydroxy fatty acids and alkyl-diacylglycerols: minor but bioactive components in human milk. 羟基脂肪酸和烷基二酰基甘油的脂肪酸酯：人乳中少量但具有生物活性的成分。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-06-24 DOI: 10.1042/BST20260825

Megan Li Xian Lee, Untzizu Elejalde, Amaury Cazenave-Gassiot

{"title":"Fatty acid esters of hydroxy fatty acids and alkyl-diacylglycerols: minor but bioactive components in human milk.","authors":"Megan Li Xian Lee, Untzizu Elejalde, Amaury Cazenave-Gassiot","doi":"10.1042/BST20260825","DOIUrl":"10.1042/BST20260825","url":null,"abstract":"As the optimal source of nutrition for infants, investigations into the human milk lipidome have been quite extensive. Much of the work, however, has been focused on major lipid components such as triglycerides, possibly undermining its actual complexity. This review focuses on two minor but bioactive lipid classes in human milk: fatty acid esters of hydroxy fatty acids (FAHFAs) and alkyl-diacylglycerols (TG(O)s). FAHFAs are known to exhibit anti-diabetic and anti-inflammatory effects, while TG(O)s are important for the prevention of childhood obesity. With the knowledge that early nutrition and metabolic health influence the risk of metabolic dysfunctions later in life, a comprehensive understanding of FAHFAs and TG(O)s, along with reliable characterisations in human milk, would better allow for the development of accurate human milk fat substitutes. This could have future implications as alternative or preventive treatments for infants with early markers of metabolic dysfunction, including diabetes and obesity. The structural characteristics, pathways for biosynthesis and degradation, bioactivity, dietary sources, and characterisations of FAHFAs and TG(O)s in human milk are discussed. Their statuses as emerging lipid classes, however, is reflected in the incomplete understanding of their biochemical pathways. Characterisations of FAHFAs and TG(O)s in human milk are relatively poor, and contradicting results are reported. This review also addresses the challenges involved in the study of minor lipids in complex biological matrices, and the possible reasons underlying the slower evolution of our understanding of FAHFAs and TG(O)s in human milk and their associations with health outcomes.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"54 6","pages":"699-714"},"PeriodicalIF":4.4,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13259866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissecting conserved molecular mechanisms of biological toxin activity through CRISPR screening. 通过CRISPR筛选剖析生物毒素活性的保守分子机制。

IF 4.4 3区生物学

Biochemical Society transactions Pub Date : 2026-06-24 DOI: 10.1042/BST20250099

Matthew A Waller, Tian Y D'Araujo, Christopher E Denes, G Gregory Neely

引用次数: 0