Behavioural Pharmacology最新文献_第8页

The effectiveness of oxytocin in the treatment of stimulant use disorders: a systematic review. 催产素治疗兴奋剂使用障碍的有效性：一项系统综述。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-07-11 DOI: 10.1097/FBP.0000000000000744

Stephen Lee-Cheong, Sacha A Ludgate, Tanisse C M Epp, Christian G Schütz

{"title":"The effectiveness of oxytocin in the treatment of stimulant use disorders: a systematic review.","authors":"Stephen Lee-Cheong, Sacha A Ludgate, Tanisse C M Epp, Christian G Schütz","doi":"10.1097/FBP.0000000000000744","DOIUrl":"10.1097/FBP.0000000000000744","url":null,"abstract":"Objectives: The purpose of this review is to examine human study evidence on the effectiveness of oxytocin in this patient population. Despite stimulant use disorder being a major public health concern, there are no validated pharmacological treatments. Psychosocial interventions show limited effectiveness especially in the more severe cases of stimulant use disorder, whereas animal models suggest that oxytocin may be a useful treatment.Methods: A literature search using Medline, Embase, and PsychInfo was undertaken. Search results were subsequently imported into Covidence to identify relevant studies.Results: Six studies were included in this review, two of which were pilot studies. Although oxytocin was well tolerated across studies, no study showed a statistically significant reduction in reported cocaine use or cravings. One study suggested oxytocin increased the desire to use cocaine, although the population of participants should be taken into consideration. In contrast, one study showed a trend towards reduced self-reported cocaine use.Conclusion: Available research does not support the use of oxytocin in the management of stimulant use disorder; however, included studies are small in sample size and limited in number. There were several noteworthy findings unrelated to this review's primary and secondary outcomes, which are of interest and warrant further research. We provide suggestions for future studies in this area of research. Considering the limited data available at this time, further studies are required before any definitive conclusions can be made regarding the use of oxytocin in stimulant use disorder management.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 7","pages":"381-392"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10333230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contingency learning in zebrafish exposed to apomorphine- and levetiracetam. 暴露于阿扑吗啡和左乙拉西坦的斑马鱼的应急学习。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-08-24 DOI: 10.1097/FBP.0000000000000750

Christoffel van der Westhuizen, Tarryn L Botha, Karin Finger-Baier, Geoffrey de Brouwer, De Wet Wolmarans

{"title":"Contingency learning in zebrafish exposed to apomorphine- and levetiracetam.","authors":"Christoffel van der Westhuizen, Tarryn L Botha, Karin Finger-Baier, Geoffrey de Brouwer, De Wet Wolmarans","doi":"10.1097/FBP.0000000000000750","DOIUrl":"10.1097/FBP.0000000000000750","url":null,"abstract":"Cognitive rigidity (CR) refers to inadequate executive adaptation in the face of changing circumstances. Increased CR is associated with a number of psychiatric disorders, for example, obsessive-compulsive disorder, and improving cognitive functioning by targeting CR in these conditions, may be fruitful. Levetiracetam (LEV), clinically used to treat epilepsy, may have pro-cognitive effects by restoring balance to neuronal signalling. To explore this possibility, we applied apomorphine (APO) exposure in an attempt to induce rigid cue-directed responses following a cue (visual pattern)-reward (social conspecifics) contingency learning phase and to assess the effects of LEV on such behaviours. Briefly, zebrafish were divided into four different 39-day-long exposure groups ( n = 9-10) as follows: control (CTRL), APO (100 µg/L), LEV (750 µg/L) and APO + LEV (100 µg/L + 750 µg/L). The main findings of this experiment were that 1) all four exposure groups performed similarly with respect to reward- and cue-directed learning over the first two study phases, 2) compared to the CTRL group, all drug interventions, but notably the APO + LEV combination, lowered the degree of reward-directed behaviour during a dissociated presentation of the cue and reward, and 3) temporal and spatial factors influenced the manner in which zebrafish responded to the presentation of the reward. Future studies are needed to explore the relevance of these findings for our understanding of the potential cognitive effects of LEV.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 7","pages":"424-436"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10285578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. Zymosan A通过刺激海马小胶质细胞对慢性应激小鼠产生快速持续的抗抑郁作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-09-01 DOI: 10.1097/FBP.0000000000000738

Tao Zhu, Bingran Chen, Han Han, Xu Lu, Zhuo Chen, Ting Ye, Hui Zhao, Meng Zheng, Chao Huang

{"title":"Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia.","authors":"Tao Zhu, Bingran Chen, Han Han, Xu Lu, Zhuo Chen, Ting Ye, Hui Zhao, Meng Zheng, Chao Huang","doi":"10.1097/FBP.0000000000000738","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000738","url":null,"abstract":"Recent studies had reported that compounds that stimulate microglia could be developed as potential drugs for the treatment of depression due to their reversal effect on depression-like behaviors in chronically stressed mice. Zymosan A is a cell wall preparation of Saccharomyces cerevisiae composed of β-glucans. Based on its immuno-stimulatory activities, we hypothesized that zymosan A might have a therapeutic effect on depression. Our results showed that a single injection of zymosan A 5 h before behavioral tests at a dose of 1 or 2 mg/kg, but not at a dose of 0.5 mg/kg, reversed chronic unpredictable stress (CUS)-induced depression-like behaviors in mice in the tail suspension test, forced swimming test, and sucrose preference test. Time-dependent analysis showed that the antidepressant effect of zymosan A (2 mg/kg) in CUS mice became statistically significant at 5 and 8 h, but not at 3 h, and persisted for at least 7 days. Fourteen days after a single injection of zymosan A, no antidepressant effect was observed anymore. However, the disappeared antidepressant effect of zymosan A was restored by a second zymosan A injection (2 mg/kg, 5 h) 14 days after the first zymosan A injection. Stimulation of microglia was essential for the antidepressant effect of zymosan A because pre-inhibition of microglia by minocycline or pre-depletion of microglia by PLX3397 prevented the antidepressant effect of zymosan A. Based on these effects of zymosan A, zymosan A administration could be developed as a new strategy for the treatment of depression.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 6","pages":"318-329"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9999027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats. 雌二醇增强米氮平对雌性大鼠可卡因运动致敏表达的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-09-01 DOI: 10.1097/FBP.0000000000000743

Susana Barbosa-Méndez, Alberto Salazar-Juárez

{"title":"Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats.","authors":"Susana Barbosa-Méndez, Alberto Salazar-Juárez","doi":"10.1097/FBP.0000000000000743","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000743","url":null,"abstract":"Epidemiological studies have mentioned that cocaine use disorder (CUD) has increased in the last decade among women; these show endocrine and reproductive disorders and a high propensity to stress and depression disorders. Mirtazapine-a tetracyclic antidepressant-decreases cocaine-induced locomotor activity and locomotor sensitization in male rats. The objective of this study was to evaluate if estradiol alters the efficacy of mirtazapine to decrease cocaine-induced locomotor activity in sham and ovariectomized female rats. Three hundred and twenty adult female Wistar rats were assigned to three experimental protocols. For experiments, 1-3, female rats were daily dosed with 10 mg/kg of cocaine during the 10 days of induction and expression of locomotor sensitization. During drug withdrawal (30 days), cocaine was withdrawn and the groups received daily mirtazapine, estradiol, or saline. In addition, the females underwent sham or ovariectomy surgery. Tamoxifen was administered during the antagonism phase. After each administration, locomotor activity for each animal was recorded for 30 min in activity chambers. The dosage of mirtazapine reduces estradiol-induced enhancement in cocaine-dependent locomotor activity during the expression of locomotor sensitization in sham and ovariectomized female rats. As well as they showed that estradiol co-dosed with mirtazapine enhances the efficacy of mirtazapine to decrease cocaine-induced locomotor activity. Finally, tamoxifen enhanced the estradiol and mirtazapine-induced decrease in the cocaine motor effect in female rats. Mirtazapine may be considered an effective therapeutic option for the treatment of CUD in women, even in those who are on hormonal treatment or antidepressant therapy with estradiol.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 6","pages":"362-374"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10301333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propranolol blocks the unconditioned and conditioned hyperactive effects of methamphetamine in CD-1 mice. 普萘洛尔阻断甲基苯丙胺在CD-1小鼠中的非条件和条件过度活动作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-09-01 Epub Date: 2023-07-14 DOI: 10.1097/FBP.0000000000000742

Anthony S Rauhut

引用次数: 0

Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress. 补充肌酸保护空间记忆和长期增强对抗慢性约束压力。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-09-01 DOI: 10.1097/FBP.0000000000000739

Zahra Bahari, Zohreh Jangravi, Boshra Hatef, Habib Valipour, Gholam Hossein Meftahi

{"title":"Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress.","authors":"Zahra Bahari, Zohreh Jangravi, Boshra Hatef, Habib Valipour, Gholam Hossein Meftahi","doi":"10.1097/FBP.0000000000000739","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000739","url":null,"abstract":"Stress contributes to numerous psychopathologies, including memory impairment, and threatens one's well-being. It has been reported that creatine supplementation potentially influences cognitive processing. Hence, in this study, we examined the effects of creatine supplementation on memory, synaptic plasticity, and neuronal arborization in the CA1 region of the hippocampus in rats under chronic restraint stress (CRS). Thirty-two adult male Wistar rats (8 weeks old) weighing 200-250 g were randomly divided into four groups (n = 8/per group): control, stress, creatine, and stress + creatine. CRS was induced for 6 h per day for 14 days, and creatine supplementation was carried out by dissolving creatine (2 g/kg body weight per day) in the animals' drinking water for 14 days. We used the Barnes maze and shuttle box for spatial and passive avoidance memory examination. The in-vivo field potential recording and Golgi-Cox staining were also used to investigate long-term potentiation (LTP) and dendrite arborization in the CA1 pyramidal neurons. Chronic stress impaired spatial memory, dysregulated LTP parameters, and decreased the number of dendrites in the CA1 pyramidal neurons of stressed rats, and creatine supplementation modified these effects in stressed rats. It seems that creatine supplementation can improve spatial memory deficits and synaptic plasticity loss induced by CRS in hippocampal CA1 neurons, possibly by reducing the dendrite arborization damages. However, understanding its mechanism needs further investigation.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 6","pages":"330-339"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver tryptophan 2,3-dioxygenase: a determinant of anxiety-like behaviour - studies with chronic nicotine administration in rats. 肝色氨酸2,3-双加氧酶:焦虑样行为的决定因素——对大鼠慢性尼古丁管理的研究。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-09-01 DOI: 10.1097/FBP.0000000000000736

Samina Bano, Humaira Sharif, Faiza Sajid, Sumaiya Binte Hamid, Abdulla A-B Badawy

{"title":"Liver tryptophan 2,3-dioxygenase: a determinant of anxiety-like behaviour - studies with chronic nicotine administration in rats.","authors":"Samina Bano, Humaira Sharif, Faiza Sajid, Sumaiya Binte Hamid, Abdulla A-B Badawy","doi":"10.1097/FBP.0000000000000736","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000736","url":null,"abstract":"Deletion of the tryptophan 2,3-dioxygenase ( TDO2 ) gene induces an anxiolytic-like behaviour in mice and TDO inhibition by allopurinol elicits an antidepressant-like effect in rats exposed to restraint stress. Chronic nicotine administration inhibits TDO activity, enhances brain serotonin synthesis and exerts anxiolytic- and antidepressant-like effects in rodent models. There is a strong association between anxiety, depression and tobacco use, which is stronger in women than in men. The present study aimed to examine the relationship between behavioural measures of anxiety and depression with liver TDO activity, brain tryptophan concentration and serotonin synthesis in rats treated chronically with nicotine. Behavioural measures included the elevated plus maze (EPM), open field (OFT) and forced swim (FST) tests. Biochemical measures included TDO activity, serum corticosterone and brain Trp, 5-HT and 5-HIAA concentrations. Anxiolytic-like and antidepressant-like effects of chronic nicotine were confirmed in association with TDO inhibition and elevation of brain Trp and 5-HT. Sex differences in behaviour were independent of the biochemical changes. At baseline, female rats performed better than males in OFT and FST. Nicotine was less anxiolytic in females in the open arm test. Nicotine treatment did not elicit different responses between sexes in the FST. Our findings support the notion that liver TDO activity exhibits a strong association with behavioural measures of anxiety and depression in experimental models, but provide little evidence for sex differences in behavioural response to nicotine. The TDO-anxiety link may be underpinned by kynurenine metabolites as well as serotonin.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 6","pages":"307-317"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mGlu2/3 agonist LY379268 reduces sucrose taking, seeking, and motivation in male and female rats. mGlu2/3激动剂LY379268减少雄性和雌性大鼠的蔗糖摄取、寻求和动机。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-09-01 Epub Date: 2023-07-11 DOI: 10.1097/FBP.0000000000000740

Jeffrey William Grimm, Frances Sauter, Derek MacDougall, Emily Spaulding, Kyra Stensgaard, Mason Hardy, Kyle Griffin, Rebecca Marx

{"title":"The mGlu2/3 agonist LY379268 reduces sucrose taking, seeking, and motivation in male and female rats.","authors":"Jeffrey William Grimm, Frances Sauter, Derek MacDougall, Emily Spaulding, Kyra Stensgaard, Mason Hardy, Kyle Griffin, Rebecca Marx","doi":"10.1097/FBP.0000000000000740","DOIUrl":"10.1097/FBP.0000000000000740","url":null,"abstract":"Objectives: The mGlu2/3 receptor agonist LY379268 reduces sucrose-seeking, but not sucrose-taking, in male rats. This study explored the generality of this effect across the sexes. In addition, the effect of the drug on motivation to receive sucrose was assessed.Methods: Adult male and female Long-Evans rats ( N = 91) were challenged with LY379268 in three experiments: (1) a fixed ratio (FR) schedule of reinforcement (taking), (2) extinction of responding previously reinforced on the FR (seeking) or (3) responding reinforced on a progressive ratio (PR) schedule of reinforcement (motivation). For each experiment, rats first responded to 10% liquid sucrose on an FR in 10 daily 2-h sessions. For the PR study, this was followed by training on a PR for 7 daily 3-h sessions. Rats were then challenged in a counterbalanced order with LY379268 (0, 1.5, 3 and 6 mg/kg; IP; 30-min pretreatment) on test days, followed by either three reacquisition days of FR (experiments 1 and 2) or PR (experiment 3) responding.Results: Female rats responded more to sucrose on the FR and PR. LY379268 reduced responding in all three experiments. LY379268 challenge to sucrose taking on the FR produced an inverted U-shaped function while extinction responding and responding for sucrose on the PR were decreased dose-dependently, with PR responding insensitive to the 1.5 mg/kg dose. There were no sex-dependent effects of the drug on sucrose-directed responding.Conclusions: The sucrose anti-taking, -seeking, and -motivation effects of LY379268 across male and female rats support further evaluation of glutamate modulation as an antiaddiction pharmacotherapy.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 6","pages":"340-349"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9945018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serial feature positive and feature negative discrimination learning in a taste avoidance preparation: implications for interoceptive control of behavior. 味觉回避准备中的系列特征积极和特征消极辨别学习:对行为内感受控制的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-09-01 DOI: 10.1097/FBP.0000000000000741

Shihui Huang, Sydney E Cerveny, Anna L Ruprecht, Ethan R Steere, Terry L Davidson, Anthony L Riley

{"title":"Serial feature positive and feature negative discrimination learning in a taste avoidance preparation: implications for interoceptive control of behavior.","authors":"Shihui Huang, Sydney E Cerveny, Anna L Ruprecht, Ethan R Steere, Terry L Davidson, Anthony L Riley","doi":"10.1097/FBP.0000000000000741","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000741","url":null,"abstract":"Background: Psychoactive drugs produce interoceptive stimuli that can guide appropriate behaviors by initiating or inhibiting responding.Objective: The current study investigated whether an interoceptive morphine state produces similar patterns of serial feature positive (FP) and feature negative (FN) discrimination learning under comparable conditions in a taste avoidance design.Methods: Male Sprague-Dawley rats were trained under 10 cycles of FP or FN discrimination. In the FP task, morphine (10 mg/kg, IP) signaled that a saccharin solution was followed by LiCl (1.2 mEq, IP), while the vehicle (saline) signaled that the LiCl was withheld. In the FN task, the contingency was reversed.Results: The FP-trained rats acquired the discrimination after three training cycles, consuming significantly less saccharin on morphine, than on vehicle, sessions ( P < 0.05). The FN-trained rats acquired the discrimination after six training cycles, consuming more on morphine than on vehicle sessions ( P < 0.05). However, FN-trained rats never recovered saccharin consumption to baseline levels and 40% of the rats continued to avoid saccharin (consuming 0 ml) on morphine sessions. Control rats that never received LiCl consumed high levels of saccharin on morphine and vehicle sessions, indicating that morphine did not produce unconditioned suppression of saccharin consumption.Conclusion: The difficulty to acquire FN discrimination might reflect the limitations of learning about safety contingencies in the taste avoidance design. The rapidity of FP learning when a drug state signals an aversive contingency may have implications for the general role of interoceptive stimuli in the control of behavior.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 6","pages":"350-361"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The M 1 -muscarinic acetylcholine receptor subtype may play a role in learning and memory performance in the hippocampus of neonatal monosodium glutamate-obese rats. m1 -毒蕈碱乙酰胆碱受体亚型可能在新生儿谷氨酸钠肥胖大鼠海马学习记忆表现中起作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-08-01 DOI: 10.1097/FBP.0000000000000732

Marcelo Florencio Passos Silva, Christian Pereira Rafael, Jeferson Rubens Mamona Silva, Tiago Guardia de Souza E Silva, Rafaela Fadoni Alponti, Patricia Lucio Alves, Maria Regina Lopes Sandoval, Fernando Maurício Francis Abdalla

{"title":"The M 1 -muscarinic acetylcholine receptor subtype may play a role in learning and memory performance in the hippocampus of neonatal monosodium glutamate-obese rats.","authors":"Marcelo Florencio Passos Silva, Christian Pereira Rafael, Jeferson Rubens Mamona Silva, Tiago Guardia de Souza E Silva, Rafaela Fadoni Alponti, Patricia Lucio Alves, Maria Regina Lopes Sandoval, Fernando Maurício Francis Abdalla","doi":"10.1097/FBP.0000000000000732","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000732","url":null,"abstract":"Here, we investigate the effects of obesity induced by monosodium glutamate (MSG) on cognitive impairment and whether this model induces any alteration in the affinity, density, and subtypes of muscarinic acetylcholine receptors (mAChRs) in rat hippocampus. Healthy rats were used as controls, and MSG-obese rats were selected via the Lee index > 0.300. The effects of MSG-induced obesity on hippocampal spatial learning and memory processes were evaluated by using the working memory versions of the Morris' water maze task and the evaluation of mAChRs by binding assay and their subtypes by immunoprecipitation assays. [ 3 H]Quinuclidinyl benzilate specific binding analysis showed that the equilibrium dissociation constant (K D ) did not differ between control and MSG, indicating that affinity is not affected by obesity induced by MSG. The maximum number of binding sites (B max ) obtained in MSG subjects was lower than that obtained from control rats, indicating a decrease in the expression of total mAChRs. Immunoprecipitation assays reveal a decrease in the expression of M 1 subtype of MSG when compared with control rats (M 2 to M 5 subtypes did not differ between control and MSG). We also observed that MSG promotes a disruption of the spatial working memory which was accompanied by a decrease in the M 1 mAChR subtype in rat hippocampus, thus suggesting deleterious long-term effects besides the obesity. In conclusion, these findings provide new insights into how obesity can influence spatial learning and memory that is hippocampal-dependent. The data suggest that the M 1 mAChR subtype protein expression is a potential therapeutic target.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 5","pages":"251-262"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9857247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0