Behavioural Pharmacology最新文献_第8页

Haloperidol potentates the antinociceptive effect of buprenorphine and tramadol in rats. 氟哌啶醇增强了丁丙诺啡和曲马多对大鼠的抗感知作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-21 DOI: 10.1097/FBP.0000000000000852

Rolffy Ortiz-Andrade, Lilian Dolores Chel-Guerrero, Myrna Déciga-Campos

{"title":"Haloperidol potentates the antinociceptive effect of buprenorphine and tramadol in rats.","authors":"Rolffy Ortiz-Andrade, Lilian Dolores Chel-Guerrero, Myrna Déciga-Campos","doi":"10.1097/FBP.0000000000000852","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000852","url":null,"abstract":"This study aimed to evaluate the pharmacological effects of haloperidol on the antinociceptive effects of buprenorphine and tramadol in rats. Dose-response curves were constructed for the individual administration of haloperidol, buprenorphine, and tramadol in rats subjected to the formalin (1%) test. All the compounds demonstrated dose-dependent antinociceptive effects when administered individually. Pharmacological interactions were assessed using an isobolographic method. The doses required to achieve 50% of the maximal antinociceptive effect (ED50) for each drug were combined at a fixed 1 : 1 ratio to establish a combination series of haloperidol + buprenorphine and haloperidol + tramadol. The results showed that buprenorphine achieved a higher maximal antinociceptive effect (98%) compared with tramadol (85%) and haloperidol (84.9%) when administered individually. Isobolographic analysis revealed that the experimental values (Zexp) for haloperidol + buprenorphine (Zadd = 27.6 ± 5.5 vs. Zexp = 5.47 ± 1.2) and haloperidol + tramadol (Zadd = 4987.68 ± 651.5 vs. Zexp = 1678.23 ± 89.8) were significantly lower than the theoretical values (Zadd), indicating synergistic interactions. On the basis of the experimental data, haloperidol potentiated the antinociception in the following order: haloperidol + buprenorphine, followed by haloperidol + tramadol. These findings suggest that such drug combinations could have potential applications in the ongoing research of treatments for chronic pain, depression-related pain, and cancer-associated pain.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synbiotic diet produces antidepressant-like effects but alters ketamine activity in an avian model of treatment-resistant depression. 合成饮食产生抗抑郁的作用，但改变氯胺酮活性在一个鸟类模型的治疗难治性抑郁症。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-21 DOI: 10.1097/FBP.0000000000000850

Stephen W White, Tara D Clover, Kenneth J Sufka

{"title":"Synbiotic diet produces antidepressant-like effects but alters ketamine activity in an avian model of treatment-resistant depression.","authors":"Stephen W White, Tara D Clover, Kenneth J Sufka","doi":"10.1097/FBP.0000000000000850","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000850","url":null,"abstract":"Pre- and probiotics promote a diverse and functional gut microbiota and have demonstrated both anxiolytic and antidepressant effects; however, how synbiotic diet interacts with antidepressant medications has not been fully investigated. This study sought to evaluate the potential anxiolytic or antidepressant effects of a synbiotic diet in an avian model that presents homologies with treatment-resistant depression. In addition, we sought to evaluate the potential interaction of a synbiotic diet combined with select doses of ketamine. Socially raised Black Australorp chicks were given either standard or synbiotic feed for 7 days. At 7 days posthatch, chicks from each feed condition were administered either 0, 5, or 10 mg/kg/ml ketamine 15 min before a 90-min isolation stressor, which elicits distress vocalizations (DVocs) that temporally represent a panic-like phase followed by a depression-like phase. Saline-treated chicks given the synbiotic diet displayed significantly higher DVoc rates in the depression-like phase compared with saline-treated animals in the standard feed condition, indicative of attenuation of behavioral despair [F(1,22) = 5.45, P < 0.05]. Similarly, in the standard diet condition, ketamine 10 mg/kg produced elevated DVoc rates; however, under the synbiotic diet, both doses of ketamine produced a suppression of DVoc rates in the depression-like phase. These findings suggest that a synbiotic diet produces antidepressant-like effects in the model and a possible negative interaction between synbiotics and ketamine. While preliminary, the findings suggest the concurrent use of pre- and probiotic supplements and ketamine may produce contradictory effects and warrant further investigation.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk. 地西泮对特立尼达孔雀鱼暴露于表明捕食风险的化学线索的抗焦虑作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-15 DOI: 10.1097/FBP.0000000000000847

Adam L Crane, Laurence E A Feyten, Alix J P Brusseau, Félixe Dumaresq Synnott, Indar W Ramnarine, Maud C O Ferrari, Grant E Brown

{"title":"Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk.","authors":"Adam L Crane, Laurence E A Feyten, Alix J P Brusseau, Félixe Dumaresq Synnott, Indar W Ramnarine, Maud C O Ferrari, Grant E Brown","doi":"10.1097/FBP.0000000000000847","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000847","url":null,"abstract":"The fear of predation is pervasive among vertebrate prey species, being characterized by neurobiological and behavioral changes induced by risk exposure. To understand the acquisition and attenuation of fearful phenotypes, such as dimensions of posttraumatic stress, researchers often use animal models, with prey fishes recently emerging as a nontraditional but promising model. Much is known about fear acquisition in prey fishes such as the Trinidadian guppy, Poecilia reticulata, which inhabit high and low predation sites. Little is known, however, about whether a guppy model shows fear attenuation via therapeutic treatments, such as commonly prescribed anxiolytic drugs, like benzodiazepines. In this study, we used Trinidadian guppies from wild populations to explore the interactive effects of exposure to the anxiolytic drug, diazepam, and exposure to predation risk in the form of injured conspecific cues (i.e. alarm cues) that reliably indicate a predator attack. In Experiment 1, juvenile guppies from both high- and low-predation populations were given a 10-min exposure to diazepam (160 µg/l), resulting in the loss of fear behavior when simultaneously presented with alarm cues. In Experiment 2, we found that a prior 10-min exposure to diazepam (160 µg/l) for adult guppies significantly reduced their subsequent fear behavior toward a separate exposure to alarm cues, revealing that diazepam was having direct effects on guppy cognition rather than simply inactivating the alarm cues via chemical alteration. These anxiolytic effects thus add to the growing support for the predictive validity of prey fishes as animal models for exploring fear attenuation in humans.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin-dopamine interactions: unveiling the common link between type-2 diabetes and neuropsychiatric comorbidities. 瘦素-多巴胺相互作用：揭示2型糖尿病和神经精神合并症之间的共同联系。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1097/FBP.0000000000000820

Allyson Gill, Madison Gill, Rahul Mittal, Khemraj Hirani, Ajay Sharma

{"title":"Leptin-dopamine interactions: unveiling the common link between type-2 diabetes and neuropsychiatric comorbidities.","authors":"Allyson Gill, Madison Gill, Rahul Mittal, Khemraj Hirani, Ajay Sharma","doi":"10.1097/FBP.0000000000000820","DOIUrl":"10.1097/FBP.0000000000000820","url":null,"abstract":"Clinical evidence highlights the central nervous system as a key target in type-2 diabetes-related complications, yet the mechanisms underlying the increased prevalence of mood disorder issues, mainly depression, in patients with diabetes remain poorly understood. Leptin, an adiposity hormone known for its role in energy homeostasis, has been shown to improve insulin sensitivity and regulate blood glucose levels in diabetic populations. Beyond its metabolic effects, leptin also has the potential to mitigate psychiatric complications such as depression and anxiety. Notably, leptin receptors are predominantly expressed on dopamine (DA) neurons in the brain, hinting that leptin may orchestrate DA activity by serving as its endogenous modulator. This review examines the role of leptin as a potential common link between type-2 diabetes and mood disorders, particularly through its effects on DA function. This article proposes defective leptin signaling as a vital mechanism contributing to psychiatric complications and compromised DA functions in type-2 diabetes, highlighting leptin as a promising therapeutic target for addressing metabolic and psychiatric comorbidities.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"217-225"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pirfenidone alone or combined with either dulaglutide or empagliflozin protects against fructose-induced Parkinsonian features in rats. 吡非尼酮单独或与杜拉鲁肽或恩格列净联合对大鼠果糖诱导的帕金森特征有保护作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-06-19 DOI: 10.1097/FBP.0000000000000835

Alaa S Wahba, Hoda E Mohamad, Dina M Abo-Elmatty, Noha M Mesbah, Nehal S Wahba, Ahmed S El Azzazy, Amr T Sakr

{"title":"Pirfenidone alone or combined with either dulaglutide or empagliflozin protects against fructose-induced Parkinsonian features in rats.","authors":"Alaa S Wahba, Hoda E Mohamad, Dina M Abo-Elmatty, Noha M Mesbah, Nehal S Wahba, Ahmed S El Azzazy, Amr T Sakr","doi":"10.1097/FBP.0000000000000835","DOIUrl":"10.1097/FBP.0000000000000835","url":null,"abstract":"This study aimed to investigate and characterize Parkinson's-like behavioral, histological, and biochemical changes induced by feeding fructose (10% w/v) for 24 weeks in rats. Additionally, we aimed to evaluate the potential protective effect of dulaglutide and empagliflozin either individually or combined with pirfenidone on fructose-induced Parkinsonian features. Rats were given 10% w/v fructose solution for 24 weeks and cotreated for the last 4 weeks with either empagliflozin (30 mg/kg/day orally), dulaglutide (0.2 mg/kg/week subcutaneously), pirfenidone (100 mg/kg/day orally), or the combination of the latter with empagliflozin or dulaglutide at the same mentioned doses. Behavioral testing was done at the end of the study period, and brain tissue samples were taken at sacrifice. Fructose-fed rats showed aberrations in cognitive function and motor coordination constellated with loss of substantia nigra neurons, dopamine deficiency, and altered α-synuclein , LRRK2 , and parkin expression. This was associated with insulin resistance, dyslipidemia, enhanced neuroinflammation, and apoptosis. All treatments ameliorated these perturbations with more pronounced effects observed in the combination groups. Current results revealed the neuroprotective potential of dulaglutide, empagliflozin, and pirfenidone against fructose-induced neurobehavioral alterations in rats with an additive effect observed with the combined therapy.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"322-336"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slight and hidden hearing loss differentially affect short- and long-term memory in young rats. 轻微和隐蔽性听力损失对幼鼠短期和长期记忆的影响是不同的。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-04-17 DOI: 10.1097/FBP.0000000000000828

Joëlle D Jagersma, Sonja J Pyott, Jocelien D A Olivier

{"title":"Slight and hidden hearing loss differentially affect short- and long-term memory in young rats.","authors":"Joëlle D Jagersma, Sonja J Pyott, Jocelien D A Olivier","doi":"10.1097/FBP.0000000000000828","DOIUrl":"10.1097/FBP.0000000000000828","url":null,"abstract":"Mild forms of hearing loss (HL) have been linked to cognitive impairments in children, yet the neurobiological mechanisms underlying this connection remain unclear. Existing research using animal models mostly focuses on more severe levels of HL or investigates only limited aspects of cognition. To gain a broader understanding of how slight/hidden HL affects cognitive behaviors, we induced HL in 4-week-old Wistar rats through noise exposure. Auditory brainstem response measurements confirmed slight and hidden HL, but this auditory impairment did not alter the density of inner hair cells or their synapses with the spiral ganglion (primary auditory) neurons. Both short- and long- term memory formation were tested using the object location, novel object recognition, and social recognition task. Behaviorally, rats with slight/hidden HL performed better than normal hearing (NH) rats during short-term cognition tests. However, long-term memory was impaired in rats with slight/hidden HL when compared to NH controls. Slight/hidden HL also did not consistently affect (social) exploration. In conclusion, this study demonstrates that slight and hidden HL differentially affect short- and long-term cognitive processes in an animal model of early (noise-induced) HL, without affecting (social) exploration. These results suggest a nuanced relationship between slight and hidden HL and both short- and long-term memory formation, underscoring the importance of broader cognitive phenotyping and further investigation into the neurobiological structures linking hearing impairment with cognitive function.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"300-311"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gabapentin and D-cycloserine alone and in combination with naloxone in methadone-maintained humans responding under a naloxone novel-response discrimination procedure. 加巴喷丁和d -环丝氨酸单独使用以及与纳洛酮联合使用美沙酮在纳洛酮新反应鉴别程序下维持人的反应。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-04-08 DOI: 10.1097/FBP.0000000000000823

Lauren R Fitzgerald, Nichole C Stanley, Joseph B Guise, Christopher S Cargile, Michael J Mancino, Alison H Oliveto

{"title":"Gabapentin and D-cycloserine alone and in combination with naloxone in methadone-maintained humans responding under a naloxone novel-response discrimination procedure.","authors":"Lauren R Fitzgerald, Nichole C Stanley, Joseph B Guise, Christopher S Cargile, Michael J Mancino, Alison H Oliveto","doi":"10.1097/FBP.0000000000000823","DOIUrl":"10.1097/FBP.0000000000000823","url":null,"abstract":"The present study examined the impact of the N-type calcium channel blocker gabapentin (GBP) and the partial glycine agonist D-cycloserine (CYC) to attenuate the behavioral effects of naloxone in opioid-dependent humans responding under a naloxone discrimination procedure. Methadone-maintained participants were trained to distinguish between a low dose of naloxone (0.15 mg/70 kg, i.m.; i.e., drug A) and placebo (i.e. drug B) under an instructed novel-response drug discrimination procedure, in which participants identify the drug condition as 'A', 'B', or 'N' (neither A nor B - 'novel'). Once the discrimination was acquired, doses of CYC (0, 500, and 625 mg) and GBP (0, 100, 200, and 400 mg) each alone and in combination with the training dose of naloxone were tested. GBP alone produced only placebo-appropriate responding and did not significantly alter naloxone discrimination when coadministered with naloxone, though it modestly reduced naloxone-induced visual analog scale ratings of drug 'strength'. CYC alone also produced predominantly placebo-appropriate responding and did not modulate naloxone-appropriate responding, but increased ratings of bad effects and decreased ratings of like placebo relative to naloxone alone at the 500 mg dose. These null findings regarding the modulation of naloxone discrimination highlight the limited efficacy of GBP and CYC in this context, contributing to the understanding of pharmacological interactions with opioid antagonists and their potential implications for opioid withdrawal treatment.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"265-275"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase. 双氯芬酸的自协同抗伤感受作用：外周抑制一氧化氮合酶的作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-04-02 DOI: 10.1097/FBP.0000000000000824

Jorge Elías Torres-López, Mayra Martínez-Martínez, Leonor Ivonne Parra-Flores

{"title":"Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase.","authors":"Jorge Elías Torres-López, Mayra Martínez-Martínez, Leonor Ivonne Parra-Flores","doi":"10.1097/FBP.0000000000000824","DOIUrl":"10.1097/FBP.0000000000000824","url":null,"abstract":"This study was conducted to characterize the interaction between the systemic and local peripheral antinociceptive effect of diclofenac, a nonsteroidal anti-inflammatory drug. As well as the effect of local peripheral administration of NG -nitro-L-arginine methyl ester (L-NAME) - a nitric oxide synthesis inhibitor - on the antinociceptive effect of diclofenac. The antinociceptive effect of diclofenac in a fixed-ratio combination of local or intraperitoneal delivery diclofenac was evaluated using the formalin test. Pain-related behavior was quantified in terms of the number of flinches of the injected paw with formalin. Isobolographic analysis was employed to characterize the interaction between the two routes. ED 30 values were estimated for each route, and an isobologram was constructed. Diclofenac and its fixed-ratio combination produced a dose-dependent antinociceptive effect in the second phase, but not in the first phase of the formalin test. The analysis revealed that the simultaneous administration of diclofenac through the two routes was synergistic. Pretreatment of the injured paw with L-NAME partially blocked local, systemic, and simultaneous local and systemic diclofenac-induced antinociception. The obtained results show a synergism after simultaneous administration of diclofenac through two different routes. In addition, it is found that either the local or systemic antinociceptive effect of diclofenac involves the activation of the nitric oxide pathway at the peripheral level.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"258-264"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-HT 2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats. 5-HT2A受体逆激动剂减轻吗啡戒断综合征及其对大鼠的厌恶。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-05-16 DOI: 10.1097/FBP.0000000000000832

Ping-Hsun Tsai, Erica R Morales, Yvonne Y Reed, Hasan Qamar, Emily F Jones, Gopika Saji, Christopher P Ward, Ethan S Burstein, Georgina L Moreno, David H Malin

{"title":"5-HT 2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats.","authors":"Ping-Hsun Tsai, Erica R Morales, Yvonne Y Reed, Hasan Qamar, Emily F Jones, Gopika Saji, Christopher P Ward, Ethan S Burstein, Georgina L Moreno, David H Malin","doi":"10.1097/FBP.0000000000000832","DOIUrl":"10.1097/FBP.0000000000000832","url":null,"abstract":"This study explored a potential role for the 5-hydroxytryptamine 2A (5-HT 2A ) serotonin receptor in opiate physical dependence. Rats were rendered opiate-dependent by 7 days of continuous subcutaneous (s.c.) morphine sulfate infusion. Pimavanserin is a selective 5-HT 2A receptor inverse agonist in current medical use. A day after termination of drug infusion, rats were injected s.c. with 0.3 or 1.0 mg/kg pimavanserin or saline alone. A nondependent control group was infused with saline alone and injected with saline. One hour after injections, all rats were observed under blind conditions for somatically expressed spontaneous withdrawal signs. While both pimavanserin doses significantly reduced withdrawal signs in the dependent rats, the higher dose reduced those signs to the level exhibited by the nondependent group. In a second experiment, utilizing only nondependent, saline-infused rats, pimavanserin had no significant effect vs. saline injection on overall signs. A third experiment extended these findings to naloxone-precipitated morphine withdrawal. Relative to saline injection, pimavanserin, 1.3 mg/kg s.c., significantly reduced withdrawal signs precipitated by 0.3 mg/kg naloxone 1 h later. This effect was reconfirmed in a separate experiment. The pimavanserin injection also significantly attenuated the aversiveness of morphine withdrawal, as indicated by reduced conditioned avoidance of the chamber where precipitated withdrawal had occurred. These results indicate a major role for the 5-HT 2A receptor in opiate physical dependence and withdrawal syndrome, suggesting this receptor as a potential therapeutic target.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"234-245"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theobromine synergizes with nicotine to enhance animal motor abilities and cognitive function. 可可碱与尼古丁协同作用，增强动物的运动能力和认知功能。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-05-20 DOI: 10.1097/FBP.0000000000000821

Wenjuan Zhang, Xiao Yang, Baojiang He, Aimin He, Jiehui Li, Xiaojing Zhang, Yanfang Zhang

引用次数: 0