Antidepressive synergism between crocin and D-AP5 in acute restraint-stressed mice.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Behavioural Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI:10.1097/FBP.0000000000000784
Sana-Sadat Gerami, Mohaddeseh Ebrahimi-Ghiri, Fatemeh Khakpai, Mohammad-Reza Zarrindast
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引用次数: 0

Abstract

Emerging evidence suggests that crocin rescues stress-induced depressive symptoms in mice via stimulation of hippocampal neurogenesis. Glutamate modulators mainly involving N-methyl- d -aspartate (NMDA) receptors (NMDARs) have highlighted a role in neural development, synaptic plasticity, and depression. The research presented here was designed to appraise the interaction between NMDAR agents and crocin on depressive-related behaviors in the NMRI male mice exposed to acute restraint stress (ARS) for a period of 4 h. The mice were submitted to the splash test, forced swimming test, and tail suspension test to evaluate depressive-like behavior. The ARS decreased the grooming duration in the splash test and increased immobility time in the forced swimming test and tail suspension test, suggesting a depressive-like phenotype. NMDA (0.25 and 0.5 μg/mouse, intracerebroventricular) did not alter depression-related profiles in both non-acute restraint stress (NARS) and ARS mice, while the same doses of NMDAR antagonist D-AP5 potentiated the antidepressive-like activities in the ARS mice compared with the NARS mice. Moreover, a low dose of NMDA did not change depression-related parameters in the crocin-treated NARS or ARS mice, while D-AP5 enhanced the crocin response in the NARS and ARS mice. Isobologram analysis noted a synergism between crocin and D-AP5 on antidepressive-like behavior in the NARS and ARS mice. Collectively, the combination of crocin and D-AP5 was shown to mitigate depression symptoms and can be potentially used for the treatment of depression disorders.

巴豆素和 D-AP5 在急性束缚应激小鼠中的抗抑郁协同作用
新的证据表明,巴豆素能通过刺激海马神经发生来缓解压力诱发的小鼠抑郁症状。主要涉及 N-甲基-d-天冬氨酸(NMDA)受体(NMDARs)的谷氨酸调节剂在神经发育、突触可塑性和抑郁中发挥着重要作用。本文介绍的研究旨在评估 NMDAR 药物和巴豆苷对暴露于急性束缚应激(ARS)4 小时的 NMRI 雄性小鼠抑郁相关行为的交互作用。对小鼠进行泼水试验、强迫游泳试验和悬尾试验,以评估类似抑郁的行为。急性束缚应激减少了溅水试验中的梳理时间,增加了强迫游泳试验和悬尾试验中的不动时间,这表明小鼠出现了抑郁样表型。NMDA(0.25 和 0.5 μg/只小鼠,脑室内)不会改变非急性束缚应激(NARS)小鼠和 ARS 小鼠的抑郁相关特征,而与 NARS 小鼠相比,相同剂量的 NMDAR 拮抗剂 D-AP5 会增强 ARS 小鼠的抗抑郁样活动。此外,低剂量的 NMDA 不会改变经巴豆毒素处理的 NARS 或 ARS 小鼠的抑郁相关参数,而 D-AP5 则会增强 NARS 和 ARS 小鼠对巴豆毒素的反应。等全息图分析表明,巴豆素和 D-AP5 对 NARS 和 ARS 小鼠的抗抑郁行为具有协同作用。总之,黄花霉素和 D-AP5 的组合可减轻抑郁症状,有望用于抑郁症的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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