Behavioural Pharmacology最新文献_第7页

Chronic pharmacological activation of SERCA with CDN1163 affects spatial cognitive flexibility but not attention and impulsivity in mice. CDN1163对SERCA的慢性药理学激活影响小鼠的空间认知灵活性，但不影响注意力和冲动性。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-12-01 Epub Date: 2023-10-01 DOI: 10.1097/FBP.0000000000000756

Benjamin Klocke, Carter Moore, Hayden Ott, Pothitos M Pitychoutis

{"title":"Chronic pharmacological activation of SERCA with CDN1163 affects spatial cognitive flexibility but not attention and impulsivity in mice.","authors":"Benjamin Klocke, Carter Moore, Hayden Ott, Pothitos M Pitychoutis","doi":"10.1097/FBP.0000000000000756","DOIUrl":"10.1097/FBP.0000000000000756","url":null,"abstract":"Intracellular calcium (Ca2+) homeostasis is critical for many neural processes, including learning, memory and synaptic plasticity. The sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) is among the key regulators that preserve Ca2+ homeostasis in neurons. SERCAs comprise a set of ubiquitously expressed Ca2+ pumps that primarily function to sequester cytosolic Ca2+ into endoplasmic reticular stores. As SERCA has been implicated in the neurobiology of several neuropsychiatric and neurodegenerative diseases, pharmacological harnessing of its function is critical in understanding SERCA's role in brain physiology and pathophysiology. In the current study, we employed the Morris water maze and 5-choice serial reaction time task (5-CSRTT) to investigate the effects of chronic pharmacological activation of SERCA, using the small allosteric SERCA activator CDN1163, on spatial learning and memory, and executive functioning in naive C57BL/6J mice. Our data show that chronic pharmacological SERCA activation with CDN1163 (20 mg/kg) selectively impairs spatial cognitive flexibility and reversal learning in the Morris water maze while leaving executive functions such as attention and impulsivity intact. Present findings contribute to the growing field of the role of SERCA function in the brain and behavior and expand current knowledge on the use of the small allosteric activator CDN1163 as an investigational tool to study the role of SERCA in regulating neurobehavioral processes and as a potential therapeutic candidate for debilitating brain disorders.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 8","pages":"477-487"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological approach: using a within-subjects design in the marble burying assay. 方法论方法：在大理石掩埋试验中使用受试者内部设计。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-12-01 Epub Date: 2023-08-31 DOI: 10.1097/FBP.0000000000000752

Kaitlyn J Partridge, Ruth Olson, Todd M Hillhouse

{"title":"Methodological approach: using a within-subjects design in the marble burying assay.","authors":"Kaitlyn J Partridge, Ruth Olson, Todd M Hillhouse","doi":"10.1097/FBP.0000000000000752","DOIUrl":"10.1097/FBP.0000000000000752","url":null,"abstract":"In 2016, the National Institutes of Health mandated the use of both male and female mice in funded research. The use of both sexes is an important variable to consider; however, it comes with negative consequences such as increased animal expenses. One way to combat these negatives is to explore the option of using a within-subjects design (repeated measures) in behavioral assays that historically use a between-subjects design. Our study aimed to determine if a within-subjects design can be utilized in the marble burying assay. The marble burying assay is used as a tool for screening putative anxiolytic compounds as the assay is thought to measure obsessive-compulsive disorder- or anxiety-like behaviors. First, we compared the effects of sex and digging medium (corn cob or Sani Chip) on the number of marbles buried using CD-1 mice. Second, we determined if mice would continue to bury marbles after repeated exposures to the test arena. Lastly, we tested three positive controls (buspirone, ketamine, and fluoxetine). We found that mice buried significantly more marbles within Sani Chip digging medium, and no sex differences were observed. Next, the number of marbles buried and locomotor activity remained consistent across four test sessions. The positive controls buspirone (3.2-10 mg/kg) ketamine (32 mg/kg), and fluoxetine (10 mg/kg) decreased the number of marbles buried using the within-subjects design. These data suggest that a within-subjects design is optimal for the marble burying assay as it will reduce the number of animals and increase statistical power.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"494-499"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minocycline as a potential anxiolytic drug: systematic review and meta-analysis of evidence in murine models 米诺环素作为一种潜在的抗焦虑药物：小鼠模型证据的系统回顾和荟萃分析

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-11-21 DOI: 10.1097/fbp.0000000000000754

L. P. Iglesias, Nicia Soares, L. Asth, Fabrício A Moreira, D. Aguiar

{"title":"Minocycline as a potential anxiolytic drug: systematic review and meta-analysis of evidence in murine models","authors":"L. P. Iglesias, Nicia Soares, L. Asth, Fabrício A Moreira, D. Aguiar","doi":"10.1097/fbp.0000000000000754","DOIUrl":"https://doi.org/10.1097/fbp.0000000000000754","url":null,"abstract":"Minocycline is a tetracycline antibiotic with off-label use as an anti-inflammatory drug. Because it can cross the blood-brain barrier, minocycline has been proposed as an alternative treatment for psychiatric disorders, in which inflammation plays an important role. However, its beneficial effects on anxiety disorders are unclear. Therefore, we performed a systematic review and meta-analysis to evaluate the efficacy of minocycline as an anxiolytic drug in preclinical models. We performed a PubMed search according to the PRISMA guidelines and PICOS strategy. The risk of bias was evaluated using the SYRCLE tool. We included studies that determined the efficacy of minocycline in animal models of anxiety that may involve exposures (e.g. stressors, immunomodulators, injury). Data extracted included treatment effect, dose range, route of administration, and potential mechanisms for the anxiolytic effect. Meta-analysis of twenty studies showed that minocycline reduced anxiety-like behavior in rodents previously exposed to stress or immunostimulants but not in exposure-naïve animals. This effect was not associated with the dose administered or treatment duration. The mechanism for the anxiolytic activity of minocycline may depend on its anti-inflammatory effects in the brain regions involving anxiety. These suggest that minocycline could be repurposed as a treatment for anxiety and related disorders and warrants further evaluation.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"30 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139252477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examination of the mechanisms underlying the discriminative stimulus properties of the atypical antipsychotic amisulpride 研究非典型抗精神病药物氨磺必利的鉴别刺激特性的内在机制

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-11-16 DOI: 10.1097/fbp.0000000000000760

T. Donahue, T. Hillhouse, Kevin A. Webster, Richard Young, Eliseu O. De Oliveira, Joseph H. Porter

{"title":"Examination of the mechanisms underlying the discriminative stimulus properties of the atypical antipsychotic amisulpride","authors":"T. Donahue, T. Hillhouse, Kevin A. Webster, Richard Young, Eliseu O. De Oliveira, Joseph H. Porter","doi":"10.1097/fbp.0000000000000760","DOIUrl":"https://doi.org/10.1097/fbp.0000000000000760","url":null,"abstract":"Amisulpride is an atypical benzamide antipsychotic/antidepressant, whose mechanism of action is thought to depend mainly on dopamine D2/3 receptor activity, but also with some serotonin 5-HT2B/7 effects. The present study examined the role of D2/3 receptors and 5-HT2B/7 receptors in amisulpride’s discriminative stimulus. Selective agonists and antagonists of the above receptors were tested in adult, male C57BL/6 mice trained to discriminate 10 mg/kg amisulpride from vehicle in a two-lever drug discrimination assay. After acquisition of the two-lever discrimination, the amisulpride generalization curve yielded an ED50 = 0.56 mg/kg (95% CI = 0.42–0.76 mg/kg). Substitution tests found that the D2/3 antagonist raclopride (62.7% Drug Lever Responding), D2/3 agonist quinpirole (56.6% DLR), 5-HT7 agonist LP-44 (50.1% DLR) and 5-HT7 antagonist SB-269970 (36.7% DLR) produced various degrees of partial substitution for the amisulpride stimulus, whereas the 5-HT2B agonist BW 723C86 (17.9% DLR) and 5-HT2B antagonist SB-204741 (21.1% DLR) yielded negligible amisulpride-like effects. In combination tests with amisulpride, quinpirole decreased percent responding from 98.3% to 57.0% DLR, LP-44 decreased percent responding from 97.6% to 76.7% DLR, and BW 723C86 reduced percent responding from 95.66% to 74.11% DLR. Taken together, the results from stimulus generalization and antagonism studies suggest that amisulpride has a complex discriminative cue that involves mainly mixed D2/3 receptor antagonist/agonist effects and, to a lesser degree, mixed 5-HT7 receptor agonist/antagonist and perhaps 5-HT2B receptor antagonist effects.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"9 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139269865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antinociceptive and adverse effects of morphine:ketamine mixtures in rats 吗啡：氯胺酮混合物对大鼠的抗镇痛作用和不良反应

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-11-16 DOI: 10.1097/fbp.0000000000000761

Conor D. Strumberger, Evangeline J. D’Epagnier, Kevin H. Nguyen, John D. Rogers, Matthew P. Meyer, Yashmita Malhotra, Jillian E. Hinman, Elisabeth L. Jansen, Vanessa Minervini

{"title":"Antinociceptive and adverse effects of morphine:ketamine mixtures in rats","authors":"Conor D. Strumberger, Evangeline J. D’Epagnier, Kevin H. Nguyen, John D. Rogers, Matthew P. Meyer, Yashmita Malhotra, Jillian E. Hinman, Elisabeth L. Jansen, Vanessa Minervini","doi":"10.1097/fbp.0000000000000761","DOIUrl":"https://doi.org/10.1097/fbp.0000000000000761","url":null,"abstract":"Prescription opioids are the gold standard for treating moderate to severe pain despite their well-documented adverse effects. Of all prescription medications, opioids are abused most widely, and fatal overdoses have reached epidemic levels. One strategy for improving the margin of safety of opioids is combining them with non-opioid drugs to decrease the opioid dose needed for pain relief, thereby reducing adverse effects that occur with larger doses. The N-methyl-D-aspartate receptor antagonist ketamine has been used safely as an analgesic but only under a very limited range of conditions. The current studies characterized the antinociceptive, behavioral suppressant, and gastrointestinal effects of morphine and ketamine alone and in mixtures to determine their interaction in 24 adult male Sprague–Dawley rats (n = 8 per assay). Given alone, both morphine and ketamine produced antinociception, decreased responding for food, and reduced gastrointestinal transit (i.e. produced constipation). The effects of morphine:ketamine mixtures generally were additive, except for the antinociceptive effects of 1:1 mixtures for which the difference in slope (i.e. non-parallel shift) between the observed and predicted effects suggested synergy at smaller doses and additivity at larger doses. The potency of morphine to produce constipation was not enhanced by administration of morphine:ketamine mixtures with antinociceptive effects. The nature of the interaction between morphine and ketamine for adverse effects such as dependence, withdrawal, abuse, or respiratory depression remains unknown but also might be related to the ratio of each drug in mixtures. It will be important to identify conditions that produce the largest potential therapeutic window in humans.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"35 10","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139269483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anorectic effect of COR659 in a rat model of overeating. COR659在大鼠暴饮模型中的厌食作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-08-31 DOI: 10.1097/FBP.0000000000000751

Paola Maccioni, Claudia Mugnaini, Mauro A M Carai, Gian Luigi Gessa, Federico Corelli, Giancarlo Colombo

{"title":"Anorectic effect of COR659 in a rat model of overeating.","authors":"Paola Maccioni, Claudia Mugnaini, Mauro A M Carai, Gian Luigi Gessa, Federico Corelli, Giancarlo Colombo","doi":"10.1097/FBP.0000000000000751","DOIUrl":"10.1097/FBP.0000000000000751","url":null,"abstract":"COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1 receptor. Recent lines of experimental evidence have indicated that COR659 potently and effectively reduced operant self-administration of and reinstatement of seeking behaviour for a chocolate-flavoured beverage. The present study was designed to assess whether the ability of COR659 to diminish these addictive-like, food-motivated behaviours extended to a rat model of overeating palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-hour chow-feeding session was followed by a 1-hour feeding session with highly palatable, calorie-rich Danish butter cookies. Even though satiated, rats overconsumed cookies. COR659 (0, 2.5, 5, and 10 mg/kg, i.p.) was administered before the start of the cookie-feeding session. Treatment with all 3 doses of COR659 produced a substantial decrease in intake of cookies and calories from cookies. These results extend the anorectic profile of COR659 to overconsumption of a highly palatable food and intake of large amounts of unnecessary calories.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 7","pages":"437-442"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10288709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we change automatic processes: the influence of social priming on alcohol attentional bias. 我们能改变自动过程吗：社会启动对酒精注意力偏差的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI: 10.1097/FBP.0000000000000749

Stephen A Cantarutti, Emmanuel M Pothos, Eleni Ziori, Katy Tapper

{"title":"Can we change automatic processes: the influence of social priming on alcohol attentional bias.","authors":"Stephen A Cantarutti, Emmanuel M Pothos, Eleni Ziori, Katy Tapper","doi":"10.1097/FBP.0000000000000749","DOIUrl":"10.1097/FBP.0000000000000749","url":null,"abstract":"The Stroop Effect has been linked to social concept priming, suggesting that the latter may trigger automatic behaviour aligned with the primed concept. This study examined the effects of social priming on alcohol attentional bias, with a sample of mostly light drinkers; it used a social priming task and an alcohol-Stroop test to measure participants' response times (RTs) before and after they had been socially primed. Participants were separated into one of three social priming conditions: Neutral, Alcohol Addiction, and Alcohol Preoccupation. A mixed ANOVA was run to determine whether participants' RTs to alcohol-related stimuli, \"rather than to neutral sitmuli,\" slowed significantly after the alcohol interference tasks, relative to the neutral interference task, suggesting an alcohol attentional bias had been induced by the social priming exercise. Key interaction terms did not reveal such an interaction, but rather a general slowing down (for both neutral and alcohol stimuli), in the Alcohol conditions, relative to the Neutral one. As a result, we can conclude that while we did not induce an alcohol-specific bias in participants, we did discover a generalised interference effect, following alcohol-related social priming tasks.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 7","pages":"443-448"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10288711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attenuation of morphine conditioned place preference and reinstatement by vitamin D. 维生素D对吗啡条件性位置偏好的减弱和恢复。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-08-15 DOI: 10.1097/FBP.0000000000000747

Mahdieh Akbari, Houman Parsaei, Katayoun Sedaghat, Fatemeh Mousavi

{"title":"Attenuation of morphine conditioned place preference and reinstatement by vitamin D.","authors":"Mahdieh Akbari, Houman Parsaei, Katayoun Sedaghat, Fatemeh Mousavi","doi":"10.1097/FBP.0000000000000747","DOIUrl":"10.1097/FBP.0000000000000747","url":null,"abstract":"Opioid action in the brain involves the dopamine-reward system as well as non-dopamine pathways. Since vitamin D also modulates the brain's dopamine system, the question of this study was how vitamin D might affect the opioid influences on the reward system. Therefore, the objective of this study was to investigate the possible effect of vitamin D on the conditioned place preference (CPP) induced by morphine, as a valuable model of assessment of the reinforcing properties of opioids by associating the context to the rewarding properties of the addictive drugs. Male Wistar rats were randomly divided into two main groups that either received saline (morphine vehicle) or morphine (5 mg/kg, intraperitoneally) for CPP. Each of the main groups was divided into three vitamin D treatment subgroups: vitamin D vehicle and vitamin D (5 and 10 μg/kg, intraperitoneally). Vitamin D injections were started 1 week ahead of the experiment (two injections) or immediately after post-conditioning and in both cases, it was continued twice weekly throughout the CPP. Administration of vitamin D (10 μg/kg) before conditioning in CPP markedly attenuated morphine expression in the post-conditioning test. Receiving vitamin D (5 or 10 μg/kg) before or after conditioning significantly attenuated morphine reinstatement. Administration of vitamin D after opioid conditioning facilitated morphine memory extinction and attenuated morphine reinstatement. Vitamin D is probably a valuable addition to be considered as a part of the treatment for prevention or minimizing the dependency or relapse to opioids.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 7","pages":"404-410"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10274793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. 5-HT1B受体的杂合和纯合基因敲除对甲基苯丙胺诱导的行为敏化有不同的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-08-31 DOI: 10.1097/FBP.0000000000000745

Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sora

{"title":"Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization.","authors":"Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sora","doi":"10.1097/FBP.0000000000000745","DOIUrl":"10.1097/FBP.0000000000000745","url":null,"abstract":"The psychostimulant drug methamphetamine (METH) causes euphoria in humans and locomotor hyperactivity in rodents by acting on the mesolimbic dopamine (DA) pathway and has severe abuse and addiction liability. Behavioral sensitization, an increased behavioral response to a drug with repeated administration, can persist for many months after the last administration. Research has shown that the serotonin 1B (5-HT1B) receptor plays a critical role in the development and maintenance of drug addiction, as well as other addictive behaviors. This study examined the role of 5-HT1B receptors in METH-induced locomotor sensitization using 5-HT1B knockout (KO) mice. To clarify the action of METH in 5-HT1B KO mice the effects of METH on extracellular levels of DA (DAec) and 5-HT (5-HTec) in the caudate putamen (CPu) and the nucleus accumbens (NAc) were examined. Locomotor sensitization and extracellular monoamine levels were determined in wild-type mice (5-HT1B +/+), heterozygous 5-HT1B receptor KO (5-HT1B +/-) mice and homozygous 5-HT1B receptor KO mice (5-HT1B -/-). Behavioral sensitization to METH was enhanced in 5-HT1B -/- mice compared to 5-HT1B +/+ mice but was attenuated in 5-HT1B +/- mice compared to 5-HT1B +/+ and 5-HT1B -/- mice. In vivo, microdialysis demonstrated that acute administration of METH increases DAec levels in the CPu and NAc of 5-HT1B KO mice compared to saline groups. In 5-HT1B +/- mice, METH increased 5-HTec levels in the CPu, and DAec levels in the NAc were higher than in others.5-HT1B receptors play an important role in regulating METH-induced behavioral sensitization.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 7","pages":"393-403"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10648932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary-induced binge-like eating impairs acoustic startle responses to acute nisoxetine in male mice. 在雄性小鼠中，饮食诱导的类似暴饮的饮食会削弱对急性尼索西汀的听觉惊吓反应。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-08-15 DOI: 10.1097/FBP.0000000000000748

Lori L Scarpa, Nicholas T Bello

{"title":"Dietary-induced binge-like eating impairs acoustic startle responses to acute nisoxetine in male mice.","authors":"Lori L Scarpa, Nicholas T Bello","doi":"10.1097/FBP.0000000000000748","DOIUrl":"10.1097/FBP.0000000000000748","url":null,"abstract":"Sensorimotor gating disruptions have been noted in several psychiatric and neurodegenerative disorders. However, the involvement of sensorimotor gating processes in eating disorders has not been well characterized. Our objective was to examine the sensorimotor gating of the acoustic startle response following dietary-induced binge eating and high-fat diet (HFD) induced weight gain in male C57B/6J mice. Acute administration of the norepinephrine reuptake inhibitor, nisoxetine (0.5 and 5 mg/kg), and a dopamine reuptake inhibitor, GBR 12783 (1.6 and 16 mg/kg), were either given alone or in combination to assess norepinephrine and dopamine alterations, respectively. Male mice with repeated bouts of calorie restriction (Restrict) and with limited access to a sweetened fat food (Binge) demonstrated an escalation of intake over 2.5 weeks under standard chow conditions. Restrict Binge (RB) mice had a reduced startle response to the startle pulse (110 dB) compared with the Naive control group at 5 mg/kg nisoxetine. There was an overall effect of nisoxetine (0.5 and 5 mg/kg) to increase percent inhibition at pre-pulse (74 dB), %PP74. Under HFD conditions, the RB group did not demonstrate a binge-like eating phenotype. The RB group on HFD had a higher response to 74 dB with nisoxetine (5.0 mg/kg) compared with a combinational dose of nisoxetine (5.0 mg/kg) and GBR 12783 (1.6 mg/kg). These findings suggest that dietary conditions that promote binge-like eating can influence the central noradrenergic and dopaminergic controls of the acoustic startle response and potentially influence sensorimotor gating.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 7","pages":"411-423"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10285579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0