New insights about the antidepressant-like effects of riparin A in a chronic murine model of depression.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Behavioural Pharmacology Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI:10.1097/FBP.0000000000000781
Cássio Prinholato da Silva, Denise Dias Oliveira, Bruno Iglesias Benincasa, Bruna Barbar, Raphaela Gonçalves Barros Perri, Ana Lúcia Fachin, Luiz Luciano Falconi-Sobrinho, Rene Oliveira Beleboni
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引用次数: 0

Abstract

Riparin A is a synthetic form of natural riparins. Acute scale studies that take into consideration the structure-activity relationship have shown preliminary evidence of antidepressant and anxiolytic effects of riparin A, similar to that already known for other riparins. However, for better pharmacological characterization of this new compound, further studies are required. The aim of this work was to evaluate the effect of chronic treatment with riparin A (10 mg/kg; intraperitoneally) on depressive-like behavior in the forced swimming test and tail suspension test, as well as the reduction of anhedonia in the sucrose preference test, and on anxiety-like behavior in the open field and elevated plus maze apparatus, triggered in rats previously subjected to unpredictable chronic mild stress by 4 weeks. In addition, a pentobarbital-induced sleep time test was also used. Riparin A reduced the duration of immobility in both the forced swimming test and tail suspension test, as well as attenuated the anhedonia in the sucrose preference test. Furthermore, riparin A appears to produce anxiolytic effects in rats exposed to an open field and elevated plus maze, while increasing the alertness/vigilance in rats submitted to pentobarbital-induced sleep time test, without altering their locomotor integrity. Our results suggest that chronic riparin A appears to be a potential pharmacological target for new studies on the control of depression- and anxiety-like behaviors in stressed rats.

里帕林 A 在慢性抑郁症小鼠模型中的抗抑郁样作用的新见解。
瑞香素 A 是天然瑞香素的合成形式。考虑到结构-活性关系的急性规模研究显示,有初步证据表明瑞香素 A 具有抗抑郁和抗焦虑作用,与已知的其他瑞香素相似。然而,为了更好地描述这种新化合物的药理特征,还需要进一步的研究。这项工作的目的是评估长期服用瑞香素 A(10 毫克/千克;腹腔注射)对大鼠在强迫游泳试验和悬尾试验中的抑郁样行为、蔗糖偏好试验中的失神以及在开放场地和高架加迷宫装置中的焦虑样行为的影响。此外,还使用了戊巴比妥诱导睡眠时间测试。瑞帕灵 A 可缩短强迫游泳试验和尾悬试验中的不动持续时间,并减轻蔗糖偏好试验中的失神状态。此外,瑞香素 A 似乎还能对暴露于开放场地和高架加迷宫的大鼠产生抗焦虑作用,同时提高接受戊巴比妥诱导睡眠时间试验的大鼠的警觉性/警惕性,而不改变其运动完整性。我们的研究结果表明,长期服用瑞香素 A 似乎是一种潜在的药理学靶点,可用于控制应激大鼠的抑郁和焦虑类行为的新研究。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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