Baylor University Medical Center Proceedings最新文献

{"title":"One-Stop Colon and Endometrial Screening (ONCE): a prospective study of combined cancer screening for Lynch syndrome.","authors":"Christine L Frissora, Emily A Miller, Thalia Matos, Andrea Betesh, Steven Lipkin, Melissa K Frey, Felice Schnoll-Sussman","doi":"10.1080/08998280.2025.2519596","DOIUrl":"10.1080/08998280.2025.2519596","url":null,"abstract":"<p><strong>Background: </strong>Individuals with Lynch syndrome face up to a 60% lifetime risk of developing endometrial and gastrointestinal cancer. Established guidelines recommend colonoscopies every 1 to 2 years beginning at age 20 to 25 and endometrial biopsy every 1 to 2 years beginning at age 30 to 35. We evaluated the patient experience with a combined endometrial biopsy and gastrointestinal cancer screening procedure for patients with Lynch syndrome.</p><p><strong>Methods: </strong>Patients with Lynch syndrome undergoing combined colon and endometrial screening from June 2021 to September 2023 were prospectively enrolled. Patients had both procedures during a single session using propofol sedation. Appropriate patients also underwent upper endoscopy. Patient satisfaction was assessed by questionnaire. Surveys were distributed to patients via email 1 day after their procedure. Twenty patients were enrolled, and 18 completed the survey (90%).</p><p><strong>Results: </strong>None of the patients reported pain during the procedure. The average combined procedure duration was 42 minutes (range 27-59) and average total operating room time was 54 minutes (range 37-93). One patient was found to have complex atypical endometrial hyperplasia and had a hysterectomy for stage 1 A uterine clear cell carcinoma. There were no cases of colon or gastric cancer. A total of six adenomatous polyps and five serrated polyps were removed.</p><p><strong>Conclusion: </strong>Patients with Lynch syndrome undergoing One-Stop Colon and Endometrial Screening (ONCE) reported high satisfaction with the combined procedure. To maximize patient care, physicians and health care systems should consider support for and investment in the implementation of combined screening approaches.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"646-649"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When training isn't enough: lessons from a pediatric serious illness communication pilot.","authors":"Laurel B Kilpatrick, Shawnta Pittman-Hobbs","doi":"10.1080/08998280.2025.2527561","DOIUrl":"10.1080/08998280.2025.2527561","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"656-657"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital maturity scores as gatekeepers for health AI: useful proxy or false comfort?","authors":"Mohammed As'ad, Nawarh Faran","doi":"10.1080/08998280.2025.2524301","DOIUrl":"10.1080/08998280.2025.2524301","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"779-782"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boundaries.","authors":"Joanne L Blum","doi":"10.1080/08998280.2025.2523726","DOIUrl":"10.1080/08998280.2025.2523726","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"767-768"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greasing the cogs in acute stroke care.","authors":"Sadat A Shamim","doi":"10.1080/08998280.2025.2520127","DOIUrl":"10.1080/08998280.2025.2520127","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"626"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ONCE</i> is better than twice.","authors":"Lawrence R Schiller","doi":"10.1080/08998280.2025.2518799","DOIUrl":"10.1080/08998280.2025.2518799","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"650-651"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does ChatGPT help patients access reliable and comprehensive information about psoriasis?","authors":"Funda Tamer, Muhterem Polat","doi":"10.1080/08998280.2025.2518854","DOIUrl":"10.1080/08998280.2025.2518854","url":null,"abstract":"<p><strong>Background: </strong>Rapid advances in artificial intelligence have affected medical knowledge and practices. However, it is unclear whether ChatGPT positively guides patients on their health by providing accurate information. Since psoriasis lasts a lifetime and has no cure, patients commonly seek information and treatment. We evaluated ChatGPT's answers to questions on psoriasis.</p><p><strong>Methods: </strong>Based on our clinical experience, we have identified the most common questions that psoriasis patients ask us about psoriasis. The reliability of responses provided by ChatGPT was rated from 1, very poor, to 5, very good. The comprehensiveness of the responses was rated from 1, incomplete, to 3, comprehensive.</p><p><strong>Results: </strong>The reliability was scored as 5 for responses to 11 out of 12 questions and 4 for 1 question. Author 1 rated the responses to 8 of the 12 questions as comprehensive (3) and 4 as adequate (2). Author 2 rated the response to 1 question as adequate (2) and the remaining responses as comprehensive (3).</p><p><strong>Conclusion: </strong>Our results reveal that ChatGPT can provide patients with reliable and comprehensive information about psoriasis. As ChatGPT is widely used, it can be a helpful source of information that psoriasis patients can access quickly and easily and that can guide them correctly.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"658-661"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival after multidisciplinary heart team-guided management of complex coronary artery disease.","authors":"Taylor Pickering, Austin Kluis, Emily Shih, John J Squiers, Kyle McCullough, Cody Dorton, David O Moore, Srinivasa P Potluri, Molly Szerlip, Karim Al-Azizi, Ghadi Moubarak, Jonathan Ladner, Radhika Vaishnav, Shelby McCoy, Julius Ejiofor, Rahul Sawhney, Sarah Hale, Justin M Schaffer, Jasjit Banwait, Katherine B Harrington, William T Brinkman, Lee R Hafen, Robert L Smith, Timothy J George, J Michael DiMaio, William H Ryan, Kelley A Hutcheson","doi":"10.1080/08998280.2025.2516981","DOIUrl":"10.1080/08998280.2025.2516981","url":null,"abstract":"<p><strong>Objective: </strong>Guidelines recommend a multidisciplinary heart team approach for managing complex coronary artery disease (CAD), yet its impact on clinical outcomes and adherence to recommendations is rarely reported.</p><p><strong>Methods: </strong>Between June 2021 and August 2022, 210 high-risk patients with isolated, complex CAD were evaluated at our institution's weekly heart team conference for consideration of coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), hybrid PCI/CABG, or optimal medical therapy (OMT). Adherence to recommendations and clinical outcomes, including 30-day, 1-year, and 2-year mortality, were assessed.</p><p><strong>Results: </strong>Overall adherence to heart team recommendations was 92%, with 96% adherence for CABG, 90% for PCI, 87% for OMT, and 75% for hybrid PCI/CABG. CABG was the most frequently recommended treatment (53%) and demonstrated the lowest mortality at 1 year (4%) and 2 years (6%) compared with PCI (1 year, 28%; 2 year, 40%) and OMT (1 year, 10%; 2 year, 20%). CABG patients had a lower-than-expected mortality (observed-to-expected ratio 0.9), while PCI was associated with significantly higher mortality (observed-to-expected ratio 3.0).</p><p><strong>Conclusion: </strong>This single-center multidisciplinary heart team approach for complex CAD offers a collaborative, patient-centered model that facilitates high adherence rates and favorable patient outcomes. These findings highlight the potential benefits of integrating multidisciplinary evaluation and support its implementation into standard practice for high-risk CAD patients.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"589-597"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of fezolinetant for vasomotor symptoms in postmenopausal women: a comprehensive systematic review and meta-analysis of randomized controlled trials.","authors":"Majd M AlBarakat, Jehad Feras AlSamhori, Ahmed Abdelaziz, Amr Elrosasy, Mohamad A Elzeftawy, Rana Ahmed Youssef, Rana B Altawalbeh, Mohamed Abuelazm, Basel Abdelazeem","doi":"10.1080/08998280.2025.2491894","DOIUrl":"10.1080/08998280.2025.2491894","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately 360 million women globally experience hot flashes, with varying rates influenced by cultural and racial factors. Vasomotor symptoms (VMS) impact 80% of US women during menopause, with emerging risk factors including high body mass index and African American ancestry. Fezolinetant, an oral neurokinin-3 receptor antagonist, showed promising efficacy in managing VMS. We aimed to comprehensively assess the impact of fezolinetant on VMS in postmenopausal women.</p><p><strong>Methods: </strong>We searched PubMed, Cochrane, Web of Science, SCOPUS, and EMBASE until July 2023 for randomized controlled trials comparing fezolinetant to placebo in women with moderate to severe VMS. Primary outcomes encompassed VMS frequency and severity, and secondary outcomes included treatment effects, quality of life, and safety. Data were collected and analyzed using STATA 17 MP.</p><p><strong>Results: </strong>We included six studies with 3657 patients. Fezolinetant significantly reduced VMS frequency at both 4 weeks (Cohen's d = -0.56; 95% confidence interval [CI], -0.79, -0.34; <i>P</i> < 0.001) and 12 weeks (Cohen's d = -0.34; 95% CI, -0.45, -0.14; <i>P</i> < 0.001). In terms of secondary outcomes, fezolinetant significantly improved health-related functioning and global clinical summary scores, particularly with the 90 mg twice per day dosage. Crucially, there were no statistically significant differences between fezolinetant and placebo concerning the occurrence of any treatment-emergent (odds ratio [OR] = 1.01, <i>P</i> = 0.81) or serious (OR = 1.57, <i>P</i> = 0.90) adverse events.</p><p><strong>Conclusion: </strong>Fezolinetant effectively reduces VMS in postmenopausal women at both 4 and 12 weeks, aligning with previous research. It also improves quality of life, with a promising safety profile. Given fezolinetant's potential for liver enzyme elevations, it is essential to monitor liver function at baseline and regularly thereafter (monthly for the first 3 months and at 6 and 9 months) to ensure patient safety. Further studies with larger sample sizes are needed to confirm these findings.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 4","pages":"535-546"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital notification in acute stroke: a retrospective cohort study.","authors":"Joshua Kimbrell, Aditya C Shekhar, Jacob Stebel, Dana Poke, Jacob Geldner, Judah Kreinbrook, Abigail Hasan, John Vega, Brian Mac Grory, R Jonathan Robitsek","doi":"10.1080/08998280.2025.2514984","DOIUrl":"10.1080/08998280.2025.2514984","url":null,"abstract":"<p><strong>Background: </strong>Emergency medical services (EMS) play a key role in identifying stroke patients and transporting them to specialty care centers. We aimed to quantify the time saved in stroke care by EMS prehospital notification.</p><p><strong>Methods: </strong>We performed a retrospective cohort study at a large comprehensive stroke center in a major metropolitan system including patients treated between 2021 and 2022. Inclusion criteria were adult patients transported to the hospital by EMS with a discharge diagnosis of stroke or transient ischemic attack (TIA).</p><p><strong>Results: </strong>A total of 1053 patients were included, of whom 637 (60.5%) received prehospital notification. Prehospital notification was associated with a median 3-minute adjusted decrease in the door-to-computed-tomography (CT) time (median 18 min, 95% confidence interval [CI] 17-19 vs 21 min, 95% CI 20-22). Among patients who received intravenous thrombolysis (IVT), notification was associated with a faster adjusted time-to-IVT (median 52 min, 95% CI 50-56 vs 63 min, 95% CI 56-69). Of those who underwent endovascular thrombectomy (EVT), notification was associated with faster unadjusted time-to-EVT (median 97 min, 95% CI 93-105 vs 107 min, 95% CI 97-126), but this difference was no longer significant after adjustment.</p><p><strong>Conclusions: </strong>Prehospital notification is associated with reduced door-to-CT and door-to-IVT times. Prehospital notification in nationwide quality improvement efforts may improve stroke care.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 5","pages":"622-625"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}