Baylor University Medical Center Proceedings最新文献

{"title":"A systematic review and meta-analysis assessing the safety and efficacy of the hepatitis E virus vaccine.","authors":"Islam Mohamed, Hazem Abosheiashaa, Anna Boda, Felix Yang, Emily Kamali, Regina Scott, Kate Huntress, Tejas Saravanan, Ahmed E Saelm, Fouad Jaber, Yazan Abboud, Dushyant Dahiya, Laura Alba, Nikki Duong","doi":"10.1080/08998280.2025.2474893","DOIUrl":"https://doi.org/10.1080/08998280.2025.2474893","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis E virus (HEV) is a global cause of viral hepatitis. While genotypes 1 and 2 cause acute hepatitis in Asia and Africa, genotypes 3 and 4 lead to sporadic acute or chronic hepatitis in America and Europe. Pregnant women, immunosuppressed individuals, and those with chronic liver disease face a higher risk of severe outcomes. HEV recombinant vaccine is approved for outbreak use in China but awaits Food and Drug Administration approval in the USA. This systematic review and meta-analysis aims to assess the safety and efficacy of the HEV vaccine.</p><p><strong>Methods: </strong>We conducted a systematic search in Medline, Cochrane, Scopus, and Embase, employing specific terms for the recombinant HEV vaccine. Eligibility criteria involved all-age individuals receiving recombinant HEV vaccine in randomized controlled trials. Covidence software was used to screen studies, and data extraction encompassed study characteristics, baseline data, and efficacy outcomes by four reviewers. Bias evaluation was completed using Cochrane's RoB 2 tool. Statistical analysis involved use of Revman v5.4 with a random effect model, considering <i>P</i> < 0.05 as statistically significant. Heterogeneity was assessed using the <i>I</i> <sup>2</sup> test.</p><p><strong>Results: </strong>The analysis revealed a statistically significant difference in HEV vaccine efficacy compared to placebo (odds ratio [OR]: 25.16, 95% confidence interval [CI] 9.21, 68.75, <i>P</i> < 0.00001) with a substantial reduction in hepatitis E cases (OR: 0.04, 95% CI 0.01, 0.11, <i>P</i> < 0.00001). In terms of safety, the HEV vaccine exhibited a significant increase in injection pain (OR: 1.56, 95% CI 1.03, 2.36, <i>P</i> = 0.04) and injection bruising (OR: 3.62, 95% CI 1.76, 7.48, <i>P</i> = 0.0005). No statistically significant differences were observed in fever (OR: 1.03, 95% CI 0.86, 1.23, <i>P</i> = 0.76) or headache (OR: 1.15, 95% CI 0.72, 1.84, <i>P</i> = 0.56). Local events significantly increased with the vaccine (OR: 1.50, 95% CI 1.38, 1.63, <i>P</i> < 0.00001). There were no significant differences in systemic events (OR: 1.06, 95% CI 0.86, 1.31, <i>P</i> = 0.59) or serious adverse events (OR: 0.58, 95% CI 0.16, 2.07, <i>P</i> = 0.40).</p><p><strong>Conclusion: </strong>Our systematic review and meta-analysis demonstrates the significant and favorable impact of the recombinant HEV vaccine on the reduction of HEV cases. However, safety considerations are notable, as the vaccine is associated with a significant increase in injection-related pain and bruising. While localized adverse events were more frequent with the vaccine, there were no statistically significant differences in systemic events, serious adverse events, fever, or headache compared to placebo. These findings emphasize the overall effectiveness of the HEV vaccine in preventing HEV infections but highlight the need for careful monitoring and consideration of potential localized side ef","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"327-333"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis E vaccination: the promise of prevention.","authors":"Stevan A Gonzalez","doi":"10.1080/08998280.2025.2487362","DOIUrl":"https://doi.org/10.1080/08998280.2025.2487362","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"334-335"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparity in clinical and management outcomes in patients with pulmonary embolism: a systematic review and meta-analysis.","authors":"Ubaid Khan, Mohamed Abuelazm, Abdallah Saeed, Ahmed Abdelhalem, Ahmed Badawy, Majd M AlBarakat, Zaid Hatamleh, Mohamed R Abdelraouf, Muhammad Moiz Nasir, Hazem Rezq, Basel Abdelazeem","doi":"10.1080/08998280.2025.2475429","DOIUrl":"https://doi.org/10.1080/08998280.2025.2475429","url":null,"abstract":"<p><strong>Background: </strong>Gender may contribute significantly to the variation in prognostic aspects and outcomes in various clinical conditions. We reviewed original studies to determine the impact of gender on the clinical outcomes in patients with pulmonary embolism.</p><p><strong>Methods: </strong>A systematic review and meta-analysis synthesizing observational studies was conducted by systematically searching PubMed, Web of Science, SCOPUS, and Cochrane through April 12, 2023. We reported dichotomous outcomes using risk ratio (RR) and the corresponding 95% confidence interval (CI).</p><p><strong>Results: </strong>We included 18 studies with a total of 1,339,937 patients. There was no difference between men and women for all-cause mortality (RR: 0.99; 95% CI [0.89, 1.10]; <i>P</i> = 0.81), in-hospital mortality (RR: 0.94; 95% CI [0.88, 1.02]; <i>P</i> = 0.13), PE-related mortality (RR: 0.86; 95% CI [0.68, 1.09]; <i>P</i> = 0.21), and recurrence (RR: 1.00; 95% CI [0.82, 1.22]; <i>P</i> = 0.99). However, the major bleeding rate was significantly higher among women (RR: 0.69; 95% CI [0.48, 0.98]; <i>P</i> = 0.04), as was hospital length of stay (mean difference: -0.29; 95% CI: [-0.36, -0.22], <i>P</i> < 0.00001; I²= 96%). Also, there was no difference between men and women regarding catheter-directed thrombolysis (RR: 0.96; 95% CI [0.81, 1.14]; <i>P</i> = 0.66) and risk of heparin infusion (RR: 1.00; 95% CI [0.95, 1.04]; <i>P</i> = 0.90).</p><p><strong>Conclusion: </strong>There was no difference between men and women for the clinical outcomes and management of PE. However, women undergoing treatment for pulmonary thromboembolic disease had a significantly higher risk of major bleeding and longer length of stay compared to men. Further research is required to investigate the reasons behind these differences and assess their potential impact on patient management and prognosis.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"313-324"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Questions and answers following SEER database analysis of pulmonary typical carcinoids.","authors":"Catherine H Davis","doi":"10.1080/08998280.2025.2478761","DOIUrl":"https://doi.org/10.1080/08998280.2025.2478761","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"246"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>\"I wished I had caught that earlier\":</i> the timely diagnosis of AKI.","authors":"Samiya Yasin, Michael Wiederkehr","doi":"10.1080/08998280.2025.2478791","DOIUrl":"https://doi.org/10.1080/08998280.2025.2478791","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"272-273"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A closer look at gender disparities in patients with pulmonary embolism.","authors":"Claire Chen, Randall Rosenblatt","doi":"10.1080/08998280.2025.2475634","DOIUrl":"https://doi.org/10.1080/08998280.2025.2475634","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"325-326"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A balancing act: the promise and pitfalls of clinical decision support.","authors":"Jacob Minor, Kenneth Youens","doi":"10.1080/08998280.2025.2478758","DOIUrl":"https://doi.org/10.1080/08998280.2025.2478758","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"233-234"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient outcomes of rheumatoid arthritis in hospitalized patients using cannabis: data from the National Inpatient Sample.","authors":"Karun Shrestha, Prakriti Subedi, Anil Regmi, Manoj Ghimire, Sajana Poudel, Mahmoud Hashim, Mohammed Hasan, Clement Tagoe","doi":"10.1080/08998280.2025.2473863","DOIUrl":"https://doi.org/10.1080/08998280.2025.2473863","url":null,"abstract":"<p><strong>Background: </strong>Despite advancements in rheumatoid arthritis (RA) treatment, effective pain management remains challenging, with many patients also experiencing insomnia, anxiety, and depression. Cannabis, with its analgesic properties, offers a promising nonopioid alternative. This study evaluated outcomes in hospitalized RA patients using cannabis through the National Inpatient Sample (NIS) database.</p><p><strong>Methods: </strong>This retrospective study analyzed NIS data (2016-2021) using ICD-10 codes to identify RA patients. Demographic and clinical characteristics and inpatient outcomes were compared between cannabis users and nonusers.</p><p><strong>Results: </strong>RA patients using cannabis (n = 42,415) were younger (mean age 51.8 vs 67.8 years), less likely to be female (60.65% vs 73.71%), and more likely to be African American (24.02% vs 12.86%) and Native American (2.25% vs 0.86%). Cannabis use was associated with lower mortality (0.98% vs 2.71%) and hospital charges ($57,773 vs $63,681). After adjusting for age, gender, race, and comorbidities, cannabis use was linked to decreased mortality (odds ratio [OR]: 0.50), depression (OR: 0.47), chronic pain (OR: 0.45), and anxiety (OR: 0.55). Conversely, cannabis use increased the risk of opioid use (OR: 1.10), nicotine dependence (OR: 1.35), and alcohol use (OR: 1.35).</p><p><strong>Conclusion: </strong>RA patients using cannabis had lower mortality, depression, chronic pain, and anxiety, but higher risks of opioid, nicotine, and alcohol use. Further research is needed on the long-term effects of cannabis in RA management.</p>","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"259-264"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic neuroendocrine tumors: studying real-world outcomes.","authors":"Lucas Wong","doi":"10.1080/08998280.2025.2478756","DOIUrl":"https://doi.org/10.1080/08998280.2025.2478756","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"220"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis: an opioid alternative for pain management in rheumatic diseases?","authors":"Brooke Mills","doi":"10.1080/08998280.2025.2478762","DOIUrl":"https://doi.org/10.1080/08998280.2025.2478762","url":null,"abstract":"","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"38 3","pages":"265"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}