Baylor University Medical Center Proceedings最新文献_第10页

Ruptured hydrocele: a case report highlighting the diagnostic value of early MRI in acute scrotal pathology. 囊膜破裂：早期MRI对急性阴囊病理的诊断价值1例报告。

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-04-06 DOI: 10.1080/08998280.2026.2646040

Marissa N Rosa, Sara Vidovic, Stephanie E Harris, Marawan M El Tayeb

引用次数: 0

Bridging the gap between guidelines and practice: comparative effectiveness of ustekinumab and vedolizumab in Crohn's disease. 弥合指南和实践之间的差距：ustekinumab和vedolizumab在克罗恩病中的比较有效性

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-06-15 DOI: 10.1080/08998280.2026.2686024

Rajesh R Shah

引用次数: 0

Beyond comorbidity scores: medication burden as a window into surgical risk following ankle fracture fixation. 超越合并症评分：药物负担作为踝关节骨折固定手术风险的窗口。

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-06-30 DOI: 10.1080/08998280.2026.2690843

Kempland C Walley, Jacob R Zide

引用次数: 0

Correction. 修正。

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-07-27 DOI: 10.1080/08998280.2026.2706407

引用次数: 0

Clicks, credibility, and consequences: social media's impact on medical professionalism. 点击量、可信度和后果：社交媒体对医疗专业的影响。

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-05-08 DOI: 10.1080/08998280.2026.2665056

Thomas Cox, Cristie Columbus, Julie Higginbotham, Emily Reynolds, Megan Crowe

引用次数: 0

Venous thromboembolic events in traumatic brain injury. Does timing of prophylaxis matter? A single-center retrospective cohort study. 外伤性脑损伤中的静脉血栓栓塞事件。预防的时机重要吗？单中心回顾性队列研究。

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-06-03 DOI: 10.1080/08998280.2026.2677108

Nicholas Hernandez, Avery Christensen, Marissa Shumaker, Colby McClaugherty, Asad Danka, Michael P Hofkamp, Awais Z Vance

{"title":"Venous thromboembolic events in traumatic brain injury. Does timing of prophylaxis matter? A single-center retrospective cohort study.","authors":"Nicholas Hernandez, Avery Christensen, Marissa Shumaker, Colby McClaugherty, Asad Danka, Michael P Hofkamp, Awais Z Vance","doi":"10.1080/08998280.2026.2677108","DOIUrl":"10.1080/08998280.2026.2677108","url":null,"abstract":"Background: Patients with traumatic brain injury (TBI) are at increased risk for venous thromboembolism (VTE) due to immobilization and a hypercoagulable state. The administration and optimal timing for chemoprophylaxis remain unclear because of concerns about safety and efficacy.Methods: We conducted a retrospective review of adult patients admitted with TBI to a level I trauma center between January 2019 and May 2020. Patient demographics, Glasgow Coma Scale, mobility score, mechanism of injury, comorbidities, timing of chemoprophylaxis and physical therapy, VTE events, and intracranial hemorrhage complications were analyzed. Multivariate logistic regression was performed to identify predictors of VTE.Results: Among 405 patients, 161 received chemoprophylaxis. Eight patients experienced VTE. Receipt of prophylaxis in ≤48 hours was not associated with reduced VTE risk (P = 0.81). However, a 5-point increase in admission mobility score was independently associated with an 84% lower risk of VTE (P = 0.02). Intracranial hemorrhage expansion occurred in 25 patients, with no significant difference between those who did and did not receive prophylaxis.Discussion: Higher admission mobility scores predict lower VTE risk in TBI. Early prophylaxis timing was not statistically associated with VTE. These findings underscore the need for prospective studies to determine safe and effective chemoprophylaxis strategies.","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":" ","pages":"809-813"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of polypharmacy and medication class diversity with postoperative complications following operative ankle fracture repair. 踝关节骨折手术修复术后并发症与多种药物及药物种类的关系。

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-06-08 DOI: 10.1080/08998280.2026.2676479

Isaac Edwards, Thane Thomas, Cameron Miller, Bryce L Palmer, Jenny Hudnall, Jerry S Grimes

{"title":"Association of polypharmacy and medication class diversity with postoperative complications following operative ankle fracture repair.","authors":"Isaac Edwards, Thane Thomas, Cameron Miller, Bryce L Palmer, Jenny Hudnall, Jerry S Grimes","doi":"10.1080/08998280.2026.2676479","DOIUrl":"10.1080/08998280.2026.2676479","url":null,"abstract":"Background: Polypharmacy is increasingly common and may influence outcomes following orthopedic trauma. While specific medication classes have been associated with complications in arthroplasty and spine surgery, the role of total preoperative medication count in ankle trauma remains unclear. This study evaluated whether polypharmacy and medication class diversity were independently associated with postoperative complications after operative ankle fracture repair.Methods: A retrospective cohort study included 178 adult patients who underwent operative fixation of ankle fractures at a single academic medical center. Preoperative medication burden was assessed using total outpatient medication count and medication class diversity. Postoperative outcomes included deep vein thrombosis (DVT), surgical site infection, nonunion, malunion, and surgical revision. Multivariable logistic regression models were constructed for each medication exposure, adjusting for age, sex, Charlson Comorbidity Index, American Society of Anesthesiologists class, and smoking status.Results: Polypharmacy was independently associated with postoperative DVT (P = 0.008). Greater medication class diversity was associated with DVT (P = 0.006), infection (P = 0.002), and surgical revision (P = 0.021). Associations with nonunion and malunion were not significant.Conclusions: Preoperative medication burden may be associated with postoperative complications after ankle fracture repair. Medication class diversity shows broader associative utility and may serve as a useful adjunct to risk stratification.","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":" ","pages":"771-775"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical immune dysfunction in G6PD deficiency: a case of mosaic neutrophil oxidative burst. G6PD缺乏症的非典型免疫功能障碍：花叶性中性粒细胞氧化破裂1例。

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-04-01 DOI: 10.1080/08998280.2026.2651618

Henry Pham, Srividya Sridhara

{"title":"Atypical immune dysfunction in G6PD deficiency: a case of mosaic neutrophil oxidative burst.","authors":"Henry Pham, Srividya Sridhara","doi":"10.1080/08998280.2026.2651618","DOIUrl":"10.1080/08998280.2026.2651618","url":null,"abstract":"Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder typically causing hemolysis from oxidative damage, but severe variants can impair phagocyte function. While low levels of neutrophil activity are usually sufficient, the interplay of cis-acting regulatory elements and variable X-inactivation can lead to atypical clinical presentations. We present the case of a 50-year-old woman with recurrent infections including multiple pneumonias, a pertinent history that includes splenectomy, and genetic tests revealing c.202G > A and c.376A > G variants consistent with G6PD deficiency. G6PD activity in red blood cells was at 2.6 U/g Hb, corresponding to an enzyme activity level of 30% or less, previously classified as class III by the World Health Organization. Neutrophil oxidative burst assay showed a mosaic pattern, indicating both normal and abnormal granulocyte fluorescence. This case highlights that a dihydrorhodamine reduction in G6PD-mutated cells can be mosaic and can mimic X-linked chronic granulomatous disease patterns and that lyonization ratios can vary between hematopoietic lineages, with a potential for clinically relevant neutrophil dysfunction.","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"39 5","pages":"909-911"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148824321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute-onset autoimmune type 1 diabetes presenting with diabetic ketoacidosis in an obese adult. 1例肥胖成人出现糖尿病酮症酸中毒的急性发作自身免疫性1型糖尿病

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-04-20 DOI: 10.1080/08998280.2026.2657125

David Kweku Aseda Donkor, Venkata Siva Dilisha Chandanala, Toluwalase Akinfisoye, Parth Adrejiya, Adanech Gichamo

{"title":"Acute-onset autoimmune type 1 diabetes presenting with diabetic ketoacidosis in an obese adult.","authors":"David Kweku Aseda Donkor, Venkata Siva Dilisha Chandanala, Toluwalase Akinfisoye, Parth Adrejiya, Adanech Gichamo","doi":"10.1080/08998280.2026.2657125","DOIUrl":"10.1080/08998280.2026.2657125","url":null,"abstract":"Autoimmune type 1 diabetes mellitus (T1DM) has traditionally been associated with early onset disease and a lean phenotype; however, adult-onset disease increasingly presents with heterogeneous features that overlap with type 2 diabetes. We describe a 51-year-old obese man presenting with severe diabetic ketoacidosis (DKA). Laboratory evaluation demonstrated marked hyperglycemia (1297 mg/dL), metabolic acidosis (bicarbonate 7 mmol/L, anion gap 42), β-hydroxybutyrate >9 mmol/L, and hemoglobin A1c 13.3%. Autoimmune testing revealed strong glutamic acid decarboxylase antibody positivity with very low C-peptide, confirming profound insulin deficiency despite obesity. The patient improved with standard DKA management and was discharged on basal bolus insulin therapy. This case highlights the evolving phenotype of adult-onset autoimmune diabetes and emphasizes that obesity does not exclude T1DM. Early recognition using antibody testing and assessment of endogenous insulin secretion is essential to guide therapy and reduce recurrent metabolic decompensation.","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"39 5","pages":"905-908"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148824062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of durvalumab with or without tremelimumab in the treatment of metastatic non-small cell lung cancer: a meta-analysis of randomized controlled trials. durvalumab联合或不联合tremelimumab治疗转移性非小细胞肺癌的疗效和安全性：随机对照试验的荟萃分析

Baylor University Medical Center Proceedings Pub Date : 2026-09-01 Epub Date: 2026-05-29 DOI: 10.1080/08998280.2026.2673660

Ursula Medeiros Araujo de Matos, Moana Divina da Silva Santiago, Henrique Guimaraes Barbosa Coelho, Fatih Kaner, Nathaniel Robinson

{"title":"Efficacy and safety of durvalumab with or without tremelimumab in the treatment of metastatic non-small cell lung cancer: a meta-analysis of randomized controlled trials.","authors":"Ursula Medeiros Araujo de Matos, Moana Divina da Silva Santiago, Henrique Guimaraes Barbosa Coelho, Fatih Kaner, Nathaniel Robinson","doi":"10.1080/08998280.2026.2673660","DOIUrl":"10.1080/08998280.2026.2673660","url":null,"abstract":"Background: The therapeutic role of combining PD-L1 and CTLA-4 blockade in metastatic non-small cell lung cancer (NSCLC) remains unclear, with individual trials yielding discrepant results.Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and safety of durvalumab with or without tremelimumab in advanced NSCLC. The primary outcome was overall survival. Secondary outcomes included immune-related adverse events. Hazard ratios (HRs) and odds ratios with 95% confidence intervals (CIs) were pooled using random- or fixed-effects models according to heterogeneity.Results: Three RCTs (MYSTIC, ARCTIC, and POSEIDON) enrolling 2726 patients met inclusion criteria. Combined analysis showed no significant overall survival benefit with durvalumab plus tremelimumab compared to durvalumab alone (HR 0.97; 95% CI, 0.74-1.27). Pooled analysis of immune-related adverse events demonstrated significantly higher risks in the tremelimumab-containing arms.Conclusions: In metastatic NSCLC, the addition of tremelimumab to durvalumab does not confer a statistically significant overall survival advantage in unselected populations and is associated with a marked increase in immune-mediated toxicities. Benefits may be restricted to biomarker-defined subgroups, but these findings remain exploratory. Further prospective studies are needed to clarify the optimal role of CTLA-4 blockade in combination immunotherapy.","PeriodicalId":8828,"journal":{"name":"Baylor University Medical Center Proceedings","volume":"39 5","pages":"850-855"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148824357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0