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Beilstein Journal of Organic Chemistry最新文献

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Salen-scandium(III) complex-catalyzed asymmetric (3 + 2) annulation of aziridines and aldehydes. salen -钪（III）配合物催化氮嘧啶和醛的不对称（3 + 2）环化。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.86
Linqiang Wang, Jiaxi Xu
{"title":"Salen-scandium(III) complex-catalyzed asymmetric (3 + 2) annulation of aziridines and aldehydes.","authors":"Linqiang Wang, Jiaxi Xu","doi":"10.3762/bjoc.21.86","DOIUrl":"10.3762/bjoc.21.86","url":null,"abstract":"<p><p>Oxazolidine is one of the crucial structural moieties of biologically active compounds. A salen-scandium triflate complex-catalyzed asymmetric (3 + 2) annulation of dialkyl 1-sulfonylaziridine-2,2-dicarboxylates and aldehydes generated optically active functionalized oxazolidine derivatives in moderate to good yields and good to excellent enantioselectivities and high diastereoselectivities. A reasonable reaction mechanism was proposed and rationalized the experimental results.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"1087-1094"},"PeriodicalIF":2.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in synthetic approaches for bioactive cinnamic acid derivatives. 生物活性肉桂酸衍生物合成方法的最新进展。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.85
Betty A Kustiana, Galuh Widiyarti, Teni Ernawati
{"title":"Recent advances in synthetic approaches for bioactive cinnamic acid derivatives.","authors":"Betty A Kustiana, Galuh Widiyarti, Teni Ernawati","doi":"10.3762/bjoc.21.85","DOIUrl":"10.3762/bjoc.21.85","url":null,"abstract":"<p><p>Cinnamic acid derivatives represent a significant class of biologically active compounds exhibiting a broad spectrum of activities, such as antifungal, antidengue, antimetastatic, antimicrobial, antibacterial, and anticancer properties. Their preparation has attracted considerable attention due to their versatile applications across the pharmaceutical, food, and chemical sectors. This review elucidates the functional groups of cinnamic acid that are instrumental in the rational design of biologically active derivatives. A comprehensive representative of recent advancements in synthetic methodologies over the past five years is presented, particularly emphasizing the active scaffolds of bioactive cinnamic acid derivatives. The review provides a strategic overview of alternative synthetic routes and highlights the latest innovations, including more efficient, highly selective, and environmentally sustainable approaches. Given the widespread incorporation of the cinnamic acid framework in various therapeutic agents, this review delivers critical insights into a molecular design for hit-to-lead optimization, offering detailed synthetic strategies for diverse functional modifications. By critically examining these methodologies, the paper underscores their role in expanding the utility of cinnamic acid derivatives and addressing prevailing challenges.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"1031-1086"},"PeriodicalIF":2.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biobased carbon dots as photoreductants - an investigation by using triarylsulfonium salts. 生物基碳点作为光还原剂——用三芳基磺酸盐的研究。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.84
Valentina Benazzi, Arianna Bini, Ilaria Bertuol, Mariangela Novello, Federica Baldi, Matteo Hoch, Alvise Perosa, Stefano Protti
{"title":"Biobased carbon dots as photoreductants - an investigation by using triarylsulfonium salts.","authors":"Valentina Benazzi, Arianna Bini, Ilaria Bertuol, Mariangela Novello, Federica Baldi, Matteo Hoch, Alvise Perosa, Stefano Protti","doi":"10.3762/bjoc.21.84","DOIUrl":"10.3762/bjoc.21.84","url":null,"abstract":"<p><p>We investigated the potential application of six types of carbon dots (CDs) obtained from different organic sources as photoreductants. Such carbon nanomaterials were synthesized by two different approaches, either hydrothermal or pyrolytic, from citric acid and glucose as the starting organic substrates. On the other hand, carbon dots deriving from fishery waste (bass scales) and fruit processing waste (blackberries) have been also prepared. Diethylenetriamine was employed in some cases as the nitrogen source. The hydrothermal syntheses yielded amorphous CDs, which were either non-doped (a-CDs) or nitrogen-doped (a-N-CDs), whereas the pyrolytic treatment afforded graphitic CDs (g-CDs). The efficiency of the so obtained carbon nanomaterials was studied in the model photoreduction reaction of triarylsulfonium salts to diaryl sulfides. A comparison carried out on the results obtained points out the key role of the starting substrates in determining the photophysics and the photochemical efficiency of the resulting CDs. In this context, citric acid-derived materials (both graphitic and amorphous) were found as the most promising materials, while less satisfactory results have been observed when using CDs derived from glucose and biowastes.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"1024-1030"},"PeriodicalIF":2.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pd-Catalyzed asymmetric allylic amination with isatin using a P,olefin-type chiral ligand with C-N bond axial chirality. 用具有C-N键轴向手性的P -烯烃型手性配体催化与isatin的不对称烯丙基胺化反应。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-23 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.83
Natsume Akimoto, Kaho Takaya, Yoshio Kasashima, Kohei Watanabe, Yasushi Yoshida, Takashi Mino
{"title":"Pd-Catalyzed asymmetric allylic amination with isatin using a P,olefin-type chiral ligand with C-N bond axial chirality.","authors":"Natsume Akimoto, Kaho Takaya, Yoshio Kasashima, Kohei Watanabe, Yasushi Yoshida, Takashi Mino","doi":"10.3762/bjoc.21.83","DOIUrl":"10.3762/bjoc.21.83","url":null,"abstract":"<p><p>In this study, we implemented the P,olefin-type chiral ligand (a<i>R</i>)-(-)-<b>6</b>, which contains a cyclohexyl group and a cinnamoyl group on the nitrogen atom, in the Pd-catalyzed asymmetric allylic amination of allylic esters with isatin derivatives <b>11</b> as nucleophiles. The reaction proceeds efficiently, yielding the products (<i>S</i>)-<b>13</b> with good-to-high enantioselectivity. A scale-up reaction was also successfully conducted at a 1 mmol scale. Additionally, when malononitrile was added to the resulting product (<i>S</i>)-<b>13a</b> in the presence of FeCl<sub>3</sub> as the catalyst, the corresponding malononitrile derivative (<i>S</i>)-<b>16</b> was obtained without any loss in optical purity.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"1018-1023"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of pyrrolo[3,2-d]pyrimidine-2,4(3H)-diones by domino C-N coupling/hydroamination reactions. 用多米诺C-N偶联/氢胺化反应合成吡咯[3,2-d]嘧啶-2,4(3H)-二酮
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.82
Ruben Manuel Figueira de Abreu, Robin Tiedemann, Peter Ehlers, Peter Langer
{"title":"Synthesis of pyrrolo[3,2-<i>d</i>]pyrimidine-2,4(3<i>H</i>)-diones by domino C-N coupling/hydroamination reactions.","authors":"Ruben Manuel Figueira de Abreu, Robin Tiedemann, Peter Ehlers, Peter Langer","doi":"10.3762/bjoc.21.82","DOIUrl":"10.3762/bjoc.21.82","url":null,"abstract":"<p><p>A variety of pyrrolo[3,2-<i>d</i>]pyrimidine-2,4(3<i>H</i>)-diones were prepared by a combination of Sonogashira reaction and subsequent cyclization by domino C-N coupling/hydroamination reaction. The optical properties (UV-vis absorption and fluorescence) depend on the substitution pattern of the compounds.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"1010-1017"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent total synthesis of natural products leveraging a strategy of enamide cyclization. 最近利用酰胺环化策略的天然产物的全合成。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.81
Chun-Yu Mi, Jia-Yuan Zhai, Xiao-Ming Zhang
{"title":"Recent total synthesis of natural products leveraging a strategy of enamide cyclization.","authors":"Chun-Yu Mi, Jia-Yuan Zhai, Xiao-Ming Zhang","doi":"10.3762/bjoc.21.81","DOIUrl":"10.3762/bjoc.21.81","url":null,"abstract":"<p><p>Enamides are distinctive amphiphilic synthons that can be strategically incorporated into cyclization reactions. The iminium species generated from enamides via nucleophilic addition or substitution are capable of engaging in further electrophilic additions or isomerization processes. Exploiting the multiple reactivities of enamides facilitates the development of diverse cyclization modes that provide entries to various <i>N</i>-heterocycles, some of which serve as key structural motifs in natural alkaloids. This review highlights recent advancements in enamide-based cyclization reactions, including enamide-alkyne cycloisomerization, [3 + 2] annulation, and polycyclization, with a particular emphasis on their pivotal role as a strategy in the total synthesis of natural products.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"999-1009"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the photoluminescence in triarylmethyl-centered mono-, di-, and multiradicals. 三芳基甲基中心单自由基、二自由基和多自由基的光致发光研究。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-21 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.80
Daniel Straub, Markus Gross, Mona E Arnold, Julia Zolg, Alexander J C Kuehne
{"title":"On the photoluminescence in triarylmethyl-centered mono-, di-, and multiradicals.","authors":"Daniel Straub, Markus Gross, Mona E Arnold, Julia Zolg, Alexander J C Kuehne","doi":"10.3762/bjoc.21.80","DOIUrl":"10.3762/bjoc.21.80","url":null,"abstract":"<p><p>Organic radicals with light-emitting properties and exceptional stability offer exciting opportunities to address spin-statistical limitations in organic electronics and advance quantum technologies. These radicals, acting as small molecular magnets, exhibit sensitivity to minute magnetic fields and can be tailored with diverse spin centers, making them ideal for spin-optical interfaces, representing key components in quantum communication systems. Furthermore, their ability to form organized, higher-dimensional assemblies presents a promising avenue for overcoming scalability challenges in quantum technologies. Despite their potential, achieving high luminescence quantum yields has largely been limited to donor-functionalized monoradicals, and a detailed understanding of the luminescent behavior of open-shell organic molecules remains elusive. This review delves into the photoluminescent properties and spin ground states of trityl-based mono-, di-, and multiradicals, examining the strategies employed to enhance their performance. Additionally, we review predictive methods for determining the luminescence and spin states of radicals, highlighting critical unresolved questions that must be addressed to unlock the full potential of trityl-based radicals in advanced technological applications.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"964-998"},"PeriodicalIF":2.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline. β-碳碱类生物碱灯盏花碱和灯盏花碱的合成研究。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.79
Benedek Batizi, Patrik Pollák, András Dancsó, Péter Keglevich, Gyula Simig, Balázs Volk, Mátyás Milen
{"title":"Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline.","authors":"Benedek Batizi, Patrik Pollák, András Dancsó, Péter Keglevich, Gyula Simig, Balázs Volk, Mátyás Milen","doi":"10.3762/bjoc.21.79","DOIUrl":"10.3762/bjoc.21.79","url":null,"abstract":"<p><p>A new total synthesis of the β-carboline alkaloid brevicarine is disclosed. The synthesis was carried out starting from an aromatic triflate key intermediate, allowing the introduction of various substituents into position 4 of β-carboline by cross-coupling reactions. Thanks to its scalability, this novel approach ensures a broad accessibility to the target compound for potential pharmacological measurements. Using detailed NMR studies, the NMR signals have been assigned for both the base and its dihydrochloride salt for further confirming their structures. A new synthesis of the related alkaloid brevicolline was also attempted from the same intermediate. However, after successful coupling of β-carboline with <i>N</i>-methylpyrrole, the trials to saturate the pyrrole ring under various conditions led to unexpected reactions: reduction of ring A of the β-carboline skeleton or trifluoroethylation of the pyrrole moiety occurred, leading to interesting and potentially useful derivatives.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"955-963"},"PeriodicalIF":2.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing tethered nitreniums for diastereoselective amino-sulfonoxylation of alkenes. 利用系留硝基进行烯烃非对映选择性氨基磺酰化。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.78
Shyam Sathyamoorthi, Appasaheb K Nirpal, Dnyaneshwar A Gorve, Steven P Kelley
{"title":"Harnessing tethered nitreniums for diastereoselective amino-sulfonoxylation of alkenes.","authors":"Shyam Sathyamoorthi, Appasaheb K Nirpal, Dnyaneshwar A Gorve, Steven P Kelley","doi":"10.3762/bjoc.21.78","DOIUrl":"10.3762/bjoc.21.78","url":null,"abstract":"<p><p>We present the first examples of alkene amino-sulfonoxylation reactions that leverage the unique reactivity of carbamate tethered <i>N</i>-alkoxy nitrenium ions. In almost all cases examined, the reactions deliver product with exquisite regioselectivity and diastereoselectivity. The protocols followed are operationally very simple and only use commercial I(III) reagents and sulfonic acids, amounting to a metal-free protocol for alkene amino-oxygenation. No special precautions need be taken to exclude air or ambient moisture, and the products are amenable to further transformations.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"947-954"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern radical chemistry. 现代自由基化学。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.3762/bjoc.21.77
Huan-Ming Huang
{"title":"Modern radical chemistry.","authors":"Huan-Ming Huang","doi":"10.3762/bjoc.21.77","DOIUrl":"10.3762/bjoc.21.77","url":null,"abstract":"","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"21 ","pages":"945-946"},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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