Beilstein Journal of Organic Chemistry最新文献

Continuous-flow carbonyl hydrogenation under subatmospheric to atmospheric hydrogen pressure enabled by robust heterogeneous Pt-Fe catalysts. 坚固的非均相Pt-Fe催化剂实现了亚常压到常压下连续流动羰基加氢。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-04-10 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.43

Hiroyuki Miyamura, Ryosuke Kajiyama, Shun-Ya Onozawa, Yoshihiro Kon, Shū Kobayashi

引用次数: 0

Kinetic resolution of racemic planar-chiral vinylcymantrenes by molybdenum-catalyzed asymmetric metathesis dimerization. 钼催化不对称复合二聚化对外消旋平面手性乙烯基氰烯的动力学拆分。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-31 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.42

Haruna Imazu, Hitoshi Izu, Yasuhiro Ohki, Masamichi Ogasawara

引用次数: 0

Molecular tweezer-peptide conjugates disrupt the protein-protein interaction between survivin and histone H3 essential in mitosis. 分子镊子-肽偶联物破坏有丝分裂中必需的survivin和组蛋白H3之间的蛋白质相互作用。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-27 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.41

Catherine Gsell, Philipp Rebmann, Karina Opara, Christine Beuck, Peter Bayer, David Bier, Ingrid R Vetter, Thomas Schrader

{"title":"Molecular tweezer-peptide conjugates disrupt the protein-protein interaction between survivin and histone H3 essential in mitosis.","authors":"Catherine Gsell, Philipp Rebmann, Karina Opara, Christine Beuck, Peter Bayer, David Bier, Ingrid R Vetter, Thomas Schrader","doi":"10.3762/bjoc.22.41","DOIUrl":"https://doi.org/10.3762/bjoc.22.41","url":null,"abstract":"Peptide-modified supramolecular tweezers, a promising new class of chemical tools, were designed and employed to inhibit the interaction of the BIR domain of human survivin, a member of the chromosomal passenger complex (CPC), with the phosphorylated histone H3 N-terminal peptide. Fluorescence polarization measurements revealed a nanomolar affinity of the BIR domain for the peptide-tweezer, depending on the presence of lysine residue 121, as proven by the K121A mutant of survivin. Two crystal structures of C-terminally truncated human survivin with the peptide-tweezer molecules demonstrated that the peptide moiety binds the BIR domain as expected from the well-known published crystal structures of survivin with various peptides, but the tweezer itself, surprisingly, was bound to a putative Ca2+ ion and the side chain of Pro26, corresponding to a previously unknown binding mode. Guided by the accessibility of survivin's lysine residues in the CPC, a number of new promising peptide tweezers was synthesized, able to connect both binding sites on the protein.","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"557-567"},"PeriodicalIF":2.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and DFT studies on the regioselective methanolysis of 5-azido-9-oxabicyclo[6.1.0]nonan-4-yl 4-nitrobenzoate isomers. 5-叠氮-9-恶沙环[6.1.0]壬胺-4-酰基4-硝基苯甲酸异构体区域选择性甲醇分解的实验和DFT研究。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-26 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.40

İlknur Polat, Selçuk Eşsiz, Emine Salamci

引用次数: 0

Melifoliox B, a novel phloroglucin derivative isolated from Melicope barbigera (Rutaceae) and synthesis of new oxidation products from melifoliones A and B. 从芸香科百合花中分离得到一种新的间苯绿素衍生物Melifoliox B，并合成了新的氧化产物。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-24 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.39

Horst Weber, Kim-Thao Tran-Cong, Bernhard Mayer, Guido J Reiss, Iryna S Konovalova, Marc S Appelhans, Kenneth R Wood, Claus M Passreiter

{"title":"Melifoliox B, a novel phloroglucin derivative isolated from Melicope barbigera (Rutaceae) and synthesis of new oxidation products from melifoliones A and B.","authors":"Horst Weber, Kim-Thao Tran-Cong, Bernhard Mayer, Guido J Reiss, Iryna S Konovalova, Marc S Appelhans, Kenneth R Wood, Claus M Passreiter","doi":"10.3762/bjoc.22.39","DOIUrl":"https://doi.org/10.3762/bjoc.22.39","url":null,"abstract":"In addition to new acetophenones and 2H-chromenes, the dichlormethane extract from leaves of Melicope barbigera A. Gray (Rutaceae) afforded a mixture of the isomeric melifoliones A (1) and B (2) as well as an oxidation product of 2, whose structure was elucidated as the para-quinol 4. For an independent synthesis of 4 and its possible isomer 3, the required compounds 1 and 2 were synthesized as a mixture of the isomers starting from chromene 5, briefly heated in a closed microwave apparatus with catalytic amounts of acetic acid. Forced heating of 5 in acetic acid or use of stronger acids lead to the benzoxocin derivatives 6 and 7. Oxidation of melifoliones 1 and 2 under a great variety of oxidants and conditions failed to give 3 and 4. Iodine-containing oxidants yielded the products 8, 9, and 10. Combined oxidation with hydrogen peroxide and ferricyanide in alkaline solution resulted in an unexpected contraction of the acetyl phenol to a furanone ring, forming the derivatives 11 and 12, whose structures were confirmed by X-ray analysis. A hypothetical mechanism for the oxidative ring contraction is proposed. 11 and 12 are the first representatives of new heterocyclic ring systems that have not previously been described in the literature.","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"535-546"},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Get a better glimpse on sequential photoreactions of trisnorbornadienes with ¹⁹F NMR spectroscopy. 用19F核磁共振光谱学更好地观察三降冰片二烯的顺序光反应。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-23 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.38

Julian Felix Maria Hebborn, Ben Eric Merten, Thomas Paululat, Heiko Ihmels

{"title":"Get a better glimpse on sequential photoreactions of trisnorbornadienes with 19F NMR spectroscopy.","authors":"Julian Felix Maria Hebborn, Ben Eric Merten, Thomas Paululat, Heiko Ihmels","doi":"10.3762/bjoc.22.38","DOIUrl":"https://doi.org/10.3762/bjoc.22.38","url":null,"abstract":"It is shown exemplarily with a trifluorinated trisnorbornadienylbenzene that 19F NMR spectroscopy may be applied as a useful complementary method for the investigation of sequential photoreactions. The trisnorbornadiene core structure was used as it figures as promising scaffold for molecular solar thermal (MOST) energy storage. The target compound was readily synthesized by a Suzuki-Miyaura coupling reaction and examined with respect to the key properties for MOST applications. Upon direct or photosensitized irradiation, the trisnorbornadiene was transformed stepwise and almost quantitatively into the corresponding trisquadricyclane. Even though the reaction can be monitored by photometry or by in situ 1H NMR spectroscopy, unambiguous assignment of the distinct intermediate mono- and bisquadricyclanes was not possible because of signal overlap. In contrast, this shortcoming is circumvented with in situ 19F NMR-spectroscopic analysis. Contrary to the 1H NMR spectra, the 19F NMR spectra show significantly fewer characteristic and sufficiently separated signals that allow the unambiguous identification of all photoproducts and, thus, their detection in the course of the photoreaction.","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"527-534"},"PeriodicalIF":2.1,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modern synthetic pathways towards eribulin and its subunits. 现代合成阿瑞布林及其亚基的途径。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-19 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.37

Sebastian Dominik Graf

引用次数: 0

Synthesis and uranyl(VI) extraction performance of a calix[4]pyrrole-tetrahydroxamic acid receptor. 杯状[4]吡咯-四羟肟酸受体的合成及其铀酰（VI）萃取性能

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-18 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.36

Sara Karnib, Rana Baydoun, Wissam Zaidan, Nancy AlHaddad, Omar El Samad, Bilal Nsouli, Francine Cazier-Dennin, Pierre-Edouard Danjou

{"title":"Synthesis and uranyl(VI) extraction performance of a calix[4]pyrrole-tetrahydroxamic acid receptor.","authors":"Sara Karnib, Rana Baydoun, Wissam Zaidan, Nancy AlHaddad, Omar El Samad, Bilal Nsouli, Francine Cazier-Dennin, Pierre-Edouard Danjou","doi":"10.3762/bjoc.22.36","DOIUrl":"10.3762/bjoc.22.36","url":null,"abstract":"The contamination of water by uranium poses a serious threat to ecosystems and human health, creating a need for efficient and selective remediation strategies. Supramolecular materials, with their pre-organized structures, offer a promising route for uranium removal. Phenoxycalix[4]pyrroles (PCP) are well-known supramolecular scaffolds capable of selective metal binding, making them attractive candidates for designing uranium extractants. Here, we report the design and synthesis of PCP HA, a phenoxycalix[4]pyrrole scaffold functionalized with four hydroxamic acid (HA) groups, and evaluate its uranium(VI) extraction potential. PCP HA was synthesized from its ester precursor (PCP E) via hydroxyaminolysis using KOH, achieving a 95% yield. Its structure was confirmed by 1H NMR, 13C NMR, and HRMS. The uranium(VI) extraction efficiency of PCP HA was evaluated by solid-liquid extraction experiments, using uranyl acetate as the uranium source, with measurements performed by gamma spectroscopy. PCP HA demonstrated good performance, removing up to 95% of uranyl(VI) from aqueous solutions (1 mM) at acidic pH, likely due to the strong coordination provided by its hydroxamic acid groups. Further studies revealed that the extraction efficiency also depends on the ligand-to-metal molar ratio. These findings establish PCP HA as a promising supramolecular material for the removal of uranyl from aqueous media.","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"486-494"},"PeriodicalIF":2.1,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of a HDAC inhibitor-nanogold probe for cryo-EM visualization in class I HDAC co-repressor complexes. HDAC抑制剂-纳米金探针的合成及其在HDAC辅助抑制物中的低温电镜可视化研究。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-17 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.35

Wiktoria A Pytel, John W R Schwabe, James T Hodgkinson

引用次数: 0

Recent advances in the stereoselective synthesis of distal biaxially chiral molecules. 远端双轴手性分子的立体选择性合成研究进展。

IF 2.1 4区化学

Beilstein Journal of Organic Chemistry Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.34

Fanxing Zhou, Chen Zhang, Lingyu Sun, Yiyun Fang, Siming Zheng, Lina Hu, Mengyang Shen, Zhen Zhao, Wei Xu, Yunqiang Sun, Zi-Qiang Rong

引用次数: 0