天然产物合成中前手性1,3-二醇的对映选择性去对称策略。

IF 2.1 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-09-18 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.151

Lihua Wei, Rui Yang, Zhifeng Shi, Zhiqiang Ma

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引用次数: 0

摘要

对映选择性去对称是产生手性中心的有力工具。在此范围内，通过一个羟基的对映选择性功能化产生手性中心的前手性1,3-二醇的对映选择性去对称为获取不同的结构基序提供了有益的过程。在这篇综述中，我们重点介绍了前手性1,3-二醇的对映选择性去对称在天然产物和生物活性分子合成中的应用。根据反应类型，讨论了三种策略：酶促酰化、过渡金属催化酰化和局部去对称。

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Enantioselective desymmetrization strategy of prochiral 1,3-diols in natural product synthesis.

Enantioselective desymmetrization is employed as a powerful tool for the creation of chiral centers. Within this scope, the enantioselective desymmetrization of prochiral 1,3-diols, which generates chiral centers by enantioselective functionalization of one hydroxy group, offers beneficial procedures for accessing diverse structural motifs. In this review, we highlight a curated compilation of publications, focusing on the applications of enantioselective desymmetrization of prochiral 1,3-diols in the synthesis of natural products and biologically active molecules. Based on the reaction types, three strategies are discussed: enzymatic acylation, transition-metal-catalyzed acylation, and local desymmetrization.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.