Salen-scandium(III) complex-catalyzed asymmetric (3 + 2) annulation of aziridines and aldehydes.

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.86

Linqiang Wang, Jiaxi Xu

引用次数: 0

Abstract

Oxazolidine is one of the crucial structural moieties of biologically active compounds. A salen-scandium triflate complex-catalyzed asymmetric (3 + 2) annulation of dialkyl 1-sulfonylaziridine-2,2-dicarboxylates and aldehydes generated optically active functionalized oxazolidine derivatives in moderate to good yields and good to excellent enantioselectivities and high diastereoselectivities. A reasonable reaction mechanism was proposed and rationalized the experimental results.

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salen -钪（III）配合物催化氮嘧啶和醛的不对称（3 + 2）环化。

恶唑烷是生物活性化合物的重要结构成分之一。在salen三氟化钪络合物催化下，二烷基1-磺酰基氮基吡啶-2,2-二羧酸酯和醛的不对称（3 + 2）环反应生成了具有光学活性的功能化恶唑烷衍生物，收率中至高，对映选择性好至优异，非对映选择性高。提出了合理的反应机理，并对实验结果进行了合理化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

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