Artificial Cells, Nanomedicine, and Biotechnology最新文献_第8页

Correction. 修正。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/21691401.2025.2473244

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Retraction Statement: Abnormal expression of long noncoding RNA FGD5-AS1 affects the development of periodontitis through regulating miR-142-3p/SOCS6/NF-κB pathway. 撤回声明：长链非编码RNA FGD5-AS1的异常表达通过调控miR-142-3p/SOCS6/NF-κB通路影响牙周炎的发生。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1080/21691401.2025.2575232

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Investigating the anticancer and synergistic effects of the combination of green synthesized silver nanoparticles and papaverine on breast cancer cell lines: focusing on the apoptosis pathway and microRNA regulation. 研究绿色合成纳米银与罂粟碱联合对乳腺癌细胞株的抗癌和协同作用：重点研究凋亡途径和microRNA调控。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-06-01 DOI: 10.1080/21691401.2025.2507372

Maryam Fekri Soufiabadi, Reza Haji Hosseini, Zolfaghar Lotfi

{"title":"Investigating the anticancer and synergistic effects of the combination of green synthesized silver nanoparticles and papaverine on breast cancer cell lines: focusing on the apoptosis pathway and microRNA regulation.","authors":"Maryam Fekri Soufiabadi, Reza Haji Hosseini, Zolfaghar Lotfi","doi":"10.1080/21691401.2025.2507372","DOIUrl":"https://doi.org/10.1080/21691401.2025.2507372","url":null,"abstract":"The study investigates the anticancer effects of green silver nanoparticles (Ag-NPs) synthesized from Viola cornuta extract combined with papaverine on breast cancer cells. Ag-NPs were characterized using various analytical techniques, confirming their presence with UV-vis spectroscopy showing a peak at 413 nm and an average size of 42 nm via field emission scanning electron microscopy (FE-SEM) analysis. The particles demonstrated a face-centred cubic structure, with energy-dispersive X-ray spectroscopy (EDX) confirming elemental composition. Additionally, the zeta potential measurement of -6.75 mV indicated favourable electrostatic repulsion between nanoparticles, thereby confirming their stability. Antioxidant activity was significant, with an EC50 value of 38.78 μg/mL. The combination treatment of Ag-NPs and papaverine exhibited synergistic effects, lowering IC50 values to 2.8 + 112.7 μg/mL for MCF-7 cells and 6.2 + 112 μg/mL for MDA-MB-231 cells, without toxicity to normal cells. Flow cytometry revealed G0/G1 phase inhibition and increased sub-G1 populations, indicating cell cycle arrest, alongside increased reactive oxygen species generation and apoptosis. Notably, the experimental group showed altered expression of oncogenic and tumour suppressor microRNAs and apoptotic genes (p < .0001), underscoring the potential of this nanoparticle-papaverine combination as an effective anticancer strategy against breast cancer treatment resistance.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"1-19"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Correction. 修正。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-07-16 DOI: 10.1080/21691401.2025.2532221

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Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment. 外泌体介导的免疫-骨代谢轴的扰动：模拟微重力环境下骨质流失的机制研究。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1080/21691401.2025.2576277

Fei Yang, Changshun Chen, Chenghui Yang, Rongjin Chen, Zirui Liu, Lei Wen, Hefang Xiao, Libo Zhou, Bin Geng, Yayi Xia

{"title":"Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment.","authors":"Fei Yang, Changshun Chen, Chenghui Yang, Rongjin Chen, Zirui Liu, Lei Wen, Hefang Xiao, Libo Zhou, Bin Geng, Yayi Xia","doi":"10.1080/21691401.2025.2576277","DOIUrl":"https://doi.org/10.1080/21691401.2025.2576277","url":null,"abstract":"Spaceflight-related bone loss represents a critical health concern for astronauts undertaking prolonged space missions. This study investigated the mechanistic role of macrophage-derived exosomes in microgravity-induced bone loss using a simulated microgravity model. Phenotypic analysis of macrophages demonstrated that simulated microgravity promoted polarization towards the M2 phenotype and markedly suppressed the secretion of most pro-inflammatory cytokines. Exosomes were isolated and purified from macrophages cultured under normal gravity (1 g) and simulated microgravity (μg) conditions via ultracentrifugation. In vitro experiments revealed that exosomes from the μg group significantly inhibited the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, without affecting cell migration. Subsequent in vivo studies involving tail-vein injection of exosomes into mice demonstrated a significant reduction in bone mass and impaired new bone formation in the μg group, exhibiting a distinct osteoporotic phenotype. Collectively, this study provides evidence at both cellular and animal levels that macrophage-derived exosomes play a role in microgravity-induced bone loss by inhibiting the proliferation and osteogenic differentiation of BMSCs and osteoblasts in a simulated microgravity environment. These findings offer a potential strategy for targeting the immune-bone metabolism axis to prevent spaceflight-associated osteoporosis.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"494-513"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial capping agents on silver nanoparticles made via green method using natural products from banana plant waste. 利用香蕉植物废料中的天然产物，通过绿色方法制备纳米银抗菌封盖剂。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-02-07 DOI: 10.1080/21691401.2025.2462335

Jimmy K Kabeya, Nadège K Ngombe, Paulin K Mutwale, Justin B Safari, Gauta Gold Matlou, Rui W M Krause, Christian I Nkanga

{"title":"Antimicrobial capping agents on silver nanoparticles made via green method using natural products from banana plant waste.","authors":"Jimmy K Kabeya, Nadège K Ngombe, Paulin K Mutwale, Justin B Safari, Gauta Gold Matlou, Rui W M Krause, Christian I Nkanga","doi":"10.1080/21691401.2025.2462335","DOIUrl":"10.1080/21691401.2025.2462335","url":null,"abstract":"Herein, we investigated the phytochemical composition and antibacterial activities of the organic layers from biosynthesized silver nanoparticles (AgNPs). AgNPs were synthesized using Musa paradisiaca and Musa sapientum extracts. UV-vis absorption in the 400-450 nm range indicated surface plasmonic resonance peak of AgNPs. Samples analyses using dynamic light scattering and transmission electron microscopy revealed the presence of particles within nanometric ranges, with sizes of 30-140 nm and 8-40 nm, respectively. Fourier transform infrared (FTIR) unveiled the presence of several organic functional groups on the surface of AgNPs, indicating the presence of phytochemicals from plant extracts. Thin layer chromatography (TLC) of the phytochemicals (capping agents) from AgNPs identified multiple groups of secondary metabolites. These phytochemical capping agents exhibited antibacterial activities against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, with minimum inhibitory concentrations ranging from 62.5 to 1000 µg/mL. Regardless of the bacterial species or plant parts (leaves or pseudo-stems), capping agents from M. sapientum nanoparticles displayed significantly enhanced antibacterial effectiveness compared to all other samples, including the raw plant extracts and biosynthesized capped and uncapped AgNPs. These results suggest the presence of antimicrobial phytochemicals on biosynthesized AgNPs, highlighting the promise of green nanoparticle synthesis as a valuable approach in bioprospecting antimicrobial agents.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"29-42"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green synthesis of silver nanoparticles for functional cotton fabrics: antimicrobial efficacy against multidrug-resistant bacteria and cytotoxicity evaluation. 功能棉织物用纳米银的绿色合成：对多重耐药细菌的抗菌效果及细胞毒性评价。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-04-01 DOI: 10.1080/21691401.2025.2485115

Sérgio Antunes Filho, Clara M Almeida, Maria Teresa Villela Romanos, Bianca Pizzorno Backx, Raquel Regina Bonelli

{"title":"Green synthesis of silver nanoparticles for functional cotton fabrics: antimicrobial efficacy against multidrug-resistant bacteria and cytotoxicity evaluation.","authors":"Sérgio Antunes Filho, Clara M Almeida, Maria Teresa Villela Romanos, Bianca Pizzorno Backx, Raquel Regina Bonelli","doi":"10.1080/21691401.2025.2485115","DOIUrl":"10.1080/21691401.2025.2485115","url":null,"abstract":"Bacterial infections associated with healthcare are a challenge on a global scale due to the high morbidity and mortality rates, especially those caused by multidrug-resistant isolates. Hospital textiles are abiotic surfaces that may serve as a means of disseminating and persisting microorganisms in hospitals, as microorganisms can remain viable on these surfaces for up to months. In this study, we employed a green synthesis approach utilizing guava leaf extract (Psidium guajava) to produce silver nanoparticles, which were then incorporated into a cotton fabric. Antimicrobial properties and the cytotoxicity of the functional textile were assessed. The finding indicated that the green synthesis method was efficient and resulted in a predominant population of nanoparticles with diameters ranging from 25 to 84 nm that were uniformly dispersed in the textile. The functional textile exhibited low toxicity and high antimicrobial efficiency, even against multidrug-resistant microorganisms of particular concern in hospital settings. Atomic force microscopy carried out evidenced invaginations in the cell wall of bacteria submitted to this textile, suggesting surface damage as an important mechanism of action silver nanoparticles incorporated.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"153-165"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function. 从小鼠骨髓间充质基质细胞中分离的微囊泡和外泌体对造血干细胞功能的调控存在差异。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-10 DOI: 10.1080/21691401.2025.2475095

Pallavi Budgude, Vaijayanti Kale, Anuradha Vaidya

{"title":"Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function.","authors":"Pallavi Budgude, Vaijayanti Kale, Anuradha Vaidya","doi":"10.1080/21691401.2025.2475095","DOIUrl":"10.1080/21691401.2025.2475095","url":null,"abstract":"The signaling mechanisms active within mesenchymal stromal cells (MSCs) influence the composition of microvesicles (MVs) and exosomes (Exos) secreted by them. Previously, we showed that priming MSCs with a p38 pharmacological inhibitor (pMSCs) rejuvenates them and improves their ability to promote ex vivo hematopoietic stem cell (HSC) expansion. This study examined whether pMSCs exerted HSC-supportive ability via MVs (pMVs) and Exos (pExos). Our findings demonstrate distinct regulation of HSC fate by pMVs and pExos. pMVs promoted the expansion of long-term HSCs (LT-HSCs), distinguished by their robust self-renewal capacity and superior engraftment ability. In contrast, pExos facilitated expansion of short-term HSCs (ST-HSCs) with high proliferative and differentiation potential. Infusing a combination of pMVs- and pExos-expanded HSCs as a composite graft resulted in significantly higher HSC engraftment, emphasizing the synergistic interaction between LT- and ST-HSC populations. Gene expression studies, functional and phenotypic experiments showed that pMVs regulate HSC quiescence via the Egr1/Cdkn1a axis, while pExos control HSC proliferation via the Nfya/Cdkn1a axis. These findings provide insights into the molecular mechanisms underlying the differential regulation of HSC function by pMVs and pExos. It also proposes a composite graft strategy of using pMVs and pExos as \"MSC-derived biologics\" for improving the HSC transplantation success.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"122-137"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis. 撤回声明：长链非编码RNA DDX11-AS1通过调节miR-873-5p/SPC18轴促进胃癌进展。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-08-12 DOI: 10.1080/21691401.2025.2543681

引用次数: 0

An integrated in vitro and in silico approach to assess targeted cytotoxicity against MDA-MB-231 triple-negative breast cancer cells with Psidium guajava peel-derived chitosan nanoparticles. 瓜石榴皮衍生壳聚糖纳米颗粒对MDA-MB-231三阴性乳腺癌细胞的靶向细胞毒性研究

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI: 10.1080/21691401.2025.2462333

Vino Udappusamy, Rajan Thinagaran, Vijayakumar Mayakrishnan, Janani Balakarthikeyan, Priya Kannappan, Sameer Al-Ghamdi, Naif Abdurhman Alrudian, Mohammed Saad Alqahtani, Khalid Albasheer, Chandrabose Sureka, Mahmoud H El-Bidawy, Nesreen Alsanousi, Sahar Gamil, Thiyagarajan Ramesh

{"title":"An integrated in vitro and in silico approach to assess targeted cytotoxicity against MDA-MB-231 triple-negative breast cancer cells with Psidium guajava peel-derived chitosan nanoparticles.","authors":"Vino Udappusamy, Rajan Thinagaran, Vijayakumar Mayakrishnan, Janani Balakarthikeyan, Priya Kannappan, Sameer Al-Ghamdi, Naif Abdurhman Alrudian, Mohammed Saad Alqahtani, Khalid Albasheer, Chandrabose Sureka, Mahmoud H El-Bidawy, Nesreen Alsanousi, Sahar Gamil, Thiyagarajan Ramesh","doi":"10.1080/21691401.2025.2462333","DOIUrl":"10.1080/21691401.2025.2462333","url":null,"abstract":"Triple-negative breast cancer (TNBC) is a significant global health issue, with high mortality rates. The chemotherapeutic drugs currently used for TNBC have significant side effects, impacting both normal and cancer cells. In this study, we investigated a potential use of fruit peel extract of Psidium guajava (PGP) encapsulated with chitosan nanoparticles (CSNPs) to combat TNBC. The synthesized PGP-CSNPs were characterized using UV-vis spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, TEM and GC-MS. The maximum loading capacity and encapsulation efficacy of PGP-CSNPs were found to be 72.5 ± 0.49% and 92.9 ± 0.10%, respectively. Furthermore, in vitro cytotoxicity was assessed, and the IC50 value for PGP-CSNPs was 50.13 µg/mL. It was observed that PGP-CSNPs could induce apoptosis in MDA-MB-231 cells in dose-dependent manner. Furthermore, molecular docking was performed for bioactive compounds retrieved from PGP-CSNPs against human tumour suppressor proteins Bcl2, and results showed that the PGP-CSNPs had lower binding energy than cisplatin. This suggests that, the synthesized PGP-CSNPs have the potential to serve as a therapeutic agent for tackling TNBC. However, to validate its efficacy in human therapy, furthermore pre-clinical and clinical procedures should be examined, as this is an ongoing and significant step towards developing an effective and safe anticancer drug.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"43-55"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0