Artificial Cells, Nanomedicine, and Biotechnology最新文献_第6页

MMP9 as a shared immune-related gene in Alzheimer's and Huntington's diseases: a cross-tissue transcriptomic analysis. MMP9作为阿尔茨海默病和亨廷顿病的共享免疫相关基因：跨组织转录组学分析

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-04-24 DOI: 10.1080/21691401.2026.2644164

Xuepan Li, Chunlong Zhang, Haisen Ni, Peng Sun, Jing Ren, Shan Huang

{"title":"MMP9 as a shared immune-related gene in Alzheimer's and Huntington's diseases: a cross-tissue transcriptomic analysis.","authors":"Xuepan Li, Chunlong Zhang, Haisen Ni, Peng Sun, Jing Ren, Shan Huang","doi":"10.1080/21691401.2026.2644164","DOIUrl":"10.1080/21691401.2026.2644164","url":null,"abstract":"Alzheimer's disease (AD) and Huntington's disease (HD) share neuroinflammatory mechanisms, yet their specific immune microenvironments remain poorly understood. Integrating transcriptomic profiles of peripheral blood and frontal cortex tissues with 2,160 immune-related genes, we analysed their shared immunopathology. Differential analysis identified 64 peripheral and 159 central consistently dysregulated immune genes, intersecting to isolate 10 co-expressed all-immune genes. Functional enrichment highlighted neutrophil and monocyte activation, alongside IL-17 and T-cell receptor signalling pathways. Machine learning (LASSO and Boruta) robustly pinpointed MMP9 as the core shared immune hub gene. External validation revealed MMP9 exhibited modest diagnostic performance in peripheral blood (AD AUC = 0.616; HD AUC = 0.619) but stronger predictive accuracy in brain tissues (AD AUC = 0.825; HD AUC = 0.876). Furthermore, MMP9 expression positively correlated with neutrophil and M0 macrophage infiltration. While modest peripheral accuracy limits its standalone diagnostic utility, this cross-tissue analysis establishes MMP9 as a consistently upregulated candidate molecular indicator of shared neuroinflammation, offering a valuable target for future mechanistic research.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"316-331"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel insights into immunology-driven nanomaterials for immunomodulatory bone regeneration: from basics to biological functions. 免疫驱动的纳米材料免疫调节骨再生的新见解：从基础到生物功能。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-05-28 DOI: 10.1080/21691401.2026.2676367

C Grolle, R D K Misra, Tapash R Rautray

{"title":"Novel insights into immunology-driven nanomaterials for immunomodulatory bone regeneration: from basics to biological functions.","authors":"C Grolle, R D K Misra, Tapash R Rautray","doi":"10.1080/21691401.2026.2676367","DOIUrl":"10.1080/21691401.2026.2676367","url":null,"abstract":"Nanomaterials are gaining prominence in regenerative medicine because their nanoscale features enable precise drug delivery, cellular regulation and targeted tissue repair. A particularly exciting opportunity lies in their application to immunomodulatory bone regeneration, where nanoscience and immunology intersect to address persistent challenges in bone healing. The recent progress in nanoparticle (NP) design, fabrication and characterization, with emphasis on their dual role as therapeutic carriers and modulators of immune responses, has been highlighted in this study. Both top-down and bottom-up synthesis strategies are discussed, illustrating how particle size, morphology and surface chemistry influence cell-nanosystem interactions. The immune system's responses to nanomaterials are explored in some detail, from beneficial adaptive memory formation to adverse inflammatory reactions, underscoring the delicate balance between efficacy and safety. Limitations of conventional NP systems include cytotoxicity, instability and regulatory hurdles, are examined in conjunction with advanced characterization techniques that relate material properties to biological outcomes. By integrating fundamental nanoscience with immunological perspectives, these fundamental insights into the rational design of nanomaterials for bone regeneration are discussed. The ultimate objective is to provide guidelines for developing safer, more effective strategies that can translate into meaningful clinical applications.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"152-179"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Statement: The long noncoding RNA linc00858 promotes progress of lung cancer through miR-3182/MMP2 axis. 撤回声明：长链非编码RNA linc00858通过miR-3182/MMP2轴促进肺癌的进展。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-07-27 DOI: 10.1080/21691401.2026.2708468

引用次数: 0

Retraction Statement: Overexpression of the long non-coding RNA Oprm1 alleviates apoptosis from cerebral ischemia-reperfusion injury through the Oprm1/miR-155/GATA3 axis. 结论：过表达长链非编码RNA Oprm1可通过Oprm1/miR-155/GATA3轴缓解脑缺血再灌注损伤后的细胞凋亡。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-07-27 DOI: 10.1080/21691401.2026.2708418

引用次数: 0

Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells. 优化的聚乙二醇化紫杉醇和6-姜辣素共载脂质体诱导MDA-MB-231乳腺癌和A549肺癌细胞G2/M期阻滞和凋亡。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-10-27 DOI: 10.1080/21691401.2025.2566711

Priyadharshini Thangavelu, Kaavya Gunasekaran, Senthilkumar Periyathambi, Abeer Hashem, Nouf H Alotaibi, Elsayed Fathi Abd Allah, Rama Jayaraj, Naveen Kumar Kalagatur, Suja Samiappan

{"title":"Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells.","authors":"Priyadharshini Thangavelu, Kaavya Gunasekaran, Senthilkumar Periyathambi, Abeer Hashem, Nouf H Alotaibi, Elsayed Fathi Abd Allah, Rama Jayaraj, Naveen Kumar Kalagatur, Suja Samiappan","doi":"10.1080/21691401.2025.2566711","DOIUrl":"https://doi.org/10.1080/21691401.2025.2566711","url":null,"abstract":"The study aimed to optimize and develop novel PEGylated co-loaded nanoliposome entrapped with paclitaxel (PTX) and 6-gingerol (Gn) (PEG-Lipo-PTX-Gn) by response surface methodology (RSM) approach to prevent the diffusion and resistant-related issues of PTX in oncotherapy. Physiochemical characterization studies results revealed that the prepared PEG-Lipo-PTX-Gn attained optimum particle size, shape, charge, polydispersity index (PDI) as well as showed synergistic entrapment of PTX and Gn, sustained drug release, better colloidal stability and structural integrity. PEG-Lipo-PTX-Gn exhibited a noteworthy antiproliferative effect, apoptotic percentage and a higher proportion of G2/M cell cycle arrest in MDA-MB-231 and A549 cell lines. Meanwhile, no significant toxicity was observed in normal cell lines (HEK 293 kidney embryonic cells and L929 fibroblast cells). Another testament to its efficacy is the dramatic decline in Bcl-2 levels in the PEG-Lipo-PTX-Gn-treated group. Hence, optimized PEG-Lipo-PTX-Gn could be a promising novel approach in cancer treatment regimens.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"468-488"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-07 DOI: 10.1080/21691401.2025.2476906

引用次数: 0

Statement of Retraction: Myricetin nanoliposomes induced SIRT3-mediated glycolytic metabolism leading to glioblastoma cell death. 撤回声明：杨梅素纳米脂质体诱导sirt3介导的糖酵解代谢导致胶质母细胞瘤细胞死亡。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-27 DOI: 10.1080/21691401.2025.2465942

引用次数: 0

Statement of Retraction. 撤回声明。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1080/21691401.2025.2558474

引用次数: 0

Purinergic ecto-enzymes in human and ovine aortic valves: indicators of bacterial nanocellulose scaffold cellularization. 人和羊主动脉瓣的嘌呤能外泌酶：细菌纳米纤维素支架细胞化的指标。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-05-12 DOI: 10.1080/21691401.2025.2502033

Barbara Kutryb-Zając, Ada Kawecka, Gabriela Harasim, Michał Bieńkowski, Klaudia Stawarska, Krzysztof Urbanowicz, Ryszard T Smoleński, Maciej M Kowalik, Magdalena Kołaczkowska, Piotr Siondalski

{"title":"Purinergic ecto-enzymes in human and ovine aortic valves: indicators of bacterial nanocellulose scaffold cellularization.","authors":"Barbara Kutryb-Zając, Ada Kawecka, Gabriela Harasim, Michał Bieńkowski, Klaudia Stawarska, Krzysztof Urbanowicz, Ryszard T Smoleński, Maciej M Kowalik, Magdalena Kołaczkowska, Piotr Siondalski","doi":"10.1080/21691401.2025.2502033","DOIUrl":"https://doi.org/10.1080/21691401.2025.2502033","url":null,"abstract":"Purinergic signalling pathways play a vital role in the biological functions of the aortic valve (AV) through nucleotide and adenosine-dependent receptor effects. This study focused on characterizing a side-specific purinergic cascade in human non-stenotic and stenotic AVs, ovine native AVs and a novel bacterial nanocellulose (BNC) bio-prosthesis in an ovine model. Human stenotic AVs were collected during replacement surgeries, while non-stenotic AVs came from heart transplant patients. Ovine native AVs were sourced from domestic sheep, and the BNC prosthesis was implanted in the ovine aorta for six months, with hemodynamic monitoring throughout. Biochemical assessments revealed a beneficial ecto-enzyme pattern in non-stenotic and native AVs, contrasting with a detrimental pattern in stenotic valves. The BNC prosthesis demonstrated significantly lower nucleotide conversion activities than native valves and displayed increased peripheral blood mononuclear cell adhesion on its aortic surface. These findings suggest that nucleotide-converting ecto-enzymes could serve as markers for the biological activity of AV prostheses, highlighting the need for further studies to enhance the cellularization of BNC prostheses, potentially through adenosine-releasing scaffold modifications.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"219-230"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics analysis of the potential association between ageing and rheumatoid arthritis and screening of potential therapeutic targets. 衰老与类风湿关节炎潜在关联的多组学分析及潜在治疗靶点的筛选。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-11-03 DOI: 10.1080/21691401.2025.2582448

Xue Yun, Lintao Zhang, Zhaopeng Fan, Hua Guo

{"title":"Multi-omics analysis of the potential association between ageing and rheumatoid arthritis and screening of potential therapeutic targets.","authors":"Xue Yun, Lintao Zhang, Zhaopeng Fan, Hua Guo","doi":"10.1080/21691401.2025.2582448","DOIUrl":"https://doi.org/10.1080/21691401.2025.2582448","url":null,"abstract":"Ageing is increasingly recognized as a significant risk factor for RA, yet the molecular mechanisms linking the two remain poorly understood. This study aimed to explore the association between ageing and RA and to identify potential therapeutic targets using multi-omics approaches. By analysing the GBD database, we observed a notable increase in RA incidence and prevalence among individuals aged 55 and older from 1990 to 2021. Through integrative analysis of transcriptomic data and ageing-related gene sets, we identified 145 shared genes between ageing and RA. Machine learning algorithms further refined these to five hub genes, among which STAT1, MCL1, and BCL6 were validated via single-cell RNA sequencing as key players in RA pathogenesis. Immune infiltration analysis revealed distinct immune cell profiles in RA patients compared to controls. These findings underscore the strong molecular link between ageing and RA and highlight STAT1, MCL1, and BCL6 as promising therapeutic targets. This study provides a foundation for developing targeted interventions for RA in the context of ageing.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"514-530"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0