Meghdad Ashtiyani, Parmida Moradi Birgani, Maryam Soleimani, Behnam Jameie, Amin Shahrokhi, Mohammad Reze Deevband, Mohammad Mehdi Mirbagheri
{"title":"Short-term Therapeutic Effects of Antigravity Treadmill Training on Brain Activities and Walking Capacity in Children With Cerebral Palsy.","authors":"Meghdad Ashtiyani, Parmida Moradi Birgani, Maryam Soleimani, Behnam Jameie, Amin Shahrokhi, Mohammad Reze Deevband, Mohammad Mehdi Mirbagheri","doi":"10.32598/bcn.2022.3683.2","DOIUrl":"10.32598/bcn.2022.3683.2","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral palsy (CP) is one of the most common causes of motor disability in childhood. Since CP is a corollary of brain damage, persistent treatment should accompany alterations in brain functional activity in line with clinical improvements.</p><p><strong>Methods: </strong>A total of 14 children with spastic hemiplegic CP were randomly divided into 2 groups. The training group (8.5 years) underwent 45 min anti-gravity treadmill training sessions 3 times/week for 8 weeks, while the control group (8.2 years) received the same amount of occupational therapy (OT). Functional magnetic resonance imaging (fMRI) was conducted to quantify brain activation during the performance of passive tasks, including ankle plantarflexion to dorsiflexion and knee flexion to extension over the range of motion. Walking capacity was assessed using the timed-up-and-go, 10-m, and 6-m walking tests. All evaluations were performed before and after training and compared between the two groups.</p><p><strong>Results: </strong>This study could detect the signatures of ankle and knee passive movement tasks in the fMRI and characterize them in terms of activated voxels. The pre-post activation changes following the completion of the training course showed that the elicited motor cortex activation was greater for the ankle than the knee tasks. For the ankle, the primary motor cortex, precentral gyrus, and corpus callosum showed significant enhancement in most study participants. The results indicated 16.1% more active voxels in the study than control groups. Similarly, clinical outcome measures improved over twice as much in this group.</p><p><strong>Conclusion: </strong>Anti-gravity treadmill training could be a potentially effective therapeutic intervention for improving gait and balance impairments in children with CP.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"26 1","pages":"737-750"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77672438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amin Asgharzadeh Alvar, Ali Esteki, Iraj Abdollahi
{"title":"A Virtual reality-based System for Hand Rehabilitation and Its Impact on the Emotional and Physiological Responses of Users.","authors":"Amin Asgharzadeh Alvar, Ali Esteki, Iraj Abdollahi","doi":"10.32598/bcn.2021.3532.1","DOIUrl":"10.32598/bcn.2021.3532.1","url":null,"abstract":"<p><strong>Introduction: </strong>Maintaining motivation is one of the most important characteristics of rehabilitation strategies for successful treatment. Understanding the underlying mechanism of mental state helps develop new therapeutic methods based on virtual reality (VR) and serious game technologies. The present study develops a cost-benefit game-based hand rehabilitation system and assesses the influence on the psychological state of subjects when they interact with a VR environment in different task difficulty levels.</p><p><strong>Methods: </strong>First, we introduced a low-cost smart hand rehabilitation system based on the Leap Motion Tracker. Subsequently, the experimental study was performed with 20 healthy participants. Their mental states were evoked using interaction with two separate games in four different difficulty levels. Three measures from the self-assessment manikin (SAM) self-reported test were described as a psychological response to this condition, and four features were extracted from the photoplethysmogram signal to quantify psychophysiological responses of the autonomic nervous system (ANS).</p><p><strong>Results: </strong>Comparison of the different difficulty levels revealed significant changes in arousal and dominance corresponding to the under-challenging and over-challenging conditions, respectively. The results of psychophysiological feature analysis showed significant differences only for the standard deviation of intervals between consecutive heartbeats.</p><p><strong>Conclusion: </strong>The developed system is a low-cost smart solution that can be useful for upper limb neurological rehabilitation. Regulating difficulty parameters of the implemented game can be used to influence the motivation of users through rehabilitation procedures. Photoplethysmogram is an appropriate psychophysiological indicator of mental states, but further studies are required.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"22 1","pages":"727-736"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83235879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing Electrocardiographic Parameters in the Patients With Drug-resistant Temporal Lobe Epilepsy: A Case-control Study.","authors":"Jafar Mehvari, Zeinab Jaafari, Mohamad Zare, Nasim Tabrizi, Alireza Khosravi Farsani","doi":"10.32598/bcn.2023.4724.1","DOIUrl":"10.32598/bcn.2023.4724.1","url":null,"abstract":"<p><strong>Introduction: </strong>Sudden, unexpected death in epilepsy (SUDEP) is a substantial cause of death in patients with epilepsy. Although electroconductive disorders leading to life-threatening arrhythmia are supposed to play a crucial role, there is a paucity of knowledge in variables among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls.</p><p><strong>Methods: </strong>The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. Electrocardiographic (ECG) were taken from the cases when admitted at the hospital (baseline), immediately after a seizure incidence, and within an hour after the end of the seizure and compared with a random ECG of the controls considering parameters, including PR-, RR-, and corrected QT interval (QTc), P wave duration, and heart rate (HR) variability.</p><p><strong>Results: </strong>A shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P=0.017) in the baseline taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P=0.005) and HR (P=0.005). Postictal ECGs did not differ between the groups (P>0.05).</p><p><strong>Conclusion: </strong>According to the findings of this study, shortened QTc interval at baseline ECGs, shortened RR interval, and increased HR during the seizure were the ECG elements that affected drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"48 1","pages":"441-448"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75660581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of High-voltage Electrical Field Exposure on Neurobiological Factors and Visual Working Memory of Macaques.","authors":"Hamed Aliyari, Mohsen Hosseinian, Mohammad Bagher Menhaj, Hedayat Sahraei, Mohsen Shabani, Masoomeh Kazemi","doi":"10.32598/bcn.2023.2368.1","DOIUrl":"10.32598/bcn.2023.2368.1","url":null,"abstract":"<p><strong>Introduction: </strong>High-voltage (HV) power transmission lines running near cities and villages can cause severe damage (mental and physical) due to the magnetic and electric fields they produce. This study aimed to investigate the effects of HV electric fields on the spiking neural network (SNN) model of the brain and biological and behavioral models of visual working memory.</p><p><strong>Methods: </strong>To achieve this goal, macaques were studied for their cognitive functions, expression of the NMDA receptor gene, MRI-assisted analysis of brain anatomy, and variations in blood sodium and potassium concentrations. The experimental group of macaques was exposed to a 3 kV/m HV field for 4 hours a day for 1 month. Computational models were then evaluated using experimental parameters.</p><p><strong>Results: </strong>According to the results, exposure to HV electric fields reduced the expression of the NMDA receptor gene, as well as a decrease in the levels of sodium and potassium ions in the blood plasma. Additionally, MRI-assisted analysis showed reduced hippocampus and amygdala size after exposure to the electric field.</p><p><strong>Conclusion: </strong>The results of cognitive, genetic, blood, and MRI tests, along with the SNN model, elucidate the mechanism of the visual working memory deterioration in macaques due to HV electric field exposure.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"63 1","pages":"251-264"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79355819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hoda Taghilou, Mazaher Rezaei, Mohammad Ali Nazari, Alireza Valizadeh
{"title":"Electroencephalography Oscillations During Prehypnosis and Hypnosis in Subjects With High and Low Dissociative Experiences.","authors":"Hoda Taghilou, Mazaher Rezaei, Mohammad Ali Nazari, Alireza Valizadeh","doi":"10.32598/bcn.2023.1206.2","DOIUrl":"10.32598/bcn.2023.1206.2","url":null,"abstract":"<p><strong>Introduction: </strong>Hypnosis is a multifaceted phenomenon that refers to suggestions for creating desirable behavior, experience, and physiological changes. Most electroencephalographic (EEG) research in hypnosis has allocated people into two groups of high and low hypnotizables. Hence, the empirical data are somewhat controversial, and there is no general agreement about the neurophysiology of hypnosis. On the other hand, the dissociation theory of hypnosis posits that people candidates for hypnosis are typically prone to dissociation, and individuals divide into two groups: High dissociative (HD) and low dissociative (LD). If this assumption is true, such a state should be visible as a distinct pattern of changes in absolute power and functional connectivity between brain districts after a hypnotic induction in high but not in LD suggestible.</p><p><strong>Methods: </strong>The final sample consisted of 20 participants who scored 6 or higher on the Stanford hypnotic susceptibility scale form C (SHSS: C). Then, we completed dissociative experiences scales (DES) on them. To assess the brain's electrical activity during hypnosis, a 19-channel EEG was recorded from 10 HD and 10 LD participants with their eyes closed before (baseline) and after the induction of hypnosis. We used EEG to measure absolute power and functional connectivity using coherence. We expected the two groups to have dissimilar EEG signal patterns despite equivalent hypnotizability.</p><p><strong>Results: </strong>We found that in the delta, theta, alpha, beta, and gamma bands, both groups were different from the baseline to hypnosis. In addition, both groups showed different connectivity in hypnosis in four bands (delta, theta, alpha, and beta).</p><p><strong>Conclusion: </strong>These findings indicate that although the LD and HD groups had equal hypnotizability, the episodic prospection tasks did not involve the same neural networks in the two groups.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"1 1","pages":"367-378"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89779750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing Theta Beta Ratio in Children With Attention-deficit/hyperactive Disorder and Specific Learning Disorder During Active EEG.","authors":"Fatemeh Gholamali Nezhad, Mahdieh Sadat Mirmohammad, Reza Rostami, Hanie Ahmadi","doi":"10.32598/bcn.2021.3359.1","DOIUrl":"10.32598/bcn.2021.3359.1","url":null,"abstract":"<p><strong>Introduction: </strong>Theta-to-beta ratio (TBR) has been claimed as a biomarker to diagnose attention-deficit/hyperactivity disorder (ADHD). However, the effectiveness of this index in identifying different groups of ADHD is still under discussion. Our primary purpose was to determine to what extent active TBR can differentiate between children with ADHD and specific learning disorder (SLD) as the most common comorbid disorder.</p><p><strong>Methods: </strong>Two groups of school-aged children with SLD (n=15) and ADHD (n=15) were diagnosed through a process of clinical interview and observation. Electroencephalography (EEG) was recorded in both groups during active conditions. The implemented cognitive task was the visual continuous performance task (VCPT). TBR in sites of CZ and Fz and cognitive measures of VCPT were calculated in the study groups.</p><p><strong>Results: </strong>There were no significant differences in cognitive measures (commission, omission, reaction time, and variability of reaction times) shown in two matched groups of children with SLD and ADHD. According to TBR, the two groups demonstrated no significant differences in comparison.</p><p><strong>Conclusion: </strong>TBR cannot be considered a reliable biomarker to differentiate between those groups of psychological disorders that contain primary cognitive deficits and require the allocation of attention and working memory loads.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"85 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79361972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T A Suhail, K P Indiradevi, E M Suhara, Suresh A Poovathinal, Ayyappan Anitha
{"title":"Smartphone Distractions and Cognitive Performance in Adolescents: An Electroencephalography Approach.","authors":"T A Suhail, K P Indiradevi, E M Suhara, Suresh A Poovathinal, Ayyappan Anitha","doi":"10.32598/bcn.2021.2295.2","DOIUrl":"10.32598/bcn.2021.2295.2","url":null,"abstract":"<p><strong>Introduction: </strong>The dependence on smartphones has become widespread among all age groups in every realm of daily life. There has been increased concern about the adverse effects of problematic smartphone use and media multitasking among adolescents. Recent studies used various performance measures like questionnaire surveys to examine the association between smartphone addiction and learning performance, and such studies have yielded varied findings. The current study investigates the effects of media multitasking on cognitive performance using electroencephalography (EEG) features and a self-report questionnaire survey.</p><p><strong>Methods: </strong>The patterns of smartphone use among adolescents in South India were investigated in this study using a questionnaire survey. Further, the impact of smartphone usage on cognitive task performance was examined using EEG features. To this end, EEGs of 22 healthy subjects were recorded during learning tasks before and after using a social networking site on smartphones. Subsequently, various EEG features were extracted, including ratios of wavelet decomposed EEG bands, attention index, and sample entropy. Finally, these cognitive performance indices were evaluated and compared with a control group.</p><p><strong>Results: </strong>A total of 600 healthy individuals (341 males and 259 females) participated in the survey, and 310(50.91%) belonged to the high-user group. Performance degradation (P=0.005), sleep problems (P=0.040), and mental stress (P=0.049) were more prevalent among the high-user group. A significant decline in EEG-based cognitive performance indices was also observed in the phone-use group compared to the control group.</p><p><strong>Conclusion: </strong>The findings of this study highlight the importance of controlling phone use when engaged in cognitive tasks. The study also offers insight into developing neurofeedback techniques that enhance cognitive skills.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"15 1","pages":"31-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78907613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atefeh Fadaei, Mahmoud Najafi, Hossein Miladi-Gorji, Mohammad Ali Tajik-Mansoury, Mohammad Afkar
{"title":"Effect of Neurofeedback Training and Swimming Exercise on the Electroencephalographic Changes and Craving in Methamphetamine-dependent Patients.","authors":"Atefeh Fadaei, Mahmoud Najafi, Hossein Miladi-Gorji, Mohammad Ali Tajik-Mansoury, Mohammad Afkar","doi":"10.32598/bcn.2023.886.4","DOIUrl":"10.32598/bcn.2023.886.4","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we investigated whether neurofeedback (NFB) training and swimming exercise would decrease the electroencephalographic (EEG) changes and visual image-induced craving in methamphetamine (METH)-dependent patients.</p><p><strong>Methods: </strong>This research was a randomized controlled trial. A total of 32 METH-dependent patients were allocated randomly to four groups: Control, NFB, swim, and NFB/swim. The EEG and visual image-induced craving were recorded before and after the intervention in all four groups.</p><p><strong>Results: </strong>The NFB, swim, and NFB/swim groups showed significantly lower absolute power for 4 frequency bands. Also, the swim and NFB/swim groups had less and greater relative power in the alpha and delta bands, respectively. In addition, the NFB/swim group exhibited an increase in delta/alpha power ratio compared to the control and the NFB groups. Also, the NFB/swim group showed a significant reduction in visual image-induced craving score compared to the control, swim, and NFB groups.</p><p><strong>Conclusion: </strong>This study provides novel evidence that combined NFB training and swimming exercise during METH abstinence was effective in normalizing METH-induced EEG changes, which may help patients manage their cravings.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"21 1","pages":"179-192"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85283687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Personality and Aesthetic Preferences in Architecture: A Review of the Study Approaches and Assessment Methods.","authors":"Mohsen Dehghani Tafti, Masoud Ahmadzad-Asl, Mehrnaz Fallah Tafti, Gholamhossein Memarian, Sarvenaz Soltani, Farhang Mozaffar","doi":"10.32598/bcn.2021.3257.2","DOIUrl":"10.32598/bcn.2021.3257.2","url":null,"abstract":"<p><strong>Introduction: </strong>A clear relationship exists between human personality and architectural preferences. However, reviewing the findings of previous studies reveals that this expectation is not necessarily accurate, as contradictory results have been reported. This study aims to review various research and assessment methods used in previous studies for assessing the relationship between personality and architectural preferences and identify the theoretical and practical shortcomings of each method.</p><p><strong>Methods: </strong>This is a critical review study. A search was conducted in Google Scholar and Web of Science database for published articles in English using the following keywords: \"Visual aesthetics,\" \"personality traits,\" \"architectural preferences,\" \"art preferences,\" and \"aesthetic judgments.\" These articles were first categorized into four groups based on their methodological approaches (physiological, neurobiological, practical, and psychological) and then their degree of success and generalizability were assessed briefly. Finally, due to having lower implementation limitations and a higher theoretical background, the group using the psychological approaches was structurally analyzed from the methodological and practical aspects to develop a conceptual quadruple model. After presenting the model, neural network modeling was used to discover of hidden patterns.</p><p><strong>Results: </strong>Based on the analysis of the reviewed studies, the psychological approach was a more feasible option for assessing the relationship between personality and architectural preferences. The quadruple model that proposed for this purpose included <b>aesthetic variables/environm</b>ental stimuli, context, personality traits, and responses. The machine learning method facilitated the discovery of hidden patterns in relationship between personality and human preferences.</p><p><strong>Conclusion: </strong>This study proposes a new systematic quadruple model for evaluating aesthetic preferences.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"1 1","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85506318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Motavalli, Javad Mahmoudi, Alireza Majdi, Saeed Sadigh-Eteghad
{"title":"Ask, and You Shall Receive: A Closer Look on Unsolved Consciousness Issue.","authors":"Ali Motavalli, Javad Mahmoudi, Alireza Majdi, Saeed Sadigh-Eteghad","doi":"10.32598/bcn.2021.2308.1","DOIUrl":"10.32598/bcn.2021.2308.1","url":null,"abstract":"<p><p>There are numerous views about the concept of consciousness, and no consensus exists regarding its meaning. However, the latest neuroscientific developments have eliminated the misleading obstacles related to consciousness. Over the last few decades, neuroscientific efforts in determining the function of the brain and merging these findings with philosophical theories have brought a more comprehensive perception of the notion of consciousness. In addition to metaphysical or ontological views of consciousness, e.g. higher-order theories, reflexive theories, and representationalist theories, there are some brain-directed topics in this matter, which include but are not limited to neural correlates of consciousness (NCC), brain loop connectivity, and lateralization. This narrative review sheds light on cultural and historical aspects of consciousness in the old and middle ages and introduces some prominent philosophical discussions about mind and body. Also, it illustrates the correlation of brain function with states of consciousness with a focus on the roles of function and connectivity.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"41 1","pages":"569-582"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85559473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}