Basic and Clinical Neuroscience Journal最新文献

A Review of Binaural Bates and the Brain. 双耳贝茨与大脑》评论。

Basic and Clinical Neuroscience Journal Pub Date : 2024-03-01 DOI: 10.32598/bcn.2022.1406.2

Seyedmohamad Mirmohamadi, Yaser Norozpour, Shahram Zarrabian

引用次数: 0

Effect of Parenchymal Arachnoid on Brain Fluid Transport. 实质蛛网膜对脑液运输的影响

Basic and Clinical Neuroscience Journal Pub Date : 2024-03-01 DOI: 10.32598/bcn.2022.3089.1

Eric Hansen, Christopher Janson, Liudmila Romanova, Cornelius Lam

{"title":"Effect of Parenchymal Arachnoid on Brain Fluid Transport.","authors":"Eric Hansen, Christopher Janson, Liudmila Romanova, Cornelius Lam","doi":"10.32598/bcn.2022.3089.1","DOIUrl":"10.32598/bcn.2022.3089.1","url":null,"abstract":"Introduction: The pia-arachnoid is a critical component of cerebrospinal fluid removal. It covers and invaginates into the brain parenchyma, and physiologic failure results in hydrocephalus and cerebral edema. The purpose of this study was to characterize the role of arachnoid within brain parenchyma and determine if water flux and solute transport are affected by these intra-parenchymal cells.Methods: An immortalized arachnoid rat cell line was used to seed 300-μm organotypic rat brain slices of 4-week-old rats. Fluid and tracer transport analyses were conducted following a 7-10 day intraparenchymal growth period. The development of an arachnoid brain slice model was characterized using diffusion chamber experiments to calculate permeability, diffusion coefficient, and flux.Results: Labeled rat arachnoid cells readily penetrated organotypic cultures for up to 10 days. A significant reduction of dye and water flux across arachnoid-impregnated brain slices was observed after 3 hours in the diffusion chamber. Permeability decreased in whole brain slices containing arachnoid cells compared to slices without arachnoid cells. In comparison, a significant reduction of dextran across all slices occurred when molecular weights increased from 40 to 70 kDa.Conclusion: Tracer and small molecule studies show that arachnoid cells' presence significantly impacts water's movement through brain parenchyma. Size differential experiments indicate that the permeability of solute changed substantially between 40 and 70 kDa, an essential marker of blood-CSF barrier definition. We have developed an arachnoid organotypic model that reveals their ability to alter permeability and transport.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86176808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Full-wave Solution of Deep Sources in the Lossy Human Head to Accurate Electroencephalography and Magnetoencephalography. 精确脑电图和脑磁图的有损人体头部深源全波解决方案

Basic and Clinical Neuroscience Journal Pub Date : 2024-03-01 DOI: 10.32598/bcn.2022.3821.1

Sattar Samadi, Bijan Zakeri, Reza Khanbabaie

{"title":"A Full-wave Solution of Deep Sources in the Lossy Human Head to Accurate Electroencephalography and Magnetoencephalography.","authors":"Sattar Samadi, Bijan Zakeri, Reza Khanbabaie","doi":"10.32598/bcn.2022.3821.1","DOIUrl":"10.32598/bcn.2022.3821.1","url":null,"abstract":"Introduction: Currents in the brain flow inside neurons and across their boundaries into the extracellular medium, create electric and magnetic fields. These fields, which contain suitable information on brain activity, can be measured by electroencephalography (EEG), magnetoencephalography (MEG), and direct neural imaging.Methods: In this paper, we employed an electromagnetic model of the neuron activity and human head to derive electric and magnetic fields (brain waves) using a full-wave approach (ie. without any approximation). Currently, the brain waves are only derived using the quasi-static approximation (QSA) of Maxwell's equations in electromagnetic theory.Results: As a result, source localization in brain imaging will produce some errors. So far, the error rate of the QSA on the output results of electric and magnetic fields has not been investigated. This issue has become more noticeable due to the increased sensitivity of modern electroencephalography (EEG) and magnetoencephalography (MEG) devices. This work introduces issues that QSA encounters in this problem and reveals the necessity of a full-wave solution. Then, a full-wave solution of the problem in closed-form format is presented for the first time. This solution is done in two scenarios: the source (active neurons) is in the center of a sphere, and when the source is out of the center but deeply inside the sphere. The first scenario is simpler, but the second one is much more complicated and is solved using a partial-wave series expression.Conclusion: One of the significant achievements of this model is improving the interpretation of EEG and MEG measurements, resulting in more accurate source localization.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90728042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Approach for Mucosal and Bulbar Olfactory Ensheathing Cells Isolation Based on the Non-adherent Subculture Technique. 基于非粘附亚培养技术的粘膜和球部嗅鞘膜细胞分离新方法

Basic and Clinical Neuroscience Journal Pub Date : 2024-03-01 DOI: 10.32598/bcn.2022.3579.1

Fatemeh Tirgar, Zahra Azizi, Mahmoudreza Hadjighassem

{"title":"A Novel Approach for Mucosal and Bulbar Olfactory Ensheathing Cells Isolation Based on the Non-adherent Subculture Technique.","authors":"Fatemeh Tirgar, Zahra Azizi, Mahmoudreza Hadjighassem","doi":"10.32598/bcn.2022.3579.1","DOIUrl":"10.32598/bcn.2022.3579.1","url":null,"abstract":"Introduction: Olfactory ensheathing cells (OECs) are widely used in transplantation studies. The high purification of this unique cell type is valuable for medical applications. Although recent improvements in OECs isolation procedures opened a new era in this field, the high purification efficacy and viability rate are still of concern. The most widely used OECs isolation techniques can be broadly classified based on adherence properties, particularly in olfactory bulb-derived OEC isolation. Considering the invasive nature of harvesting OECs from human olfactory bulbs, a highly efficient purification of these cells from olfactory mucosa can benefit clinical trials. In this study, we isolated OECs from rats' olfactory bulbs and mucosa due to their differential adherence properties and compared them.Methods: Cell preparations were characterized by NGFR p75 and S100β antibodies, the specific markers for OECs, using immunocytochemistry and western blot analysis, respectively. OECs morphology and viability were monitored over time by microscopy and MTT (3-[4,5-dimethylthiazol2-yl]-2,5-diphenyltetrazolium bromide) assay.Results: We found that OECs could be purified from the olfactory mucosa using our suggested method as efficiently as the olfactory bulb. Both derived OECs showed high levels of NGFR p75 and S100β expression, although the S100β expression was higher in olfactory mucosa-derived OECs preparations (P<0.05). Moreover, there was no significant difference between the two sources in cell viability in our suggested protocol.Conclusion: Due to the non-invasive harvesting method, olfactory mucosa-derived OECs are preferred from a clinical point of view in transplantation studies.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80803319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Targets of Probiotics in Parkinson Disease: A Systematic Review of Randomized Controlled Trials. 益生菌在帕金森病中的治疗靶点：随机对照试验的系统回顾》。

Basic and Clinical Neuroscience Journal Pub Date : 2024-03-01 DOI: 10.32598/bcn.2022.3665.1

Elif Sina Atak, Dilara Yıldız, Rümeysa Rabia Kocatürk, Arzu Temizyürek, Öznur Özge Özcan, Türker Tekin Ergüzel, Mesut Karahan, Nevzat Tarhan

{"title":"Therapeutic Targets of Probiotics in Parkinson Disease: A Systematic Review of Randomized Controlled Trials.","authors":"Elif Sina Atak, Dilara Yıldız, Rümeysa Rabia Kocatürk, Arzu Temizyürek, Öznur Özge Özcan, Türker Tekin Ergüzel, Mesut Karahan, Nevzat Tarhan","doi":"10.32598/bcn.2022.3665.1","DOIUrl":"10.32598/bcn.2022.3665.1","url":null,"abstract":"Introduction: Parkinson disease is the world's second most prevalent neurological disease. In this disease, intracytoplasmic neuronal inclusions are observed in enteric neurons in the gastrointestinal tract, and the composition of the intestinal microbiome is altered. These changes correlate with the motor phenotype. A systematic review was conducted to determine the effect of using probiotics in Parkinson disease.Methods: Scopus, PubMed, Web of Science, the Cochrane Library, ScienceDirect, and Ovıd-LWW were searched until April 2021. A total of 27395 records were found according to inclusion and exclusion criteria with the following outcomes: Parkinson disease rating, oxidative stress, and gastrointestinal system markers. Data search, article selection, and data extraction assessments were performed according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines. The Jadad scale was used to rate the evidence's quality.Results: Our study information was gathered from 5 randomized controlled trials involving 350 individuals with Parkinson disease receiving probiotic supplements. Parkinson disease rating and non-motor symptoms test were performed in the samples. Also, oxidative stress (glutathione, malondialdehyde) and gastrointestinal system symptoms (bowel opening frequency, gut transit time, complete bowel movement, spontaneous bowel movements) were evaluated during 4-12 weeks of using probiotics in these patients.Conclusion: While all high-quality studies demonstrate improvement in disease symptoms of the patients, currently sufficient data are not available to recommend the use of probiotics for people with Parkinson disease in clinical practice.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83262350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive Multiple Sclerosis Patients Requiring Special Attention as a Group at Risk for Coronavirus Infection. 进展期多发性硬化症患者作为冠状病毒感染高危人群需要特别关注。

Basic and Clinical Neuroscience Journal Pub Date : 2024-03-01 DOI: 10.32598/bcn.2022.2736.1

Abdorreza Naser Moghadasi, Mohammad Ali Sahraian, Sharareh Eskandarieh

引用次数: 0

Effect of Deep Brain Stimulation on Parkinson Disease Dementia: A Systematic Review and Meta-analysis. 脑深部刺激对帕金森病痴呆症的影响：系统回顾与元分析》。

Basic and Clinical Neuroscience Journal Pub Date : 2024-03-01 DOI: 10.32598/bcn.2021.3420.1

Ali Razmkon, Saeed Abdollahifard, Hirad Rezaei, Amir Reza Bahadori, Parham Eskandarzadeh, AmirAli Rastegar Kazerooni

{"title":"Effect of Deep Brain Stimulation on Parkinson Disease Dementia: A Systematic Review and Meta-analysis.","authors":"Ali Razmkon, Saeed Abdollahifard, Hirad Rezaei, Amir Reza Bahadori, Parham Eskandarzadeh, AmirAli Rastegar Kazerooni","doi":"10.32598/bcn.2021.3420.1","DOIUrl":"10.32598/bcn.2021.3420.1","url":null,"abstract":"Introduction: Patients in the early stages of Parkinson disease (PD) may have subtle cognitive deficits, while overt cognitive deficits are usually manifestations of late-stage PD. There is still a debate on the outcome of deep brain stimulation (DBS) on the cognitive function of PD patients. This study aimed to investigate the effect of subthalamic nucleus (STN)-DBS on the dementia of PD patients after surgery compared to medical therapy and other procedures.Methods: We searched PubMed, Scopus, Cochrane Library, and Web of Science database on October 2020, with keywords: \"Deep brain stimulation,\" \"Parkinson disease,\" \"dementia,\" and \"memory.\" Reviews, abstracts, case presentations, and letters were excluded.Results: In total, 491 studies were screened after removing the duplicates. The screening results yielded 81 articles to be screened for eligibility. Finally, 6 studies were included in this meta-analysis for synthesis. Overall, 800 patients were included in this meta-analysis, using the Mattis dementia rating scale (MDRS) and descriptive data from the articles extracted to assess global dementia.Conclusion: Our results suggest that the STN-DBS group showed a larger cognitive decline than the patients receiving the best medical treatment (BMT). However, comparing STN-DBS with globus pallidus interna stimulation and pallidotomy could not demonstrate a significant statistical effect on the global dementia of patients. More long-term studies with larger sample sizes are needed to validate current findings.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77273219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients With Bipolar Disease: A Randomized Double-blind Controlled Clinical Trial 补充 Omega-3 对躁郁症患者血清中抗氧化剂水平的影响：随机双盲对照临床试验

Basic and Clinical Neuroscience Journal Pub Date : 2024-01-01 DOI: 10.32598/bcn.2022.4292.1

Dina Gholipour, Mansour Shahraki, Mohsen Saravani, Abolfazl Payandeh, Hadi Eslahi

引用次数: 0

Gender Effect on Neural Correlates of Autobiographical False Memories for Brand Images 性别对品牌形象自传性假记忆神经相关因素的影响

Basic and Clinical Neuroscience Journal Pub Date : 2024-01-01 DOI: 10.32598/bcn.2022.3891.1

Mohsen Shabani, Javad Salehi, Reza Khosrowabadi

引用次数: 0

Experimental Evidence on Age-related Differential Outcomes Associated With Substance Abuse. 与药物滥用相关的年龄差异结果的实验证据。

Basic and Clinical Neuroscience Journal Pub Date : 2024-01-01 DOI: 10.32598/bcn.2023.587.1

S Mohammad Ahmadi-Soleimani, Hamed Salmanzadeh, Hossein Azizi

{"title":"Experimental Evidence on Age-related Differential Outcomes Associated With Substance Abuse.","authors":"S Mohammad Ahmadi-Soleimani, Hamed Salmanzadeh, Hossein Azizi","doi":"10.32598/bcn.2023.587.1","DOIUrl":"10.32598/bcn.2023.587.1","url":null,"abstract":"Growing evidence indicates that adolescent substance abuse is now an alarming concern that imposes a considerable socio-economic burden on societies. On the other hand, numerous studies have shown that due to specific neurophysiological features, the brain is more vulnerable to the adverse effects of psychoactive drugs at an early age. Unfortunately, these negative effects are not limited to the period of drug use, but can persistently affect the brain's responsiveness to future exposures to the same or other types of drug. For researchers to develop pharmacological strategies for managing substance abuse disorders, they need to gain a deep understanding of the differences in behavioral outcomes associated with each type of drug across different age groups. The present study was conducted to review the experimental evidence revealing the mentioned differential effects with an emphasis on common drugs of abuse, including cocaine, nicotine, cannabis, and opioids. Although the cellular mechanisms underlying age-related effects have not been exclusively addressed for each drug, the most recent results are presented and discussed. Future studies are required to focus on these mechanisms and reveal how molecular changes during brain development can result in differential responses to drugs at the behavioral level.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84573793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0