Basic and Clinical Neuroscience Journal最新文献

{"title":"Ask, and You Shall Receive: A Closer Look on Unsolved Consciousness Issue.","authors":"Ali Motavalli, Javad Mahmoudi, Alireza Majdi, Saeed Sadigh-Eteghad","doi":"10.32598/bcn.2021.2308.1","DOIUrl":"10.32598/bcn.2021.2308.1","url":null,"abstract":"<p><p>There are numerous views about the concept of consciousness, and no consensus exists regarding its meaning. However, the latest neuroscientific developments have eliminated the misleading obstacles related to consciousness. Over the last few decades, neuroscientific efforts in determining the function of the brain and merging these findings with philosophical theories have brought a more comprehensive perception of the notion of consciousness. In addition to metaphysical or ontological views of consciousness, e.g. higher-order theories, reflexive theories, and representationalist theories, there are some brain-directed topics in this matter, which include but are not limited to neural correlates of consciousness (NCC), brain loop connectivity, and lateralization. This narrative review sheds light on cultural and historical aspects of consciousness in the old and middle ages and introduces some prominent philosophical discussions about mind and body. Also, it illustrates the correlation of brain function with states of consciousness with a focus on the roles of function and connectivity.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"41 1","pages":"569-582"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85559473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Seizure-induced Impairment of Short-term Plasticity in Dorsal and Ventral Hippocampus in Kindled Mice.","authors":"Nahid Roohi, Mahboubeh Ahmadi, Yaghoub Fathollahi, Amir Shojaei, Javad Mirnajafi-Zadeh","doi":"10.32598/bcn.2021.1854.1","DOIUrl":"10.32598/bcn.2021.1854.1","url":null,"abstract":"<p><strong>Introduction: </strong>The differences among dorsal and ventral hippocampal neural circuits affect synaptic plasticity. In this study, we aim to compare the occurrence of short-term plasticity in the field excitatory postsynaptic potential (fEPSP) in dorsal and ventral hippocampal CA1 areas following kindled seizures.</p><p><strong>Methods: </strong>Animals (male C57 B6/J mice, 12 weeks of age) were kindled by intraperitoneal injections of pentylenetetrazole (PTZ), and fEPSPs were recorded from dorsal and ventral hippocampal slices. Short-term plasticity was evaluated by measuring fEPSP-slope and fEPSP-area following paired-pulse stimulation delivered at three inter-pulse intervals (20, 80, and 160 ms).</p><p><strong>Results: </strong>In control slices, the fEPSP-slope was greater in the ventral hippocampus compared to the dorsal hippocampus, but there was no difference in the fEPSP-area between the two regions. In hippocampal slices, the fEPSP-slope was similar in the dorsal and ventral regions, but the fEPSP-area was greater in the ventral region compared to the dorsal region. In addition, the fEPSP-area was greater in the kindled group than in the control group only in the ventral hippocampus. PTZ-induced kindled slices showed impaired short-term facilitation, and the paired-pulse index decreased only in the dorsal hippocampus. Kindling had no significant effect on the paired-pulse ratio in the ventral hippocampus.</p><p><strong>Conclusion: </strong>The seizure occurrence affects the neural activity of the hippocampus in a region-dependent manner. Although kindling increases the fEPSP area in the ventral hippocampus of mice, kindling-induced changes in short-term synaptic plasticity are significant only in the dorsal hippocampus. The difference in the responses of dorsal and ventral poles should be considered in future studies.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"7 1","pages":"595-606"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75141374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Dipeptide H-MGL Partially Ameliorating Memory Impairment in an STZ-induced Alzheimer Model in Male Rats.","authors":"Sarieh Ghasempour, Nader Maghsoudi, Homa Manaheji, Rasoul Ghasemi, Ali Jaafarisuha, Jalal Zaringhalam","doi":"10.32598/bcn.2023.401.3","DOIUrl":"10.32598/bcn.2023.401.3","url":null,"abstract":"<p><strong>Introduction: </strong>Alzheimer disease (AD) is a progressive neurodegenerative disorder that is identified by the gradual decline in memory and cognitive function. It is classified by the deposition of Aβ plaques, the build-up of intracellular neurofibrillary tangle (NFT), and neuron loss. Neurotrophic factors play a critical role in the treatment of AD. However, utilizing such neurotrophins has encountered certain difficulties and side effects. Novel technological advancements prioritize innovative dipeptide usage, which offers fewer side effects.</p><p><strong>Methods: </strong>The present study endeavors to analyze the compound hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine) (lab name: H-MGL), a newly discovered neurotrophin mimetic dipeptide, to alleviate memory impairment in an intracerebroventricular single dose streptozotocin (STZ)-induced Alzheimer model in rats. We arranged 4 groups: Sham and groups receiving STZ and STZ + H-MGL (1 and 2 mg/kg). The H-MGL was administered consecutively for 14 days following the STZ injection. Then, the Morris water maze test was performed.</p><p><strong>Results: </strong>The findings suggest that administration of STZ caused a significantly increment in mean escape latency and mean traveled distance in acquisition days. H-MGL at a 1 mg/kg dosage failed to yield any notable improvement in rats compared to STZ. By contrast, 2 mg/kg of H-MGL dosage led to a significant decrease in the latency to first platform crossing and frequency of platform crossings.</p><p><strong>Conclusion: </strong>Consequently, the findings above have engendered the notion that H-MGL partially ameliorates cognitive impairment, so it may hold promise for having low side effects to alleviate cognitive deficits in AD or potentially decrease the symptoms associated with its progression.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"76 1","pages":"583-594"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87207091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Induction and Release: Electroencephalography Study on Brain Networks and Cortisol.","authors":"Zahra Rezvani, Reza Khosrowabadi, Afrooz Seyedebrahimi, Golam-Hossein Meftahi, Boshra Hatef","doi":"10.32598/bcn.2021.2525.1","DOIUrl":"10.32598/bcn.2021.2525.1","url":null,"abstract":"<p><strong>Introduction: </strong>Acute stress over a long time period can drastically influence the behavioral and cognitive performances. Therefore, it is important to control and eliminate the stressor after a stressful event. In this regard, understanding of brain mechanism of stress release will help to introduce new practical approaches. In this study, we aimed to investigate the changes in the brain's functional connectivity (FC) patterns and salivary cortisol level during stress induction and release in healthy young male adults.</p><p><strong>Method: </strong>In this study, 20 healthy young male adults were exposed to stressful events using the Trier social stress paradigm in one session consisting of 23 minutes of psychological stress induction and 20 minutes of recovery, Their stress was measured by the visual analog scale (VAS). In addition, their salivary cortisol levels and electroencephalography (EEG) data were recorded. Subsequently, brain FC maps were prepared in a frequency-specific manner. Then, the effects of inducing and releasing stress on the VAS, cortisol level, and FC were assessed.</p><p><strong>Results: </strong>The inter-hemispheric FC of the right frontal lobes with other brain regions decreased, while the FC was increased in the left frontal lobes during the induction of stress. Interestingly, the release of stress presented a recovery pattern of inter-hemispheric FC. These changes in FC significantly correlated with changes in the cortisol level.</p><p><strong>Conclusion: </strong>Our findings highlight the important role of bihemispheric associations in adaptation and coping with stressful conditions.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"4 1","pages":"607-616"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87444516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients With Bipolar Disease: A Randomized Double-blind Controlled Clinical Trial","authors":"Dina Gholipour, Mansour Shahraki, Mohsen Saravani, Abolfazl Payandeh, Hadi Eslahi","doi":"10.32598/bcn.2022.4292.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.4292.1","url":null,"abstract":"","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"158 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140523140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Effect on Neural Correlates of Autobiographical False Memories for Brand Images","authors":"Mohsen Shabani, Javad Salehi, Reza Khosrowabadi","doi":"10.32598/bcn.2022.3891.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.3891.1","url":null,"abstract":"","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"30 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioned Medium Derived from the Human Amniotic Membrane Prevents Brain Damage against Cerebral Ischemia/Reperfusion in Three Phases, Subacute, Acute, and Chronic in a Stroke Model in Rats","authors":"Seyyed Mohammad Taghi Razavi-Toosi, Yasin Asadi, N. Aboutaleb, Masoumeh Faezi","doi":"10.32598/bcn.2023.5693.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.5693.1","url":null,"abstract":"Introduction: Stem cells isolated from amniotic membrane can produce and freedom substances that have the ability to regenerate damaged tissues and contain proteins and other factors that apply via numerous major and minor mechanisms leading to increasing angiogenesis and tissue survival. The research was conducted to prove the defensive characteristics of the secretome in the face of temporary focal cerebral ischemia in mouse stroke models. Methods: Cerebral ischemia protocol in a specific area was implemented in rats with middle cerebral artery occlusion for 60 minutes and then reperfusion was given for 6, 20 and 30 minutes. Within 30 minutes after the start of reperfusion, conditioned medium derived from human amniotic membrane (AMSC-CM) was poured into the right ventricle (ICV) with a dose of 0.5 microliters. Finally, the volume of the injury, cerebral tissue water, sensorimotor activity and the strength of the blood-brain barrier integrity were evaluated 24 hours after drug injection. Results: ICV injection of conditioned medium at the start of reperfusion phase considerably decrease the volume of the injury in 6, 20, and 30 hours after reperfusion compared MCAO operated group (p < 0.01), cerebral tissue water in the treatment group decreased considerably after intervention in comparison with the MCAO group in core and penumbral area not in the subcortical area (p < 0.05), Also, the Evans Blue penetration rate in all times in the core and penumbral area in AMSC-CM group considerably decreased paralleled with the MCAO group (p < 0.05). Conclusion: The results show that treatment with AMSC-CM during 6-30 h after ischemia-reperfusion insult exerts some beneficial effects against ischemia-reperfusion injury. These findings provide an important vision for more complementary research and treatment of stroke.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139213099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat","authors":"H. Ghazvini, F. Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, E. Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshiri","doi":"10.32598/bcn.2022.2297.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.2297.1","url":null,"abstract":"Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalograph Emotion Classification Using a Novel Adaptive Ensemble Classifier Considering Personality Traits","authors":"Mohammad Saleh Khajeh Hosseini, Mohammad Pourmir Firoozabadi, Kambiz Badie, Parviz Azad Fallah","doi":"10.32598/bcn.2022.3830.2","DOIUrl":"https://doi.org/10.32598/bcn.2022.3830.2","url":null,"abstract":"Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing methods face challenges. Features extracted from EEG signals may not accurately represent an individual's emotional patterns due to interference from time-varying factors and noise. Additionally, higher-level cognitive factors, such as personality, mood, and past experiences, further complicate emotion recognition. The dynamic nature of EEG data in terms of time series introduces variability in feature distribution and interclass discrimination across different time stages. Methods: To address these challenges, the paper proposes a novel adaptive ensemble classification method. The study introduces a new method for providing emotional stimuli, categorizing them into three groups (sadness, neutral, and happiness) based on their valence-arousal (VA) scores. The experiment involved 60 participants aged 19–30 years, and the proposed method aimed to mitigate the limitations associated with conventional classifiers. Results: The results demonstrate a significant improvement in the performance of emotion classifiers compared to conventional methods. The classification accuracy achieved by the proposed adaptive ensemble classification method is reported at 87.96%. This suggests a promising advancement in the ability to accurately classify emotions using EEG signals, overcoming the limitations outlined in the introduction. Conclusion: In conclusion, the paper introduces an innovative approach to emotion classification based on EEG signals, addressing key challenges associated with existing methods. By employing a new adaptive ensemble classification method and refining the process of providing emotional stimuli, the study achieves a noteworthy improvement in classification accuracy. This advancement is crucial for enhancing our understanding of the complexities of emotion recognition through EEG signals, paving the way for more effective applications in fields such as neuroinformatics and affective computing.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Assessments of Electrocardiographic Parameters in the Patients with Drug-Resistant Temporal Lobe Epilepsy; A Case-Control Study","authors":"J. Mehvari, Zeinab Jaafari, Mohamad Zare, N. Tabrizi, Alireza Khosravi Farsani","doi":"10.32598/bcn.2023.4724.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.4724.1","url":null,"abstract":"Introduction: Sudden unexpected death in epilepsy (SUDEP) is the substantial cause of death in patients with epilepsy (PWE). Electroconductive disorders leading to life-threatening arrhythmia are mostly hypothesized to play a crucial role; however, there is paucity of knowledge in variable among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls. Methods: The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. ECGs were taken when admitted at the hospital (base line), immediately after a seizure incidence and within an hour after the end of the seizure from the cases compared with a random ECG of the controls considering parameters including PR-, RR-, and corrected QT interval (QTc), P wave duration and heart rate (HR) variability. Results: Shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P-value=0.017) in the base line taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P-value=0.005) and heart rate (P-value=0.005). Post-ictal ECGs did not differ between the groups (P-value>0.05). Conclusion: According to the findings of this study, shortened QTc interval at base line ECGs, shortened RR interval and increased HR during the seizure were the ECG elements affected in drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75660581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}