Basic and Clinical Neuroscience Journal最新文献

{"title":"Comparing the Seizure-induced Impairment of Short-term Plasticity in Dorsal and Ventral Hippocampus in Kindled Mice.","authors":"Nahid Roohi, Mahboubeh Ahmadi, Yaghoub Fathollahi, Amir Shojaei, Javad Mirnajafi-Zadeh","doi":"10.32598/bcn.2021.1854.1","DOIUrl":"10.32598/bcn.2021.1854.1","url":null,"abstract":"<p><strong>Introduction: </strong>The differences among dorsal and ventral hippocampal neural circuits affect synaptic plasticity. In this study, we aim to compare the occurrence of short-term plasticity in the field excitatory postsynaptic potential (fEPSP) in dorsal and ventral hippocampal CA1 areas following kindled seizures.</p><p><strong>Methods: </strong>Animals (male C57 B6/J mice, 12 weeks of age) were kindled by intraperitoneal injections of pentylenetetrazole (PTZ), and fEPSPs were recorded from dorsal and ventral hippocampal slices. Short-term plasticity was evaluated by measuring fEPSP-slope and fEPSP-area following paired-pulse stimulation delivered at three inter-pulse intervals (20, 80, and 160 ms).</p><p><strong>Results: </strong>In control slices, the fEPSP-slope was greater in the ventral hippocampus compared to the dorsal hippocampus, but there was no difference in the fEPSP-area between the two regions. In hippocampal slices, the fEPSP-slope was similar in the dorsal and ventral regions, but the fEPSP-area was greater in the ventral region compared to the dorsal region. In addition, the fEPSP-area was greater in the kindled group than in the control group only in the ventral hippocampus. PTZ-induced kindled slices showed impaired short-term facilitation, and the paired-pulse index decreased only in the dorsal hippocampus. Kindling had no significant effect on the paired-pulse ratio in the ventral hippocampus.</p><p><strong>Conclusion: </strong>The seizure occurrence affects the neural activity of the hippocampus in a region-dependent manner. Although kindling increases the fEPSP area in the ventral hippocampus of mice, kindling-induced changes in short-term synaptic plasticity are significant only in the dorsal hippocampus. The difference in the responses of dorsal and ventral poles should be considered in future studies.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"7 1","pages":"595-606"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75141374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Dipeptide H-MGL Partially Ameliorating Memory Impairment in an STZ-induced Alzheimer Model in Male Rats.","authors":"Sarieh Ghasempour, Nader Maghsoudi, Homa Manaheji, Rasoul Ghasemi, Ali Jaafarisuha, Jalal Zaringhalam","doi":"10.32598/bcn.2023.401.3","DOIUrl":"10.32598/bcn.2023.401.3","url":null,"abstract":"<p><strong>Introduction: </strong>Alzheimer disease (AD) is a progressive neurodegenerative disorder that is identified by the gradual decline in memory and cognitive function. It is classified by the deposition of Aβ plaques, the build-up of intracellular neurofibrillary tangle (NFT), and neuron loss. Neurotrophic factors play a critical role in the treatment of AD. However, utilizing such neurotrophins has encountered certain difficulties and side effects. Novel technological advancements prioritize innovative dipeptide usage, which offers fewer side effects.</p><p><strong>Methods: </strong>The present study endeavors to analyze the compound hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine) (lab name: H-MGL), a newly discovered neurotrophin mimetic dipeptide, to alleviate memory impairment in an intracerebroventricular single dose streptozotocin (STZ)-induced Alzheimer model in rats. We arranged 4 groups: Sham and groups receiving STZ and STZ + H-MGL (1 and 2 mg/kg). The H-MGL was administered consecutively for 14 days following the STZ injection. Then, the Morris water maze test was performed.</p><p><strong>Results: </strong>The findings suggest that administration of STZ caused a significantly increment in mean escape latency and mean traveled distance in acquisition days. H-MGL at a 1 mg/kg dosage failed to yield any notable improvement in rats compared to STZ. By contrast, 2 mg/kg of H-MGL dosage led to a significant decrease in the latency to first platform crossing and frequency of platform crossings.</p><p><strong>Conclusion: </strong>Consequently, the findings above have engendered the notion that H-MGL partially ameliorates cognitive impairment, so it may hold promise for having low side effects to alleviate cognitive deficits in AD or potentially decrease the symptoms associated with its progression.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"76 1","pages":"583-594"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87207091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Induction and Release: Electroencephalography Study on Brain Networks and Cortisol.","authors":"Zahra Rezvani, Reza Khosrowabadi, Afrooz Seyedebrahimi, Golam-Hossein Meftahi, Boshra Hatef","doi":"10.32598/bcn.2021.2525.1","DOIUrl":"10.32598/bcn.2021.2525.1","url":null,"abstract":"<p><strong>Introduction: </strong>Acute stress over a long time period can drastically influence the behavioral and cognitive performances. Therefore, it is important to control and eliminate the stressor after a stressful event. In this regard, understanding of brain mechanism of stress release will help to introduce new practical approaches. In this study, we aimed to investigate the changes in the brain's functional connectivity (FC) patterns and salivary cortisol level during stress induction and release in healthy young male adults.</p><p><strong>Method: </strong>In this study, 20 healthy young male adults were exposed to stressful events using the Trier social stress paradigm in one session consisting of 23 minutes of psychological stress induction and 20 minutes of recovery, Their stress was measured by the visual analog scale (VAS). In addition, their salivary cortisol levels and electroencephalography (EEG) data were recorded. Subsequently, brain FC maps were prepared in a frequency-specific manner. Then, the effects of inducing and releasing stress on the VAS, cortisol level, and FC were assessed.</p><p><strong>Results: </strong>The inter-hemispheric FC of the right frontal lobes with other brain regions decreased, while the FC was increased in the left frontal lobes during the induction of stress. Interestingly, the release of stress presented a recovery pattern of inter-hemispheric FC. These changes in FC significantly correlated with changes in the cortisol level.</p><p><strong>Conclusion: </strong>Our findings highlight the important role of bihemispheric associations in adaptation and coping with stressful conditions.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"4 1","pages":"607-616"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87444516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients With Bipolar Disease: A Randomized Double-blind Controlled Clinical Trial","authors":"Dina Gholipour, Mansour Shahraki, Mohsen Saravani, Abolfazl Payandeh, Hadi Eslahi","doi":"10.32598/bcn.2022.4292.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.4292.1","url":null,"abstract":"","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"158 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140523140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Effect on Neural Correlates of Autobiographical False Memories for Brand Images","authors":"Mohsen Shabani, Javad Salehi, Reza Khosrowabadi","doi":"10.32598/bcn.2022.3891.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.3891.1","url":null,"abstract":"","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"30 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioned Medium Derived from the Human Amniotic Membrane Prevents Brain Damage against Cerebral Ischemia/Reperfusion in Three Phases, Subacute, Acute, and Chronic in a Stroke Model in Rats","authors":"Seyyed Mohammad Taghi Razavi-Toosi, Yasin Asadi, N. Aboutaleb, Masoumeh Faezi","doi":"10.32598/bcn.2023.5693.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.5693.1","url":null,"abstract":"Introduction: Stem cells isolated from amniotic membrane can produce and freedom substances that have the ability to regenerate damaged tissues and contain proteins and other factors that apply via numerous major and minor mechanisms leading to increasing angiogenesis and tissue survival. The research was conducted to prove the defensive characteristics of the secretome in the face of temporary focal cerebral ischemia in mouse stroke models. Methods: Cerebral ischemia protocol in a specific area was implemented in rats with middle cerebral artery occlusion for 60 minutes and then reperfusion was given for 6, 20 and 30 minutes. Within 30 minutes after the start of reperfusion, conditioned medium derived from human amniotic membrane (AMSC-CM) was poured into the right ventricle (ICV) with a dose of 0.5 microliters. Finally, the volume of the injury, cerebral tissue water, sensorimotor activity and the strength of the blood-brain barrier integrity were evaluated 24 hours after drug injection. Results: ICV injection of conditioned medium at the start of reperfusion phase considerably decrease the volume of the injury in 6, 20, and 30 hours after reperfusion compared MCAO operated group (p < 0.01), cerebral tissue water in the treatment group decreased considerably after intervention in comparison with the MCAO group in core and penumbral area not in the subcortical area (p < 0.05), Also, the Evans Blue penetration rate in all times in the core and penumbral area in AMSC-CM group considerably decreased paralleled with the MCAO group (p < 0.05). Conclusion: The results show that treatment with AMSC-CM during 6-30 h after ischemia-reperfusion insult exerts some beneficial effects against ischemia-reperfusion injury. These findings provide an important vision for more complementary research and treatment of stroke.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139213099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat","authors":"H. Ghazvini, F. Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, E. Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshiri","doi":"10.32598/bcn.2022.2297.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.2297.1","url":null,"abstract":"Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalograph Emotion Classification Using a Novel Adaptive Ensemble Classifier Considering Personality Traits","authors":"Mohammad Saleh Khajeh Hosseini, Mohammad Pourmir Firoozabadi, Kambiz Badie, Parviz Azad Fallah","doi":"10.32598/bcn.2022.3830.2","DOIUrl":"https://doi.org/10.32598/bcn.2022.3830.2","url":null,"abstract":"Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing methods face challenges. Features extracted from EEG signals may not accurately represent an individual's emotional patterns due to interference from time-varying factors and noise. Additionally, higher-level cognitive factors, such as personality, mood, and past experiences, further complicate emotion recognition. The dynamic nature of EEG data in terms of time series introduces variability in feature distribution and interclass discrimination across different time stages. Methods: To address these challenges, the paper proposes a novel adaptive ensemble classification method. The study introduces a new method for providing emotional stimuli, categorizing them into three groups (sadness, neutral, and happiness) based on their valence-arousal (VA) scores. The experiment involved 60 participants aged 19–30 years, and the proposed method aimed to mitigate the limitations associated with conventional classifiers. Results: The results demonstrate a significant improvement in the performance of emotion classifiers compared to conventional methods. The classification accuracy achieved by the proposed adaptive ensemble classification method is reported at 87.96%. This suggests a promising advancement in the ability to accurately classify emotions using EEG signals, overcoming the limitations outlined in the introduction. Conclusion: In conclusion, the paper introduces an innovative approach to emotion classification based on EEG signals, addressing key challenges associated with existing methods. By employing a new adaptive ensemble classification method and refining the process of providing emotional stimuli, the study achieves a noteworthy improvement in classification accuracy. This advancement is crucial for enhancing our understanding of the complexities of emotion recognition through EEG signals, paving the way for more effective applications in fields such as neuroinformatics and affective computing.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hypertonic Sodium Lactate on Intracranial Pressure in Patients with Traumatic Brain Injury: A Systematic Review and Metanalysis on Clinical Trial Studies","authors":"R. Mosaed, Arash Akhavan Rezayat, Behnaz Rohani, Aida Ayati Afin, F. Najmeddin, Shahideh Amini, Maryam Taghizadeh-Ghehi, Mohamad Afshar Ardalan, A. Najafi, M. Mojtahedzadeh","doi":"10.32598/bcn.2022.4037.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.4037.1","url":null,"abstract":"Introduction: Intracranial pressure (ICP) elevation leading to cerebral edema is a critical condition that should be identified and treated immediately. In this study, we systematically reviewed the articles investigating the role of hypertonic sodium lactate (HSL) in patients with traumatic brain injury. Method: PubMed, Scopus, EMBASE, and Web of Science were searched to find published articles on the effects of HSL on ICP in patients with a traumatic brain injury until December 2020. Animal studies, case reports, and studies, including liver and renal failure patients, cardiac dysfunction, or hypovolemic shock, were excluded. The Newcastle–Ottawa Scale checklist was used to assess the methodological quality of eligible articles. Information was gathered based on the following: Demographic data, methods, intervention, and outcomes. Results: Our initial search with the predefined search strategy proceeded 113 studies. Finally, seven studies were eligible for systematic review, which three of them were eligible for meta-analysis. A random meta-analysis of three articles comparing ICP before and after the infusion of HSL showed a reduced ICP following the use of HSL in traumatic brain injuries (P=0.015). Conclusion: Our study demonstrated hypertonic sodium lactate's undeniable role in managing increased ICP in patients with brain injury. Nevertheless, conducting more clinical studies for assessing the possible side effects of HSL seems crucial.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89763033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of KIAA0319, DYXIC1 and DCDC2 Gene Polymorphisms in Children with Dyslexia in Indian Population","authors":"Shilpa Reddy Ganasyam, Manaswini Namilakonda, Sujatha Madireddy, V. Ananthapur, Srinadh Buragadda, Sunitha Tella","doi":"10.32598/bcn.2022.3258.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.3258.1","url":null,"abstract":"Background:Dyslexia is a typical learning disability that does not affect intelligence but causes problems with reading, writing, and spelling. It is influenced by certain genes, due to which several researchers have attempted to identify the susceptible gene. Dyslexia is incurable and diagnosis is difficult because it always overlaps with other learning disabilities. Hence, timely assessment and intervention consequently give the best results. Therefore, our aim was to find the relation between dyslexia and single nucleotide polymorphisms (SNPs) in several candidate genes like DYX1C1, KIAA0319, and DCDC2 in Indian population. Methods:In the present study, 103 individuals with dyslexia and 100 controls in the age group between 6 to 15 years were taken. Thirteen SNPs in the KIAA gene, seven SNPs of DCDC2, and three SNPs of the DYX1C1 gene were analysed by the Mass Array technique. Results:The association of dyslexia with SNPs rs3756821, rs6935076, rs4576240 of the KIAA gene was found significant. A significant association was found with rs600753 of the DYX1C1 gene and dyslexia and we could not find any association of the DCDC2 gene with dyslexia. Conclusions:Prerequisite genetic analysis is necessary for the diagnosis of dyslexia as it is a crucial educational barrier. Treatment is known to be most effective if dyslexia is identified in the early stages for effective intervention for children before they experience prolonged reading failure. Further, it helps in prenatal diagnosis for early intervention.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81817417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}