Basic and Clinical Neuroscience Journal最新文献

{"title":"COVID-19 and the Brain: A Psychological and Resting-state Functional Magnetic Resonance Imagin (fMRI) Study of the Whole-brain Functional Connectivity.","authors":"Mohammad Niroumand Sarvandani, Javad Sheikhi Koohsar, Raheleh Rafaiee, Maryam Saeedi, Seyedeh Masoumeh Seyedhosseini Tamijani, Hamed Ghazvini, Hossein Sheibani","doi":"10.32598/bcn.2021.1425.4","DOIUrl":"10.32598/bcn.2021.1425.4","url":null,"abstract":"<p><strong>Introduction: </strong>Coronavirus-2019 (COVID-19) spreads rapidly worldwide and causes severe acute respiratory syndrome. The current study aims to evaluate the relationship between the whole-brain functional connections in a resting state and cognitive impairments in patients with COVID-19 compared to the healthy control group.</p><p><strong>Methods: </strong>Resting-state functional magnetic resonance imaging (rs-fMRI) and Montreal cognitive assessment (MoCA) data were obtained from 29 patients of the acute stage of COVID-19 on the third day of admission and 20 healthy controls. Cross-correlation of the mean resting-state signals was determined in the voxels of 23 independent components (IC) of brain neural circuits. To assess cognitive function and neuropsychological status, MoCA was performed on all participants. The relationship between rs-fMRI information, neuropsychological status, and paraclinical data was analyzed.</p><p><strong>Results: </strong>The COVID-19 group got a lower mean MoCA score and showed a significant reduction in the functional connectivity of the IC14 (P<0.001) and IC38 (P<0.001) regions compared to the controls. The increase in functional connectivity was observed in the COVID-19 group compared to the controls at baseline in the default mode network (DMN) IC00 (P<0.001) and dorsal attention network (DAN) IC08 (P<0.001) regions. Furthermore, the alternation of functional connectivity in the mentioned ICs was significantly correlated with the mean MoCA scores and inflammatory parameters, i.e. erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).</p><p><strong>Conclusion: </strong>Functional connectivity abnormalities in four brain neural circuits are associated with cognitive impairment and increased inflammatory markers in patients with COVID-19.</p><p><strong>Highlights: </strong>The patients with coronavirus-2019 (COVID-19) got a lower mean Montreal cognitive assessment (MoCA) score.The patients with COVID-19 showed significant reduction in the functional connectivity of the IC14 and IC38 regions.The patients with COVID-19 showed significant increase of functional connectivity in the default mode network (DMN) IC00 and dorsal attention network (DAN) IC08 regions.Alternation of functional connectivity was significantly correlated with the mean MoCA scores and ESR and CRP.</p><p><strong>Plain language summary: </strong>The researcher aimed at assessing cognitive impairments and investigating the whole-brain functional connectivity using resting state fMRI in patients with COVID-19 compared with healthy control group. The result showed That COVID-19 group got a lower mean cognitive score and showed a significant reduction in the functional connectivity of the IC14 and IC38 regions of brain compared with controls. Also, the increase of functional connectivity was observed in the COVID-19 group compared with controls at baseline in the default mode network (DMN) and dorsal attention network (DAN) ","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91519842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory Emotion in Words: Evidence From an Event-related Potential (ERP) Study in Light of the Emotioncy Model.","authors":"Sahar Tabatabaee Farani, Reza Pishghadam, Azin Khodaverdi","doi":"10.32598/bcn.2021.1870.1","DOIUrl":"10.32598/bcn.2021.1870.1","url":null,"abstract":"<p><strong>Introduction: </strong>Delving into the prominent role of emotions and senses in language is not something new in the field. Thereupon, the newly developed notion of emotioncy has been introduced to foreign language education to underscore the role of sense-induced emotions in the language learning and teaching process.</p><p><strong>Methods: </strong>The present study implemented event-related potentials (ERPs) to provide evidence of the significance of employing emosensory instructional strategies in teaching vocabulary items. Hence, 18 female participants were randomly instructed on six English nouns toward which they had no prior knowledge and received no instruction for the other three words. Then, while the participants' electroencephalogram (EEG) was being recorded, they took a sentence comprehension task.</p><p><strong>Results: </strong>Behavioral results demonstrated significant differences among the avolved, the exvolved, and the involved nouns. However, ERP analyses of target words indicated the modulations of N100 and N480 components while no significant effect was observed at P200. Further, the analysis of sensory N100 for the critical words revealed no significant effect.</p><p><strong>Conclusion: </strong>In conclusion, emotioncy-based language instruction can affect neural correlates of emotional word comprehension from the early stages of EEG recording. The results of this study can clarify the importance of including senses and emotions in language teaching, learning, and testing, along with materials development.</p><p><strong>Highlights: </strong>Direct emosensory involvement can affect word semantic processing.Indirect emosensory involvement can affect sensorial comprehension of the word.Direct sensory involvement may enhance the accuracy of the responses.Direct sensory involvement may reduce the response time.</p><p><strong>Plain language summary: </strong>Nowadays, learning a foreign language is considered one of the challenges in our lives. It is believed that including senses and emotions in education can foster learning new words in a foreign language. One concept that focuses on the use of sensory emotions is called emotioncy. This study employed brain imaging to analyze the effects of teaching through emotioncy on related neural modulations. Based on the results of the study, higher levels of employing senses and emotions can affect the processing and comprehension of words.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84048357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Therapeutics Effects of Oral Cavity Derived Stem Cells on Neurodegenerative Diseases: A Systematic Review.","authors":"Emel Uzunoglu-Ozyurek, Gizem Önal, Serap Dökmeci","doi":"10.32598/bcn.2021.2892.1","DOIUrl":"10.32598/bcn.2021.2892.1","url":null,"abstract":"<p><strong>Introduction: </strong>Published data obtained from in vitro and in vivo studies was reviewed systematically and analyzed critically to evaluate the effect of oral cavity-derived stem cells (OCDSCs) on the recovery or therapy of neurodegenerative diseases (NDs), such as Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), Huntington (HD) diseases, and Parkinson disease (PD).</p><p><strong>Methods: </strong>An electronic search was accomplished. References of included articles were also manually searched. Studies were critically evaluated for suitability against the inclusion/exclusion criteria and the data was extracted. Bias risk evaluation of the studies and evidence synthesis were conducted.</p><p><strong>Results: </strong>A total of 14 in vivo and 10 in vitro studies met the inclusion criteria. PD was induced in 10 in vivo and 7 in vitro studies, while AD was induced in 2 in vivo and 4 in vitro studies. Two studies (1 in vitro and 1 in vivo) evaluated ALS disease and 1 in vivo study evaluated HD. Moderate evidence was found for in vitro studies reporting the positive effect of OCDSCs on PD or AD recovery. Strong evidence was found for in vivo studies in which PD animal models were used; meanwhile, moderate evidence was found for the impact of OCDSCs on AD recovery. Limited evidence was found for in vivo studies evaluating HD and ALS.</p><p><strong>Conclusion: </strong>Although studies reported favorable data regarding the OCDSCs on NDs, they presented a considerable risk of bias. Because of heterogeneous study characteristics, the current study recommends improving standardized methods to evaluate the therapeutic effects of OCDSCs on the NDs.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80906053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Acyl CoA Oxidase1 Inhibition Modifies Brain Lipids and Electrical Properties of Dentate Gyrus.","authors":"Shahrbanoo Rafiei, Fariba Khodagholi, Hamid Gholami Pourbadie, Leila Dargahi, Fereshteh Motamedi","doi":"10.32598/bcn.2021.3500.1","DOIUrl":"10.32598/bcn.2021.3500.1","url":null,"abstract":"<p><strong>Introduction: </strong>Peroxisomes are essential organelles in lipid metabolism. They contain enzymes for β-oxidation of very long-chain fatty acids (VLCFA) that cannot be broken down in mitochondria. Reduced expression in hepatic acyl-CoA oxidase 1 (ACOX1), a peroxisome β-oxidation enzyme, followed by modification of the brain fatty acid profile has been observed in aged rodents. These studies have suggested a potential role for peroxisome β-oxidation in brain aging. This study was designed to examine the effect of hepatic ACOX1 inhibition on brain fatty acid composition and neuronal cell activities of young rats (200-250 g).</p><p><strong>Methods: </strong>A specific ACOX1 inhibitor, 10, 12- tricosadiynoic acid (TDYA), 100 μg/kg (in olive oil) was administered by daily gavage for 25 days in male Wistar rats. The brain fatty acid composition and electrophysiological properties of dentate gyrus granule cells were determined using gas chromatography and whole-cell patch-clamp, respectively.</p><p><strong>Results: </strong>A significant increase in C20, C22, C18:1, C20:1, and a decrease of C18, C24, C20:3n6, and C22:6n3 were found in 10, 12- tricosadiynoic acid (TDYA) treated rats compared to the control group. The results showed that ACOX1 inhibition changes fatty acid composition similar to old rats. ACOX1 inhibition caused hyperpolarization of resting membrane potential, and also reduction of input resistance, action potential duration, and spike firing. Moreover, ACOX1 inhibition increased rheobase current and afterhyperpolarization amplitude in granule cells.</p><p><strong>Conclusion: </strong>The results indicated that systemic inhibition of ACOX1 causes hypo-excitability of neuronal cells. These results provide new evidence on the involvement of peroxisome function and hepatic ACOX1 activity in brain fatty acid profile and the electrophysiological properties of dentate gyrus cells.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86169171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Comparison of Brain Waves of Dyslexic Students With Perceptual and Linguistic Types With Normal Students in Reading.","authors":"Danial Fathi Khorasani, Mitra Rastgou Moghadam, Mohammad Reza Saebipour, Majid Ghoshuni","doi":"10.32598/bcn.2022.144.5","DOIUrl":"10.32598/bcn.2022.144.5","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to compare the brain wave pattern of two groups of dyslexic students with perceptual and linguistic types with normal students in reading.</p><p><strong>Methods: </strong>In this study, 27 students (24 boys and 3 girls) from first to fifth grade with an Mean±SD of age 8.16±10.09 years participated. Eight students with perceptual type dyslexia, ten students with linguistic type dyslexia, and nine normal students with reading were selected by purposive sampling method.</p><p><strong>Results: </strong>After removing noise and artifacts, the data were converted into quantitative digits using Neuroguide software and analyzed using multivariate analysis of variance (MANOVA) and univariate analysis of variance (ANOVA). Based on the results, the linguistic group and the normal group differed in the relative power of the alpha wave in the two channels Fp1 and Fp2, but there was no difference between the three linguistic, perceptual, and normal groups in the absolute power of the four waves of the delta, theta, alpha, and beta.</p><p><strong>Conclusion: </strong>The relative power spectrum of the alpha band in the forehead can be significantly related to dyslexia problems as seen in the linguistic type.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84164950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Modeling Methods on Mirror Neuron Activity and a Motor Skill Acquisition and Retention.","authors":"Ramin Ashraf, Behrouz Abdoli, Reza Khosrowabadi, Alireza Farsi, Jaime A Pineda","doi":"10.32598/bcn.2021.3245.1","DOIUrl":"10.32598/bcn.2021.3245.1","url":null,"abstract":"<p><strong>Introduction: </strong>Mirror neurons have been suggested as a potential neural mechanism of observational learning. This study aims to investigate the effect of self-modeling, skilled model, and learning model on mu rhythm suppression and golf putting acquisition and retention.</p><p><strong>Methods: </strong>The study was conducted on 45 male volunteer students (aged 19.4±0.37 years) in three experimental groups, self-modeling, skilled, and learning models with six sessions of physical and observational training in three periods of pre-test, acquisition, and retention. In the pre-test, after the initial familiarity with the skill, participants performed 10 golf putting actions while scores were recorded. Then, electrical brain waves in C3, C4, and Cz regions were recorded during the observation of 10 golf putting actions by their group-related models. The acquisition period consisted of golf putting training during six sessions, each consisting of six blocks of 10 trials. Before each training block, participants observed golf putting related to their group 10 times in the form of a video. Acquisition and delayed retention tests were also performed by recording scores of 10 golf putting actions, as well as recording electrical brain waves while observing the skill performed by the related model.</p><p><strong>Results: </strong>Mixed analysis of variance (ANOVA) showed that the mu rhythm suppression in the pre-test was more in the self-modeling group compared to the skilled model and learning model groups, but this suppression was not significantly different in all three groups in the acquisition and retention tests. In putting task variables, all three groups that had no significant difference in the pre-test period made considerable progress in learning the desired skill from the pre-test to the acquisition test, and this progress was somewhat stable until the retention test. Also, both in the acquisition and retention periods, the self-modeling group showed better performance than the other two groups; however, no significant difference was observed between these groups.</p><p><strong>Conclusion: </strong>These results suggest that the model-observer similarity is a crucial factor in modeling interventions and can affect the rate of mu rhythm suppression.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90078309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Dominant Presence of Brain Grey Matter in Autism During Functional Magnetic Resonance Imaging.","authors":"Seyed Amir Hossein Batouli, Foroogh Razavi, Minoo Sisakhti, Zeinab Oghabian, Haady Ahmadzade, Mehdi Tehrani Doost","doi":"10.32598/bcn.2021.1774.3","DOIUrl":"10.32598/bcn.2021.1774.3","url":null,"abstract":"<p><strong>Introduction: </strong>Autism spectrum disorder (ASD) is a neurodevelopmental disorder with symptoms appearing from early childhood. Behavioral modifications, special education, and medicines are used to treat ASD; however, the effectiveness of the treatments depends on early diagnosis of the disorder. The primary approach in diagnosing ASD is based on clinical interviews and valid scales. Still, methods based on brain imaging could also be possible diagnostic biomarkers for ASD.</p><p><strong>Methods: </strong>To identify the amount of information the functional magnetic resonance imaging (fMRI) reveals on ASD, we reviewed 292 task-based fMRI studies on ASD individuals. This study is part of a systematic review with the registration number CRD42017070975.</p><p><strong>Results: </strong>We observed that face perception, language, attention, and social processing tasks were mainly studied in ASD. In addition, 73 brain regions, nearly 83% of brain grey matter, showed an altered activation between the ASD and normal individuals during these four tasks, either in a lower or a higher activation.</p><p><strong>Conclusion: </strong>Using imaging methods, such as fMRI, to diagnose and predict ASD is a great objective; research similar to the present study could be the initial step.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73792925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probable Neuropsychological and Cognitive Complications Due to Cytokine Storm in Patients With COVID-19.","authors":"Zahra Keshtgar, Gholamreza Chalabianloo, Niloofar Esmaeili","doi":"10.32598/bcn.2022.3202.1","DOIUrl":"10.32598/bcn.2022.3202.1","url":null,"abstract":"<p><strong>Introduction: </strong>COVID-19 (coronavirus disease 2019) was first identified in China in December 2019 and is rapidly spreading worldwide as a pandemic. Since COVID-19 causes mild to severe acute respiratory syndrome, most studies in this context have focused on pathogenesis primarily in the respiratory system. However, evidence shows that the central nervous system (CNS) may also be affected by COVID-19. Since COVID-19 is spreading, it is necessary to study its possible cognitive effects on COVID-19 patients and their recovery.</p><p><strong>Methods: </strong>The articles used in this study were searched by keywords, such as cytokine storm and COVID-19, COVID-19 and executive dysfunction, cognitive disorder, and COVID-19, central nervous system (CNS) and COVID-19, coronavirus, neuroinvasion in Science Direct, Scopus, PubMed, Embase, and Web of Science databases based on preferred reporting items for systematic reviews and meta-analysis (PRISMA) checklist. The study evaluates all observational studies published between December 2019 and April 2021 in peer-reviewed journals, including cross-sectional, cohort, case-control studies, case reports, and case series. The search result was 106 articles, of which 73 articles related to COVID-19, the stages of infection by this virus, its effect on the nervous system and neurological symptoms, the cytokine storm caused by this infection, and the possible cognitive consequences caused by this virus in patients, has been reviewed. Other articles were not checked due to their limited relevance to the topic under discussion.</p><p><strong>Results: </strong>Studies showed that neurons may be directly affected by severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and SARS-CoV-2. Furthermore, various studies indicated that systemic inflammation (so-called \"cytokine storm\") is also responsible for brain damage induced by infection with SARS-CoV-1 and SARS-CoV-2. In such a way that these patients showed elevated levels of interleukin (IL-), 6, 8, and 10 and of tumor necrosis factor-alpha (TNF-α) in their blood.</p><p><strong>Conclusion: </strong>Various cognitive defects have been observed following an increased level of cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6, 8. Therefore, due to the increased level of these pro-inflammatory factors in the brains of these patients, cognitive deficits can be expected, which need further investigation.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82865973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Morphology in Cannabis Use Disorder: Implications for Transcranial Direct Current Stimulation Treatment.","authors":"Ghazaleh Soleimani, Farzad Towhidkhah, Mehrdad Saviz, Hamed Ekhtiari","doi":"10.32598/bcn.2021.3400.1","DOIUrl":"10.32598/bcn.2021.3400.1","url":null,"abstract":"<p><strong>Introduction: </strong>Transcranial direct current stimulation (tDCS) has been studied as an adjunctive treatment option for substance use disorders (SUDs). Alterations in brain structure following SUD may change tDCS-induced electric field (EF) and subsequent responses; however, group-level differences between healthy controls (HC) and participants with SUDs in terms of EF and its association with cortical architecture have not yet been modeled quantitatively. This study provides a methodology for group-level analysis of computational head models to investigate the influence of cortical morphology metrics on EFs.</p><p><strong>Methods: </strong>Whole-brain surface-based morphology was conducted, and cortical thickness, volume, and surface area were compared between participants with cannabis use disorders (CUD) (n=20) and age-matched HC (n=22). Meanwhile, EFs were simulated for bilateral tDCS over the dorsolateral prefrontal cortex. The effects of structural alterations on EF distribution were investigated based on individualized computational head models.</p><p><strong>Results: </strong>Regarding EF, no significant difference was found within the prefrontal cortex; however, EFs were significantly different in left-postcentral and right-superior temporal gyrus (P<0.05) with higher levels of variance in CUD compared to HC [F_{(39, 43)}=5.31, P<0.0001, C=0.95]. Significant differences were observed in cortical area (caudal anterior cingulate and rostral middle frontal), thickness (lateral orbitofrontal), and volume (paracentral and fusiform) between the two groups.</p><p><strong>Conclusion: </strong>Brain morphology and tDCS-induced EFs may be changed following CUD; however, differences between CUD and HCs in EFs do not always overlap with brain areas that show structural alterations. To sufficiently modulate stimulation targets, whether individuals with CUD need different stimulation doses based on tDCS target location should be checked.</p>","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85981103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat","authors":"H. Ghazvini, F. Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, E. Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshiri","doi":"10.32598/bcn.2022.2297.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.2297.1","url":null,"abstract":"Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}