Basic and Clinical Neuroscience Journal最新文献_第3页

Comparing the Seizure-Induced Impairment of Short-Term Plasticity in Dorsal and Ventral Hippocampus in Kindled Mice 癫痫致点燃小鼠海马背侧和腹侧短期可塑性损伤的比较

Basic and Clinical Neuroscience Journal Pub Date : 2021-06-28 DOI: 10.32598/bcn.2021.1854.1

Nahid Roohi, M. Ahmadi, Yaghoun Fathollahi, A. Shojaei, J. Mirnajafi-zadeh

{"title":"Comparing the Seizure-Induced Impairment of Short-Term Plasticity in Dorsal and Ventral Hippocampus in Kindled Mice","authors":"Nahid Roohi, M. Ahmadi, Yaghoun Fathollahi, A. Shojaei, J. Mirnajafi-zadeh","doi":"10.32598/bcn.2021.1854.1","DOIUrl":"https://doi.org/10.32598/bcn.2021.1854.1","url":null,"abstract":"There are many differences among dorsal and ventral hippocampal neural circuits that affect the synaptic plasticity. In this study we compared the occurrence of short-term plasticity in the field excitatory post synaptic potentials (fEPSP) in dorsal and ventral hippocampal CA1 area following kindled seizures. Animals (male C57 B6/J mice, 12 weeks of age) were kindled by intraperitoneal injections of pentylenetetrazole (PTZ) and fEPSPs were recorded from dorsal and ventral hippocampal slices. Short-term plasticity was evaluated by measuring fEPSP-slope and fEPSP-area following paired-pulse stimulation delivered at three inter-pulse intervals (20, 80 and 160 ms). Obtained results showed that in control slices fEPSP-slope was greater in ventral- compared to dorsal hippocampus, but there was no difference in fEPSP-area among two regions. In hippocampal slices of kindled animals, fEPSP-slope was similar in dorsal and ventral regions, but fEPSP-area was greater in ventral- compared to dorsal hippocampus. In addition, fEPSP-area was greater in kindled compared to control group only in ventral hippocampus. PTZ kindled slices showed impaired short-term facilitation and the paired-pulse index was reduced only at dorsal hippocampal slices. Kindling had no significant effect on paired-pulse ratio in ventral hippocampal slices. Our findings indicated that the seizure occurrence affected the neural activity of hippocampus in a regional dependent manner. Although kindling increased fEPSP-area in ventral hippocampus, kindling-induced changes in short-term synaptic plasticity was significant only in dorsal hippocampal slices compared to control group. The difference in the responses of hippocampal dorsal and ventral poles has to be considered in the future researches.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75141374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparing Face and Object Processing in Perception and Recognition 感知与识别中人脸与物体加工的比较

Basic and Clinical Neuroscience Journal Pub Date : 2021-06-28 DOI: 10.32598/bcn.2021.2689.1

N. Dehaghani, B. Maess, R. Khosrowabadi, M. Zarei, S. Braeutigam

引用次数: 0

Ask and You Shall Receive: A closer look on unsolved consciousness issue 问而得:对未解决的意识问题的更仔细的观察

Basic and Clinical Neuroscience Journal Pub Date : 2021-06-20 DOI: 10.32598/bcn.2021.2308.1

A. Motavalli, J. Mahmoudi, A. Majdi, S. Sadigh-Eteghad

引用次数: 0

Alteration of Brain Functional Network and Cortisol Level During Induction and Release of Stress: An EEG Study in Young Male Adults 应激诱导和释放过程中脑功能网络和皮质醇水平的改变:一项年轻成年男性的脑电图研究

Basic and Clinical Neuroscience Journal Pub Date : 2021-06-20 DOI: 10.32598/bcn.2021.2525.1

Z. Rezvani, R. Khosrowabadi, Afrooz Seyedebrahimi, G. Meftahi, B. Hatef

{"title":"Alteration of Brain Functional Network and Cortisol Level During Induction and Release of Stress: An EEG Study in Young Male Adults","authors":"Z. Rezvani, R. Khosrowabadi, Afrooz Seyedebrahimi, G. Meftahi, B. Hatef","doi":"10.32598/bcn.2021.2525.1","DOIUrl":"https://doi.org/10.32598/bcn.2021.2525.1","url":null,"abstract":"Acute stress in a long period of time could drastically influence one's behavioral and cognitive performances. Therefore, it is important to control the stressful situation and release it after a stressful event. In this regard, understanding of brain mechanism of the stress release will help to introduce new practical approaches. In this study, we hypothesized that induction and release of stress will change the brain functional connectivity pattern. Therefore, by recruiting 20 healthy-subjects and exposing them to stressful events using the trier social stress paradigm, we aimed to investigate patterns of these changes. In a session consist of 23 minutes of psychological stress induction and 20 minutes of recovery, subjects' stress was scored by visual analogue scale (VAS). In addition, salivary cortisol level and EEG data of the subjects were also recorded. Subsequently, brain functional connectivity (FC) maps were calculated in a frequency-specific manner. Then, the effects of inducing and release of stress on the changes of VAS, cortisol level, and FC maps were assessed. Our results revealed that inter-hemispheric FCs of the right frontal regions with other regions of the brain decrease; while it increases at the left frontal regions during inducing of mental stress. Interestingly, the release of stress presented a recovery pattern of inter-hemispheric FCs and meaningful FC changes significantly correlate with changes in the cortisol level. our findings highlight important roles of bihemispheric associations in adaptation and coping with stressful conditions.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87444516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Seven Ambiguities in Explaining the Human Memory System in the Principles of Neural Science Book 《神经科学原理》书中解释人类记忆系统的七个歧义

Basic and Clinical Neuroscience Journal Pub Date : 2021-04-02 DOI: 10.20944/PREPRINTS202104.0060.V1

S. A. Batouli

引用次数: 1

Evaluation of the GABAA Receptor Expression and the Effects of Muscimol on the Activity of Wide Dynamic Range Neurons Following Chronic Constriction Injury of the Sciatic Nerve in Rats 大鼠坐骨神经慢性收缩损伤后GABAA受体表达及Muscimol对宽动态范围神经元活性的影响

Basic and Clinical Neuroscience Journal Pub Date : 2021-01-01 DOI: 10.32598/bcn.2021.1726.2

M. Sadeghi, H. Manaheji, J. Zaringhalam, A. Haghparast, S. Nazemi, Z. Bahari, S. Noorbakhsh

{"title":"Evaluation of the GABAA Receptor Expression and the Effects of Muscimol on the Activity of Wide Dynamic Range Neurons Following Chronic Constriction Injury of the Sciatic Nerve in Rats","authors":"M. Sadeghi, H. Manaheji, J. Zaringhalam, A. Haghparast, S. Nazemi, Z. Bahari, S. Noorbakhsh","doi":"10.32598/bcn.2021.1726.2","DOIUrl":"https://doi.org/10.32598/bcn.2021.1726.2","url":null,"abstract":"Introduction: The modality of γ-aminobutyric acid receptors (GABAA) in control of dorsal horn neuronal excitability and inhibition of sensory information is ambiguous. The aim of the present study was to investigate the expression of GABAA receptor and the effects of its agonist muscimol on wide dynamic range (WDR) neuronal activity in the chronic constriction injury (CCI) model of neuropathic pain. Methods: Adult male Wistar rats weighing 200 to 250 g were used for the induction of CCI neuropathy. 14 days after surgery, muscimol (0.5, 1, and 2 mg/kg i.p.) was injected. Then, the behavioral tests were performed. Thereafter, the animals were sacrificed, and the lumbar segments of the spinal cords were collected for Western blot analysis of the GABAA receptor α1 subunit expression. The electrophysiological properties of WDR neurons were studied by single unit recordings in separate groups on the 14th day after CCI. Results: The outcomes indicated the development of thermal hyperalgesia and mechanical allodynia after neuropathy; nonetheless, the expression of GABAA receptor α1 subunit did not change significantly. Moreover, the evoked responses of the WDR neurons to electrical, mechanical, and thermal stimuli were signiﬁcantly increased. 14 days after CCI, muscimol administration decreased thermal hyperalgesia, mechanical allodynia, and hyper-responsiveness of the WDR neurons in CCI rats. Conclusion: It confirms that the modulation of the spinal GABAA receptors after nerve injury can offer further insights to design new therapeutic agents in order to reduce the neuropathic pain symptoms.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89909763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Scale for Activity of Daily Living for Iranian Children (ADLIC): Development and Validation 伊朗儿童日常生活活动量表(ADLIC):发展与验证

Basic and Clinical Neuroscience Journal Pub Date : 2021-01-01 DOI: 10.32598/bcn.2021.2732.2

Hossein Solltaninejad, Mehdi Alizadeh zaree, M. Akbarfahimi, A. Azad, F. Rabiei

{"title":"An Scale for Activity of Daily Living for Iranian Children (ADLIC): Development and Validation","authors":"Hossein Solltaninejad, Mehdi Alizadeh zaree, M. Akbarfahimi, A. Azad, F. Rabiei","doi":"10.32598/bcn.2021.2732.2","DOIUrl":"https://doi.org/10.32598/bcn.2021.2732.2","url":null,"abstract":"Background: Activity of daily living as an ultimate goal of rehabilitation relies on cultural and environmental factor. The purpose of this study was to develop a questionnaire based on Occupational therapy practice frame to accurately evaluate the occupational performance of Iranian children. Methods: This scale was developed in two phases of planning and constructing. The planning phase involved a literature review and a collection of the available evaluation tools in the area. The advice of two expert panels was used to develop a preliminary 87-item questionnaire. In the construction phase, 40 parents were surveyed to assess the popularity of the activities in Iran. After a face to content validation, the final version of the questionnaire was prepared with 93 items. Results: The final 93-item questionnaire was used to assess the daily activity of 3-6 year old children. The 93 items, selected according to criteria found in the literature and the panel of experts, were categorized in 6 areas of occupational therapy practice framework (bathing/showering, washing, personal hygiene, toileting, eating/feeding, functional mobility). Conclusion: The activity of daily living for Iranian children is a useful and culturally relevant tool for measuring the occupational performance of Iranian children. It can be utilized in clinical and population-based researches.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88687208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autobiographical Brand Images Give a Higher Chance to False Memory as Compared to Neutral Images 与中性形象相比，自传式品牌形象更容易产生错误记忆

Basic and Clinical Neuroscience Journal Pub Date : 2021-01-01 DOI: 10.32598/bcn.2021.2275.3

M. Shabani, J. Salehi

{"title":"Autobiographical Brand Images Give a Higher Chance to False Memory as Compared to Neutral Images","authors":"M. Shabani, J. Salehi","doi":"10.32598/bcn.2021.2275.3","DOIUrl":"https://doi.org/10.32598/bcn.2021.2275.3","url":null,"abstract":"Consumers’ prior experiences shape an episodic memory which largely influences their decision-making process. This episodic memory is mainly linked to cognitive and emotional perception and we know that a brand image influences our cognitive and emotional perception. Nevertheless, it has not been well described how autobiographical memories of brand images differ from those of other types of images. In this study, we hypothesized that brand pictures have a higher chance to create false memories as compared to neutral ones. We investigated this hypothesis using the Deese–Roediger–McDermott paradigm with lists of brand pictures from the local market and associated neutral images from the international affective picture system. Thirty graduate students were exposed to image stimuli followed by a distractor task and a recognition task. After the test of normality, reaction times, and false recognition rates of brands and neutral images were statistically compared using a pairwise t-test. The results showed a significant decrease in reaction times and an increase in false recognition rates of brand pictures as compared to neutral ones. Interestingly, the effect of gender on the creation of false memory by autobiographical brand images was not significant. We hope these findings could pave the way for a better understanding of the false memory mechanism.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76669885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System 与中枢神经系统人畜共患结核相关的诊断挑战和前景

Basic and Clinical Neuroscience Journal Pub Date : 2020-09-01 DOI: 10.32598/bcn.9.10.11.5.803.3

Prachi R. Bapat, Seema D. Shekhawat, Aliabbas A. Husain, Renuka S. Dodkey, Hatim F. Daginawala, Lokendra K. Singh

{"title":"Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System","authors":"Prachi R. Bapat, Seema D. Shekhawat, Aliabbas A. Husain, Renuka S. Dodkey, Hatim F. Daginawala, Lokendra K. Singh","doi":"10.32598/bcn.9.10.11.5.803.3","DOIUrl":"https://doi.org/10.32598/bcn.9.10.11.5.803.3","url":null,"abstract":"Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis. Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen. Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level. Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82479109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paying Attention to Circadian Rhythms in the Treatment of COVID-19 在COVID-19治疗中关注昼夜节律

Basic and Clinical Neuroscience Journal Pub Date : 2020-04-10 DOI: 10.32598/BCN.11.COVID19.2584.1

Atefeh Bakhtazad, Reza Jafari, M. Khaksari, H. Khastar, M. Salehi, M. Jafarisani, B. Garmabi

引用次数: 2